LOCUS       NM_133798               3323 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus exonuclease 3'-5' domain containing 2 (Exd2), mRNA.
ACCESSION   NM_133798
VERSION     NM_133798.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3323)
  AUTHORS   Olotu,O., Dowling,M., Homolka,D., Wojtas,M.N., Tran,P.,
            Lehtiniemi,T., Da Ros,M., Pillai,R.S. and Kotaja,N.
  TITLE     Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery
            and exonuclease domain-containing proteins EXD1 and EXD2 in mouse
            spermatocytes
  JOURNAL   Andrology 11 (4), 710-723 (2023)
   PUBMED   36624638
  REMARK    GeneRIF: Intermitochondrial cement (IMC) harbors piRNA biogenesis
            machinery and exonuclease domain-containing proteins EXD1 and EXD2
            in mouse spermatocytes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK167692.1, AK162206.1 and AK164329.1.
            
            On May 16, 2009 this sequence version replaced NM_133798.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164329.1, AK167692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-948               AK167692.1         2-949
            949-3040            AK162206.1         717-2808
            3041-3323           AK164329.1         2917-3199
FEATURES             Location/Qualifiers
     source          1..3323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 36.73 cM"
     gene            1..3323
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /note="exonuclease 3'-5' domain containing 2"
                     /db_xref="GeneID:97827"
                     /db_xref="MGI:MGI:1922485"
     exon            1..186
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            187..652
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2185
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /EC_number="3.1.11.1"
                     /note="exonuclease 3'-5' domain-like-containing protein 2;
                     exonuclease 3''-5'' domain-like 2; 3'-5' exoribonuclease
                     EXD2"
                     /codon_start=1
                     /product="exonuclease 3'-5' domain-containing protein 2"
                     /protein_id="NP_598559.2"
                     /db_xref="CCDS:CCDS49098.1"
                     /db_xref="GeneID:97827"
                     /db_xref="MGI:MGI:1922485"
                     /translation="MSRQNLVALTVTTLLGVAMGGFVLWKGIQRRWSKTSRVMQQQPQ
                     QPQQPQQPQPQPQPQPQPQPEHPQPQQQVPGGREWPPPEDDQLPFGALRAPRASWEER
                     ILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSG
                     FCALVRLPRLIYGGRTLPRTLLDILADGAILKVGVGCSEDANKLLQDYGLIVRGCLDL
                     RYLAMKQGNNILCNGLSLKSLAETILNFPLDKSLLLRCSNWDAENLTEDQVTYAARDA
                     QISVALFLHLLGYPFSRDSYEEESTDQINWQKALERCRNMVDIPFRSKGLGRLVEEVN
                     GEALESQLKPRNRKAKTDRMVPGNNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAP
                     DGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCV
                     VCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAK
                     EFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIIT
                     EEMLHEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHL
                     PQQWSVDHNHQKLLRKYGDDLPIKLS"
     exon            653..909
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1036
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1368
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1475
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1611
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1968
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..3323
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /note="hexamer: AATAAA"
     polyA_site      3310
                     /gene="Exd2"
                     /gene_synonym="4930539P14Rik; Exdl2"
                     /note="major polyA site"
ORIGIN      
        1 ggcttccgta caaaatggcg cggcccatag gcacacacca cgggggttgt atcctcctgg
       61 ccagccactg ggccggaagt ggctacggct tttatgcatc cgggtgggtg cgcccagacc
