LOCUS       NM_009148               4781 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus exocyst complex component 4 (Exoc4), transcript
            variant 1, mRNA.
ACCESSION   NM_009148
VERSION     NM_009148.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4781)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4781)
  AUTHORS   Liang,S., Wang,Y., Kang,M., Deng,J., Chen,L., Hong,X., Hou,F.F. and
            Zhang,F.
  TITLE     Generation and characterization of an inducible renal proximal
            tubule-specific CreERT2 mouse
  JOURNAL   Front Cell Dev Biol 11, 1171637 (2023)
   PUBMED   37215091
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4781)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4781)
  AUTHORS   Blake,G.E.T., Zhao,X., Yung,H.W., Burton,G.J., Ferguson-Smith,A.C.,
            Hamilton,R.S. and Watson,E.D.
  TITLE     Defective folate metabolism causes germline epigenetic instability
            and distinguishes Hira as a phenotype inheritance biomarker
  JOURNAL   Nat Commun 12 (1), 3714 (2021)
   PUBMED   34140513
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4781)
  AUTHORS   Fais,M., Sanna,G., Galioto,M., Nguyen,T.T.D., Tran,M.U.T., Sini,P.,
            Carta,F., Turrini,F., Xiong,Y., Dawson,T.M., Dawson,V.L., Crosio,C.
            and Iaccarino,C.
  TITLE     LRRK2 Modulates the Exocyst Complex Assembly by Interacting with
            Sec8
  JOURNAL   Cells 10 (2), 203 (2021)
   PUBMED   33498474
  REMARK    GeneRIF: LRRK2 Modulates the Exocyst Complex Assembly by
            Interacting with Sec8.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4781)
  AUTHORS   Tsuboi,T., Ravier,M.A., Xie,H., Ewart,M.A., Gould,G.W.,
            Baldwin,S.A. and Rutter,G.A.
  TITLE     Mammalian exocyst complex is required for the docking step of
            insulin vesicle exocytosis
  JOURNAL   J Biol Chem 280 (27), 25565-25570 (2005)
   PUBMED   15878854
  REMARK    GeneRIF: the exocyst complex serves to selectively regulate the
            docking of insulin-containing vesicles at sites of release close to
            the plasma membrane
REFERENCE   7  (bases 1 to 4781)
  AUTHORS   Sans,N., Prybylowski,K., Petralia,R.S., Chang,K., Wang,Y.X.,
            Racca,C., Vicini,S. and Wenthold,R.J.
  TITLE     NMDA receptor trafficking through an interaction between PDZ
            proteins and the exocyst complex
  JOURNAL   Nat Cell Biol 5 (6), 520-530 (2003)
   PUBMED   12738960
  REMARK    GeneRIF: SAP102 interacts with the PDZ-binding domain of Sec8, a
            member of the exocyst complex.  Interactions between the two
            proteins are involved in the delivery of N-methyl-D-aspartate
            receptors to the cell surface in heterologous cells and neurons.
REFERENCE   8  (bases 1 to 4781)
  AUTHORS   Peng,X.R., Jia,Z., Zhang,Y., Ware,J. and Trimble,W.S.
  TITLE     The septin CDCrel-1 is dispensable for normal development and
            neurotransmitter release
  JOURNAL   Mol Cell Biol 22 (1), 378-387 (2002)
   PUBMED   11739749
REFERENCE   9  (bases 1 to 4781)
  AUTHORS   Thomas,J.W., Lee-Lin,S.Q. and Green,E.D.
  TITLE     Human-mouse comparative mapping of the genomic region containing
            CDK6: localization of an evolutionary breakpoint
  JOURNAL   Mamm Genome 10 (7), 764-767 (1999)
   PUBMED   10384057
REFERENCE   10 (bases 1 to 4781)
  AUTHORS   Friedrich,G.A., Hildebrand,J.D. and Soriano,P.
  TITLE     The secretory protein Sec8 is required for paraxial mesoderm
            formation in the mouse
  JOURNAL   Dev Biol 192 (2), 364-374 (1997)
   PUBMED   9441674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132453.3, AC152961.2, AC141927.3, AC154020.3 and AC155915.2.
