LOCUS       NM_025276               6398 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus envoplakin (Evpl), mRNA.
ACCESSION   NM_025276 XM_283024
VERSION     NM_025276.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6398)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   2  (bases 1 to 6398)
  AUTHORS   Natsuga,K. and Watt,F.M.
  TITLE     Galectin-6 is a novel skin anti-microbial peptide that is modulated
            by the skin barrier and microbiome
  JOURNAL   J Dermatol Sci 84 (1), 97-99 (2016)
   PUBMED   27427436
REFERENCE   3  (bases 1 to 6398)
  AUTHORS   Natsuga,K., Cipolat,S. and Watt,F.M.
  TITLE     Increased Bacterial Load and Expression of Antimicrobial Peptides
            in Skin of Barrier-Deficient Mice with Reduced Cancer
            Susceptibility
  JOURNAL   J Invest Dermatol 136 (1), 99-106 (2016)
   PUBMED   26763429
REFERENCE   4  (bases 1 to 6398)
  AUTHORS   Kumar,V., Bouameur,J.E., Bar,J., Rice,R.H., Hornig-Do,H.T.,
            Roop,D.R., Schwarz,N., Brodesser,S., Thiering,S., Leube,R.E.,
            Wiesner,R.J., Vijayaraj,P., Brazel,C.B., Heller,S., Binder,H.,
            Loffler-Wirth,H., Seibel,P. and Magin,T.M.
  TITLE     A keratin scaffold regulates epidermal barrier formation,
            mitochondrial lipid composition, and activity
  JOURNAL   J Cell Biol 211 (5), 1057-1075 (2015)
   PUBMED   26644517
  REMARK    Erratum:[J Cell Biol. 2016 Mar 28;212(7):877. doi:
            10.1083/jcb.20140414703042016c. PMID: 27002167]
REFERENCE   5  (bases 1 to 6398)
  AUTHORS   Cipolat,S., Hoste,E., Natsuga,K., Quist,S.R. and Watt,F.M.
  TITLE     Epidermal barrier defects link atopic dermatitis with altered skin
            cancer susceptibility
  JOURNAL   Elife 3, e01888 (2014)
   PUBMED   24843010
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6398)
  AUTHORS   Sevilla,L.M., Nachat,R., Groot,K.R., Klement,J.F., Uitto,J.,
            Djian,P., Maatta,A. and Watt,F.M.
  TITLE     Mice deficient in involucrin, envoplakin, and periplakin have a
            defective epidermal barrier
  JOURNAL   J Cell Biol 179 (7), 1599-1612 (2007)
   PUBMED   18166659
  REMARK    GeneRIF: Thus, combined loss of the cornified envelope proteins not
            only impairs the epidermal barrier, but also changes the
            composition of T cell subpopulations in the skin.
REFERENCE   7  (bases 1 to 6398)
  AUTHORS   Maatta,A., DiColandrea,T., Groot,K. and Watt,F.M.
  TITLE     Gene targeting of envoplakin, a cytoskeletal linker protein and
            precursor of the epidermal cornified envelope
  JOURNAL   Mol Cell Biol 21 (20), 7047-7053 (2001)
   PUBMED   11564887
  REMARK    GeneRIF: although envoplakin is part of the scaffolding on which
            the epidermal cornified envelope is assembled, it is not essential
            for envelope formation or epidermal barrier function.
REFERENCE   8  (bases 1 to 6398)
  AUTHORS   Maatta,A., Ruhrberg,C. and Watt,F.M.
  TITLE     Structure and regulation of the envoplakin gene
  JOURNAL   J Biol Chem 275 (26), 19857-19865 (2000)
   PUBMED   10747979
REFERENCE   9  (bases 1 to 6398)
  AUTHORS   Ruhrberg,C., Hajibagheri,M.A., Parry,D.A. and Watt,F.M.
  TITLE     Periplakin, a novel component of cornified envelopes and desmosomes
            that belongs to the plakin family and forms complexes with
            envoplakin
  JOURNAL   J Cell Biol 139 (7), 1835-1849 (1997)
   PUBMED   9412476
REFERENCE   10 (bases 1 to 6398)
  AUTHORS   Ruhrberg,C., Hajibagheri,M.A., Simon,M., Dooley,T.P. and Watt,F.M.
  TITLE     Envoplakin, a novel precursor of the cornified envelope that has
            homology to desmoplakin
  JOURNAL   J Cell Biol 134 (3), 715-729 (1996)
   PUBMED   8707850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669925.8.
