LOCUS       NM_025588               4277 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus exocyst complex component 2 (Exoc2), transcript
            variant 1, mRNA.
ACCESSION   NM_025588
VERSION     NM_025588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4277)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4277)
  AUTHORS   Xu,J., Liu,H., Lan,Y. and Jiang,R.
  TITLE     Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene
            Expression in Palate Development
  JOURNAL   Front Cell Dev Biol 9, 665109 (2021)
   PUBMED   33898467
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4277)
  AUTHORS   Xu,J., Liu,H., Lan,Y., Park,J.S. and Jiang,R.
  TITLE     Genome-wide Identification of Foxf2 Target Genes in Palate
            Development
  JOURNAL   J Dent Res 99 (4), 463-471 (2020)
   PUBMED   32040930
REFERENCE   4  (bases 1 to 4277)
  AUTHORS   Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X.,
            Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B.,
            Caspary,T., Lipschutz,J.H. and Barral,D.C.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   5  (bases 1 to 4277)
  AUTHORS   Xie,L., Zhu,D., Kang,Y., Liang,T., He,Y. and Gaisano,H.Y.
  TITLE     Exocyst sec5 regulates exocytosis of newcomer insulin granules
            underlying biphasic insulin secretion
  JOURNAL   PLoS One 8 (7), e67561 (2013)
   PUBMED   23844030
  REMARK    GeneRIF: Exocyst sec5 regulates exocytosis of newcomer insulin
            granules underlying biphasic insulin secretion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4277)
  AUTHORS   Nichols,C.D. and Casanova,J.E.
  TITLE     Salmonella-directed recruitment of new membrane to invasion foci
            via the host exocyst complex
  JOURNAL   Curr Biol 20 (14), 1316-1320 (2010)
   PUBMED   20579884
REFERENCE   7  (bases 1 to 4277)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 4277)
  AUTHORS   Saito,T., Shibasaki,T. and Seino,S.
  TITLE     Involvement of Exoc3l, a protein structurally related to the
            exocyst subunit Sec6, in insulin secretion
  JOURNAL   Biomed Res 29 (2), 85-91 (2008)
   PUBMED   18480549
REFERENCE   9  (bases 1 to 4277)
  AUTHORS   Mott,H.R., Nietlispach,D., Hopkins,L.J., Mirey,G., Camonis,J.H. and
            Owen,D.
  TITLE     Structure of the GTPase-binding domain of Sec5 and elucidation of
            its Ral binding site
  JOURNAL   J Biol Chem 278 (19), 17053-17059 (2003)
   PUBMED   12624092
  REMARK    GeneRIF: the structure of the Ral-binding domain of Sec5
REFERENCE   10 (bases 1 to 4277)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049102.1.
            
            On Jun 9, 2003 this sequence version replaced NM_025588.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048154.1, SRR1660815.201104.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..4277
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="exocyst complex component 2"
                     /db_xref="GeneID:66482"
                     /db_xref="MGI:MGI:1913732"
     exon            1..52
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            53..213
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2870
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     exocyst complex component Sec5; SEC5-like 1; SEC5 homolog"
                     /codon_start=1
                     /product="exocyst complex component 2 isoform 1"
                     /protein_id="NP_079864.1"
                     /db_xref="CCDS:CCDS26420.1"
                     /db_xref="GeneID:66482"
                     /db_xref="MGI:MGI:1913732"
                     /translation="MSRSRQPPLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTIC
                     GHNCLLTAEWMSASKIVCRVGQAKNDKGDIIVTTKSGGKGTSTVSFKLLKPEKIGILD
                     QSAVWVDEMNYYDMRTDRNKGIPPLSLRPANPLGIEIEKCKLPQKNLEVLFHGMSADF
                     TSENFSAAWYLIENHSTTSFEQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDA
                     LSAIHQKLEADGTEKVEGSMTQKLENVLNRASNTADTLFQEVLGRKDKADSTRNALNV
                     LQRFKFLFNLPLNIKRNIQKGDYDVVINDYEKAKSLFGKTEVQVFKKYYAEVEAGIED
