LOCUS       NM_012012               5506 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus exonuclease 1 (Exo1), mRNA.
ACCESSION   NM_012012
VERSION     NM_012012.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5506)
  AUTHORS   Li,M., Huang,F., Zhu,W., Peng,Y., Xu,F., Li,W., Zhao,Q. and Liu,L.
  TITLE     Dynamic regulation of EXO1 promotes the progression from liver
            fibrosis to HCC through TGF-beta1/Smad signaling feedback loop
  JOURNAL   Hepatol Commun 8 (1), e0342 (2023)
   PUBMED   38126949
  REMARK    GeneRIF: Dynamic regulation of EXO1 promotes the progression from
            liver fibrosis to HCC through TGF-beta1/Smad signaling feedback
            loop.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5506)
  AUTHORS   Dickinson,K., Hammond,L., Akpa,M., Chu,L.L., Lalonde,C.T.,
            Goumba,A. and Goodyer,P.
  TITLE     WT1 regulates expression of DNA repair gene Neil3 during
            nephrogenesis
  JOURNAL   Am J Physiol Renal Physiol 324 (3), F245-F255 (2023)
   PUBMED   36546838
REFERENCE   3  (bases 1 to 5506)
  AUTHORS   Wang,S., Lee,K., Gray,S., Zhang,Y., Tang,C., Morrish,R.B.,
            Tosti,E., van Oers,J., Amin,M.R., Cohen,P.E., MacCarthy,T., Roa,S.,
            Scharff,M.D., Edelmann,W. and Chahwan,R.
  TITLE     Role of EXO1 nuclease activity in genome maintenance, the immune
            response and tumor suppression in Exo1D173A mice
  JOURNAL   Nucleic Acids Res 50 (14), 8093-8106 (2022)
   PUBMED   35849338
  REMARK    GeneRIF: Role of EXO1 nuclease activity in genome maintenance, the
            immune response and tumor suppression in Exo1D173A mice.
REFERENCE   4  (bases 1 to 5506)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5506)
  AUTHORS   Paiano,J., Wu,W., Yamada,S., Sciascia,N., Callen,E., Paola
            Cotrim,A., Deshpande,R.A., Maman,Y., Day,A., Paull,T.T. and
            Nussenzweig,A.
  TITLE     ATM and PRDM9 regulate SPO11-bound recombination intermediates
            during meiosis
  JOURNAL   Nat Commun 11 (1), 857 (2020)
   PUBMED   32051414
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5506)
  AUTHORS   Wei,K., Clark,A.B., Wong,E., Kane,M.F., Mazur,D.J., Parris,T.,
            Kolas,N.K., Russell,R., Hou,H. Jr., Kneitz,B., Yang,G.,
            Kunkel,T.A., Kolodner,R.D., Cohen,P.E. and Edelmann,W.
  TITLE     Inactivation of Exonuclease 1 in mice results in DNA mismatch
            repair defects, increased cancer susceptibility, and male and
            female sterility
  JOURNAL   Genes Dev 17 (5), 603-614 (2003)
   PUBMED   12629043
  REMARK    GeneRIF: Functions in mutation avoidance and is essential for male
            and female meiosis.
REFERENCE   7  (bases 1 to 5506)
  AUTHORS   Namiki,Y., Endoh,D. and Kon,Y.
  TITLE     Genetic mutation associated with meiotic metaphase-specific
            apoptosis in MRL/MpJ mice
  JOURNAL   Mol Reprod Dev 64 (2), 179-188 (2003)
   PUBMED   12506350
REFERENCE   8  (bases 1 to 5506)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5506)
  AUTHORS   Jagmohan-Changur,S., Poikonen,T., Vilkki,S., Launonen,V.,
            Wikman,F., Orntoft,T.F., Moller,P., Vasen,H., Tops,C.,
            Kolodner,R.D., Mecklin,J.P., Jarvinen,H., Bevan,S., Houlston,R.S.,
            Aaltonen,L.A., Fodde,R., Wijnen,J. and Karhu,A.
  TITLE     EXO1 variants occur commonly in normal population: evidence against
            a role in hereditary nonpolyposis colorectal cancer
  JOURNAL   Cancer Res 63 (1), 154-158 (2003)
   PUBMED   12517792
REFERENCE   10 (bases 1 to 5506)
  AUTHORS   Lee,B.I., Shannon,M., Stubbs,L. and Wilson,D.M. 3rd.
  TITLE     Expression specificity of the mouse exonuclease 1 (mExo1) gene
  JOURNAL   Nucleic Acids Res 27 (20), 4114-4120 (1999)
   PUBMED   10497278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122854.4.