            
            On Mar 19, 2018 this sequence version replaced NM_009148.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173235.1, BC034644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC132453.3         139109-139219       c
            112-301             AC132453.3         122218-122407       c
            302-496             AC132453.3         110966-111160       c
            497-681             AC132453.3         91430-91614         c
            682-791             AC132453.3         82953-83062         c
            792-1035            AC132453.3         55893-56136         c
            1036-1210           AC132453.3         40390-40564         c
            1211-1356           AC152961.2         104973-105118
            1357-1445           AC152961.2         108544-108632
            1446-1542           AC141927.3         103966-104062       c
            1543-1762           AC154020.3         74179-74398
            1763-1899           AC154020.3         131886-132022
            1900-2055           AC154020.3         155187-155342
            2056-2234           AC155915.2         134206-134384       c
            2235-2376           AC155915.2         85816-85957         c
            2377-2555           AC155915.2         77866-78044         c
            2556-2715           AC155915.2         74908-75067         c
            2716-4781           AC155915.2         22466-24531         c
FEATURES             Location/Qualifiers
     source          1..4781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 14.59 cM"
     gene            1..4781
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /note="exocyst complex component 4"
                     /db_xref="GeneID:20336"
                     /db_xref="MGI:MGI:1096376"
     exon            1..111
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2953
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exocyst complex component Sec8; SEC8-like 1"
                     /codon_start=1
                     /product="exocyst complex component 4 isoform 1"
                     /protein_id="NP_033174.2"
                     /db_xref="CCDS:CCDS19987.1"
                     /db_xref="GeneID:20336"
                     /db_xref="MGI:MGI:1096376"
                     /translation="MAAEAAGGKYRSTVSKSKDPSGLLISVIRTLSTSDDVEDRENEK
                     GRLEEAYEKCDRDLDELIVQHYTELTTAIRTYQSITERITNSRNKIKQVKENLLSCKM
                     LLHCKRDELRKLWIEGIEHKHVLNLLDEIENIKQVPQKLEQCMASKHYLSATDMLVSA
                     VESLEGPLLQVEGLSDLRLELHSKKMNLHLVLIEELHRHLYIKSTSRVVQRNKEKGKM
                     SSHGKDPSPGPLIDVSNIPTPRKFLDASQYSAAGGSSVREMNLQDVKEDLECDPEENS
                     TLFMGILIQGLARLKKIPETVKAIKERLEQELKQIVKRSTTQVADSAYQRGESLTVDN
                     QPRLLLELLELLFDKFNAVATAHSVVLGYLQDSVGTQLTQQEEIKLYDMADVWVKIQD
                     VLQMLLTEYLDMKNTRTASEPSAQLSYASTGREFAAFFAKKKPQRPKNSLFKFESSSH
                     AISMSAYLREQRRELYSRSGELQGGPDDNLIEGGGTKFVCKPGARNITVIFHPLLRFI
                     QEIEHALGLGPAKQCPLREFLTVYIKSIFLNQVLAEINKEIEGVTKTSDPLKILANAD
                     TMKVLGVQRPLLQSTIIVEKTVQDLMNLMHDLSAYSDQFLNMVCVKLQEYKDTCSTAY
                     RGIVQSEEKLVISASWAKDDDISRLLKSLPNWTNMAQPKQLRPKREEEEDFIRAAFGK
                     ESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLAGRTKSAFSNLSTSQMLSP
                     AQESHVNMDLPPVSEQIMQTLSELAKTFQDMADRCLLVLHLEVRVHCFHYLIPLAKEG
                     NYAIVANVESMDYDPLVVKLNKDISAMEEAMSASLQQHKFQYIFEGLGHLISCILING
                     AQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTADELLNLV
                     VDQGVKYTELEYIHALTLLHRSQTGVGDQTTQNTRLQRLKEIICEQAAIKQATKDKKI
                     TTV"
