LOCUS       NM_001199210            2366 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus eva-1 homolog C (Eva1c), transcript variant 1, mRNA.
ACCESSION   NM_001199210
VERSION     NM_001199210.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Chan,K.K., Seetharaman,A., Bagg,R., Selman,G., Zhang,Y., Kim,J. and
            Roy,P.J.
  TITLE     EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to
            the MADD-4 guidance cue in Caenorhabditis elegans
  JOURNAL   PLoS Genet 10 (8), e1004521 (2014)
   PUBMED   25122090
  REMARK    GeneRIF: we demonstrate that MADD-4 interacts with an EVA-1/UNC-40
            co-receptor complex to attract cell extensions
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2366)
  AUTHORS   James,G., Foster,S.R., Key,B. and Beverdam,A.
  TITLE     The expression pattern of EVA1C, a novel Slit receptor, is
            consistent with an axon guidance role in the mouse nervous system
  JOURNAL   PLoS One 8 (9), e74115 (2013)
   PUBMED   24040182
  REMARK    GeneRIF: We report that EVA1C is expressed by axons contributing to
            commissures, tracts and nerve pathways of the developing spinal
            cord and forebrain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2366)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 2366)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   6  (bases 1 to 2366)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 2366)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 2366)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037486.1, BC100350.1, AK016443.1 and AC134560.5.
            
            On Oct 24, 2015 this sequence version replaced NM_001199210.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132305.1, AF358257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AK037486.1         53-306
            255-1048            BC100350.1         1-794
            1049-1950           AK016443.1         1045-1946
            1951-1965           AC134560.5         52642-52656         c
            1966-2366           AK037486.1         1677-2077
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 52.02 cM"
     gene            1..2366
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /note="eva-1 homolog C"
                     /db_xref="GeneID:70967"
                     /db_xref="MGI:MGI:1918217"
     exon            1..574
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1737
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein FAM176C; protein eva-1 homolog C"
                     /codon_start=1
                     /product="protein eva-1 homolog C isoform 1 precursor"
                     /protein_id="NP_001186139.1"
                     /db_xref="CCDS:CCDS57038.1"
                     /db_xref="GeneID:70967"
                     /db_xref="MGI:MGI:1918217"
                     /translation="MLLPGHPRPPPAPQSAQNQGLRRQVEPPGQLLRLFYCTVLVCSK
                     ETSALTDFSGYLTKLLQNHTAYACDGDYLNLQCPRHSTISVQSAFYGQDYQMCSSQEP
                     ISQREDNLTCVASTTLQKVLDECQNQRACHLLVNSRVFGPDLCPGSSKYLLVSFKCQP
                     NELKNKTVCENQELKLHCHESKFLNIYSAAYGRRTQQRDICSSGAELLPPFDCLSYTA
                     LQVLSRRCYGKQRCKVLVDNYHFGSPCLPGVKKYLTVAYACVPKNILTAVDPAVANLN
                     PSLKKDDEHGITFNPSGSRVVRKDGVIVSNSLAAFAYIRAHPERAALLFMSSVCIGLL
                     LTLCALVIRVSCTKDFRELRQGREHLVLGSDKAEEDSEEDLEEEDSSDSQFPEELSRF
                     CRTSYPAYSSIEAAELAERIERREQVIQEIWMNSGLDSSLPRNVGHFY"
     exon            575..771
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /inference="alignment:Splign:2.1.0"
     exon            772..895
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1048
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1192
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1270