                     LRELLLKKLLETPSTLHDQKRYIRYLSDLHAPGDPAWQCIGAQHKWTLKLMQDCKEGH
                     MKSLKGHPGPHSPMLDLDNDVRPSVLGHLSQTASLKRGSSFQSGRDDTWRYKTPHRVA
                     FVEKLTKLVLSQLPNFWKLWISYVNGSLFSETAEKSGQSERSKNVRQRQNDFKKMIQE
                     VMHSLVKLIRGALLPLSLREGDGRQYGGWEVQAELSGQWLAHVIQTIRLTYESLTALE
                     IPNDMLQIIQDLILDLRIRCIMVTLQHTAEEIKRLAEKEDWVVDNEGLTSLPCQFEQS
                     IVHSLQSLKGVVDCKPGEASVFQQPKTQEEVCQLCINIMQVFIYCLEQLSTKPDADID
                     TTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCYLERHTFLNIAEHFEKHNFQG
                     IEKITQVSMASLKELDQRLFENYIELKADPIVGSLEPGIYAGYFDWKDCLPPAGVRNY
                     LKEALVNIIAVHAEVFTISKELVPRVLARVVEAVSEELSRLMQCVSSFSRNGALQARL
                     EICALRDTVAIYLTSESRSSFKQALEALPQLASGADKKSLEELLNKFKSSMHLQLTCF
                     QAASPAVMKT"
     exon            214..390
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..517
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..631
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..756
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..837
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..983
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1065
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1168
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1287
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1413
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1538
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1604
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1762
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1884
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1946
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2027
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2087
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2149
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2216
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2333
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2475
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2531
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2654
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2716
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2776
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..4250
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="hexamer: AATAAA"
     polyA_site      3067
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
     regulatory      4113..4118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="hexamer: AATAAA"
     polyA_site      4135
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
     regulatory      4225..4230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="hexamer: AATAAA"
     polyA_site      4250
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggcct ggaaccggtt ggctgggacc tgacaccgcc tgcaagctgc aggttgcttc
       61 tataactgga tcacgagttt gctgcacaaa gtaccatgtc tcgatcccgg cagcccccac
      121 ttgtaacagg catctctcca aatgaaggaa taccttggac caaagtcaca attagagggg
      181 agaacctggg tactggtccc actgacctca taggcttgac aatttgtgga cataattgcc
      241 tcctcacggc agaatggatg tctgcgagta aaattgtctg tcgagtggga caagccaaaa
      301 atgacaaagg agacattatt gtcacaacta agtcaggggg taaaggaacc tcaactgtct
      361 cttttaagct actcaagcct gaaaaaatag gcattttaga tcagtctgca gtgtgggtgg
      421 atgaaatgaa ttattatgat atgcggactg acaggaacaa agggattcct cccttgtctc
      481 tccgtcctgc gaatcctctt ggcattgaaa ttgagaaatg taaacttcct cagaagaact
      541 tagaagtgtt attccatggc atgagtgctg attttacaag tgagaatttt tcagcagcct
      601 ggtatctcat agagaatcac tccaccacca gttttgagca gctcaagatg gcggtcacca
      661 acctcaaaag gcaggccaac aagaagagtg agggtagtct ggcatatgtg aagggcggcc
      721 tcagtacctt ctttgaagct caagatgctc tctcagctat ccatcaaaaa ctagaagcag
      781 atggaactga aaaagtagaa ggatccatga cacagaaatt ggagaatgtc ctcaatagag
      841 caagtaacac cgctgacaca ttgttccaag aagtattagg tcggaaagac aaggcagatt
      901 ccactaggaa cgccctcaac gtacttcagc gatttaaatt tctcttcaac cttcctctca
      961 atattaaacg gaatattcaa aagggggatt atgatgtagt tattaatgat tatgaaaaag