     exon            112..301
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..496
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..681
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..791
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1035
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1210
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1356
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1445
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1542
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1762
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1899
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2055
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2234
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2376
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2555
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2715
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..4781
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4755..4760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /note="hexamer: ATTAAA"
     polyA_site      4781
                     /gene="Exoc4"
                     /gene_synonym="Sec8; Sec8l1"
                     /note="major polyA site"
ORIGIN      
        1 acctggctct cgctcccgta ccaagatggc ggcagaagca gctggtggga aatacaggag
       61 cacagtcagc aaaagcaaag acccctcggg gctgctcatc tcggtgatca ggactctgtc
      121 taccagtgat gatgttgaag accgagaaaa tgagaaaggt cgccttgaag aagcctatga
      181 gaagtgtgac cgtgacctgg atgaattgat cgttcagcac tacacagaat tgaccacagc
      241 cattcgcaca taccagagta tcacagaacg catcactaac tcgaggaata aaatcaagca
      301 ggtcaaagag aatctgcttt cctgcaagat gctgctgcat tgcaaacggg atgagcttcg
      361 taagctgtgg attgaaggaa tcgagcataa gcacgtcctg aacctactgg atgagattga
      421 gaacatcaag caagtgcctc aaaagctgga acagtgcatg gccagcaagc actacctcag
      481 cgccaccgac atgctggtgt cagcagtgga gtccctggag ggtccactgc tccaggtgga
      541 agggctcagt gatctcaggc tggaacttca cagcaagaag atgaacctgc acttggttct
      601 catagaggaa ctgcaccgcc atctgtatat caaatccact agccgggtgg tacagcgtaa
      661 caaggaaaag gggaagatga gttctcatgg caaagatccc tctcctggtc ctctgattga
      721 tgtttcaaac atccctactc cacgcaaatt ccttgatgct tctcaatatt ctgctgctgg
      781 aggctcaagt gtgagggaga tgaacctgca agacgtcaag gaggacttgg agtgtgaccc
      841 agaggagaac agcactcttt tcatgggaat tcttattcag ggcctggcca gactgaagaa
      901 gatccctgag acagttaaag ccattaaaga gcgtctggag caggagctaa agcagattgt
      961 gaagaggtca accacccagg tagcagacag tgcttatcag aggggagaga gcctcactgt
     1021 ggacaatcag ccaaggttac tcctagaact gctggaactg ttgtttgata agtttaatgc
     1081 cgtagccact gcacactcag tggtcctggg gtacctccag gactctgttg ggacccagct
     1141 aacacagcag gaggagatca aattatatga catggcagat gtgtgggtga agatccagga
     1201 tgtgctgcag atgctgttga ctgagtactt ggatatgaag aacacacgca ccgcctcaga
     1261 gccatcagcc caactaagct atgccagtac tggacgagag ttcgcagcct tttttgccaa
     1321 gaagaaacca cagaggccaa agaattctct tttcaagttt gaatcatcct cccatgctat
     1381 cagcatgagc gcctatctcc gagaacaaag aagggagctc tacagtcgga gtggagaact
     1441 ccagggaggt cctgatgaca acttaattga aggtggagga acaaaatttg tctgcaaacc
     1501 tggagccaga aatattaccg tcatattcca tccattactg agatttattc aggagattga
     1561 acatgccctg ggacttggcc ctgccaaaca gtgtcctctt cgagagtttc ttaccgtgta
     1621 tatcaagagc atcttcctta atcaggtctt ggctgagatc aacaaggaga ttgaaggcgt
     1681 caccaaaacc tcagacccct tgaagatcct ggctaatgca gacaccatga aggttctggg
     1741 agtgcagcgg cctcttctac agagcacaat catcgtggag aagacagtac aagacctcat
     1801 gaaccttatg catgacttga gtgcgtattc agatcagttc ctcaacatgg tgtgtgtgaa
