LOCUS       NM_175353               2737 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus exocyst complex component 6 (Exoc6), mRNA.
ACCESSION   NM_175353 XM_914925
VERSION     NM_175353.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Mirciov,C.S., Wilkins,S.J., Dunn,L.A., Anderson,G.J. and
            Frazer,D.M.
  TITLE     Characterization of Putative Erythroid Regulators of Hepcidin in
            Mouse Models of Anemia
  JOURNAL   PLoS One 12 (1), e0171054 (2017)
   PUBMED   28135344
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2737)
  AUTHORS   Sano,H., Peck,G.R., Blachon,S. and Lienhard,G.E.
  TITLE     A potential link between insulin signaling and GLUT4 translocation:
            Association of Rab10-GTP with the exocyst subunit Exoc6/6b
  JOURNAL   Biochem Biophys Res Commun 465 (3), 601-605 (2015)
   PUBMED   26299925
  REMARK    GeneRIF: These results suggest that the association of Rab10-GTP
            with Exoc6/6b is a molecular link between insulin signaling and the
            exocytic machinery in GLUT4 translocation.
REFERENCE   5  (bases 1 to 2737)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2737)
  AUTHORS   Bloom,M.L., Simon-Stoos,K.L. and Mabon,M.E.
  TITLE     The hemoglobin-deficit mutation is located on mouse chromosome 19
  JOURNAL   Mamm Genome 9 (8), 666-667 (1998)
   PUBMED   9680389
REFERENCE   7  (bases 1 to 2737)
  AUTHORS   Bloom,M.L. and Simon-Stoos,K.L.
  TITLE     The hemoglobin-deficit mouse: analysis of phenotype and
            hematopoiesis in the transplant model
  JOURNAL   Blood 90 (5), 2062-2067 (1997)
   PUBMED   9292544
REFERENCE   8  (bases 1 to 2737)
  AUTHORS   Bannerman,R.M., Garrick,L.M., Rusnak-Smalley,P., Hoke,J.E. and
            Edwards,J.A.
  TITLE     Hemoglobin deficit: an inherited hypochromic anemia in the mouse
  JOURNAL   Proc Soc Exp Biol Med 182 (1), 52-57 (1986)
   PUBMED   3960859
REFERENCE   9  (bases 1 to 2737)
  AUTHORS   Bannerman,R.M., Edwards,J.A. and Pinkerton,P.H.
  TITLE     Hereditary disorders of the red cell in animals
  JOURNAL   Prog Hematol 8, 131-179 (1973)
   PUBMED   4596202
REFERENCE   10 (bases 1 to 2737)
  AUTHORS   Scheufler,H.
  TITLE     [An additional house mouse mutant with anemia (hemoglobin
            deficiency)]
  JOURNAL   Z Versuchstierkd 11 (5), 348-353 (1969)
   PUBMED   5405927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY100185.1, AK082881.1, CD806857.1, AK076455.1 and AC110212.12.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_914925.1, NM_175353.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151524.1, AK151838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               BY100185.1         2-406
            406-826             AK082881.1         385-805
            827-829             CD806857.1         326-328
            830-2000            AK082881.1         809-1979
            2001-2463           AK076455.1         174-636
            2464-2737           AC110212.12        102908-103181       c
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.32 cM"
     gene            1..2737
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /note="exocyst complex component 6"
                     /db_xref="GeneID:107371"
                     /db_xref="MGI:MGI:1351611"
     exon            1..148
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2462
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /note="SEC15-like 1; SEC15 homolog; SEC15-like protein 1;
                     exocyst complex component Sec15A"
                     /codon_start=1
                     /product="exocyst complex component 6"
                     /protein_id="NP_780562.2"
                     /db_xref="CCDS:CCDS29779.1"
                     /db_xref="GeneID:107371"
                     /db_xref="MGI:MGI:1351611"
                     /translation="MAESCEALGTVPEHERILQEIESTDTACVGPTLRSVYDDQPNAH
                     KKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITELLKVRADAEKLKVQVTDTNRRFQ
                     DAGKEVIIQTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSMKRYYSALKT
                     MEQLENVYFPRVSQYRFCQLMMETLPKLREDIKDISMSDLKDFLESIRKHSDKIGEAA
                     MKQAQQQKSFSVALQKQNNMRFGKNMHVNNDRILEEKSDVIPKHALEEEAENDEEVLT
                     VQDLVDFSPVYRCLHIYSALGDEETFENYYRKQRKKQARLVLQPQSSVHETVDGYRRY
                     FTQIVGFFVVEDHILHVTQGLVTRVYTEELWNMALSKIIAVLRAHSSYCTDPDLVLEL
                     KNLIVIFADTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGIFRDIFEEDNYSPIPI
                     GSEEEYKVVISRFPFQDPDLEKQSFPKKFPMSQSVPLIYIQVKEFIYASLKFSESLHR
                     SSTEIDDMLRKSTNLLLTRILSSCLLNLIRKPHIGLTELVQIIINTTHLEQACKYLED
                     FITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMAE
                     SDGRASGYLMDLINFLRSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQI
                     SMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFIDLRQLLDLFMVWDWSTYLADY
                     GQPASKYLRVNPHAALTLLEKMKDTSKKNNIFAQFRKNDRDRQKLIETVVRQLRGLVT