            
            On Aug 5, 2006 this sequence version replaced NM_025276.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AL669925.8         53415-53606         c
            193-292             AL669925.8         50447-50546         c
            293-447             AL669925.8         49884-50038         c
            448-574             AL669925.8         49670-49796         c
            575-700             AL669925.8         48901-49026         c
            701-739             AL669925.8         48619-48657         c
            740-901             AL669925.8         48340-48501         c
            902-1009            AL669925.8         48145-48252         c
            1010-1105           AL669925.8         47909-48004         c
            1106-1231           AL669925.8         46433-46558         c
            1232-1378           AL669925.8         45931-46077         c
            1379-1533           AL669925.8         45484-45638         c
            1534-1631           AL669925.8         45260-45357         c
            1632-1804           AL669925.8         44916-45088         c
            1805-1983           AL669925.8         43574-43752         c
            1984-2122           AL669925.8         43357-43495         c
            2123-2316           AL669925.8         43073-43266         c
            2317-2467           AL669925.8         42504-42654         c
            2468-2551           AL669925.8         40999-41082         c
            2552-2662           AL669925.8         40777-40887         c
            2663-2755           AL669925.8         40583-40675         c
            2756-6398           AL669925.8         36074-39716         c
FEATURES             Location/Qualifiers
     source          1..6398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.02 cM"
     gene            1..6398
                     /gene="Evpl"
                     /note="envoplakin"
                     /db_xref="GeneID:14027"
                     /db_xref="MGI:MGI:107507"
     exon            1..192
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            193..292
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            293..447
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            448..574
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            575..700
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            701..739
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            740..901
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1009
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1105
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1231
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1378
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1533
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1631
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1804
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1983
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2122
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2316
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2467
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2551
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2662
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2755
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..6398
                     /gene="Evpl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6379..6384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Evpl"
                     /note="hexamer: AATAAA"
     polyA_site      6398
                     /gene="Evpl"
                     /note="major polyA site"
ORIGIN      
        1 agagcccggc tagtagccag cgaggacgcg cgtcgccttc ccgccgccct cctcccagga
       61 gagcccagcc tgagccggca cctgcttcac caccatgttc aaggggctga gcaaaggctc
      121 ccaggggaag gggtccccca agggctcccc agccaagggg tcccctaagg gctcccccaa
