LOCUS       NM_001077496            3529 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ecotropic viral integration site 2b (Evi2b), mRNA.
ACCESSION   NM_001077496
VERSION     NM_001077496.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3529)
  AUTHORS   Zjablovskaja,P., Kardosova,M., Danek,P., Angelisova,P.,
            Benoukraf,T., Wurm,A.A., Kalina,T., Sian,S., Balastik,M.,
            Delwel,R., Brdicka,T., Tenen,D.G., Behre,G., Fiore,F., Malissen,B.,
            Horejsi,V. and Alberich-Jorda,M.
  TITLE     EVI2B is a C/EBPalpha target gene required for granulocytic
            differentiation and functionality of hematopoietic progenitors
  JOURNAL   Cell Death Differ 24 (4), 705-716 (2017)
   PUBMED   28186500
  REMARK    Erratum:[Cell Death Differ. 2019 Jan;26(1):198. doi:
            10.1038/s41418-018-0146-z.. PMID: 29991745]
REFERENCE   3  (bases 1 to 3529)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3529)
  AUTHORS   Venturin,M., Bentivegna,A., Moroni,R., Larizza,L. and Riva,P.
  TITLE     Evidence by expression analysis of candidate genes for congenital
            heart defects in the NF1 microdeletion interval
  JOURNAL   Ann Hum Genet 69 (Pt 5), 508-516 (2005)
   PUBMED   16138909
REFERENCE   5  (bases 1 to 3529)
  AUTHORS   Buchberg,A.M., Bedigian,H.G., Jenkins,N.A. and Copeland,N.G.
  TITLE     Evi-2, a common integration site involved in murine myeloid
            leukemogenesis
  JOURNAL   Mol Cell Biol 10 (9), 4658-4666 (1990)
   PUBMED   2167436
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196178.1, AK039968.1 and AL591174.13.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY196178.1, AK171686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY196178.1         1-23
            24-1858             AK039968.1         1-1835
            1859-3529           AL591174.13        186585-188255
FEATURES             Location/Qualifiers
     source          1..3529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.8 cM"
     gene            1..3529
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /note="ecotropic viral integration site 2b"
                     /db_xref="GeneID:216984"
                     /db_xref="MGI:MGI:1890682"
     exon            1..151
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /inference="alignment:Splign:2.1.0"
     exon            152..3529
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1501
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /note="protein EVI2B; EVI-2B; ecotropic viral integration
                     site 2B protein"
                     /codon_start=1
                     /product="protein EVI2B precursor"
                     /protein_id="NP_001070964.1"
                     /db_xref="CCDS:CCDS25121.1"
                     /db_xref="GeneID:216984"
                     /db_xref="MGI:MGI:1890682"
                     /translation="MEFKYLVFIVLCQYLDNTFFSETEAITTEQQSLSTLITPSLYVT
                     TDSQNTAGNALSQTTRFKNISSGQQASPAQITPEQATPAVYVSSSPLTYNITRQAESA
                     VNNSLPQTSPSGFTLTNQPSPSTYNSTGQPPKHLVYTSTQQPPSPAPTSSGKPEVEST
                     HNQPTKSTPTIYLQRDTPPPPPPPLTSEPPSGKGTAHKNNHNAIAAILIGTIIISMLV
                     AILMIILWKYLRKPVLNDQNWAGRSPFADGETPEMCMDNIRESEASTKRASVVSLMTW
                     KPSKSTLLADDLEVKLFESSEHINDTSNLKTDNVEVQINGLSEDSADGSTVGTAVSSD
                     DADLALPPPLLDLDENLPNKPTVTVVSPLPNDSINPQPSPDGLNQVCEEQHSKIQEPF
                     PPPPDSFNVPLSAGDFINNQESAHEAQCQEFSTPDLHPDLTDSLPPPPTELL"
     regulatory      1834..1839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /note="hexamer: AATAAA"
     polyA_site      1862
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /note="major polyA site"
     regulatory      1873..1878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /note="hexamer: AATAAA"
     polyA_site      1898
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /note="hexamer: ATTAAA"
     polyA_site      2084
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
     regulatory      3154..3159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
                     /note="hexamer: AATAAA"
     polyA_site      3177
                     /gene="Evi2b"
                     /gene_synonym="Evi-2; Evi2"
ORIGIN      
        1 tactgataaa cttcctctgc tgcacagaag ccgtctcagt gcgctggaga ccaccgttaa