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1360
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2366
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1920..1925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /note="hexamer: AATAAA"
     polyA_site      1952
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /note="major polyA site"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /note="hexamer: AATAAT"
     polyA_site      2005
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
     regulatory      2072..2077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
                     /note="hexamer: ATTAAA"
     polyA_site      2094
                     /gene="Eva1c"
                     /gene_synonym="1700092M14Rik; 4931408A02Rik; Fam176c"
ORIGIN      
        1 tagagacacc ggcgtggaaa gcgctcaagc tgcgcagcat cgggtcgctg ctggagacgc
       61 tctccgcttt gggctcggcg cccccgatcg gcctcggcca agctccggag cacgaggtga
      121 caccccctaa actccctagg ctggctccct aggttcatgg agccaggaag atttcttctg
      181 aagaaactac gcctcggcct ccctgggatc ctcgccccgc cccgggtctc cgccccctcc
      241 ccttggctgg ggatcccgga cccggcggcg accgcctaag aagctccagc agcctggaca
      301 aggaggcggc agggggccgg gagctggtgg ctacagactc gccccgccat gtgacgcggt
      361 cctccttgcc tgcgatccca gcgccagcgc ccgcgcccag ccgcgccgcg catcatgctc
      421 ctgccaggac acccgcgtcc accacccgcg ccccaatcgg cgcagaatca gggcctccgc
      481 aggcaggtag agcctccggg gcagcttctg cgcctgttct actgcacggt cctagtgtgc
      541 tccaaagaga cctccgcgct caccgatttc tctggttact taaccaaact cctgcaaaac
      601 cacactgcct atgcctgtga cggggactat ctgaatctac agtgccctcg gcattcaaca
      661 ataagtgtcc agtcggcatt ttatgggcaa gattaccaaa tgtgtagttc ccaggagccc
      721 atctcccaga gggaagacaa cctgacctgt gtggcatcca ccactttgca gaaggtgctg
      781 gacgagtgcc agaaccagcg ggcctgccac ctcctggtca atagccgagt cttcggacct
      841 gacctttgtc caggaagcag taaatacctc ctggtctcct ttaaatgcca acctaatgag
      901 ttgaaaaaca agacagtgtg tgaaaaccag gagttgaagc tacactgcca tgagtccaag
      961 ttcctcaaca tctactccgc cgcctacggc cggaggaccc agcaaagaga catctgctcc
     1021 tccggggcgg agctgctgcc ccccttcgac tgcctgtctt acacggcttt acaagtcctg
     1081 tccaggaggt gctatgggaa gcagagatgt aaggtcctcg tcgataatta ccacttcgga
     1141 agcccctgtc ttccaggagt gaaaaaatac ctcactgttg cctacgcatg tgttcccaag
     1201 aacatactca cggcagtgga tccggctgtt gctaatctaa atccttctct gaagaaagat
     1261 gatgaacacg gtataacatt caacccaagc gggtcgaggg ttgtgcggaa agatggcgtt
     1321 atcgtcagca actctctggc cgcgttcgct tacattcgag cccacccaga gagagccgct
     1381 ctgctgttca tgtccagtgt ctgcatcggc ctgctcctca cactgtgtgc cctggtcatc
     1441 agggtgtcct gtacgaagga cttccgggag ctgaggcagg ggagggagca cctggtgcta
     1501 gggagcgaca aggcggagga ggacagcgag gaagacttgg aagaggagga ctcctcggat
     1561 tcgcagtttc ccgaggagtt gtccaggttt tgtaggactt catatccagc ctatagctct
     1621 atagaagccg ccgagctggc ggaaaggatt gaacgcaggg agcaagtcat tcaagagata
     1681 tggatgaaca gtggcctgga ttcctcactc cccaggaacg tcggccactt ctactgacaa
     1741 cagaggcatc tggaggagat cagactctct gaagaaggaa gggtccagaa tgcgctgtct
     1801 ccccagccct ctccagttcc acttgtacct tctgtgaagg agaatctgtc ttgtcatccg
     1861 agatgggtga agccagaaag ctgtcaaagg gacgtcgcac tgtttacagc acaccctgga
     1921 ataaattggg aggaagccgt ggtgtcttgc aatcctatct gtacattaat aattctatac
     1981 agacttgaga ttctcattta ctcaacattt acaatgccag gtgtcatcta tacttgtgac
     2041 ctgagtaaat ggaggagggg cacatatatt cattaaaaat tatgctggtg ggaagcggtg
     2101 agatgggtca gtgggtgaaa ggtgagtgct agcaaggctg gccacctaag ttcactccac
     2161 agtgtggatg gagggaagca actccttcaa gctgccctct gaccttctaa catgtgtcat
     2221 gatacagaga caaaaaccta agcaaggggt aatagtggtg catgatcata aaatccacaa
     2281 atggcctggg agtgtagaga aagcagggaa gaaattctgc atgtcagaat caaggaggat
     2341 agtataaatg tcggctgtga tgcttg
//