      121 gccgcggggg ttccagcttg tcagcgtggg gtgccgcagg tgttcggtcg aggctggagg
      181 ccgcagattg taggatcagt gaaatgcttt cctaaaaagt gaaaggctaa agatgtctag
      241 acaaaattta gtggctttga cagtgaccac ccttctgggt gtggccatgg ggggatttgt
      301 cctgtggaaa ggcatccagc gtagatggag taagacaagc agagtgatgc agcagcagcc
      361 tcagcagcca cagcagccgc agcagccgca gccacagcca cagccacagc cacagccaca
      421 gccagagcat ccacagccac agcagcaagt gcctggtggg agggagtggc cccctccaga
      481 agatgaccag ctaccctttg gtgccctgag agcacccaga gcctcatggg aggagaggat
      541 actccaggca gaggtggtga cggtatctca ggaggcagag tggaatcaaa tccagccctt
      601 tcttaaaaga gagttggaag attttcctgt acttggaatt gactgtgaat gggtgaattt
      661 ggaaggcaaa gccagtcctt tgtcactcct acagatggct tccccaagtg gcttctgtgc
      721 actggttcgc ttgcccaggc tgatatatgg aggcagaaca ctacccagga cgcttttgga
      781 tatattggca gatggtgcta tcttaaaagt aggagtggga tgttcagaag atgccaacaa
      841 gcttctacag gattatggtc tcattgtcag gggatgtctg gaccttcgct acctagccat
      901 gaagcaggga aacaatatac tctgtaatgg gcttagcctg aaatcacttg ctgagactat
      961 tttgaacttc ccacttgaca agtcccttct acttcgttgc agcaactggg atgctgagaa
     1021 tcttactgaa gaccaggtaa cttatgctgc cagggatgcg cagatttcag tggctctctt
     1081 tctccatctt cttggatacc ctttctctag agattcctat gaagaggaaa gtacggacca
     1141 aatcaactgg caaaaagcct tggagagatg caggaatatg gtagacatcc cattccgaag
     1201 caaaggactt ggccggctgg ttgaagaggt taatggggaa gcactggagt cgcagctgaa
     1261 gccgagaaat aggaaggcta agactgatag aatggtgcca ggcaacaacc aagggagaga
     1321 ccccaggaag cataagagga agcccctggg ggtgggctat tctgccagaa aatcccctct
     1381 ctatgataac tgcttcctcc aagctcctga tggacagccc ttgtgcacct gtgaccgcag
     1441 gaaagctcag tggtacctgg acaaaggcat tggagagctg gtgagtaaag aaccttttgt
     1501 ggtcaggcta cagtttgaac ctgcaggaag acctgagtcc ccaggagatt attacttgat
     1561 ggttaaagag aatctgtgtg ttgtctgtgg caagacagat acctacatcc ggaaaaatat
     1621 aattccacat gagtaccgca agcatttccc tattgagatg aaggaccaca actcccatga
     1681 tgtgctgttg ctctgcacct cctgccatgc catctctaac tactatgaca accatctgaa
     1741 gcaacagctg gccaaggagt tccaggctcc cattggctca gaggagggcc tacgcctgct
     1801 ggaagactta gagcggagac aggtgcgttc tggagccaga gccctgctca acgcagagag
     1861 cctacctgct catcggaaag aagagctgct gcacgcactc agggagtttt acaacacaga
     1921 tattattaca gaggagatgc ttcacgaggc cgccagcctg gagaccagga tatacaatga
     1981 aagttatatt cctcatgggc taaaggtggt acagcgtcac accgagggtg ggctgcgctc
     2041 cctcatgcag ctggagagcc gctggcgtca gcacttcctg gactccatgc agcctaagca
     2101 cctgccccag cagtggtcag tggaccacaa ccatcagaag ctgctccgaa agtacgggga
     2161 tgaccttccc atcaagctgt catgactgct gctgcctgca ggtcaggaca ggcaggaagc
     2221 aggagccaag gtcaaaatca cctcctactg tttaatgttc ttaatggggg aagccctggt
     2281 aactcagctc agagtgctaa cctacactga tcccctggta cttctgatgg agcaaggctg
     2341 ttgtttgaag gggagcttat ggttttgagt ttagttgggg agtctattct tttctcctcc
     2401 tttctctcct atttttgtgt gcaaaagaag cttggccttc attttcactc tccctctctg
     2461 cttttcctaa gagggagaag tcttctctga agtaacttgt caggccctgg gaagacgttt
     2521 gtaattctct ctgctgcatt ggtttttcca ggccagggag aactttttcc agagttgaag
     2581 aagtgaccca agagtcactt tcctattccc agttcagcct cactatttta atctttcttg
     2641 ctctcccata tgtatttgtt tggggcccat tccaactgta ttacttggat ttattttaca
     2701 tgcttgaaaa tgttctcatt caatgcatac aggaccaaag gccagcttgc tatgggcttc
     2761 ttccctgtcc caggggaagt ccttttctgg aaatgggtgt tcagctggct gggctgacaa
     2821 gcgctgaccc tttcccagga gagctttgac acatggctca gcctctcctc tggttgcatg
     2881 tctcttgtcc tgcttctgag gaccatgatt tctcagagtc tgcgcccact tcctttggtg
     2941 ttcatgttca tgcaatacta acctctcctt agtccttaat tcactcccag agccatttgg
     3001 ccaggtttca gtatgaggac ttcgcctccc ctagagcctg agacactaaa attatctgat
     3061 acaatagaag tttaaaaggg taatgtttca cctttcaaaa tgttagacta ctactttgag
     3121 tatgaaatca atttattagc aattagaatt ttttctaaac tattaggaaa actttcttat
     3181 tttataagat cttaacaaga ttgaaaagaa ttttatgccc agaatccaac aagagttcta
     3241 ttttggaatt gtacccaagt tgcttataac tgatctgaca ttgataaata aaacaacttc
     3301 aaagcacaaa gctcagtgat tgt
//
