LOCUS       NM_177333               4596 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus exocyst complex component 3 (Exoc3), mRNA.
ACCESSION   NM_177333
VERSION     NM_177333.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4596)
  AUTHORS   Mikami,N., Nguyen,C.L.K., Osawa,Y., Kato,K., Ishida,M.,
            Tanimoto,Y., Morimoto,K., Murata,K., Kang,W., Sugiyama,F., Ema,M.,
            Takahashi,S. and Mizuno,S.
  TITLE     Deletion of Exoc7, but not Exoc3, in male germ cells causes severe
            spermatogenesis failure with spermatocyte aggregation in mice
  JOURNAL   Exp Anim 73 (3), 286-292 (2024)
   PUBMED   38325858
  REMARK    GeneRIF: Deletion of Exoc7, but not Exoc3, in male germ cells
            causes severe spermatogenesis failure with spermatocyte aggregation
            in mice.
REFERENCE   2  (bases 1 to 4596)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4596)
  AUTHORS   Walsh,T.G., Li,Y., Williams,C.M., Aitken,E.W., Andrews,R.K. and
            Poole,A.W.
  TITLE     Loss of the exocyst complex component EXOC3 promotes hemostasis and
            accelerates arterial thrombosis
  JOURNAL   Blood Adv 5 (3), 674-686 (2021)
   PUBMED   33560379
REFERENCE   4  (bases 1 to 4596)
  AUTHORS   Heider,M.R. and Munson,M.
  TITLE     Exorcising the exocyst complex
  JOURNAL   Traffic 13 (7), 898-907 (2012)
   PUBMED   22420621
  REMARK    Review article
REFERENCE   5  (bases 1 to 4596)
  AUTHORS   Tsuboi,T., Ravier,M.A., Xie,H., Ewart,M.A., Gould,G.W.,
            Baldwin,S.A. and Rutter,G.A.
  TITLE     Mammalian exocyst complex is required for the docking step of
            insulin vesicle exocytosis
  JOURNAL   J Biol Chem 280 (27), 25565-25570 (2005)
   PUBMED   15878854
  REMARK    GeneRIF: the exocyst complex serves to selectively regulate the
            docking of insulin-containing vesicles at sites of release close to
            the plasma membrane
REFERENCE   6  (bases 1 to 4596)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   7  (bases 1 to 4596)
  AUTHORS   Chin,L.S., Weigel,C. and Li,L.
  TITLE     Transcriptional regulation of gene expression of sec6, a component
            of mammalian exocyst complex at the synapse
  JOURNAL   Brain Res Mol Brain Res 79 (1-2), 127-137 (2000)
   PUBMED   10925150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123833.3 and AC154839.3.
            
            On Aug 17, 2018 this sequence version replaced NM_177333.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141537.1, AK131141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC123833.3         60973-61015
            44-234              AC123833.3         62576-62766
            235-454             AC123833.3         69998-70217
            455-1136            AC154839.3         235-916
            1137-1254           AC154839.3         3337-3454
            1255-1380           AC154839.3         4238-4363
            1381-1481           AC154839.3         8751-8851
            1482-1592           AC154839.3         11137-11247
            1593-1743           AC154839.3         11330-11480
            1744-1866           AC154839.3         12967-13089
            1867-2028           AC154839.3         19376-19537
            2029-2156           AC154839.3         20101-20228
            2157-4596           AC154839.3         21280-23719
FEATURES             Location/Qualifiers
     source          1..4596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..4596
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /note="exocyst complex component 3"
                     /db_xref="GeneID:211446"
                     /db_xref="MGI:MGI:2443972"
     exon            1..43
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            44..234
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2328
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /note="exocyst complex component Sec6; SEC6-like 1"
                     /codon_start=1
                     /product="exocyst complex component 3"
