LOCUS       NM_001347636            3302 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus exocyst complex component 7 (Exoc7), transcript
            variant 3, mRNA.
ACCESSION   NM_001347636 XM_006533735
VERSION     NM_001347636.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Mikami,N., Nguyen,C.L.K., Osawa,Y., Kato,K., Ishida,M.,
            Tanimoto,Y., Morimoto,K., Murata,K., Kang,W., Sugiyama,F., Ema,M.,
            Takahashi,S. and Mizuno,S.
  TITLE     Deletion of Exoc7, but not Exoc3, in male germ cells causes severe
            spermatogenesis failure with spermatocyte aggregation in mice
  JOURNAL   Exp Anim 73 (3), 286-292 (2024)
   PUBMED   38325858
  REMARK    GeneRIF: Deletion of Exoc7, but not Exoc3, in male germ cells
            causes severe spermatogenesis failure with spermatocyte aggregation
            in mice.
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Kuno,A., Ikeda,Y., Ayabe,S., Kato,K., Sakamoto,K., Suzuki,S.R.,
            Morimoto,K., Wakimoto,A., Mikami,N., Ishida,M., Iki,N., Hamada,Y.,
            Takemura,M., Daitoku,Y., Tanimoto,Y., Dinh,T.T.H., Murata,K.,
            Hamada,M., Muratani,M., Yoshiki,A., Sugiyama,F., Takahashi,S. and
            Mizuno,S.
  TITLE     DAJIN enables multiplex genotyping to simultaneously validate
            intended and unintended target genome editing outcomes
  JOURNAL   PLoS Biol 20 (1), e3001507 (2022)
   PUBMED   35041655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3302)
  AUTHORS   Wang,S., Crisman,L., Miller,J., Datta,I., Gulbranson,D.R., Tian,Y.,
            Yin,Q., Yu,H. and Shen,J.
  TITLE     Inducible Exoc7/Exo70 knockout reveals a critical role of the
            exocyst in insulin-regulated GLUT4 exocytosis
  JOURNAL   J Biol Chem 294 (52), 19988-19996 (2019)
   PUBMED   31740584
  REMARK    GeneRIF: Insulin-stimulated GLUT4 exocytosis was markedly inhibited
            in Exoc7 KO adipocytes.
REFERENCE   4  (bases 1 to 3302)
  AUTHORS   Saez,J.J., Diaz,J., Ibanez,J., Bozo,J.P., Cabrera Reyes,F.,
            Alamo,M., Gobert,F.X., Obino,D., Bono,M.R., Lennon-Dumenil,A.M.,
            Yeaman,C. and Yuseff,M.I.
  TITLE     The exocyst controls lysosome secretion and antigen extraction at
            the immune synapse of B cells
  JOURNAL   J Cell Biol 218 (7), 2247-2264 (2019)
   PUBMED   31197029
  REMARK    GeneRIF: Here we show that microtubule stabilization, triggered by
            engagement of the B cell receptor, acts as a cue to release
            centrosome-associated Exo70, which is redistributed to the immune
            synapse. This process is coupled to the recruitment and activation
            of GEF-H1, which is required for assembly of the exocyst complex,
            used to promote tethering and fusion of lysosomes at the immune
            synapse.
REFERENCE   5  (bases 1 to 3302)
  AUTHORS   Shin,S.W., Vogt,E.J., Jimenez-Movilla,M., Baibakov,B. and Dean,J.
  TITLE     Cytoplasmic cleavage of DPPA3 is required for intracellular
            trafficking and cleavage-stage development in mice
  JOURNAL   Nat Commun 8 (1), 1643 (2017)
   PUBMED   29158485
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3302)
  AUTHORS   Moore,B.A., Robinson,H.H. and Xu,Z.
  TITLE     The crystal structure of mouse Exo70 reveals unique features of the
            mammalian exocyst
  JOURNAL   J Mol Biol 371 (2), 410-421 (2007)
   PUBMED   17583731
  REMARK    GeneRIF: Given the low level of sequence conservation within Exo70,
            this structure provides new insights into our understanding of many
            species-specific functions of the exocyst
REFERENCE   7  (bases 1 to 3302)
  AUTHORS   Gerges,N.Z., Backos,D.S., Rupasinghe,C.N., Spaller,M.R. and
            Esteban,J.A.
  TITLE     Dual role of the exocyst in AMPA receptor targeting and insertion
            into the postsynaptic membrane
  JOURNAL   EMBO J 25 (8), 1623-1634 (2006)
   PUBMED   16601687
  REMARK    GeneRIF: Exo70 mediates AMPA receptor insertion at the postsynaptic
            membrane, but it does not participate in receptor targeting.
