LOCUS       NM_001359370            3354 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus exocyst complex component 1 (Exoc1), transcript
            variant 4, mRNA.
ACCESSION   NM_001359370
VERSION     NM_001359370.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3354)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3354)
  AUTHORS   Ogonuki,N., Kyogoku,H., Hino,T., Osawa,Y., Fujiwara,Y., Inoue,K.,
            Kunieda,T., Mizuno,S., Tateno,H., Sugiyama,F., Kitajima,T.S. and
            Ogura,A.
  TITLE     Birth of mice from meiotically arrested spermatocytes following
            biparental meiosis in halved oocytes
  JOURNAL   EMBO Rep 23 (7), e54992 (2022)
   PUBMED   35587095
REFERENCE   3  (bases 1 to 3354)
  AUTHORS   Osawa,Y., Murata,K., Usui,M., Kuba,Y., Le,H.T., Mikami,N.,
            Nakagawa,T., Daitoku,Y., Kato,K., Shawki,H.H., Ikeda,Y., Kuno,A.,
            Morimoto,K., Tanimoto,Y., Dinh,T.T.H., Yagami,K.I., Ema,M.,
            Yoshida,S., Takahashi,S., Mizuno,S. and Sugiyama,F.
  TITLE     EXOC1 plays an integral role in spermatogonia pseudopod elongation
            and spermatocyte stable syncytium formation in mice
  JOURNAL   Elife 10, e59759 (2021)
   PUBMED   33973520
  REMARK    GeneRIF: EXOC1 plays an integral role in spermatogonia pseudopod
            elongation and spermatocyte stable syncytium formation in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3354)
  AUTHORS   Hooper,J.E., Jones,K.L., Smith,F.J., Williams,T. and Li,H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3354)
  AUTHORS   Lee,A.J., Polgar,N., Napoli,J.A., Lui,V.H., Tamashiro,K.K.,
            Fujimoto,B.A., Thompson,K.S. and Fogelgren,B.
  TITLE     Fibroproliferative response to urothelial failure obliterates the
            ureter lumen in a mouse model of prenatal congenital obstructive
            nephropathy
  JOURNAL   Sci Rep 6, 31137 (2016)
   PUBMED   27511831
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3354)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3354)
  AUTHORS   Mizuno,S., Takami,K., Daitoku,Y., Tanimoto,Y., Dinh,T.T.,
            Mizuno-Iijima,S., Hasegawa,Y., Takahashi,S., Sugiyama,F. and
            Yagami,K.
  TITLE     Peri-implantation lethality in mice carrying megabase-scale
            deletion on 5qc3.3 is caused by Exoc1 null mutation
  JOURNAL   Sci Rep 5, 13632 (2015)
   PUBMED   26346620
  REMARK    GeneRIF: Peri-implantation lethality in mice carrying
            megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3354)
  AUTHORS   Heider,M.R. and Munson,M.
  TITLE     Exorcising the exocyst complex
  JOURNAL   Traffic 13 (7), 898-907 (2012)
   PUBMED   22420621
  REMARK    Review article
REFERENCE   9  (bases 1 to 3354)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3354)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127332.3.
