LOCUS       NP_031992                416 aa            linear   ROD 04-MAR-2025
DEFINITION  homeobox even-skipped homolog protein 1 [Mus musculus].
ACCESSION   NP_031992
VERSION     NP_031992.1
DBSOURCE    REFSEQ: accession NM_007966.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 416)
  AUTHORS   Vermeiren,S., Cabochette,P., Dannawi,M., Desiderio,S., San
            Jose,A.S., Achouri,Y., Kricha,S., Sitte,M., Salinas-Riester,G.,
            Vanhollebeke,B., Brunet,J.F. and Bellefroid,E.J.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 416)
  AUTHORS   Sartoretti,M.M., Campetella,C.A. and Lanuza,G.M.
  TITLE     Dbx1 controls the development of astrocytes of the intermediate
            spinal cord by modulating Notch signaling
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35815610
REFERENCE   3  (residues 1 to 416)
  AUTHORS   Wang,Y.B., Song,N.N., Zhang,L., Ma,P., Chen,J.Y., Huang,Y., Hu,L.,
            Mao,B. and Ding,Y.Q.
  TITLE     Rnf220 is Implicated in the Dorsoventral Patterning of the
            Hindbrain Neural Tube in Mice
  JOURNAL   Front Cell Dev Biol 10, 831365 (2022)
   PUBMED   35399523
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 416)
  AUTHORS   Bernhardt,N., Memic,F., Velica,A., Tran,M.A., Vieillard,J.,
            Sayyab,S., Chersa,T., Andersson,L., Whelan,P.J., Boije,H. and
            Kullander,K.
  TITLE     Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally
            Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26
  JOURNAL   eNeuro 9 (2) (2022)
   PUBMED   35210288
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 416)
  AUTHORS   Schnerwitzki,D., Hayn,C., Perner,B. and Englert,C.
  TITLE     Wt1 Positive dB4 Neurons in the Hindbrain Are Crucial for
            Respiration
  JOURNAL   Front Neurosci 14, 529487 (2020)
   PUBMED   33328840
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 416)
  AUTHORS   Niswander,L. and Martin,G.R.
  TITLE     FGF-4 regulates expression of Evx-1 in the developing mouse limb
  JOURNAL   Development 119 (1), 287-294 (1993)
   PUBMED   7506139
REFERENCE   7  (residues 1 to 416)
  AUTHORS   Dush,M.K. and Martin,G.R.
  TITLE     Analysis of mouse Evx genes: Evx-1 displays graded expression in
            the primitive streak
  JOURNAL   Dev Biol 151 (1), 273-287 (1992)
   PUBMED   1349539
REFERENCE   8  (residues 1 to 416)
  AUTHORS   Jones,F.S., Chalepakis,G., Gruss,P. and Edelman,G.M.
  TITLE     Activation of the cytotactin promoter by the homeobox-containing
            gene Evx-1
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2091-2095 (1992)
   PUBMED   1372434
REFERENCE   9  (residues 1 to 416)
  AUTHORS   Faiella,A., D'Esposito,M., Rambaldi,M., Acampora,D., Balsofiore,S.,
            Stornaiuolo,A., Mallamaci,A., Migliaccio,E., Gulisano,M. and
            Simeone,A.
  TITLE     Isolation and mapping of EVX1, a human homeobox gene homologous to
            even-skipped, localized at the 5' end of HOX1 locus on chromosome 7
  JOURNAL   Nucleic Acids Res 19 (23), 6541-6545 (1991)
   PUBMED   1684419
REFERENCE   10 (residues 1 to 416)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113985.11.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X54239.1, SRR7345562.5148373.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.44 cM"
     Protein         1..416
                     /product="homeobox even-skipped homolog protein 1"
                     /note="even skipped homeotic gene 1 homolog"
                     /calculated_mol_wt=43067
     Region          30..120
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P23683.1)"
     Region          138..178
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P23683.1)"
     Region          184..240
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..416
                     /gene="Evx1"
                     /gene_synonym="Evx-1"
                     /coded_by="NM_007966.4:348..1598"
                     /db_xref="CCDS:CCDS20149.1"
                     /db_xref="GeneID:14028"
                     /db_xref="MGI:MGI:95461"
ORIGIN      
        1 mesrkdmvmf ldggqlgtlv gkrvsnlsea vssplpeppe kmvphgclsp ragpptsrer
       61 ggggqeeepv dglagsaagl gaeprsagaa mlgpgppvps adslsgqgqp sssdtesdfy
      121 eeievsctpd catgnaeyqh skapgsdalg ssptsgseap ksnggsggsg sqgtlacsas
      181 dqmrryrtaf treqiarlek efyrenyvsr prrcelaaal nlpettikvw fqnrrmkdkr
      241 qrlamtwphp adpafytymm shaaaagglp ypfpshlplp yyspvglgaa saasaaaspf
      301 sgplrpldtf rvlsqpyprp ellcafrhpp lypgpahglg asaaaaaaag pcsclachsg
      361 panglapraa aaaaasdftc astsrsdsfl tfapsvlska ssvaaldqre evpltr
//