                     GMSQHT"
     exon            149..320
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..368
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..459
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..505
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..710
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..866
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..935
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1019
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1066
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1187
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1259
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1357
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1463
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1573
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1685
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1820
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2000
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2142
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2216
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2329
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2737
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /note="hexamer: AATAAA"
     polyA_site      2737
                     /gene="Exoc6"
                     /gene_synonym="4833405E05Rik; C430002C19; hbd; msec15;
                     Sec15; Sec15l1"
                     /note="major polyA site"
ORIGIN      
        1 ggtccgcgcg ccgccgcgcc cggccggcgc ctccgcttcc agccaagatg gcggagagct
       61 gcgaggctct gggcacggtc ccggagcacg agcggatctt gcaggagatc gaaagcaccg
      121 acaccgcctg cgtagggccc accctccgat ctgtgtatga tgatcagcca aacgcacaca
      181 agaagtttat ggaaaagcta gacgcttgta tccgcaatca tgacaaggaa attgaaaaaa
      241 tgtgtaactt ccatcaccag ggctttgtgg atgcgattac ggaactcctc aaagtaaggg
      301 ccgatgcgga aaaactgaag gtgcaggtta ccgataccaa ccgaaggttt caagatgcag
      361 gaaaagaggt gataatccaa acagaagata ttattcggtg taggattcag cagagaaata
      421 ttacaaccgt agtagagaaa ttacagttat gcctcccagt gttggagatg tacagtaagc
      481 tgaaggaaca gatgagcatg aaaaggtatt actccgcact taaaacaatg gaacagctag
      541 agaatgtgta ctttccccgg gtcagccagt accgcttctg ccagctcatg atggagacac
      601 tccctaaact ccgggaagac atcaaagaca tctccatgtc tgatctcaag gactttctgg
      661 aaagcatccg aaagcattct gacaaaatag gtgaagcagc catgaagcag gcacaacagc
      721 agaagagctt cagtgttgct ctgcagaagc aaaataatat gaggtttggg aaaaacatgc
      781 atgtaaataa tgacaggatt ctagaagaga agagtgatgt tataccgaag catgcacttg
      841 aagaggaggc ggagaacgac gaggaggtct taactgttca agatctcgtt gatttttccc
      901 ctgtttaccg atgcttgcac atttattctg ctttgggtga tgaagaaaca tttgaaaatt
      961 attaccggaa gcaaaggaag aagcaggcac gcctggttct gcagccgcag tcgagtgtgc
     1021 atgaaacagt tgatggctat agaagatatt tcactcaaat tgtagggttc tttgttgtgg
     1081 aagatcacat tttacacgtg acccaaggat tagtaaccag ggtctacact gaggaactct
     1141 ggaacatggc cctctcaaag ataattgctg tcctcagagc tcactcatct tactgcactg
     1201 accctgacct tgttctggag ctgaagaatc tcatcgtaat ttttgcagac actctgcagg
     1261 gttatggctt cccagtcaac cggctctttg accttttatt cgaaataaga gatcaatata
     1321 acgaaacact gctgaagaag tgggctggta ttttcaggga catttttgaa gaagataatt
     1381 acagccccat ccctattggc agtgaggaag aatataaagt agtcatcagt agattcccgt
     1441 ttcaggatcc agacctcgaa aagcaatctt tcccaaagaa gtttcctatg tcccagtctg
     1501 tgcctcttat ttatattcaa gttaaagaat ttatttatgc cagtcttaaa ttttcagagt
     1561 cgctacaccg aagctcaaca gaaatagatg acatgcttag gaaatcaacc aatctgctgc
     1621 tgaccagaat tctgagtagc tgtttactga accttattag aaaacctcat ataggtttga
     1681 cagagctggt gcaaattatc ataaacacaa cacacctgga acaagcttgc aaatacctag
     1741 aggactttat aactaacatt acaaatattt ctcaagaaac cgttcacacc acaagacttt
     1801 atggactttc tacttttaag gatgctcgac atgcggcaga aggagaaata tataccaaac
     1861 tcaatcaaaa aattgatgaa tttgttcagc tggctgatta tgactggacc atggctgagt
     1921 cagatgggag agcaagtggt tatttaatgg atcttattaa ttttctgaga agcatctttc
     1981 aagtgtttac ccatttgcct gggaaagttg cccagacagc ttgcatgtca gcctgccaac
     2041 atctgtccac atccttaatg cagatgctac tggacagtga gttaaagcag atcagcatgg
     2101 gagccgtgca gcagtttaac ctcgatgtca tacagtgcga actgtttgcc agctctgagc
     2161 ctgtgccagg attccaaggg gacaccctgc agctggcctt cattgacctc agacagctcc
     2221 ttgacctgtt tatggtttgg gattggtcta cttacctggc tgactatggg cagccggctt
     2281 ccaagtacct ccgagtgaac ccacacgcag ccctcactct tttggagaag atgaaggaca
     2341 ccagcaagaa gaataacata ttcgcccagt tccggaagaa tgaccgagac agacagaagc
     2401 tgatagagac agtggtgaga cagctcagag gcttggtgac tggtatgtcc cagcacacgt
     2461 agaccagacc catgcctgag tgcttctctg tggccagcac tggtcgtgag acaataactt
     2521 gtttacagaa gccaaaaact gtagtagagg aaagacactg atgagggctt aaacaagcaa
     2581 tggcggcaaa catcatttgt atggattttt aaatgactga ttactatttt atatataaaa
     2641 atataacaac ttttttcaat tttagaagaa aagtcaaaag tgtaatatat aatcccaata
     2701 aattgtgtac aaaactgatt gcaaatatta gaaaaaa
//