      181 caagcacaat cgggctgcaa cccaggaact ggctctgctc atctcccgca tgcaagccaa
      241 cgctgaccag gtggaaagag acattttgga gacgcagaag aagctgcaac aggatcggca
      301 gaatggtgag cagaaccagg ctttacaaca ccagcaggag actggccgca acctgaagga
      361 agcggaggta ctcctcaaag atctcttcct ggatgtagac aaggcgcggc ggctcaagca
      421 cccacaggct gaggagattg agaaagacat caagcagctg catgagcggg tgacccagga
      481 gtgctcggag taccgtgctc tgtatgagaa gatggtactt ccgcctgatg tggggcccag
      541 ggtcgactgg gcgcgtgtgt tggagcagaa acagaatctg gtccgtgagg gccactatgg
      601 gcctgggatg gcagagctgg aacagcaggt ggccgagcac aacatcctgc agagagaaat
      661 cgaggcttac gggcagcagc tgcggacgct ggtgggaccg gatgcaaaca ccatcaggaa
      721 ccaataccgt gagctgctga aggcggcctc gtggcgccga cagagtctgg gcagcctgta
      781 cacccacctg caaggctgca cgaagcagct gagcgccctg gccgatcaac aaggccgcat
      841 cctgcagcag gattggagtg acctcatgcc ggaccccgct ggcgtgaggc gagagtatga
      901 gcacttcaag cagcatgagc tgctggccca ggagcggagc ataaaccagc tggaagatga
      961 cgcagatcgc atggtggagc ttgggcaccc ggccattggg cccatccagg tccaccagga
     1021 ggccctcaag atggagtggc agaatttcct aaacctttgc atctgtcagg agagccagct
     1081 gcaacgggtg gaggactacc gtaggttcca ggaagaggcg gactcagtca gccagaccct
     1141 ggcaaagctc agctccaacc tggataccaa gtacggcttt ggcactgggg actcctccgg
     1201 ctcccccaca gagctcctgc tacagctgga ggcagaggag aagcagctgg ccatagcaga
     1261 gagggctgtt ggagatctgc agcagcgaag ccaggaggtg gccccactgc cacagcgcag
     1321 gaacccatcc aagcagcccc tgcacgtgga cagcatctgt gactgggact cgggagaagt
     1381 tcagctgctt cggggagagc ggtacacact caaggataat gctgacccat acacgtggct
     1441 ggttcagggc cctggaggag agaccaaaag tgccccagct gcctgcctct gcatcccagc
     1501 accagaccct gaagctgtgg ccaaagcctc taggctggcc acggagctgc agaccctgaa
     1561 gcagaagctg tctacagaga agaaccgcct gaaggctgct gctgtggaac acttacagcc
     1621 tggccagcag gctccggcag gctcagcccc cgctgaccca caaggtcaga cgctcctgtc
     1681 acagatgacc cagctggatg gggatctggg gcagatagag aggcaggtgc tgagctgggc
     1741 ccggagccca ctgagccagt cttcttcact gaaggacctc gagggccgca tccacagctg
     1801 tgagggcaca gcacagcgcc ttcagagtct gggagcggag aaggaggcag cccagcagga
     1861 gtgtgaggcg tttctgtcta ccaagcctac gggctccgct gccctgcaac tgcccgtggt
     1921 cctcaacagt gtgaagaaca gatacaatga tgtgcagagc ctgtgccacc tctatgggga
     1981 gaaagccaag gctgctctgg gcctggagaa gcagatccag gaggcagaca gggtcatcca
     2041 aggctttgaa gccgccctgg cacttgaggg ccccgtcccc gaaggctctg gggcactgca
     2101 ggagagggtc agcgagctgc agcgccagcg caaagaactc cttcagcagc aggcctgtgt
     2161 gctggggctg caccgccagc tgaaggccac tgagcatgcg tgcagtgcgc tgcagaacaa
     2221 tttccaagag ttctgccaag acctgccgcg ccagcagcgc caggttcgtg ccctcactga
     2281 ccgttaccac gctgtggggg accagctgga tttgagggag aagatagtac aggatgccag
     2341 cctcacctac cagcagctca ggaacagcag ggacaacctg agctcttggc tggagcagct
     2401 gccccaccac cgggtgcagc ccagcgacgg gccaagccag atttcctaca agctgcaagc
     2461 acagaagaga ctgatacaag aaatcctggg gcgcgagcag gaccaggcca ccgtgtcccg
     2521 cctcacccgg gacctgcagg aggccctcca ggactatgag ctgcaagcag atacctaccg
     2581 ctgctcctta gagcccgcct tggcagtgtc cgccccgaag agactcagag tgatttcctt
     2641 gcaggagagc atccaggctc aggagaagaa ccttgcgaag gcttacactg aggttgccgc
     2701 agctgagcag cagcagctgc gccagctgga gtttgctaaa aagatgctca ggaagaagga
     2761 acttgatgag gacatccaag ccatccacag cgcgagacag ggatctggga gtccggcaca
     2821 cgcaaggacg gcggagtcag aggtcctgaa gacccagctt gaggaagaga ggaagcgggt
     2881 ggctgaggtg cagcgtgacc tggaggagca gaggcagcgg ctgctgcagc tgaggaccca
     2941 gcagcctgtg gcgcggctgg aggagaagga agtggtggaa ttctaccggg acccccagct
     3001 ggagagtaac ctgtctcagg cagcatcccg ggtggaggaa gagggcaaga ggcgggcccg
     3061 cctgcaggcc gagctggagg cggtggccca gaaggttgtc cacttggagg gcaagaggaa
     3121 gaccatgcaa cctcacctgc tgaccaaaga ggtcacccaa atcgagaggg accctggcct
     3181 ggacagccag gttacccagc tccacagtga gatgcaacgg ttgcgcgggg agaacggcgt
     3241 cctcacagcc aggctggaag agctgaagga cgagctgcta gccctggagc agaaggagat