     1861 gctccaggag tacaaggaca cgtgctccac agcctacagg ggcattgtcc agtcagaaga
     1921 gaaacttgtc atcagtgctt cttgggcaaa ggatgatgat atcagcagac tcttgaaatc
     1981 gctgccaaac tggactaaca tggctcagcc caaacagcta aggcctaaga gggaggagga
     2041 agaagacttc ataagggcag cctttggcaa ggagtctgaa gtcctgattg gaaaccttgg
     2101 tgacaaactc attcctccac aagacattct ccgtgacgtt agtgacctca aagccttggc
     2161 caacatgcac gaaagcctgg aatggctggc aggtcgaaca aagtcagctt tctccaacct
     2221 ttctacatcc cagatgcttt cccctgctca agagagccac gtgaacatgg accttccccc
     2281 agtgtctgaa cagatcatgc agacactgag tgagcttgcc aagaccttcc aggacatggc
     2341 tgaccgctgc ttgctcgtcc tgcatctgga agtgagagtt cattgtttcc actatctcat
     2401 ccctctggca aaggagggga actatgccat cgttgccaat gtggagagta tggattacga
     2461 ccctctagtg gtcaagctca acaaagacat cagtgccatg gaagaggcca tgagcgccag
     2521 cctccagcaa cataagttcc agtacatctt tgaaggtctg ggacacctca tctcctgtat
     2581 cctcattaat ggggcccaat acttccggcg catcagtgag tctggcatca agaaaatgtg
     2641 taggaacatt tttgttcttc agcagaactt gaccaacatc accatgtcac gggaggcaga
     2701 cttggacttt gcaaggcagt actacgagat gctgtacaac acagccgacg agctcctgaa
     2761 cctggtggtg gaccagggtg tgaagtacac agagctagag tacatccatg ccctgaccct
     2821 gctgcaccga agccagactg gtgtggggga ccagaccacc cagaacacca ggctgcagag
     2881 actcaaggag atcatctgtg agcaggctgc catcaagcaa gccaccaagg acaagaaaat
     2941 aaccactgtg tgatggagtg cacctcactg ggtgtgggtg gggttcccag tatgcacggc
     3001 cacagactct agctgctcag catggcctga gctggctgtg ctccatctac actgaggctt
     3061 agtgggtagg cggtggatta ttttctcttt agttttgctt tttcatatga acgctaagaa
     3121 agtttgcagt acagaatgtt gcctaacaaa cactttagtc tattctcaag ggatgagggt
     3181 gggacaggga ggaggccatg ccaagttgct ggactctgag aaaggaatga aggaaagccg
     3241 actgccacct aagttttagg accatcctga aatacttaat aaggcctgtg gcataagcag
     3301 tcggctttct ctggtcttag ccttgtcagt ttatagttta gtgtagtaag tatatgcaca
     3361 ttgctttgtc tccattgcca aaatcaagta agcgcttctc agctggcttc ccagcccaaa
     3421 acagatctct gtgagcctag gagatagcgg tcctttatcc caaccctggg acagactgca
     3481 cactctagca ggattgttcg caggctgctg gtttggtttt acaagcttct tgttttattc
     3541 cttctgtatt aaaaccagtt aagagcagtg actgtccttc cagaggacca gggttcaagt
     3601 ctcaacaccc gcaaacagag gctcataacc ctctgtaact tcagcttcat ctgacctgag
     3661 gccctcgtag tactacatgc acgtggtgca cagacataca tgcaggcaaa aatactcata
     3721 cacacaaagt aaaaaaaaaa aaaaatgatc ataaaactat tgctaaaaat agtagggagg
     3781 gagaaaggtg actcactgtt aaagaacttc catctcacac accatccagg gtaaattgta
     3841 aggagcgtcc tcttgctccc atgcacactg tcttactgac ttggcttgtt gctgtgacaa
     3901 aacactcctc gacacaagca cctcaagaaa ggaaggttta tttagctaac ctcaaaaggt
     3961 acagctcatc agagcaggga gggtgacagc aggagcctga ggcaggggca ctcaggaagc
     4021 atggagcagt gcatgctgtg ttcagcccgc ttcctccttt ccgtgcagtc cagggtctca
     4081 gccacagtca gagtgggcct tccaacctca actaatataa ctcaaataat tccacataag
     4141 caaggcctat aaaacactga ccaaaatcaa cacacgcaca caccatctac acagacacac
     4201 aaaaataact ttaaaaaatt ttgacaatga aaaagtaaat caattattat aataaacatt
     4261 gaaactacta aaaagttgag agaggtctaa agcagtacaa gtattttgta taaagcaata
     4321 cagctcaggt ctgcttggct gaaagcaggg aagacgggac atttccccac gcagctgcct
     4381 ctgaagcttc ttttttctgt ttgttggttt ttggtttttc aaggcagtat ttctgtcctg
     4441 aactcactct acagaccagg ctggcccggc cttgaactca gagatcccct tgggattaaa
     4501 ggtttgcacc accacaccca gctgacttgc cctttcctga tatggctgcc tgcaatgctc
     4561 caggccctca agtcctctcg ctactcaagg ttcataggtc actggacaca acagtttatc
     4621 aacaaggatt catcttgaat acactaggga aggagagaca gaggactggc cattcaaggt
     4681 cactgtcaga ccctgaggga gggaattttc acacttgttt ctaacaactt tggactggat
     4741 gggaataacc aaaaattaaa aactgttttg agatgcttaa a
//
