LOCUS       NP_079864                924 aa            linear   ROD 28-APR-2025
DEFINITION  exocyst complex component 2 isoform 1 [Mus musculus].
ACCESSION   NP_079864
VERSION     NP_079864.1
DBSOURCE    REFSEQ: accession NM_025588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 924)
  AUTHORS   Xu,J., Liu,H., Lan,Y. and Jiang,R.
  TITLE     Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene
            Expression in Palate Development
  JOURNAL   Front Cell Dev Biol 9, 665109 (2021)
   PUBMED   33898467
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 924)
  AUTHORS   Xu,J., Liu,H., Lan,Y., Park,J.S. and Jiang,R.
  TITLE     Genome-wide Identification of Foxf2 Target Genes in Palate
            Development
  JOURNAL   J Dent Res 99 (4), 463-471 (2020)
   PUBMED   32040930
REFERENCE   4  (residues 1 to 924)
  AUTHORS   Seixas,C., Choi,S.Y., Polgar,N., Umberger,N.L., East,M.P., Zuo,X.,
            Moreiras,H., Ghossoub,R., Benmerah,A., Kahn,R.A., Fogelgren,B.,
            Caspary,T., Lipschutz,J.H. and Barral,D.C.
  TITLE     Arl13b and the exocyst interact synergistically in ciliogenesis
  JOURNAL   Mol Biol Cell 27 (2), 308-320 (2016)
   PUBMED   26582389
REFERENCE   5  (residues 1 to 924)
  AUTHORS   Xie,L., Zhu,D., Kang,Y., Liang,T., He,Y. and Gaisano,H.Y.
  TITLE     Exocyst sec5 regulates exocytosis of newcomer insulin granules
            underlying biphasic insulin secretion
  JOURNAL   PLoS One 8 (7), e67561 (2013)
   PUBMED   23844030
  REMARK    GeneRIF: Exocyst sec5 regulates exocytosis of newcomer insulin
            granules underlying biphasic insulin secretion.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 924)
  AUTHORS   Nichols,C.D. and Casanova,J.E.
  TITLE     Salmonella-directed recruitment of new membrane to invasion foci
            via the host exocyst complex
  JOURNAL   Curr Biol 20 (14), 1316-1320 (2010)
   PUBMED   20579884
REFERENCE   7  (residues 1 to 924)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (residues 1 to 924)
  AUTHORS   Saito,T., Shibasaki,T. and Seino,S.
  TITLE     Involvement of Exoc3l, a protein structurally related to the
            exocyst subunit Sec6, in insulin secretion
  JOURNAL   Biomed Res 29 (2), 85-91 (2008)
   PUBMED   18480549
REFERENCE   9  (residues 1 to 924)
  AUTHORS   Mott,H.R., Nietlispach,D., Hopkins,L.J., Mirey,G., Camonis,J.H. and
            Owen,D.
  TITLE     Structure of the GTPase-binding domain of Sec5 and elucidation of
            its Ral binding site
  JOURNAL   J Biol Chem 278 (19), 17053-17059 (2003)
   PUBMED   12624092
  REMARK    GeneRIF: the structure of the Ral-binding domain of Sec5
REFERENCE   10 (residues 1 to 924)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049102.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048154.1, SRR1660815.201104.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     Protein         1..924
                     /product="exocyst complex component 2 isoform 1"
                     /note="exocyst complex component Sec5; SEC5-like 1; SEC5
                     homolog"
                     /calculated_mol_wt=103829
     Region          8..91
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          132..914
                     /region_name="Sec5"
                     /note="Exocyst complex component Sec5; pfam15469"
                     /db_xref="CDD:464733"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1)"
     Site            432
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1)"
     Site            435
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1)"
     Site            440
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1)"
     Site            454
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96KP1; propagated from
                     UniProtKB/Swiss-Prot (Q9D4H1.1)"
     CDS             1..924
                     /gene="Exoc2"
                     /gene_synonym="2410030I24Rik; Gm29675; Sec5; Sec5l1"
                     /coded_by="NM_025588.2:96..2870"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS26420.1"
                     /db_xref="GeneID:66482"
                     /db_xref="MGI:MGI:1913732"
ORIGIN      
        1 msrsrqpplv tgispnegip wtkvtirgen lgtgptdlig lticghncll taewmsaski
       61 vcrvgqaknd kgdiivttks ggkgtstvsf kllkpekigi ldqsavwvde mnyydmrtdr
      121 nkgipplslr panplgieie kcklpqknle vlfhgmsadf tsenfsaawy lienhsttsf
      181 eqlkmavtnl krqankkseg slayvkggls tffeaqdals aihqkleadg tekvegsmtq
      241 klenvlnras ntadtlfqev lgrkdkadst rnalnvlqrf kflfnlplni krniqkgdyd
      301 vvindyekak slfgktevqv fkkyyaevea giedlrelll kklletpstl hdqkryiryl
      361 sdlhapgdpa wqcigaqhkw tlklmqdcke ghmkslkghp gphspmldld ndvrpsvlgh
      421 lsqtaslkrg ssfqsgrddt wryktphrva fvekltklvl sqlpnfwklw isyvngslfs
      481 etaeksgqse rsknvrqrqn dfkkmiqevm hslvklirga llplslregd grqyggwevq
      541 aelsgqwlah viqtirltye sltaleipnd mlqiiqdlil dlrircimvt lqhtaeeikr
      601 laekedwvvd negltslpcq feqsivhslq slkgvvdckp geasvfqqpk tqeevcqlci
      661 nimqvfiycl eqlstkpdad idtthlsvdv sspdlfgsih edfsltseqr llivlsnccy
      721 lerhtflnia ehfekhnfqg iekitqvsma slkeldqrlf enyielkadp ivgslepgiy
      781 agyfdwkdcl ppagvrnylk ealvniiavh aevftiskel vprvlarvve avseelsrlm
      841 qcvssfsrng alqarleica lrdtvaiylt sesrssfkqa lealpqlasg adkksleell
      901 nkfkssmhlq ltcfqaaspa vmkt
//