     1021 ccaaatcgct ctttgggaaa acggaggtgc aagttttcaa gaaatattat gctgaagtag
     1081 aagcaggaat tgaagatcta agagagttac ttctaaagaa attgctcgag actccatcaa
     1141 ccttacatga ccagaagcgc tacataaggt atctttccga cctccatgca cctggtgacc
     1201 ctgcttggca gtgtattgga gctcagcaca agtggaccct caagctcatg caagactgca
     1261 aagaaggcca catgaagagc ctaaaaggtc acccaggccc gcacagcccc atgctcgacc
     1321 tagacaacga tgtgcgcccc tcggtgttgg gccacctcag tcagacagcg tcactgaaga
     1381 gggggagcag ctttcagtct ggccgagatg acacatggag gtataagact ccccacagag
     1441 tggcatttgt tgaaaaatta accaagcttg tgttaagtca gctgcctaac ttctggaaac
     1501 tctggatttc atatgttaat ggaagtcttt tcagtgagac ggctgagaag tcaggccaga
     1561 gtgaaagatc aaagaatgtg aggcagagac aaaacgattt caagaaaatg attcaagaag
     1621 taatgcactc cctggtgaag ctgatccggg gagccctgct tccactcagc ctccgagaag
     1681 gggatgggag gcagtatggc ggctgggagg tgcaggcaga gctttcgggg cagtggctcg
     1741 cacacgttat ccagaccata aggctaacat atgaatcact gaccgccctg gagattccca
     1801 atgacatgtt acagattatc caggacctaa ttttggatct ccgaatacgt tgcataatgg
     1861 tgacattgca gcatacggcc gaagagataa agagattagc tgaaaaagaa gactgggttg
     1921 ttgataatga aggactgact tccctaccat gtcagtttga acagagcatt gttcactccc
     1981 tgcagtcctt gaagggtgtt gtcgattgca aacctggaga agccagcgtc tttcaacagc
     2041 ctaaaacgca ggaggaggtt tgccagttat gcatcaatat catgcaggtt tttatatact
     2101 gcctggaaca actgagcacc aagcctgatg cagacataga tactactcat ctttctgttg
     2161 atgtttcttc tcctgatttg tttggaagca tccatgaaga cttcagtttg acttcagagc
     2221 agaggctttt gatagtcctg agtaattgct gctatttaga acgtcacacc ttcctaaaca
     2281 tagcagaaca ttttgaaaaa cacaacttcc agggaataga gaaaataaca caggttagca
     2341 tggcatcgct gaaagaactg gatcaacgac tctttgaaaa ttacattgag ctaaaagcag
     2401 atcccattgt tggatcctta gaacctggga tctacgcagg ctactttgat tggaaggact
     2461 gcctgcctcc ggcaggtgtc agaaactatt taaaagaagc attggtgaat ataattgctg
     2521 tgcatgcaga ggtattcact atttccaagg aactggtgcc acgggtcttg gccagagtgg
     2581 tagaagcagt ctctgaagag ctgagccggc tgatgcagtg cgtctcatcc ttcagcagaa
     2641 atggagcact gcaggccaga cttgaaatct gtgctctgag ggacactgta gccatttacc
     2701 tgacctcgga aagcaggtct agttttaaac aggccctgga ggccctgcct cagcttgcaa
     2761 gtggtgcgga caaaaagtca ctggaagagc tgctcaacaa gttcaagagc agcatgcact
     2821 tgcagctcac ctgcttccaa gctgcgtctc cagcagtcat gaaaacatag gctctgcaag
     2881 aagagcatca gacatggcgg tggagactgt cctcgtgctg tgcagcagag attacacgtc
     2941 aagcactgca tttaacgtct cttttcccca gcatggtggt gcagaaagat gcccatggat
     3001 atttaatttc aatctattta aactaccata gtttaaacat ccaaataaac agtttttgtt
     3061 attgctagct ttggtcctga aaggctgtgt agcatactct tcaaaatgct gtgagtctgg
     3121 ggatttctcc atcatggtcc agagcggccc atggtgtgtg tgtgtgccct tctcagtgcc
     3181 cctcttctag gcctactgtt ggcagtttcc agcccaggtg agacatttga gaagagattt
     3241 gaagtcacag tttttagagc tttgtcctaa actttaaaat aaccatttca tacaagtggt
     3301 tctaagctcc ccaccctgtt tctgtaaaga aaaatataca gtctacacat aaaaatgtta
     3361 atatttggat aaatttgtga tccacaagtc ctcgtatgaa ctctgaattt catagtctga
     3421 ctttcatttc tcccagtgct aaacactgaa gcttgtggtt ctcactcagc cttaagctga
     3481 tggatcactg cagtggtgtg gggagggttc acaaggacct gtatgtggag gccctgtcac
     3541 acccacaagg cctggggaag gcttgtggtc ttcaatgcag cctaaagatg aagccaggct
     3601 cctcggcaag gcagcactcc ctccccctct gccacttccc acgcggtgaa atgtcttgct
     3661 ccatagctgg aaagaggctg ctctggcatg ggctgtgttt tgtaaagatt tgaggtgccc
     3721 caagtgacca ggcactgagc tgtgactcag tggtgagtgg cttgcgcagt agagtcaggt
     3781 cattgtgacc tgcaggcagc tttcacctca ctccatcctt ccgtcagcct ctgttgcact
     3841 tcactcttca gactgatctg tggataatgt aggctcctct tctagagttg acaaaactaa
     3901 ttccagagca cagcatatgt accctgtgga ttatttaagg taaatgagtg tatgtttatt
     3961 tatcacagtg actggaagta gaaattgtaa tcctttgttg caaaataagt atgtaccgca
     4021 ttgtctcctc cctgtgtgct gttattatat ctgacataaa caaactaaat tccaaagcag
     4081 aagtacagaa ccatttgtta ttttaaacac ctaataaata cagtgcacaa agccagtagt
     4141 tgtccttctc tgtaagaccc ctatctttat ttcaccattt ttattagctc tgtaattgct
     4201 tatattcctg attttaaaat ccacaataaa tagtggagtt ctctctttta aaaaaaaaaa
     4261 aaaaaaaaaa aaaaaaa
//
