LOCUS       NM_001370800            3968 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus exocyst complex component 3-like 2 (Exoc3l2), mRNA.
ACCESSION   NM_001370800 XM_006540475
VERSION     NM_001370800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3968)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3968)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3968)
  AUTHORS   O'Callaghan,P., Zarb,Y., Noborn,F. and Kreuger,J.
  TITLE     Modeling the structural implications of an alternatively spliced
            Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec
  JOURNAL   PLoS One 13 (8), e0201557 (2018)
   PUBMED   30086153
  REMARK    GeneRIF: Data describe a novel splice variant of murine Exoc3l2,
            termed Exoc3l2a and suggest a possible functional implications of
            the resulting domain excision from this isoform of EXOC3L2 based on
            structural similarities with its paralog EXOC3L3, which is
            implicated in tunneling nanotube formation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3968)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   5  (bases 1 to 3968)
  AUTHORS   Geyer,S.H., Reissig,L., Rose,J., Wilson,R., Prin,F., Szumska,D.,
            Ramirez-Solis,R., Tudor,C., White,J., Mohun,T.J. and Weninger,W.J.
  TITLE     A staging system for correct phenotype interpretation of mouse
            embryos harvested on embryonic day 14 (E14.5)
  JOURNAL   J Anat 230 (5), 710-719 (2017)
   PUBMED   28185240
REFERENCE   6  (bases 1 to 3968)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3968)
  AUTHORS   Kreuger,J. and O'Callaghan,P.
  TITLE     Failure to Genotype: A Cautionary Note on an Elusive loxP Sequence
  JOURNAL   PLoS One 11 (10), e0165012 (2016)
   PUBMED   27768725
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3968)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   9  (bases 1 to 3968)
  AUTHORS   Barkefors,I., Fuchs,P.F., Heldin,J., Bergstrom,T.,
            Forsberg-Nilsson,K. and Kreuger,J.
  TITLE     Exocyst complex component 3-like 2 (EXOC3L2) associates with the
            exocyst complex and mediates directional migration of endothelial
            cells
  JOURNAL   J Biol Chem 286 (27), 24189-24199 (2011)
   PUBMED   21566143
  REMARK    GeneRIF: exoc3l2 silencing inhibits VEGF receptor 2 phosphorylation
            and VEGFA-directed migration of cultured endothelial cells.
REFERENCE   10 (bases 1 to 3968)
  AUTHORS   Pang,A.L., Taylor,H.C., Johnson,W., Alexander,S., Chen,Y., Su,Y.A.,
            Li,X., Ravindranath,N., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149052.3.
            
            On Jun 3, 2019 this sequence version replaced XM_006540475.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC149052.3         182843-182909       c
            68-604              AC149052.3         176192-176728       c
            605-1199            AC149052.3         171674-172268       c
            1200-1311           AC149052.3         167776-167887       c
            1312-1413           AC149052.3         166307-166408       c
            1414-1514           AC149052.3         166116-166216       c
            1515-1625           AC149052.3         164840-164950       c
            1626-1761           AC149052.3         161462-161597       c
            1762-1884           AC149052.3         157022-157144       c
            1885-2040           AC149052.3         156433-156588       c
            2041-2162           AC149052.3         154419-154540       c
            2163-3968           AC149052.3         149434-151239       c
FEATURES             Location/Qualifiers
     source          1..3968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.92 cM"
     gene            1..3968
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /note="exocyst complex component 3-like 2"
