LOCUS       NM_207214               4659 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus exocyst complex component 5 (Exoc5), mRNA.
ACCESSION   NM_207214 XM_127714
VERSION     NM_207214.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4659)
  AUTHORS   Wu,H., Nguyen,H., Hashim,P.H., Fogelgren,B., Duncan,F.E. and
            Ward,W.S.
  TITLE     Oocyte-specific EXOC5 expression is required for mouse oogenesis
            and folliculogenesis
  JOURNAL   Mol Hum Reprod 30 (8) (2024)
   PUBMED   39037927
  REMARK    GeneRIF: Oocyte-specific EXOC5 expression is required for mouse
            oogenesis and folliculogenesis.
REFERENCE   2  (bases 1 to 4659)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4659)
  AUTHORS   Rohrer,B., Biswal,M.R., Obert,E., Dang,Y., Su,Y., Zuo,X.,
            Fogelgren,B., Kondkar,A.A., Lobo,G.P. and Lipschutz,J.H.
  TITLE     Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment
            Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell
            Degeneration, and Decreased Visual Function
  JOURNAL   Int J Mol Sci 22 (10), 5083 (2021)
   PUBMED   34064901
  REMARK    GeneRIF: Conditional Loss of the Exocyst Component Exoc5 in Retinal
            Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor
            Cell Degeneration, and Decreased Visual Function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4659)
  AUTHORS   Fujimoto,B.A., Young,M., Nakamura,N., Ha,H., Carter,L., Pitts,M.W.,
            Torres,D., Noh,H.L., Suk,S., Kim,J.K. and Polgar,N.
  TITLE     Disrupted glucose homeostasis and skeletal-muscle-specific glucose
            uptake in an exocyst knockout mouse model
  JOURNAL   J Biol Chem 296, 100482 (2021)
   PUBMED   33647317
  REMARK    GeneRIF: Disrupted glucose homeostasis and skeletal-muscle-specific
            glucose uptake in an exocyst knockout mouse model.
REFERENCE   5  (bases 1 to 4659)
  AUTHORS   Zuo,X., Kwon,S.H., Janech,M.G., Dang,Y., Lauzon,S.D., Fogelgren,B.,
            Polgar,N. and Lipschutz,J.H.
  TITLE     Primary cilia and the exocyst are linked to urinary extracellular
            vesicle production and content
  JOURNAL   J Biol Chem 294 (50), 19099-19110 (2019)
   PUBMED   31694916
REFERENCE   6  (bases 1 to 4659)
  AUTHORS   Polgar,N., Lee,A.J., Lui,V.H., Napoli,J.A. and Fogelgren,B.
  TITLE     The exocyst gene Sec10 regulates renal epithelial monolayer
            homeostasis and apoptotic sensitivity
  JOURNAL   Am J Physiol Cell Physiol 309 (3), C190-C201 (2015)
   PUBMED   26040895
  REMARK    GeneRIF: Sec10-knockout mouse model revealed significant defects in
            renal tubule epithelial cells.
REFERENCE   7  (bases 1 to 4659)
  AUTHORS   Fogelgren,B., Polgar,N., Lui,V.H., Lee,A.J., Tamashiro,K.K.,
            Napoli,J.A., Walton,C.B., Zuo,X. and Lipschutz,J.H.
  TITLE     Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in
            Mice Cause Ureteropelvic Junction Obstructions
  JOURNAL   PLoS One 10 (6), e0129346 (2015)
   PUBMED   26046524
  REMARK    GeneRIF: Findings show exocyst complex component 5 protein Sec10 is
            critical for the development of the urothelium in ureters.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4659)
  AUTHORS   Heider,M.R. and Munson,M.
  TITLE     Exorcising the exocyst complex
  JOURNAL   Traffic 13 (7), 898-907 (2012)
   PUBMED   22420621
  REMARK    Review article
REFERENCE   9  (bases 1 to 4659)
  AUTHORS   Saito,T., Shibasaki,T. and Seino,S.
  TITLE     Involvement of Exoc3l, a protein structurally related to the
            exocyst subunit Sec6, in insulin secretion
  JOURNAL   Biomed Res 29 (2), 85-91 (2008)
   PUBMED   18480549
REFERENCE   10 (bases 1 to 4659)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025618.6, AK164067.1, AK134562.1 and AV025936.2.