            
            On Mar 1, 2008 this sequence version replaced NM_012012.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028728.1, AK166425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC122854.4         159613-159691
            80-148              AC122854.4         159967-160035
            149-322             AC122854.4         161730-161903
            323-442             AC122854.4         165525-165644
            443-566             AC122854.4         166413-166536
            567-704             AC122854.4         167559-167696
            705-917             AC122854.4         170769-170981
            918-1105            AC122854.4         171709-171896
            1106-1199           AC122854.4         172576-172669
            1200-1425           AC122854.4         174963-175188
            1426-1669           AC122854.4         178224-178467
            1670-2243           AC122854.4         179715-180288
            2244-2345           AC122854.4         183171-183272
            2346-2539           AC122854.4         184631-184824
            2540-5506           AC122854.4         187265-190231
FEATURES             Location/Qualifiers
     source          1..5506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 81.9 cM"
     gene            1..5506
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /note="exonuclease 1"
                     /db_xref="GeneID:26909"
                     /db_xref="MGI:MGI:1349427"
     exon            1..79
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            80..148
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            149..322
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2675
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /note="mExo1; exonuclease I"
                     /codon_start=1
                     /product="exonuclease 1"
                     /protein_id="NP_036142.2"
                     /db_xref="CCDS:CCDS15551.1"
                     /db_xref="GeneID:26909"
                     /db_xref="MGI:MGI:1349427"
                     /translation="MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAE
                     KLAKGEPTDRYVGFCMKFVNMLLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLK
                     GKQLLREGKVSEARDCFARSINITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNK
                     AGIVQAVITEDSDLLAFGCKKVILKMDQFGNGLEVDQARLGMCKQLGDVFTEEKFRYM
                     CILSGCDYLASLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLRMNITVPEDYITGFI
                     RANNTFLYQLVFDPIQRKLVPLNAYGDDVNPETLTYAGQYVGDSVALQIALGNRDVNT
                     FEQIDDYSPDTMPAHSRSHSWNEKAGQKPPGTNSIWHKNYCPRLEVNSVSHAPQLKEK
                     PSTLGLKQVISTKGLNLPRKSCVLKRPRNEALAEDDLLSQYSSVSKKIKENGCGDGTS
                     PNSSKMSKSCPDSGTAHKTDAHTPSKMRNKFATFLQRRNEESGAVVVPGTRSRFFCSS
                     QDFDNFIPKKESGQPLNETVATGKATTSLLGALDCPDTEGHKPVDANGTHNLSSQIPG
                     NAAVSPEDEAQSSETSKLLGAMSPPSLGTLRSCFSWSGTLREFSRTPSPSASTTLQQF
                     RRKSDPPACLPEASAVVTDRCDSKSEMLGETSQPLHELGCSSRSQESMDSSCGLNTSS
                     LSQPSSRDSGSEESDCNNKSLDNQGEQNSKQHLPHFSKKDGLRRNKVPGLCRSSSMDS
                     FSTTKIKPLVPARVSGLSKKSGSMQTRKHHDVENKPGLQTKISELWKNFGFKKDSEKL
                     PSCKKPLSPVKDNIQLTPETEDEIFNKPECVRAQRAIFH"
     exon            323..442
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            443..566
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            567..704
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            705..917
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1105
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1199
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1425
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1669
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..2243
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2345