                     /protein_id="NP_796307.2"
                     /db_xref="CCDS:CCDS26640.1"
                     /db_xref="GeneID:211446"
                     /db_xref="MGI:MGI:2443972"
                     /translation="MCKDSACFLTMKETDLEAVATAVQRVAGMLQRPDQLDKVEQYRR
                     REARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINT
                     IESLKDVKDAVVQHSQLAAAVENLKNIFSVPEIVRETQDLIEQGALLQAHRKLMDLEC
                     SRDGLMCEQYRMDSGNKRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTL
                     LVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFAILDRTVTTRIEGTQAD
                     TRESDKMWLVRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLSMYHQALSTRMQ
                     DLASEDLEANEIVSLLTWVLNTYTSAEMMGNVELAPEVDVSALEPLLSPNIVSELLDT
                     YMSTLTSNIIAWLRKALETDKKDWSKETEPEADQDGYYQTTLPAIVFQMFEQNLQVAA
                     QISEDLKTKVLVLCLQQMNSFLSRYKDEAQLYKEEHLRNRQHPHCYVQYMIAIINNCQ
                     TFKESIISLKRKYLKTEAEEGLCLSQPSMDGILDAIAKEGCSSLLEEVFLDLEQHLNE
                     LMTKKWLLGSNAVDIICVTVEDYFNDFAKIKKPYKKRMTAEAHRRVVVEYLRAVMQKR
                     ISFRSAEERKEGAEKMVREAEQLRFLFRKLASGFGEDADGHCDTIVAVAEVIKLTDPS
                     LLYLEVSTLVSKYPDIRDDHIGALLALRGDASRDMKQTIMETLEQGPMQASPNYVPIF
                     KEIVVPSLNVAKLLK"
     exon            235..454
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1136
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1254
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1380
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1481
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1592
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1743
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1866
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2028
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2156
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..4596
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /note="hexamer: ATTAAA"
     polyA_site      2409
                     /gene="Exoc3"
                     /gene_synonym="2810050O03Rik; E430013E20Rik; Sec6; Sec6l1"
                     /note="major polyA site"
ORIGIN      
        1 acttccggtc cggctccggg aggtggcagc ggcgttgcgg acgtgtacct gtggtatgac
       61 atgtgcaaag attctgcctg ctttttgaca atgaaggaga cagacctgga ggctgttgca
      121 acagcagtcc aaagggttgc tgggatgctt cagcgcccag accaactgga caaagtggag
      181 cagtatcgca gaagggaagc tcggaagaag gcctctgtag aggccaggct aaaggctgca
      241 atccagtctc aactagatgg ggtacgcaca ggcttaagcc aactgcacaa tgcactgaat
      301 gacgtcaagg atatccagca gtcactggct gatgtcagca aggactggag gcaaagcatc
      361 aacaccattg agagtctcaa agatgtaaaa gatgcagtgg tgcagcatag ccagctggct
      421 gcagctgtgg agaacctcaa gaacatattc tcagtgcctg agattgtgag ggagacccaa
      481 gatctcatcg agcaaggggc cctcctgcaa gcccaccgga agctaatgga tctggagtgc
      541 tctcgggatg ggctaatgtg tgagcagtac cgcatggaca gtgggaacaa acgggacatg
      601 accctcattc atggctactt tggtagcaca caggggctct ctgatgagct ggctaagcag
      661 ctgtggatgg tgctgcaaag atcactggtc actgtccgcc gggatcctac cttgctggtc
      721 tccgtggtca gaatcattga aagggaagaa aaaattgaca ggcggatact tgatcgaaaa
      781 aagcaaactg ggtttgttcc tcctggaagg cccaaaaact ggaaagaaaa aatgtttgcc
      841 atcttggaca gaactgtgac aactagaatc gaaggtacac aggcagacac cagagaatct
      901 gacaagatgt ggcttgtgcg ccacctggag atcattagga agtatgtcct ggatgatctc
      961 attgttgcca agaacctgat ggtccagtgc ttccctcctc actatgagat ctttaagaac
     1021 ctcctgagca tgtaccacca ggccttgagc actcggatgc aggaccttgc atcagaggac
     1081 cttgaggcca acgagattgt gagcctcttg acatgggtcc taaataccta caccagtgca
     1141 gagatgatgg ggaatgtgga actagcccca gaagtggatg ttagtgccct ggagcccctc
     1201 ctctctccaa acatcgtctc cgagctgctt gacacataca tgtcaacact cacgtccaac
     1261 atcattgcct ggcttcggaa agcactggaa acagacaaga aagactggag caaagagaca
     1321 gagccagaag cagaccagga tggttactat cagactacac ttcctgccat tgtattccag
     1381 atgttcgaac agaatcttca agttgctgct caaataagtg aagatttgaa aacaaaggta