       61 tccgcactga aacacccctt tgctctctca gccaaatcac caacatgtcc tgttagaaca
      121 agaatttaca ttctgcgaaa gaagttcaca ggagaaaaca tctgaaatgg aattcaagta
      181 tctggtcttc attgtgcttt gtcaatacct ggacaatacg tttttctcag agacagaagc
      241 aattacaaca gagcagcaat cactgtctac tttaatcaca ccgtcgttat atgttacaac
      301 tgattctcaa aacacagcag ggaatgcttt gagtcagaca acaagattca agaacatttc
      361 ttctggacag caagcatcac ctgcccaaat cactcctgaa caagcaacac cagctgttta
      421 tgtctcttca agcccactta cttataacat taccagacaa gcagaatcag cggtcaacaa
      481 ctccttgcct caaacatcac catctgggtt cactttgacc aatcagccat caccttctac
      541 ctataattct actggacaac caccaaaaca tcttgtctat acttccacac aacagccacc
      601 atcacctgct cctacctctt ctggaaaacc agaagtagag tctactcata atcagcccac
      661 aaaatcaaca ccaactattt atttacaaag ggacacacca ccaccaccac caccaccact
      721 cacttcagaa ccaccaagtg gcaaaggaac tgctcataaa aacaaccaca atgcaattgc
      781 tgccatatta atcggtacta ttataatttc tatgttggta gctatactca tgattatact
      841 gtggaaatac ttgaggaagc cagtcttaaa tgatcaaaac tgggcaggta ggtctccatt
      901 tgctgatgga gaaacaccag aaatgtgtat ggataacatc agagagagtg aggcatccac
      961 aaagcgtgca tcagttgtct cacttatgac ctggaaacca agtaaaagca cactgctagc
     1021 agatgattta gaagttaagt tgtttgaatc aagtgaacac attaatgata ccagcaacct
     1081 caagactgat aatgtagaag ttcaaataaa tggcttatca gaagacagtg ctgatgggtc
     1141 aacagttggt acagccgtgt cttcagatga tgcagatctg gccctgccac ctccccttct
     1201 tgatttggat gagaacctac caaacaagcc cacagtgaca gttgtatctc ctttaccaaa
     1261 tgattctatc aatccccaac catctccaga tggtctaaat caagtgtgtg aagaacagca
     1321 ttccaagatc caagagccat tcccgccacc ccctgactca tttaatgtgc ctctgtcagc
     1381 aggagatttt ataaacaatc aagagtcggc ccacgaggct caatgccagg agttctctac
     1441 tcctgacctc catccagacc tcacagactc cctgccacct ccacctacag agctgctgta
     1501 aagtgacagc tggctttcta gactgccctc catcctgaga tggcaccgac acgttcctgt
     1561 cttcgtggta tggcacacag gacatgacac ctggcacctg agagactctt tagggactac
     1621 ctgacccctg actgaagccc acgtacacgg gtagattatt acagtggtat gcttaccagc
     1681 tacagaagta atttttaaat cagagtgcct tttatatatg ttaatgatag atatttcaat
     1741 aacttaatca ctttggaaac atatgatcta catatactta ttattaccca atagatttcc
     1801 cccgaaaagc tgtatataaa catatcttaa ataaataaaa ttctattttt tccacctcaa
     1861 aatttggggt ataataaaaa tggaaatttt taaatggtca aagttttaat acttcaaata
     1921 ttaagtaaat attttcattt atagagatta aacacacagc taccaaactg tattaaaaca
     1981 tgaagtctga gtgctgtgtt tgggatacat ttaccctgaa aaagtgagca cttaccataa
     2041 aattttcttt tttctttata attaaaaatt ttatgtatat aagagttttg cctgaatatg
     2101 tgtgtatata ttcatatagt cacacacaca cacatatata taagacagaa gatggcacta
     2161 ctaacatttg ccaatgcccc gtgagtcctg gaactgactc caagtcctct gtaagtgctc
     2221 ttaaccaccg agcccctgca actccgttct tcccctcctc ttcctcctcc tcctcttcct
     2281 cctcctcttc ctcttcaaat gtttggggcg tgggggtgga ggtcaaagag ataggctgta
     2341 tttggggtta gaagatgact tgtgggagtt gatttttttc ttccacctca aggataaaat
     2401 tcagaactca agtcatgaga cctgacagca agcaaccttt atcctctaag cccatctcac
     2461 tgcccccaaa atgtaaacat ttttctaaaa tgttagggaa gcataaacta accacttaga
     2521 caaaaatcaa atgatatgga agacgggaga aaaaaataga agtgggctgt atctgtgtgt
     2581 ctcttcccac acatgcatga taccagcctg tgtgagggtg tctgtggaga ccacagagga
     2641 taccagccat cctggaactg aagtcccagg aagttatgag ctgctgtcta acacgggtac
     2701 tgggaactga acttgggtcc tataggacag cagcaagttc tctaaagtac tgacccatca
     2761 ctgcagcccc agcctccttt tgtaaatgca ggaatgtaat catcacctga aggttgttga
     2821 gtatgaggca ctcagaacag aagtgggcac aacttttgtt aaagtggagg cggcagtggg
     2881 tactggccta ccttttgcag atgtcaaatg ttcatctgcc caacaagcca tccttctctt
     2941 attattatta caagtccaag aaaggacagt tgcttagagc acagattttg gcacttttca
     3001 agatagtata tagtatttat tggtaacatt aatgttcaaa tactaaaaat cccatgtaga
     3061 ataaaaacaa gaaggttctc gggcagtgga gttttactac tactgctact attactacta
     3121 catactacta ctattattta gtatataatt atcaataaac aattattata catattataa
     3181 atacatgtaa atttattatt gttgttgttt gtgttctgag acaggagtcc tctggtagcc
     3241 ctggctgtcc tggcactctc tctctataga cccactgtcc tcaaactcac agatacacct
     3301 gcctctgtct cccaatcttt gtgattaacg gtgtgacctt taaacacctt aaaagacact
     3361 gggcttaagt gttattttac atacaatact taccttactt cttacaagcc acctcttact
     3421 gataacactt tttttatcta cagaaacacc tacttcaagc atgatggcgt ttcattttat
     3481 tacattggtt cttttctgtc attcacaata aaatttctca cgtgtcttc
//