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2539
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..5506
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /note="hexamer: ATTACA"
     polyA_site      2768
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
     regulatory      2825..2830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /note="hexamer: AATAAA"
     polyA_site      2860
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /note="major polyA site"
     regulatory      4942..4947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /note="hexamer: AATAAG"
     polyA_site      4965
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
     regulatory      5487..5492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
                     /note="hexamer: ATTAAA"
     polyA_site      5504
                     /gene="Exo1"
                     /gene_synonym="5730442G03Rik; Msa"
ORIGIN      
        1 ggggcttccc gatcccgcgc aaatcgaaag gtccatggct gcgcttgcag cagccgctcg
       61 ccgccgttct gaaccccagg tttgaggagc cacggcgcct ggaatggact tgtgtgctat
      121 gcctgttcgt tcgggagacg ggactaagtt aacttggcac gatggggatt caagggttac
      181 ttcagttcat ccaagaagct tctgaacctg tcaacgtgaa gaagtacaaa ggacaggcag
      241 tggctgtgga tacctactgt tggcttcaca aaggggctat tgcttgtgct gaaaagctag
      301 ccaaagggga acctacagat aggtatgtag gattttgtat gaagtttgtt aatatgctgc
      361 tgtcttatgg ggtcaagccg attctcatat ttgacggatg tactctacct tctaaaaagg
      421 aagtggagcg gtctcgaaga gagagacgac aaagcaacct tcttaaaggg aagcagcttc
      481 ttcgagaggg caaagtgtca gaagcccgag actgcttcgc tcgctctatc aacatcacgc
      541 acgccatggc ccacaaagta ataaaagctg ctcgggccct aggagtggat tgcctcgtgg
      601 ctccgtatga agctgatgct cagttggcct accttaacaa ggctggcatc gtgcaggctg
      661 tcatcacaga ggactctgac ctcctcgcat ttggctgtaa gaaggtgatt ttaaaaatgg
      721 atcagtttgg aaatggactg gaagtggacc aggcacggct aggcatgtgc aagcagcttg
      781 gggatgtatt cacggaggag aagttccggt acatgtgcat tctgtccggc tgtgactacc
      841 tcgcctccct tcgtgggatc ggcttagcca aggcctgcaa agtgctgaga ctggccaata
      901 accccgatat cgtgaaggtt atcaagaaaa ttgggcatta tctcaggatg aatataacgg
      961 tgcccgagga ttacatcaca ggatttattc gtgccaacaa tactttcctc taccagctcg
     1021 tgttcgaccc catccaaagg aagctggtcc ctctgaatgc ctacggagat gacgttaatc
     1081 ccgaaacact gacttacgct gggcagtacg tcggtgactc tgtagctctt cagatcgccc
     1141 ttggaaatag agatgtaaat acttttgaac agattgatga ctacagtcca gacaccatgc
     1201 cagcccactc aagaagccac agctggaatg agaaagcagg tcagaaacca cctggtacca
     1261 acagcatttg gcacaagaat tattgtccta gacttgaggt gaacagtgtc tcccacgctc
     1321 ctcaactgaa ggaaaagcca agcactttgg gccttaaaca agtgattagt actaaagggt
     1381 taaatcttcc caggaagtct tgtgtgttga aaagaccaag aaatgaagcg ctggctgaag
     1441 atgacctgtt gagccagtat tcgtcagttt caaagaagat caaggaaaat ggctgtgggg
     1501 atggcacatc acctaactct tctaaaatgt ccaagtcctg ccccgattct gggactgctc
     1561 acaagacaga tgcacacacc ccgtctaaga tgaggaataa atttgcaacg ttcttacaga
     1621 ggaggaatga agaaagcggt gcagtcgtgg ttccagggac cagaagcagg tttttttgca
     1681 gttctcagga ttttgacaat ttcataccaa aaaaagaaag cggccagcct ctaaatgaaa
     1741 ctgtggccac tggcaaagcc accaccagcc tcctcggggc actggactgt ccagacacgg
     1801 aaggccacaa gccggttgat gcaaatggga cgcacaatct gagctctcag attccaggca
     1861 atgcagctgt gtctcctgag gatgaggctc agtcctctga gaccagcaaa ctcttggggg
     1921 ccatgtcccc acccagtctg gggacactaa gaagctgttt cagttggtct ggcactctca
     1981 gggaattttc tcgaactcca agtccctcag caagcactac attgcagcag ttccggagaa
     2041 agagcgaccc ccctgcctgt cttcctgagg cctctgccgt ggtcactgac aggtgcgact
     2101 caaagagcga gatgctgggt gagacgtctc agcccttgca cgagctgggc tgctcctcgc
     2161 ggtctcagga aagcatggac tcctcgtgcg gcctaaacac gtcgagcctg tcccagcctt
     2221 ccagtaggga ttcaggttca gaggagtcgg attgtaacaa taagtcactt gataatcaag
     2281 gggaacagaa ctccaagcaa cacttacctc acttttcaaa gaaagacgga cttagacgga
     2341 acaaggttcc tgggctctgt aggtctagtt ctatggactc tttttctaca accaagatca