                     /db_xref="GeneID:74463"
                     /db_xref="MGI:MGI:1921713"
     exon            1..67
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            68..604
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2454
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /codon_start=1
                     /product="exocyst complex component 3-like protein 2"
                     /protein_id="NP_001357729.1"
                     /db_xref="CCDS:CCDS90173.1"
                     /db_xref="GeneID:74463"
                     /db_xref="MGI:MGI:1921713"
                     /translation="MPILKSLGVGDPKVPRAGTLPLRSSRNPFEDTPTLEEEDAELGT
                     LPNGTSCRRRATLEKLAGLAPFRLGWTSGRRAGSPGDGQVRSFLGRVLAPGIRRSSAD
                     FGLLNRLQGFRTHGDEEPAGEAARRLAFLRLGRGPKPRRASLAERLVPAGEAAPEPPP
                     KVPEPPKIKEPLSVLEILGLIQRRELARADEHILELEAEAPTAEAEAGAGRRARDVAL
                     LYEALQRELWALVRESLASPGPGTGAVSQLGLVLLQEEAADARRGPGAARKLRTHWAE
                     AVARAARERLEEAAAPGARGALAGQLEALRARLLEDVAAVRGRLAPAYPAGLRAGAVY
                     LRGYHEALAEWLGAAARRRLPLADRYALLHWHNHVYPREILGLVDLVALENGELGPLL
                     SAGTLRGLEDECVTDVKAQTRAALLRVLQEDEEQWGSMDYRPSNLAQDVCELLEEHTE
                     RAPHISQEFVERMAYCCLGGLAEFLQSFQQRVERFHENPGIRELPSDTYISRTISMVN
                     CGPPLRSLAERLARVGPPESEPAREASAIALDRVTRLCHRVLAELLFQELQPHFNKLM
                     RRKWLSSSEALDGIVGTLGAQALALRRMQDEPYQVLVAELHRRALVEYVRPLLRGRLR
                     CRSARTRSRVAGRLREDAAQLQRLFRRLESQAYWLDQVVPHLAEILQLEDTPSIQVEV
                     GVLVRDYPDIRRKHVAALLDIRGLRNTAARQEILAVARDLELSESGALPPSRDRAFFA
                     DIPVPRTSFCLGLPLLLGRLPVSRLARPNLACLPLRPRPPSPVRARADR"
     exon            605..1199
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1311
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1413
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1514
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1625
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1761
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1884
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2040
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2162
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..3968
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3945..3950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /note="hexamer: AATAAA"
     polyA_site      3968
                     /gene="Exoc3l2"
                     /gene_synonym="4933417E01Rik; Gm19857"
                     /note="major polyA site"
ORIGIN      
        1 agtcctggcc caagtagtct ggggactgga cagcaagagg ggacagaagg acaggcacag
       61 acagaaggtg ccagcctgtc aaaaatgcca atcctgaaga gcctgggggt gggagaccct
      121 aaggtgccac gagcagggac tctgcccctg cgatcctctc gcaacccctt tgaagacact
      181 ccaacgctgg aagaagagga cgcggagctg gggacactgc ccaatgggac atcgtgccgc
      241 cggcgggcca cgctggagaa gctagctggt ctggccccct tccggctggg ctggacctca
      301 ggcaggcggg caggcagccc cggagacggg caagtgcgct ctttcttggg ccgtgtgctg
      361 gcaccgggca tacggaggag ctccgcagat ttcggcctcc taaaccggct tcaggggttc
      421 cgaacccatg gcgatgagga gccagctgga gaagccgctc gaagactggc tttcctgaga
      481 ctcgggcgtg ggcccaagcc ccggcgggca tccctggcgg agagactggt acctgcagga
      541 gaggcagccc ctgagccccc acccaaagtc ccggagcccc ccaaaataaa ggaaccactg
      601 tcagtgctgg agatcctggg cctgatccag aggcgcgagc tggcgcgagc ggacgagcac
      661 atcctggagc tggaggcgga ggcgccgacg gcggaggccg aggcgggcgc ggggcggcgc
      721 gcgcgggacg tggcgctgct gtacgaggcg ctgcagcgcg agctctgggc gctggtgcgc
      781 gagtcgctgg cttccccggg acccggcacc ggcgcggtgt cgcagctggg cctcgtgctg
      841 ctgcaggagg aggcggcgga cgcgcgccgc ggccccgggg cggcccgcaa gctgcgcacg
      901 cactgggccg aggcggtggc gcgcgcagcg cgcgaacgtc tggaggaggc ggcggcgccg