            
            On Feb 9, 2022 this sequence version replaced NM_001359370.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (4).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.12596.1,
                                           ERR3363658.4156061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC127332.3         74128-74241
            115-248             AC127332.3         77534-77667
            249-379             AC127332.3         80333-80463
            380-539             AC127332.3         82477-82636
            540-560             AC127332.3         85526-85546
            561-748             AC127332.3         86830-87017
            749-976             AC127332.3         88234-88461
            977-1109            AC127332.3         88657-88789
            1110-1219           AC127332.3         90033-90142
            1220-1273           AC127332.3         90857-90910
            1274-1423           AC127332.3         94231-94380
            1424-1529           AC127332.3         98879-98984
            1530-1693           AC127332.3         103783-103946
            1694-1801           AC127332.3         104497-104604
            1802-1878           AC127332.3         105109-105185
            1879-2107           AC127332.3         106071-106299
            2108-2291           AC127332.3         108009-108192
            2292-2491           AC127332.3         111736-111935
            2492-2686           AC127332.3         112746-112940
            2687-3354           AC127332.3         114397-115064
FEATURES             Location/Qualifiers
     source          1..3354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 41.28 cM"
     gene            1..3354
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /note="exocyst complex component 1"
                     /db_xref="GeneID:69940"
                     /db_xref="MGI:MGI:2445020"
     exon            1..114
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            115..248
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2839
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /note="isoform 4 is encoded by transcript variant 4;
                     exocyst complex component Sec3; SEC3-like 1"
                     /codon_start=1
                     /product="exocyst complex component 1 isoform 4"
                     /protein_id="NP_001346299.1"
                     /db_xref="GeneID:69940"
                     /db_xref="MGI:MGI:2445020"
                     /translation="MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTT
                     ERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKVYKWVA
                     SSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEELPKVTEESVPSGENQSVAGGD
                     EEAVDEYQELNAREEQDIEIMMEGCECAISNAEAFAEKLSRELQVLDGANIQSIMASE
                     KQVNTLMQLLDEALTEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKL
                     LSEIEFLVNHMDLAKGHIKALQEGDLVSSRGIEACTNAADALLQCMNVALRPGHDMLL
                     AVKQQQQRFSDLREHFARRLASHLNNVFVQQFTQALLQLYNRSYFLSVPGHDQSSTLA
                     QHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDF
                     FEVAKMKMTGTSKESKKFGLHGSSGKLTGSTSSLNKLSVQSSGSRRSQSSSLLDMGNM
                     SASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQNMSASMTEAEDLD
                     GGSLLRQHSSGTLLPVSSEKDMIRQMMIKIFRCIEPELNNLIALGDKVDSFNSLYMLV
                     KMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEEVKISKKSKVGIL
                     PFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFINVEKVANESQKTPRDVVMM
                     ENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNHFFEGVEAR
                     VAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVV
                     WHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH"
     exon            249..379
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            380..539
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            540..560
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            561..748
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            749..976
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1109
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1219
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1273
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1423
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1529
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1693
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1801
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1878
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2107
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2291