REFERENCE   8  (bases 1 to 3302)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 3302)
  AUTHORS   Inoue,M., Chang,L., Hwang,J., Chiang,S.H. and Saltiel,A.R.
  TITLE     The exocyst complex is required for targeting of Glut4 to the
            plasma membrane by insulin
  JOURNAL   Nature 422 (6932), 629-633 (2003)
   PUBMED   12687004
  REMARK    GeneRIF: The exocyst complex is required for targeting of Glut4 to
            the plasma membrane by insulin
REFERENCE   10 (bases 1 to 3302)
  AUTHORS   Davies,P.A., Wang,W., Hales,T.G. and Kirkness,E.F.
  TITLE     A novel class of ligand-gated ion channel is activated by Zn2+
  JOURNAL   J Biol Chem 278 (2), 712-717 (2003)
   PUBMED   12381728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645861.12.
            
            On Mar 17, 2020 this sequence version replaced NM_001347636.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.543145.1,
                                           SRR7345562.1364361.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL645861.12        54609-54729         c
            122-187             AL645861.12        54383-54448         c
            188-372             AL645861.12        52859-53043         c
            373-478             AL645861.12        52572-52677         c
            479-701             AL645861.12        49099-49321         c
            702-869             AL645861.12        48261-48428         c
            870-962             AL645861.12        45566-45658         c
            963-1108            AL645861.12        43539-43684         c
            1109-1261           AL645861.12        43169-43321         c
            1262-1360           AL645861.12        42737-42835         c
            1361-1423           AL645861.12        42402-42464         c
            1424-1490           AL645861.12        41967-42033         c
            1491-1556           AL645861.12        40514-40579         c
            1557-1677           AL645861.12        39449-39569         c
            1678-1773           AL645861.12        39134-39229         c
            1774-1837           AL645861.12        38202-38265         c
            1838-1879           AL645861.12        37945-37986         c
            1880-2013           AL645861.12        37520-37653         c
            2014-3302           AL645861.12        35992-37280         c
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.11 cM"
     gene            1..3302
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /note="exocyst complex component 7"
                     /db_xref="GeneID:53413"
                     /db_xref="MGI:MGI:1859270"
     exon            1..121
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            122..187
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            188..372
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            479..701
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            702..869
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            870..962
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1108
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1261
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1360
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1423
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1490
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1556
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1677
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1773
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1837
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1879
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2013
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..3302
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2171..2176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /note="hexamer: CATAAA"
     polyA_site      2190
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /note="major polyA site"
     regulatory      3275..3280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
                     /note="hexamer: ATTAAA"
     polyA_site      3302
                     /gene="Exoc7"
                     /gene_synonym="Exo70; sec70"