     3301 gaacgtgaag gagaaggtcg tggtgaagga ggtggtgaag gtggagaagg atctagaaat
     3361 ggttaaggcg gcccagactc tgaggctcca gatcgaggaa gatgctgcac ggaggaaggg
     3421 ggcgaaggag accgttgcca agatacaggc tcgcatcaaa gacctggagc aggcgatcag
     3481 ctcagtggag cccaaggtca ttgtgaagga ggtgaagaag gtagagcagg acccgggcct
     3541 tctcaaggag gcttccaggc tgagaagcct cctggaggag gagaagaaca acaacgtcgc
     3601 gttggccagg gaactgcagg agctgcagga gaaatacagg gtggtggaaa agcagaagcc
     3661 caaggtgcag ctgcaggagc gagtcagcga gatcttccag gtgctcccgg agacagagca
     3721 ggagatccgg aggctccggg cccagctgca ggagacaggc agcaagaaga gcggcgtgga
     3781 gcaggaggta gagaagctgc tgcctgagct ggaggtcctg cgggctcaga agcccgtggt
     3841 ggaatataag gaggtgactc aggaggtggt gaggcacgag aagaacccag aggtgctgcg
     3901 ggagatcgac cgtctcaagg ctcagctcaa cgaactggtc aacaccaacg ggcgctctca
     3961 ggagcagctc atccggctcc agggcgaacg cgatgagtgg aagcgggaaa ggtccaaggt
     4021 ggagaccaag atggtgagca aagaagtcgt gcggcacgag aaggatccgg tgctggagaa
     4081 ggaggccgag aggctccggc aggaggtgcg ggaggctgtc cagaggaggc gagccacgga
     4141 ggatgctgtg tacgagctgc agaacaagtt actgctgctg gagaggaggc ggcccgagga
     4201 gcagatagtg gtgcaggagg tggtggtcac ccagaaggac ccgaagctgc gcgaggagca
     4261 cagccggctg agccgcagct tggatgagga ggtggggcgc cggcggcagc tggagctgga
     4321 ggtgcggcag ctgggcgcca gagttgagga ggaggaggcc aggctcagct tcgaggagga
     4381 tcgcagcaag aagctggccg ccgagaggga gctgcggcaa ctgaccctga agatccagga
     4441 gctggagaag cggccccctg ccctgcagga aaagatcatc atggaggaag tggtcaagtt
     4501 agagaaagat cctgacctgg agaggtctac agaagctctg cggcgcgagc tggatcagga
     4561 gaagaaccgc gtgaccgagc tgcaccggga gtgccagggt ctgcaggttc aggtcgacct
     4621 cctccagaaa actaaatcac aggagaagac catatacaag gaagtgatca gggtcgagaa
     4681 ggacccggtg ctggagggcg agagggcccg agtgtgggag atccttaacc gggagcgcgc
     4741 agcccgcaag ggccgggagg aggatgtccg gagcttgcag gagcggatcg accgagccga
     4801 ggctctgagg aggtcctggt cccgcgagga agctgagctc cagagggccc gggaccaggc
     4861 aagccaggac tgcgggcggc tgcagagaca gctgcgggag ctggagcagc agaaacagca
     4921 gaaagcccgg cagctacagg aggaggggag gctgcttagc cagaagacgg agagcgagcg
     4981 ccagaaggcc gcccagcgga gccaggcggt cacgcagctc gaggctgcca ttctccagga
     5041 aaaggacaag atctacgaga aagagaggac cctcagggac ctgcacacca aggtgagccg
     5101 ggaggagctc aaccaggaga cccagacccg ggagaccaac ctctccacca agatctgcat
     5161 cttggaaccg gagaccggca atgacatgtc tccttacgag gcctacaaga ggggtgtcat
     5221 cgacagaggc cagtatctcc agctgcagga gctggagtgt gactgggaag aagtcacaac
     5281 ctccagcccc tgcggggagg agtctgtgct cctggaccgc aagagcggga agcaatactc
     5341 catcgaggcc gccctccgct gccgccgcat ttccaaagaa gagtaccaca ggtacaaaga
     5401 tggccgcctc cccatctccg agtttgccct gcttgtggca ggggagacca agccgagttc
     5461 ttcactctcc attgggtcca tcatctccaa gtctccagtc tgctccccag gcccccagag
     5521 taccggcttc ttctccccag gcctctcttt tgggctcact gaggatagct tccccatcgc
     5581 ggggatctac gatacaacca cagacaacaa gtgtagcatc aaggcagctg tggccaagaa
     5641 catgctggat cctatcactg ggcagaagct gttggaggcc caggcagcca cgggaggcat
     5701 tgttgacctt cttagccgag aacggtactc cgtacacaag gcggtggagc ggggactcat
     5761 tgagaacacc tccactcaac ggctgctcaa tgctcagaag gccttcaccg gcatcgagga
     5821 ccctgtcacc aggaagaggc tgtcggtggg tgaggccatc cagaagggct ggatgcccca
     5881 ggaaagcgtg cttccccacc tgctggtaca gcacctgact gggggcctca tcgaccccaa
     5941 gaggacggga cgcatccccg tccctcaggc tgtgctctgc gggatgatca gcgaagacct
     6001 gggccagctc ctgcaagatg aatccggcta cgagaaggat ctgacagacc ccatcaccaa
     6061 ggagaggctg agctacaagg aggccatggg gcgctgccgc aaagatcctc taagtggcct
     6121 actactgctc cccgccatgc tagaaggcta tcgctgctac cgcgcggcct cccccaccct
     6181 gccaagatcc tgtgtgcgtt gatgaggggc tctgcagagg gggagggaga atgcacacgt
     6241 caccttgccc tggagctgcg taatccgagg cagcgggtcc tcctcctgag tgtccacctc
     6301 actgcgcaat cgtttgtggt gttgggctct gtccccaaat atgggaagtt ccgttgttcc
     6361 tccccacccc gtgcttctaa taaatggatt atctctgt
//
