LOCUS       NP_666135                444 aa            linear   ROD 28-APR-2025
DEFINITION  protein EVI2B precursor [Mus musculus].
ACCESSION   NP_666135
VERSION     NP_666135.1
DBSOURCE    REFSEQ: accession NM_146023.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 444)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
REFERENCE   2  (residues 1 to 444)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   3  (residues 1 to 444)
  AUTHORS   Zanivan,S., Gnad,F., Wickstrom,S.A., Geiger,T., Macek,B., Cox,J.,
            Fassler,R. and Mann,M.
  TITLE     Solid tumor proteome and phosphoproteome analysis by high
            resolution mass spectrometry
  JOURNAL   J Proteome Res 7 (12), 5314-5326 (2008)
   PUBMED   19367708
REFERENCE   4  (residues 1 to 444)
  AUTHORS   Villen,J., Beausoleil,S.A., Gerber,S.A. and Gygi,S.P.
  TITLE     Large-scale phosphorylation analysis of mouse liver
  JOURNAL   Proc Natl Acad Sci U S A 104 (5), 1488-1493 (2007)
   PUBMED   17242355
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591174.13 and AK034440.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring Evi2a (ecotropic viral
            integration site 2a) and Evi2b (ecotropic viral integration site
            2b) genes on chromosome 11. The readthrough transcript encodes a
            protein identical to that of the downstream gene product. [provided
            by RefSeq, May 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034440.1, AK156127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 14017, 216984
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11"
     Protein         1..444
                     /product="protein EVI2B precursor"
                     /note="ecotropic viral integration site 2B protein;
                     protein EVI2B; Evi2a-Evi2b readthrough"
                     /calculated_mol_wt=45160
     sig_peptide     1..23
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
                     /calculated_mol_wt=2851
     mat_peptide     24..444
                     /product="Protein EVI2B. /id=PRO_0000021214"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VD58.1)"
                     /calculated_mol_wt=45160
     Region          32..>169
                     /region_name="PRK13335"
                     /note="superantigen-like protein SSL3; Reviewed"
                     /db_xref="CDD:139494"
     Site            63
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            94
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
     Region          104..197
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            104
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            127
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            204..224
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            269
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            272
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            279
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VD58.1)"
     Site            295
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q8VD58.1)"
     Region          318..337
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VD58.1)"
     Region          361..444
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VD58.1)"
     CDS             1..444
                     /gene="Evi2"
                     /gene_synonym="Evi2a-evi2b; Gm21975"
                     /coded_by="NM_146023.4:602..1936"
                     /db_xref="GeneID:101488212"
                     /db_xref="MGI:MGI:5439444"
ORIGIN      
        1 mefkylvfiv lcqyldntff seteaitteq qslstlitps lyvttdsqnt agnalsqttr
       61 fknissgqqa spaqitpeqa tpavyvsssp ltynitrqae savnnslpqt spsgftltnq
      121 pspstynstg qppkhlvyts tqqppspapt ssgkpevest hnqptkstpt iylqrdtppp
      181 ppppltsepp sgkgtahknn hnaiaailig tiiismlvai lmiilwkylr kpvlndqnwa
      241 grspfadget pemcmdnire seastkrasv vslmtwkpsk stlladdlev klfessehin
      301 dtsnlktdnv evqinglsed sadgstvgta vssddadlal ppplldlden lpnkptvtvv
      361 splpndsinp qpspdglnqv ceeqhskiqe pfppppdsfn vplsagdfin nqesaheaqc
      421 qefstpdlhp dltdslpppp tell
//