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2491
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2686
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..3354
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /note="hexamer: AATAAA"
     polyA_site      3354
                     /gene="Exoc1"
                     /gene_synonym="2810407P21Rik; A730011E05Rik; SEC3; Sec3l1;
                     Sec3p"
                     /note="major polyA site"
ORIGIN      
        1 ctggccgctg cttttccctg ttcaatgaaa agtgcttcaa agctgctatt gctgccggcg
       61 cccttcctga gtccgtcttg gagcaccaac ctcggccggc cggctggcct cgcgctgaga
      121 aaagatgaca gcaatcaagc atgcgctgca gagagatatc ttcacaccaa atgatgaacg
      181 cctgctgagc atcgtgaatg tctgcaaagc tggcaagaag aagaagaact gttttctgtg
      241 tgccacagtg accactgaac gccccgtgca ggtgaaggtg gtcaaagtca agaaatccga
      301 caagggagat ttctacaaaa ggcagattgc ttgggccctg cgagaccttg ctgtggtcga
      361 cgccaaagat gccatcaaag aaaacccgga atttgatttg cattttgaga aggtctataa
      421 gtgggtggcc agcagcacgg ctgagaagaa cgccttcatc tcctgcattt ggaagctgaa
      481 ccagcgctac ctgcgcaaga aaatcgactt tgttaatgtt agctcgcagc ttttggaaga
      541 actgcctaaa gttacagaag aatctgttcc aagcggagag aatcagagtg tagcgggagg
      601 ggatgaagaa gcggtagatg agtaccaaga gttaaatgca agagaagagc aggacatcga
      661 gataatgatg gaaggctgcg agtgcgccat ttctaacgct gaagcctttg cggagaagtt
      721 gtcccgggag ctgcaggtgc tcgatggggc caacattcag tcaatcatgg cctctgagaa
      781 acaagtgaac accctgatgc agttgctgga tgaggcgcta acggaggtgg accagattga
      841 actgaaactg agcagttacg aggagatgct ccaaagtgtg aaagagcaga tggatcagat
      901 ctctgagagc aaccacctga tccatctcag caacacgaat aatgtgaagc tcctgtccga
      961 gatagagttc ctcgtgaacc acatggactt ggccaaaggt catataaagg cccttcagga
     1021 aggagatctt gtttcttccc gaggcatcga ggcctgcacc aacgctgctg acgccctgct
     1081 gcagtgcatg aacgttgctc ttcgcccagg ccatgacatg ctcctggccg tcaagcagca
     1141 gcagcagcgc ttcagtgacc tgagggaaca tttcgcccgg agactggcca gccatctcaa
     1201 caatgttttt gttcaacagt ttactcaggc cctcctacag ctctataaca ggtcctactt
     1261 tctttcggtt cctggtcatg atcagagttc aactcttgct cagcactctg ttgaactgac
     1321 tctacccaat caccatccat ttcatagaga cttgctccgc tatgccaagc tgatggagtg
     1381 gctaaagagt acagactatg gaaaatacga gggactaaca aagaattaca tggattattt
     1441 atcccgacta tatgaaagag aaatcaaaga tttctttgaa gttgcaaaga tgaagatgac
     1501 tggcacctct aaagaaagca agaagtttgg tctccatgga agctctggga aactcactgg
     1561 atcaacttct agtctgaata aactcagtgt tcagagctcg ggcagtcgca ggtcccagtc
     1621 gtcctcccta ctggacatgg ggaacatgtc tgcctctgac ctcgatgtgg ctgacagaac
     1681 caagtttgat aagatctttg aacaggtgct gagtgaactg gagccactgt gtctggcaga
     1741 acaggacttc ataagtaaat ttttcaaact acagcagcat caaaacatgt ctgcatcaat
     1801 gactgaagca gaagacctgg atggaggctc gttattacgg cagcacagtt ctggcaccct
     1861 gctccctgtt tcctctgaaa aagatatgat tcgccaaatg atgatcaaaa tattccgttg
     1921 cattgaacca gaactgaaca acctaattgc attaggagac aaagtagata gctttaactc
     1981 cctgtacatg ctggtcaaaa tgagtcacca cgtgtggacc gcacagaacg tggacccagc
     2041 atcttttcta agtactacat taggaaacgt tttggtgact gtgaagagga actttgacaa
     2101 atgcattagt aaccaaataa gacaaatgga agaagtaaag atctcaaaga aaagtaaagt
     2161 aggaattctt ccatttgttg ctgaatttga agaatttgct gggctcgcag aatcaatttt
     2221 caaaaatgct gaacgccgtg gcgatctgga caaagcatac accaaattaa tcagaggagt
     2281 gttcattaat gtggagaaag tagcaaatga gagccagaag acgcccaggg atgtggtcat
     2341 gatggagaac tttcaccata tttttgcaac actttctcgt ctgaaaatct catgtcttga
     2401 agctgagaag aaagaagcca agcagaagta cacggatcac cttcagtcct acgtcattta
     2461 ctctttagga cagccccttg aaaagctaaa tcatttcttt gaaggcgttg aagctcgagt
     2521 agcccagggc attcgggagg aggaggtgag ctaccagctt gcgttcaaca agcaagagct
     2581 tcgcaaagtc attaaagagt atccaggcaa ggaggtgaag aagggcctgg acaacctcta
     2641 caagaaggta gacaagcacc tgtgtgagga ggagaactta ctgcaggtgg tgtggcactc
     2701 catgcaagat gagtttatac gccagtacaa gcacttcgag gggttgatag cgcgctgcta
     2761 ccctggatct ggagttacga tggaattcac tattcaggac attctggatt attgctccag
     2821 catcgcacag tcccactaag ccctaggaaa gaggagaaag aagtgagcat gcattctcag
     2881 tccagcaaac actacggaaa gagtgagcaa gtgctctgag gagccagatt caagcgtttc
     2941 tgttactaaa cgtctgtgac tgtgcagtac tctgctccag agatctaaga gcagagcagc
     3001 agcctgcggc tcggttttat ttgacatcca ggtgatgcac ttaagcattt atctcatcat
     3061 gaaaagcctt cagcactttc cagggaccag gcaggacatt ttgctttact gccagcttct
     3121 tgtgttttcg agcggctgtc ctcagtggaa cagtgggagt tcctcagcac tcactatgtg
     3181 ccagttgctc acaaatcatg gaacttggaa agcattgcac agaattgttt tgtccccttg
     3241 tctaacaagt gtgcatatgg atgggcaggg gatctgatgt ggtaatcagc caccagcctg
     3301 gattgtaagg attatgtgac tctgtatatt aaataaagga cattattaaa agtt
//