      961 ggcgcgcgcg gggcgctggc tgggcagctg gaggcgctgc gcgcgcgcct gttggaggac
     1021 gtggccgctg tgcgcggacg cctggcgccc gcctaccctg cggggctgcg cgccggcgcc
     1081 gtctacctgc gtggctacca cgaggcactg gccgagtggc tcggggcggc cgcgcgccgc
     1141 aggctcccgc tggcggatcg ttatgcgctg ttgcactggc acaatcatgt gtaccccagg
     1201 gagatcctgg gcctggttga cttggttgcc ttggagaatg gagagctggg gcccctcctg
     1261 tctgctggca cactgcgggg tctggaagat gaatgtgtca cagacgtgaa ggctcagacc
     1321 cgagcagccc ttcttcgagt gttgcaagaa gatgaggaac agtggggcag catggactac
     1381 cgacccagca acctggccca ggatgtttgt gagctgctag aagagcacac ggagagagca
     1441 ccccacatca gtcaggagtt cgtggagaga atggcttact gctgcctggg aggtctggca
     1501 gagttcctgc agagcttcca gcagcgagtg gaacgatttc acgagaaccc agggatccga
     1561 gagctgccct ctgacaccta catcagcaga actatctcga tggtcaactg cgggcccccc
     1621 ctgaggtctc tggctgagcg actggccagg gtggggcccc ctgagagtga accggccagg
     1681 gaagcttcag ccatcgctct ggaccgtgtg acccgactct gccatcgtgt ccttgctgaa
     1741 ttgttgttcc aggaactaca gcctcacttc aacaagctga tgcgcaggaa gtggctgagc
     1801 agttcagaag ctctggatgg catcgtgggc acactcggcg cccaggccct ggccctgcgc
     1861 agaatgcagg atgaaccgta ccaggttctg gtggctgagc tgcaccgacg ggcgctggtg
     1921 gagtatgtgc ggccactgct ccgcgggcgc ctgcgctgtc gctctgcgag gacccgcagc
     1981 cgtgtggcgg ggaggctccg cgaggacgcg gcgcagctgc agcggttgtt tcggcggctg
     2041 gagtcccagg cttattggct tgaccaagtg gtgccacact tggcagagat cctacagttg
     2101 gaggacactc cgagcatcca ggtggaggtc ggggtgctgg tgcgggacta cccagacatc
     2161 aggcggaagc atgtggcagc cctccttgac atcagaggtc ttcgaaacac agctgcccgt
     2221 caggagatcc tggcggtggc ccgggacctg gaactatctg aaagtggtgc cctaccaccc
     2281 tctagggacc gtgccttctt tgccgacatc cctgtgcccc gcacatcttt ctgtcttggc
     2341 ctccctctcc tcttgggacg cctcccagtg tcccggctgg ccaggcccaa tctggcttgt
     2401 ctgcccctgc ggcctcgtcc tccatcacca gttagagccc gagccgatcg ctgaggcacc
     2461 cggtgcccat gttgctgctg atagaccctc ctcccttcca cgtgactccc tgcctgagac
     2521 accgacttct gggataggag gttccttaga taacccaccc agcccggagc atcccctcca
     2581 gaagggaaac tgaggccaga acgagcaaag agttccccca aggctgccag ggtcattccc
     2641 cgcaccctcc tcccttgtat cccagcatgg catggcgggg agccttctgg aaggctttac
     2701 agaaatatcc tagccccacc tcctttcccc tcacctcaag gtctggcccc aatccaacgt
     2761 attaaggaat ggtagatact tagaataaag aggtttctat ttaacactag gaagggctga
     2821 gtcccaagtg caggggcggg aaaacagggc ccagggccaa gctctcttgc acacacccaa
     2881 ggccaccagg gccggggtcc aactcctagg gaagccacaa atgaccagat actcctcagt
     2941 tgccgttgat accgagtcct tgagctgcgg ttctgaggcc tgcacttgtc tgtcctgagc
     3001 cagataacgc tgttttatcc atcccggtgt ctgatgttct tctaggtctg cttggcacag
     3061 ccctccccac ccgtgcttag cgagtggggg gaaaaccttg gcgggagagg aaggagctgg
     3121 ggggttgggc tggcagcatc cagggcgccc tcctggattg atgcaggaaa atctcagggt
     3181 gggaaatttt ccagcctctc aagccggagc ccagccggat ccaaatcccc acagagtcct
     3241 tgaggtcacc tccctgttga cctctgcccc tccggcctca gctggacagc tcgtgatgga
     3301 tgcttcctgg cccgggttat gttttatttt attttttcct taagaagtca gaaagaggag
     3361 gcagccaggg gtcagcacag gggccggggt tggaacctca cgcaacgtct tgacattggt
     3421 aacaacatgg cggccctagg ctctagactc tgagcctccg ggctgtgtgc tgcagagggg
     3481 aaggtgtcag tctctgtgct ctgcttcctg ctgtccctgg gaagtggctt aacttctctt
     3541 tgcccagagg atgtccctcc tccttccttg accttctgaa agtgacacct ctgtcattga
     3601 tgagcaggag aggggaactg actgtgggca cttgcacaat tccacatgta tttaatctca
     3661 gcgtggccat gctctgtcat tgtctgactt gctatccctg tcattcaaaa gtcagcttga
     3721 ttgtcgggct tggcgacagc agggctgtga tcccagcagt caggggctga ggcaaaataa
     3781 cagaagtgtt agactagact ggactacatc tcaagacccc accctacaaa gtgtgtggga
     3841 tcaggcgggg aacggtgcct gccaccaagc ctagcagact gagcctggtc ccaggaccca
     3901 catggtggaa tcctaaatgt ctcctgatct acacacccat gctaaataaa atggaataac
     3961 aaatgcaa
//