     2401 agcccctggt gcctgccagg gtcagtggcc tgagcaagaa gtcaggaagc atgcagacga
     2461 gaaaacacca tgatgtggag aacaagccag gcctacagac gaagatcagc gagctctgga
     2521 aaaactttgg gtttaaaaaa gattctgaaa agcttccttc ttgtaagaag cccctgtctc
     2581 cagtcaagga caatatccaa ctcactccag agacagaaga tgagatcttt aacaagcccg
     2641 agtgtgtacg cgctcagaga gcaatatttc actaagtgca gaccgttgcc tacaagaaaa
     2701 tcttatcaac tggagagatg tattagtctc aatgtcattt tttaaatgga ttacattttg
     2761 tatattaact ttgtgacttt cttttgctca gctttttata ttttcataga aagctaaata
     2821 gaagaataaa tctgtctttg acatttctgg gaagtttaaa tgctaattgg acaaatcttc
     2881 tgacatcagt agcaatctaa aggactctac catgtatgta gcatctagtc tattgtgagt
     2941 agaaagccac aggtgcctac agccacttag acccaagaac agatgactcg ccagcttcca
     3001 accactccag ccgcctttct gtcagccctg taagggtaaa ttgagaagag tgttgctggg
     3061 atgggaaggg gcagcaggag gagctgtctg cctaagattg ttcacacgcc tcggtctcaa
     3121 agctgctacc tggttttctc catgcacttc tgaagtgtgg ctcaaaagtt cctttgcatt
     3181 tacttaaccc tgtgcaagat gctgaagctg cagagcctgt gatcaatata ttctgcaaag
     3241 atccaggcag aggttttgga aggaatcagc catacctgga ccaatctgaa caatcagaag
     3301 gaaaggcatg atgaagccat ctatgataca ggcgagagtc caagacttag aatctttaaa
     3361 agggagttgg ggaggggcaa acacagattt atttggaaaa tcctaatctg aagctcagat
     3421 ttgagcccgc cgtgagcagt cctgtcacca cacaggtcag acagacagac agacagacac
     3481 catctacagg tattcatctc tggaatgtca ggaaaccagt aaaatgcact atacagcttt
     3541 tctgggaagc atcaagcaag aaggaagagt gtcagtcaag gaagggtggg ttctctgttg
     3601 gcagcagcca agcaggtctt gtggatggct tctatcagtg gtgagacagg caagctcctg
     3661 ttagccaagg gtagagggca aggctggaaa caggctattt ttttctcaaa tctttaaaac
     3721 aacaacaaga tctccaagtc actgcagtac acaagcccca ttaacagcta gtttccatga
     3781 cagtcttcat agtttgcaaa tagaaattgc tccatagtat ctgaccacag accataggat
     3841 aggccacaga taaccacgta tcacagtagt aggacttgag aactgcacca ttgacagtac
     3901 agttcaaagg atggagacca gccagagtcc ctctgattgt gactccttgt agcttctttt
     3961 ggaccatgtt tgtctatgtt tggttcctgc tcacaagaac aggtgtgggg attgggccac
     4021 actgagcaag ggacatgagc aggttgatgg ggtattaagg ttgtcactac tttgtcttta
     4081 aagtgtcatt tgtggaggga caagaaaaag gctggaaatt caggtaggtc agattttgaa
     4141 agttcagaca caggagtata gacttaagat caagtcacga gagaaagcgt tgcctggcca
     4201 gtatctcttc ccttctccat tctttattgt gaagtttcat tgagctacta tatgagagtg
     4261 ggcagaagag cgtagacgta ggtaaggcca ggagttgctg gctggactat attccagtgt
     4321 gagaatacca aaccctcacg catctttctt tatcccaggt cacacttgta gctttgcctt
     4381 gagttttgtt tgggtttatt ttctccctcc ctttccccct aagaagctat aactgcttat
     4441 aaaggtagag agagagtagc caaaaccaat ccgtgagatc tcacagtgct aggcacgcat
     4501 gcagctccca agtctcgcaa ataactatac tgtcagggat tacaataact atctccatac
     4561 ataccaagct tggtggtgca cacctttaat cccagctaac aggaggcaga agcaagatct
     4621 ccgagttgaa ccagcctggt ctacagactg agttccagga tagcgagggc taaacagaaa
     4681 aaccttgtct ccaaatccca ataataataa gcaataatct tcattttgcg acataaacca
     4741 aacgtagagg tacacacttg taatcccagc ctgggaggga gaggcggtat tagttcaagg
     4801 tctttttaca tgctgagttt aaagccagtt tttgagatcc tgcctattta ggggagaatc
     4861 taccttttta aatgcatgac caaaggagag aaaggcggcc tgggggtctg gggagatatc
     4921 tttgctgggg ttctctaatt aaataaggtt ctctcatcaa ctctacacat tgggtttccc
     4981 aggtgtcatt tgaacaaagc ccctaggctt taccattaca aatcctcatg aactcaccag
     5041 ttctgtgctc agctacaatc aacaagagct tggagcttat agatgacgga ttctgtgctg
     5101 gctatggaga ggatcaaaat ggagaactga ccagagaaga ccactcacac agggtttaag
     5161 ccaagagaaa gtattagcca gccagtgtct acactggatg ttcagggtga cagtgtagca
     5221 cttgagcctt tcttggggca agaaaaagaa aacataatct ggggtgacat tcaattaaca
     5281 agaacagtta gccagaagtg gaacaacaga agctaaaaac aaggttagta cattagaaac
     5341 tttccaagaa ctttggtaga ttagggattt gttttagttt tggcaggtgg tagtgtcagt
     5401 gtgctgagtt ttacagccta aatggtattt ccatcatgga gtcagctgta ctaatgggga
     5461 gggaggttac taaggtctgg gacttcatta aaagcacaag gaaaga
//