ORIGIN      
        1 ggaagccgag cagggtttgg agctaaaaca gcggggagtg gggacagcgc tgtccgctgc
       61 tatgattccc ccgcaggagg cttccgcccg gcggcgggag atcgaggaca aactgaagca
      121 ggaggaggag acgctgtcgt ttatccgaga cagcctggag aagagcgacc agctcactag
      181 gaacatggtg tccatcctgt cgtcctttga gagccgactc atgaagctgg agaactctat
      241 catccctgtg cacaagcaga cagagaacct acagaggctg caggagaacg tggagaagac
      301 gttatcctgc ctggaccacg ttatcagcta ctaccacgta gccagcgaca cggagaagat
      361 catccgagag ggccccacag gtaggctgga agagtacctg ggaagtatgg ccaaaatcca
      421 gaaggctgtg gagtattttc aggacaatag cccagacagc ccagaactca acaaagtgaa
      481 gctgctgttt gagcgaggga aggagtccct ggagtcggag ttccgcagtc tgatgacccg
      541 gcacagcaag gtggtctccc ccgtgctcct cctggacctc atcagtgctg acgacgagct
      601 ggaggtgcag gaggacgtgg tcctggagca cctgcccgag agcgtgctca gagacgtggt
      661 ccgcatctcc cgctggctgg tggaatatgg tcggaaccaa gacttcatga atgtctacta
      721 ccagatccgc tccagccagc tggaccgctc catcaagggt ctgaaggagc attttcgcaa
      781 aagcagttcc tcttctgggg ttccctactc ccccgccatc cccaataaga ggaaagacac
      841 gcccaccaag aagcccatca agcggccagg gacgatccgt aaggctcaga accttctgaa
      901 acagtattcc cagcatggtc tagatgggaa aaaggggggc tctaacctca ttcctctgga
      961 agggagagac gacatgctgg acgtggagac ggacgcctac attcactgcg tcagtgcctt
     1021 cgtcaagctg gcgcagagtg aataccggct gctgatggag atcatccctg agcatcacca
     1081 gaagaaaacc tttgactcct tgatacagga tgccctggac gggctgatgc ttgaagggga
     1141 gaacatcgtg tctgctgcca ggaaagccat catccgccat gacttctcca cagtgctcac
     1201 cgtcttcccc atcctgcggc acctcaagca gaccaagccc gagtttgacc aggtgctcca
     1261 gggcacagca gccagcacca agaacaagct gcccggcctc atcacctcca tggagaccat
     1321 tggggccaaa gctctagaag actttgctga taacatcaag aatgatccag acaaggaata
     1381 caacatgcct aaagacggca ctgttcatga gctcacaagc aatgccatcc tgttcctaca
     1441 gcagcttctg gacttccagg agacagcagg tgccatgctg gcctcccaag aaaccagctc
     1501 ttcggccacc agctacagct ccgagttcag caagcggctg ctgagcacct acatctgcaa
     1561 agtcttgggt aacctgcagc tgaacttact aagcaagtcc aaggtgtacg aggatccagc
     1621 gctgagcgcc atcttcctac acaacaacta caattacatc ctcaagtccc tggagaagtc
     1681 tgagctgatc cagctggtgg ctgtaaccca gaagactgcc gagcgctcct accgggagca
     1741 catcgagcag cagatccaga cctaccagcg cagctggcta aaggtgactg actacatcgc
     1801 agagaagaac ctacctgtgt tccagcctgg agtcaagctc cgggacaaag agcggcagat
     1861 gattaaggaa cgtttcaagg ggttcaatga tggactcgaa gagctgtgca agattcagaa
     1921 ggtctgggct attccagaca cagagcagag agacaagatt cgacaggctc agaaagacat
     1981 tgtcaaggag acctacgggg cctttctgca caggtatggc agcgtgccct tcaccaaaaa
     2041 cccggagaaa tacattaagt accgcgtgga gcaggtggga gacatgatcg atcgcctttt
     2101 cgacacctct gcttgagtct gccagtgttt ctgcccagtt ctgccggcat gcctagcatg
     2161 tcattggact cataaaccag tggtaactca cttccgagcc gggtgagtgt gaagtccttc
     2221 ggaacagaga cctgtgtgcc caaaccagga gccccacccc cagatagtcc tggtgtctgc
     2281 gccttccctg cagccttcat ctgcacacca gcgtcaccca gagtgtaggt cctgtcacgc
     2341 cttgggtctc catgatggag tgcatctggc cagcagccat gtggatacca agaataggat
     2401 ggcaggcttc accctggtct gctttcatcc cttcacccat ggatgtgaat gggctcaaag
     2461 agaaataggc cacatcacag ccaacagacc taaaggaaag gccgccaggc cacactctct
     2521 taggaagggc attgtccgga tgctgagctc tggaatgctc tgacacctgg gggtccgcta
     2581 gctgtcagga ggcaggactg ctctgtctct ggttcctgtg gagctaggcg cttcagaaag
     2641 tgtttggagg aattctgagc caccctctgg ggacagccgc tcagccacct gtttcctggt
     2701 ccccagcttc tgtactcgcc ggcctgggcc atgcaccagt ggttgagtgg cttaggctga
     2761 gagtgtgagg gacggggaac tagggggcaa agcagaacaa cccagggtca aaccggaggg
     2821 tcacaaatgt aaagttggcc cctactgcca ggacggccgg gaacggctgt gttccaaggg
     2881 cagcccttac catgcacttg ggagatggtt ggttcttctt atctacacag aggggagggg
     2941 agagcctcct gttagagagt ggagctgaca tgtctctctg agacactgtt gtaaccctca
     3001 cctagctgta ggacctacac tgcaccctta agtctatatc cctaggccca ctctgttaca
     3061 gaccaggctg tccaccatgc acacacaccc tgccaggggc tgggtcagac atgagccaca
     3121 cccatgagag ggaaggtgtg gtcagcggcc cctcctccag gagctgctgt cagggagagg
     3181 ggctgttctt ggctgctcca gaatgttctt ccagacagag tggtcaaagg cagaaattct
     3241 tgctccagag cctcctttct tcagatctca gctaattaaa ggttgggtct ggcccgtccc
     3301 aa
//
