LOCUS       NM_007967               4210 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus even-skipped homeobox 2 (Evx2), mRNA.
ACCESSION   NM_007967
VERSION     NM_007967.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4210)
  AUTHORS   Tulloch,A.J., Teo,S., Carvajal,B.V., Tessier-Lavigne,M. and
            Jaworski,A.
  TITLE     Diverse spinal commissural neuron populations revealed by fate
            mapping and molecular profiling using a novel Robo3Cre mouse
  JOURNAL   J Comp Neurol 527 (18), 2948-2972 (2019)
   PUBMED   31152445
REFERENCE   2  (bases 1 to 4210)
  AUTHORS   Rodriguez-Carballo,E., Lopez-Delisle,L., Yakushiji-Kaminatsui,N.,
            Ullate-Agote,A. and Duboule,D.
  TITLE     Impact of genome architecture on the functional activation and
            repression of Hox regulatory landscapes
  JOURNAL   BMC Biol 17 (1), 55 (2019)
   PUBMED   31299961
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4210)
  AUTHORS   Desiderio,S., Vermeiren,S., Van Campenhout,C., Kricha,S., Malki,E.,
            Richts,S., Fletcher,E.V., Vanwelden,T., Schmidt,B.Z.,
            Henningfeld,K.A., Pieler,T., Woods,C.G., Nagy,V., Verfaillie,C. and
            Bellefroid,E.J.
  TITLE     Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating
            the Expression of the NGF Receptor TrkA
  JOURNAL   Cell Rep 26 (13), 3522-3536 (2019)
   PUBMED   30917309
REFERENCE   4  (bases 1 to 4210)
  AUTHORS   Kim,J., Choi,T.I., Park,S., Kim,M.H., Kim,C.H. and Lee,S.
  TITLE     Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30177510
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4210)
  AUTHORS   Rodriguez-Carballo,E., Lopez-Delisle,L., Zhan,Y., Fabre,P.J.,
            Beccari,L., El-Idrissi,I., Huynh,T.H.N., Ozadam,H., Dekker,J. and
            Duboule,D.
  TITLE     The HoxD cluster is a dynamic and resilient TAD boundary
            controlling the segregation of antagonistic regulatory landscapes
  JOURNAL   Genes Dev 31 (22), 2264-2281 (2017)
   PUBMED   29273679
REFERENCE   6  (bases 1 to 4210)
  AUTHORS   Dush,M.K. and Martin,G.R.
  TITLE     Analysis of mouse Evx genes: Evx-1 displays graded expression in
            the primitive streak
  JOURNAL   Dev Biol 151 (1), 273-287 (1992)
   PUBMED   1349539
REFERENCE   7  (bases 1 to 4210)
  AUTHORS   Bastian,H., Gruss,P., Duboule,D. and Izpisua-Belmonte,J.C.
  TITLE     The murine even-skipped-like gene Evx-2 is closely linked to the
            Hox-4 complex, but is transcribed in the opposite direction
  JOURNAL   Mamm Genome 3 (4), 241-243 (1992)
   PUBMED   1611218
REFERENCE   8  (bases 1 to 4210)
  AUTHORS   Faiella,A., D'Esposito,M., Rambaldi,M., Acampora,D., Balsofiore,S.,
            Stornaiuolo,A., Mallamaci,A., Migliaccio,E., Gulisano,M. and
            Simeone,A.
  TITLE     Isolation and mapping of EVX1, a human homeobox gene homologous to
            even-skipped, localized at the 5' end of HOX1 locus on chromosome 7
  JOURNAL   Nucleic Acids Res 19 (23), 6541-6545 (1991)
   PUBMED   1684419
REFERENCE   9  (bases 1 to 4210)
  AUTHORS   Pereira,E., San Filippo,G., Pereyra,C., Ortega,J., Rosendo,A. and
            Perurena,R.
  TITLE     [Maxillofacial fractures. Our experience]
  JOURNAL   Rev Soc Odontol La Plata 4 (6), 26-29 (1991)
   PUBMED   2064805
REFERENCE   10 (bases 1 to 4210)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC061467.1 and AL928644.12.
            
            On Aug 21, 2015 this sequence version replaced NM_007967.2.