     1441 ttagtgttgt gtcttcagca aatgaattct ttcctaagta gatacaaaga tgaagcccag
     1501 ctttacaaag aagagcacct gagaaaccgg caacacccac actgttatgt gcagtacatg
     1561 attgccatca tcaataactg ccagaccttc aaagaatcca tcatcagtct gaaaaggaag
     1621 tacctaaaaa ctgaagcaga ggagggcctg tgtctgagtc agccaagcat ggatgggatt
     1681 ctagacgcca ttgctaagga aggctgcagc agtctgctag aggaggtctt cctggatcta
     1741 gagcaacatc tgaatgagct gatgacaaag aagtggttgt tagggtcaaa cgctgtggac
     1801 atcatctgtg tcactgtaga agactacttc aatgactttg ccaaaattaa aaagccatat
     1861 aaaaagagaa tgacagctga ggcacacaga cgtgtggtgg tggaatacct gcgggctgtc
     1921 atgcagaagc gtatttcctt tcggagtgct gaagagcgca aggagggcgc cgagaagatg
     1981 gtcagagagg ctgaacagct ccgcttcctg ttccggaagc tggcgtctgg atttggtgag
     2041 gatgcagatg gacactgtga tacaattgtt gcagtggcag aggtcattaa gctcacagac
     2101 ccttctctgc tctatctaga agtctcaact ctggtcagca aatatccaga catcagagat
     2161 gaccacattg gtgcactgct ggcactgcga ggagatgcca gccgggacat gaaacagacc
     2221 atcatggaga cgctggagca gggccccatg caagcaagcc ccaactatgt acccatcttc
     2281 aaggagattg ttgtgcccag tctgaacgtg gcaaagctcc ttaagtagcc ctgtcctccc
     2341 tgctgcccta tgtgtcttta ctgtgtggct tccctgttgt caccatatta aaccaaaagt
     2401 ccgtctctag gtgcttggtg tgatgtcagt tacatgttcc tgtcttctgt ggcatcacac
     2461 tgttctctac tatgagaaaa aaagatgtgt gatgggcatc cccttttctt tcctgctgaa
     2521 gttttgctct gcttcattag cacttggaac ctctgccact taattaaagg aaaagaaagc
     2581 caggaagctt ttcattccta gttgtaggtt cttctgactg gttgtgatac agccatgtcc
     2641 agaggcttca ggagatcatc agatctcagc tgatggatgg ttgtcctctt gttccagagt
     2701 tccagggact accttaaatt taacaaagtt ggaggccccg atagaggatg tccacgtgac
     2761 cttgtaccac atggccattc ttgaatgtgt agactaatgg aatattttct ttctacactt
     2821 gatgacagtg ttaacattct gattttattt cattcttaca aagtgtaaaa aaaaaaatca
     2881 caaataaccc cttttctaag tggaactaag taaaaattcc tctggaactc agaagaaaca
     2941 tgaatttctt agagggactg gctggtattg ttttgatcca ggccctgctt gacaatccac
     3001 tcagtgtgaa tgacagctgg gcagtgaaat gtacactgag aagtattgac aaacagcaat
     3061 gacctttgtg acaaaagatg cttgtgtctc cactgaggtt tctcagtgta ggctgctgct
     3121 gggcgtgtag ggtagacatt aaaatgacca ctggaatacc cacatggtta atgccatttg
     3181 gctctcaggc cttagaggtc aacagaggac aggggaaatc atatttgtga acagtgggta
     3241 gtagaatcat ggagacagga taggaattgt tagaagtcaa gtgatagtac caggctatgt
     3301 actagtgggt agacagtgtt cagtaagata cagggaaagt atggccaaga acctttttag
     3361 aagacaccta tgtacaggat tagatagact attccagtga gtggattgtg tctgcatata
     3421 tcagagttta tagtgtatgc ttcctgaaca gggatgtgtg gctgccattt gccagacagg
     3481 gaagtgtttt gagagagagc agtgaccagg ttattgatcc catgaaatga gctgttagac
     3541 atgaaagggt gtctgcagat tagccaagtc ccttgactgt tttagacaac caaggcaact
     3601 attagaaaag aaagcattta actggggact tgcttacaat ttcaaaggtt tagtccatta
     3661 acataatgga gaggagcaga gcatcataca gttgagtact ggagcaatag ctgagagctg
     3721 ttctgaaggc acagacagac agacagacag acagactctg agcttgacat gggcttttga
     3781 aacttcagag ctcatcccta cctcctgaca cacttctcca atatggccgc ctcctaatcc
     3841 tttcaaatag ttccactctg tggtgactaa gcattgaagt atatgagcct atggaggcca
     3901 ttcttattca caccaccata ttgactttat tcagttgggt ccaggataag tagatgttcc
     3961 aggtcatact ggatcaccag tgagatggag aagcagcaat gagattgatg ctgtttcatt
     4021 cccctttcct catatctgtt gatgcacagt tcaggttgat gggtgagctc cctctaaaga
     4081 aggaaagcat ggacatctag acatttgagt tcaggatgcc agaaccaggc cacctcaaca
     4141 aagtccttta atgcagagtt cagggagagc tgaacaagca gagccacatt gggtcacttc
     4201 ctttctcact gcagtggaat gaagtgtgac ttctaaaaag aaagattgag gtcttaacct
     4261 tagaaccctg aatcagactt gggttgaaag tagaatcatt gcaggtgtga tgtaacttaa
     4321 ggtattcagt cacatggaaa tcgtgtgagt acttgcatgg agatgccagc agccctcaaa
     4381 accaagagga ggcctggaag gactcctttc ctgactcctg gcatgaagca gactgtgact
     4441 cacacagtgt tctttgctag tttacccgtt atatctgctt taagatgact ctaaacttaa
     4501 cagttgagat tcctcttgta aacagccaat gtctgggaat tctgctttga tatgcaattt
     4561 taaatgatct aaaattaaaa taaaaaatgt gttgcg
//