            
            On Mar 21, 2009 this sequence version replaced NM_207214.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157473.1, AK134562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               CT025618.6         86834-87375
            543-2397            AK164067.1         265-2119
            2398-4366           AK134562.1         1911-3879
            4367-4659           AV025936.2         733-1025
FEATURES             Location/Qualifiers
     source          1..4659
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 25.36 cM"
     gene            1..4659
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /note="exocyst complex component 5"
                     /db_xref="GeneID:105504"
                     /db_xref="MGI:MGI:2145645"
     exon            1..542
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..2642
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /note="exocyst complex component Sec10; SEC10-like 1"
                     /codon_start=1
                     /product="exocyst complex component 5"
                     /protein_id="NP_997097.1"
                     /db_xref="CCDS:CCDS49474.1"
                     /db_xref="GeneID:105504"
                     /db_xref="MGI:MGI:2145645"
                     /translation="MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLE
                     EFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEH
                     ISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAA
                     DVIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEVSRMREVAAV
                     LLHFKGYSHCIDVYIKQCQEGAYLRNDIFEDAAILCQRVNKQVGDIFSNPEAVLAKLI
                     QSVFEIKLQSFVKDQLEECRKSDAEQYLKSLYDLYTRTTGLSSKLMEFNLGTDKQTFL
                     SKLIKSIFISYLENYIEVEIGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIR
                     QRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTIL
                     VEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLI
                     SSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDEN
                     NVLIQYTNACVKVCVYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLIYEHLQQYSYS
                     CMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLAN
                     LDKNILHSFVQLRADYRSARLARHFS"
     exon            543..637
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..785
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..980
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1045
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1074
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1184
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1229
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1370
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1453
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1663
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1811
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1920
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2041
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2128
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2237
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2453
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..4659
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2995..3000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
                     /note="hexamer: ATTAAA"
     polyA_site      3022
                     /gene="Exoc5"
                     /gene_synonym="Gm76; PRO1912; SEC10; Sec10l1"
ORIGIN      
        1 cactggagat gctcgctctt ccgggtgagg tgactcaagt ctcccggtcc cttcaagaga
       61 ttaaaacact cctcagaagg tcttaagaac ctacacccgg aatctcaagg gactggaata
      121 ctcttctcgc ccacttccgg gacggcggcc cgcgaggctc aagacgcgtc accctgtcgc
      181 aaacgagcgc ctccgcggcc cgctcgccgc tcgctccttt cgcccgcccc gcgaagtcgg
      241 ccgggcgcgc gcagccccac ttccggcgtg cgaggcggtg acaatgggag cggcgcgggc
      301 ggcgccggga ggcagctgac aggcgtctgc ggctccgctt catggctgct ctccctctct
      361 gccttcgctg tgtgaggacc ggggcagcca gcagcggtgc gcagcccggg ccggaggcgg
      421 taggccgagc tgggactggt gagcggcgcc gctgaggcgc agcatgtgaa gcggagacgg
      481 cctcgagcgc ggggcgagcc tctcagccgg ccggcatggc cacgacggcc gagctcttcg
      541 aggagccttt tgtggccgat gaatacattg aacgtctcgt gtggagaacc ccaggaggtg
      601 gttctagggg tggacctgaa gcttttgatc ctaaaaggtt attagaagaa tttgtgaatc
      661 atattcaaga actgcagata atggatgaaa ggattcaaag gaaagtggag aaattagaac
      721 aacagtgtca gaaggaagct aaggagtttg ctaagaaggt acaggagctc cagaaaagca
      781 accaggttgc tttccaacat ttccaagagc tagatgagca cattagctat gtagctacca
      841 aagtgtgtca ccttggagac cagttggaag gggtaaacac acctaggcaa cgtgcagtgg