            
            Summary: This gene is located at the 5' end of the Hoxd gene
            cluster on chromosome 2. The encoded protein is a homeobox
            transcription factor that is related to the protein encoded by the
            Drosophila even-skipped (eve) gene, a member of the pair-rule class
            of segmentation genes. The encoded protein plays a role in limb
            morphogenesis. [provided by RefSeq, Aug 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M93128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1136              BC061467.1         1-1136
            1137-1269           AL928644.12        140845-140977       c
            1270-1903           BC061467.1         1137-1770
            1904-1904           AL928644.12        140210-140210       c
            1905-4210           BC061467.1         1772-4077
FEATURES             Location/Qualifiers
     source          1..4210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.13 cM"
     gene            1..4210
                     /gene="Evx2"
                     /gene_synonym="Evx-2"
                     /note="even-skipped homeobox 2"
                     /db_xref="GeneID:14029"
                     /db_xref="MGI:MGI:95462"
     exon            1..565
                     /gene="Evx2"
                     /gene_synonym="Evx-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1566
                     /gene="Evx2"
                     /gene_synonym="Evx-2"
                     /note="even skipped homeotic gene 2 homolog"
                     /codon_start=1
                     /product="homeobox even-skipped homolog protein 2"
                     /protein_id="NP_031993.1"
                     /db_xref="CCDS:CCDS16138.1"
                     /db_xref="GeneID:14029"
                     /db_xref="MGI:MGI:95462"
                     /translation="MMERIRKEMILMERGLHSPTAGKRFSSLSDSAGGAVLEALENSQ
                     HPARLSPRLPSAPLHGALGDLPAKGKFEIDTLFNLQHPSSESTVSSEIASATESRKKP
                     SHYSEAAAEADMSSDVEVGCSALRSPSGLGAAPLKENNAKGYTESGSVAGTTTSASGS
                     GLGSLHGGGGGGNSGAAALGGSGSGSGADQVRRYRTAFTREQIARLEKEFYRENYVSR
                     PRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMSWPHPADPSFYTYMMTHAAATGS
                     LPYPFHSHVPLHYYPHVGVTAAAAAAAASGAAAAASSPFATSIRPLDTFRALSHPYSR
                     PELLCSFRHPGLYQAPAAAAGLNSAASAAAAAAAAAAAASSAAAAGAPPSGSSAPCSC
                     LSCHSSQSAAAAAAAAAAALGSRGGGGSGGGGGGGAGTAGGSDFGCSAAAPRSESGFL
                     PYSAAVLSKTAVSPPDQRDEAPLTR"
     exon            566..846
                     /gene="Evx2"
                     /gene_synonym="Evx-2"
                     /inference="alignment:Splign:2.1.0"
     exon            847..4191
                     /gene="Evx2"
                     /gene_synonym="Evx-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caattttttc cgcctccctc caaaagagat aataatattt agagccgctt gctggggctg
       61 aatgagaatc agccctgggc gcagcccatc attaagacgg gacagccagg ccactgtgac
      121 attttttaga aagctgagat gatggaaaga ataagaaaag agatgattct gatggaaaga
      181 gggctccaca gccctactgc tggcaagagg ttctccagtt tgtccgattc agctggcggt
      241 gctgtgctcg aggccctgga aaattcgcag cacccggctc gcctcagtcc gcgcctgccg
      301 tccgccccgc tgcacggagc tctgggagac ctccccgcca aaggcaaatt cgaaatagac
      361 actttgttca acctgcagca cccgagcagc gaaagcaccg tctcctccga aattgcctcc
      421 gctaccgaga gccgcaagaa gcctagtcat tattccgaag cggccgccga ggccgacatg
      481 agcagcgacg tggaggtggg ctgctccgca ctgcgctccc ccagcggcct gggcgctgca
      541 ccgctcaagg aaaacaatgc caaagggtac acggagagcg gctccgtcgc gggcaccacg
      601 acgtcggctt ccggctcggg cctcggtagt ctgcatggag gcggcggcgg cggcaatagc
      661 ggggctgcgg cgttgggcgg ctctggctcc ggttccggcg ccgatcaggt gcggcgatac
      721 cgtacggcat tcacccgcga acagatcgcg cgcctggaga aagagttcta cagggagaac
      781 tacgtgtctc ggccccgccg gtgcgagctg gccgctgcac tcaacctgcc cgaaaccacc
      841 atcaaggtgt ggttccagaa ccggcgcatg aaggacaaac ggcagcgcct ggccatgtcg
      901 tggccgcatc cagccgaccc cagcttctac acctacatga tgacacacgc ggcggccacc