      901 aggcacagaa attgatgaaa tactttaatg agtttctaga tggagaattg aaatctgatg
      961 tttttacaaa ttctgaaaag ataaaggaag cagcagacgt cattcaaaaa ctgcatctga
     1021 ttgcccagga gttacctttc gataggtttt cagaagtaaa atcaaaaatt gcaagtaaat
     1081 accatgactt agaatgccag ctgattcagg agtttacaag tgcccaaaga agaggggagg
     1141 tctcccggat gagggaggtg gctgcagtcc tccttcattt taagggttat tcccattgta
     1201 ttgatgttta tataaagcag tgccaggagg gtgcttactt gagaaatgac atatttgaag
     1261 atgcagcaat actctgtcag cgagtgaaca agcaggttgg agacatcttt agtaatccag
     1321 aagcagtgct ggctaagctt attcagagtg tgtttgaaat caaactacag agttttgtga
     1381 aggatcagtt agaagaatgt aggaaatctg atgctgagca gtatcttaaa agtctctatg
     1441 atctgtatac aagaaccacc ggtctttcca gcaaattgat ggagtttaac ttaggtactg
     1501 ataaacagac tttcttgtct aagcttatca aatccatttt catttcctat ctggagaact
     1561 atattgaagt ggagattgga tatttgaaaa gcagaagtgc tatgatccta cagcgctatt
     1621 atgattcaaa aaaccaccaa aagagatcca ttggcacagg aggtattcaa gatttgaaag
     1681 aaaggattag acaacgtacc aacttaccac tggggccaag tattgataca catggggaaa
     1741 ctttcctatc tcaagaagtg gtagttaatc ttttacaaga aaccaaacaa gcctttgaaa
     1801 gatgtcatag gctttctgat ccttctgatt taccaaggaa tgcctttaga atttttacca
     1861 ttcttgtgga atttttatgt attgagcata ttgattatgc tttagaaacg ggtcttgctg
     1921 gaatcccatc atcagattct aggaatgcaa atctctactt tttggatgtt gtacaacagg
     1981 ccaatactat ttttcatctt tttgacaaac agtttaatga tcacctaatg ccactaataa
     2041 gctcttctcc taagttatct gaatgcctcc agaagaaaaa agagataatt gagcagatgg
     2101 agatgaaatt ggatactggc attgatagga cattaaattg tatgattgga cagatgaagc
     2161 atatcttggc tgcagaacaa aagaaaacag attttaagcc agaagatgag aacaatgttt
     2221 tgattcagta tactaatgca tgtgtaaaag tttgtgttta tgtaagaaaa caagttgaga
     2281 agattaaaaa ttccatggat gggaagaatg tggacacagt tctgatggaa cttggagtac
     2341 gttttcatcg gcttatttat gaacatcttc aacaatattc ctatagttgt atgggtggca
     2401 tgcttgcaat ttgcgacgtg gctgagtata gaaaatgtgc caaagacttc aagattccaa
     2461 tggtattaca tctttttgat actctgcatg cactttgcaa tctcctggtc gtggctccag
     2521 ataatttaaa acaagtctgc tcgggagaac aacttgccaa tctggacaag aacatactcc
     2581 actcctttgt acaacttcgt gctgactata gatctgcccg cctggcgcga cacttcagct
     2641 gagctgaatt tacaaaggca atggattgtt ttctcagaag gcctcggtaa tgggaagcac
     2701 aggagattcc ttatgacacc gccaatattt tatgggaaaa aatgactgga agaaagcagc
     2761 agccatactt acctggaatt ttgtttgaaa tttggacacc tctagctgta tttttatctt
     2821 ttccctgtta tgttgaattc tatactttaa tttataaatt tcaaattcta taaacctaca
     2881 tgactgttat aatcctggaa aatgttggtg tcagaaaatg aatgaaattc accagtgttc
     2941 tggttcttgg tttttaacat attctacttg gaaatcttat cttcctgttt ttgcattaaa
     3001 aataggcaaa agtgcagtaa aactatattt cttatttatc agtttttcag tgaaattttc
     3061 agtgctggtg attattaatc aagctattag gttttcctaa agaacttctc acatctcaag
     3121 aggatcccgg ttgagcatca tttgtgtagg tggtgatgtg cttttcctgt agggcagcag
     3181 cagtgctggt ctaaggaaaa tctcacgagc tgaactaact gttgatgaac cattttaagt
     3241 agacactagg aacagatcag aatgttatct gctttctggg taaaacttaa agtttactat
     3301 tttttatttg ataaatagat tttaagtcaa ttaattagca agaaattaat aaaactacct
     3361 tattttatat ttaacttaag gtggaagact tttaaggacc atatttgtta ttttaatact
     3421 cttaaaggag taaaaaattg atgtatagtg taaacggtgt atgtgagaaa taacaccatg
     3481 tttagcaaca gtgcagtcag tcccttaaga ctaatcttga atgagatggg atggctaaac
     3541 atgcaggagt cttctatttt aagaggaact gagaatttta gataatgaat agtatatatt
     3601 ccaagtttgg aggcaagctt gcactgaaag cctgcttttc agacctgtag agtctgtcat
     3661 tctccattct cattctccag tctcaaagca tttctgaagt tagtacttct tgaagattat
     3721 taattgaatt ggcttaatat ggcaacataa taattcactc acaaaatttt aaatatcaaa
     3781 taaaacttta gaaaggccat tgctcataga cctatcaatt tactctaaga atacaaacta
     3841 ggttatatgt tgtccactat tctaagttgt gtgtagttca cagccatcta ggaaccaggt
     3901 aaactgcaat cttcagttca ttcatagcat tttttttctt tcagtgtagg attttggtct
     3961 aatttggagg aactgttttt cttttgagaa cctgactgaa tagttatcaa cattatcaaa
     4021 ctgcctaggt ccagagctaa ccactgcaca gcttactgtt gactgaattt tcactttctg
     4081 tttagcccag tgttaacgat ggtaagcggc gggcaatgag caggccaact tttgtcattg
     4141 tcacttttgc aggatatagt ggcaggttta gaggctttcc agatagctgt cctcagaaaa
     4201 gagagagcca gaacaggttc tcgatactag caaagctctg tgcttgtact gttaccactt
     4261 agaacgtact gatgtgaact caaattatac ctctgttact taaagccaac agtttaaggc
     4321 agtagtttta ctggccattt gaactctttg tacagtgtca atttgtaaaa aaaaaaaaaa
     4381 aaaaaaaagg aaaaaaaaaa gaaagaaaaa tatcaaatga aacatcagat gacattttaa
     4441 gacttctaaa tcagagaagc acttcaaatt attttgtttg gattaatttt taaaatgtaa
     4501 accagttact tgttgcttag atattttgtt aattattatt tccatgcttg agttctgtgc
     4561 aatattttcc attatgtcca gtgacaggac aaagaaaatt caaagtgaat accttattta
     4621 gacatgttaa cgttcatgct caataaacaa attccctgc
//