      961 ggaagcctac cctacccttt tcactcgcac gtgccgctgc actactaccc gcacgtgggc
     1021 gtcaccgcgg ctgcagcagc ggccgcagcc tcgggagcgg cggcggcagc atcctcgccc
     1081 ttcgccacat ccatccgtcc tctggacacc ttccgtgcgc tttcacatcc ttattcgcgg
     1141 ccggaactgc tctgcagctt ccgccacccg gggctctacc aggcgccagc cgccgccgcg
     1201 gggttgaaca gcgcggcgtc ggctgctgca gcagcggcgg ctgcagcggc ggcagcctcc
     1261 tcggcggcgg cggctggggc gccccccagc ggtagctcgg cgccctgctc gtgcctcagt
     1321 tgtcacagca gccagtctgc agcggcggcg gccgccgctg cagcggcagc gctgggctcc
     1381 cggggcggcg gtggcagcgg cggtggcggc ggcgggggag ccgggacggc gggtggctcg
     1441 gactttggct gcagcgccgc ggcgccgcgc tccgagagcg gcttcttgcc ctattccgcc
     1501 gcggtgctca gcaagaccgc cgtcagcccg ccggaccaga gggacgaggc gccgctcacc
     1561 agataactac gccgccgcca ggggccgcgc cagcctctcg gcgtgcgccc cgtcgggccc
     1621 cgcttggccc tcggctcctg ctgccgctag ggggcgcccc ggggggtccg ggagggcgaa
     1681 agaaacctgc ccgagttggg gggttggggg aggagggaag gggcgggcgt gaaagcctgg
     1741 cggggtcccc ccaaatgatc tctatttttg tatctccaac ctagctcccc tctccccacg
     1801 cccactccca accctacgcc ttctaaacgt ggttcccgct ttgcaggccc cgctttccac
     1861 ctgtctggag tcccgggtct ccagaagaca accccccccc cccacacaca cacacacacg
     1921 ggccagtcag acggatccag gtgtccagtt gtggctgatc agcctcgggg ccgagttacc
     1981 ctgggggtgg gggtggccag aagcaatggg ggtgccgtga caaagtgaga gaactgtggg
     2041 cgttagtact tgggtgaggc aacatcaccc ctcttaaagc ccccagattc atgctgctgc
     2101 tctttttctt gtctttgaat gagggggaga aggaaaaggc agattttctc agtttcagct
     2161 tactaggggc ctttgtccaa ggggagcagg agggtggaac tgtgagaagc cacaaggcag
     2221 acagggaatg cgtggtagac acttttgaca gcgcgcaggg ctgcagtggt ctgttctgtt
     2281 aggacccagg tgggaaaggg tgccaatcgc gcttccttct ctctggttca ctacagttag
     2341 ttcttttagt ctttggttac cgtgcttagg aaatggaagg ttttatttat ttttcctttt
     2401 ttccccttgc atattttgtg taaaacgtaa cggatataga ggttgccata gccaggactg
     2461 aaggaaaggg aaacagagag gaggtgaggg tcaaactgac attgtagttt gtggagaggc
     2521 aatttcatct cagttttcca atcttcgagt tccactcgat ctggaaagta cttgaatctc
     2581 tcggtatatg atatcatcct aaaaatttcc ttagacactt ttatgagttg gaactctgta
     2641 ttcctctgga ccctttcttt ccttgttttc cttttcctcg ggtaaaatgg ttcttggtgt
     2701 atttctcacg catgtctatt gccttcttct ctgcaaagcc accgctgggt tgctgagacc
     2761 tgctctgcca accctggcta cagggggggt ttccttgaac ttgaagaaag gtacatcaaa
     2821 acccaccagt gttaactgcc acgtcaattt tgatgctaat aatgtgcaga ttatgacgaa
     2881 aattgccaat catgctctct gatggacctc ctttgaatgt ggaattggag aaaagttccc
     2941 tgcacggaga cctgctgtca agtactaaca acccgctaag ggaagtcatt aggagagacg
     3001 gataagagac tcggtacata aaacattgtt cttggtgcat agaatgtacg ttatttaatg
     3061 ttatctctgt tacctgaagt gatttcgcag aaaaaaagcc acgttcttat catctcaatg
     3121 gccaattttc attttggtaa cttggacgcc ctgggtagac ttttctctgt taagttgata
     3181 ttccaccaat gtgaacagcc tcattaaatc aagcccagat atttccataa tgctccccgc
     3241 tgagccactt cgctcctcac ataatgagat tttctgaaga gttgaaaccc taaaataact
     3301 tgcatgctta ggcccagcaa agtgggtata tgtgtgtatg caacctgcgt gtgtatgtgt
     3361 atatatatgt atatctatgt atatgcatat atatatccgt gctcttaaat acatatataa
     3421 gaggtacaca catccataga tacacattgg cacgttttct gtgatttatt tcaaattcgt
     3481 ttcctagcat tttttttgtt gttgttattt taaagacact ggattttaaa ttttcacttc
     3541 ctgaggatag atttttttca ctatatgttg aaataattaa tttttccagg aaaattattt
     3601 ttatcaagtg aaaaagattt caaggggaag cagtatttaa aaactcttgt gatttattat
     3661 gatattccca taaaatatta aagaactttc caaggaaata acaatgatct aaaactcaac
     3721 tttttttcta aagagataag actacttatg taaaaagaat gattatacca gctcatattc
     3781 actaagttta cattaaaaat attaatatat aatttaagac taaataaaat aaaccaaaat
     3841 atggtatcct ttatcagctt tacctttcta gattgttaaa gctctttgtt atgatcagct
     3901 atcagatgta tataaggtac tttaggcaat aatgtttaca tccccctccc aaatatatat
     3961 gattgatgag aacgctggct ggtgaaatga acataaattc atcttatgtt aggtccattg
     4021 gatctggcta gtataataaa ataaatctgt aaataaagtc tttgtgcttt aaatattgct
     4081 ggctgtatga actcactgta agatatttta caaatgtgca ataattataa agctttgtat
     4141 attacgttat ttattgtgtt tgctcatgta aaataaatgt tatttaaatc aaaaaaaaaa
     4201 aaaaaaaaaa
//
