LOCUS       NM_007961               5548 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus ets variant 6 (Etv6), transcript variant 1, mRNA.
ACCESSION   NM_007961
VERSION     NM_007961.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5548)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5548)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5548)
  AUTHORS   Bloom,M., Oak,N., Baskin-Doerfler,R., Feng,R., Iacobucci,I.,
            Baviskar,P., Zhao,X., Stroh,A.N., Li,C., Ozark,P., Tillman,H.S.,
            Li,Y., Verbist,K.C., Albeituni,S., Scott,D.C., King,M.T.,
            McKinney-Freeman,S.L., Weiss,M.J., Yang,J.J. and Nichols,K.E.
  TITLE     ETV6 represses inflammatory response genes and regulates HSPC
            function during stress hematopoiesis in mice
  JOURNAL   Blood Adv 7 (18), 5608-5623 (2023)
   PUBMED   37522715
  REMARK    GeneRIF: ETV6 represses inflammatory response genes and regulates
            HSPC function during stress hematopoiesis in mice.
REFERENCE   4  (bases 1 to 5548)
  AUTHORS   Sharma,G., Tran,T.M., Bansal,I., Beg,M.S., Bhardwaj,R., Bassi,J.,
            Tan,Y., Jaiswal,A.K., Tso,C., Jain,A., Singh,J., Chattopadhyay,P.,
            Singh,A., Chopra,A., Bakhshi,S., Casero,D., Rao,D.S. and
            Palanichamy,J.K.
  TITLE     RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive
            oncogenic signaling in B-cell Acute Lymphoblastic Leukemia
  JOURNAL   J Exp Clin Cancer Res 42 (1), 231 (2023)
   PUBMED   37670323
  REMARK    GeneRIF: RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to
            drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5548)
  AUTHORS   Villar,J., Cros,A., De Juan,A., Alaoui,L., Bonte,P.E., Lau,C.M.,
            Tiniakou,I., Reizis,B. and Segura,E.
  TITLE     ETV3 and ETV6 enable monocyte differentiation into dendritic cells
            by repressing macrophage fate commitment
  JOURNAL   Nat Immunol 24 (1), 84-95 (2023)
   PUBMED   36543959
  REMARK    GeneRIF: ETV3 and ETV6 enable monocyte differentiation into
            dendritic cells by repressing macrophage fate commitment.
REFERENCE   6  (bases 1 to 5548)
  AUTHORS   Ritchie,K.A., Aprikyan,A.A., Bowen-Pope,D.F., Norby-Slycord,C.J.,
            Conyers,S., Bartelmez,S., Sitnicka,E.H. and Hickstein,D.D.
  TITLE     The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative
            syndrome in transgenic mice
  JOURNAL   Leukemia 13 (11), 1790-1803 (1999)
   PUBMED   10557054
REFERENCE   7  (bases 1 to 5548)
  AUTHORS   Orkin,S.H., Porcher,C., Fujiwara,Y., Visvader,J. and Wang,L.C.
  TITLE     Intersections between blood cell development and leukemia genes
  JOURNAL   Cancer Res 59 (7 Suppl), 1784s-1787s (1999)
   PUBMED   10197597
REFERENCE   8  (bases 1 to 5548)
  AUTHORS   Wang,L.C., Swat,W., Fujiwara,Y., Davidson,L., Visvader,J., Kuo,F.,
            Alt,F.W., Gilliland,D.G., Golub,T.R. and Orkin,S.H.
  TITLE     The TEL/ETV6 gene is required specifically for hematopoiesis in the
            bone marrow
  JOURNAL   Genes Dev 12 (15), 2392-2402 (1998)
   PUBMED   9694803
REFERENCE   9  (bases 1 to 5548)
  AUTHORS   Wang,L.C., Kuo,F., Fujiwara,Y., Gilliland,D.G., Golub,T.R. and
            Orkin,S.H.
  TITLE     Yolk sac angiogenic defect and intra-embryonic apoptosis in mice
            lacking the Ets-related factor TEL
  JOURNAL   EMBO J 16 (14), 4374-4383 (1997)
   PUBMED   9250681
REFERENCE   10 (bases 1 to 5548)
  AUTHORS   Poirel,H., Oury,C., Carron,C., Duprez,E., Laabi,Y., Tsapis,A.,
            Romana,S.P., Mauchauffe,M., Le Coniat,M., Berger,R., Ghysdael,J.
            and Bernard,O.A.
  TITLE     The TEL gene products: nuclear phosphoproteins with DNA binding
            properties
  JOURNAL   Oncogene 14 (3), 349-357 (1997)
   PUBMED   9018121
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068908.21, AC145116.3 and
            AC113600.19.
            
            On Dec 18, 2014 this sequence version replaced NM_007961.3.
            
            Summary: This gene encodes a transcriptional repressor belonging to
            the ETS family of proteins. Knockout of this gene in mice results
            in embryonic lethality due to defective angiogenesis. In humans,
            this gene is often involved in chromosome rearrangements associated
            with specific cancers. Alternate splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.128932.1,
                                           SRR9219382.172586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC068908.21        160964-160970
            8-439               AC068908.21        160971-161402
            440-572             AC145116.3         130538-130670
            573-737             AC113600.19        49704-49868
            738-872             AC113600.19        60358-60492
            873-1403            AC113600.19        75113-75643
            1404-1546           AC113600.19        88529-88671
            1547-1647           AC113600.19        89858-89958
            1648-5548           AC113600.19        93097-96997
FEATURES             Location/Qualifiers
     source          1..5548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 64.58 cM"
     gene            1..5548
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /note="ets variant 6"
                     /db_xref="GeneID:14011"
                     /db_xref="MGI:MGI:109336"
     exon            1..439
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..1864
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor ETV6; ETS-related protein Tel1;
                     translocation-ets-leukemia; ets variant gene 6 (TEL
                     oncogene)"
                     /codon_start=1
                     /product="transcription factor ETV6 isoform 1"
                     /protein_id="NP_031987.3"
                     /db_xref="CCDS:CCDS39677.1"
                     /db_xref="GeneID:14011"
                     /db_xref="MGI:MGI:109336"
                     /translation="MSETPAQSSIKQERISYTPPESPVASHRSSTPLHVHTVPRALRM
                     EEDSIHLPTHLRLQPIYWSRDDVAQWLKWAENEFSLRPIESNKFEMNGKALLLLTKED
                     FRYRSPHSGDVLYELLQHILKQRKSRMLFSPFFPPGDSIHTKPEVLLHQNHDEDNCVQ
                     RTPRTPAESVHHNPPTIELLHRPRSPITTNHRPSPDPEQQRPQRSPLDNMSRRLSPVE
                     KAQGPRLQQENNHQETYPLSVSPVENNHCLPSSPWQESTRVIQLMPSPIMHPLILNPR
                     HSHSVDFKQSRHSEDGMNREGKPINLSHREDLAYLNHIMVSMSPPEEHAMPIGRIADC
                     RLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSR
                     ALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQVLDEQTYQEDEPTI
                     ASPVGWPRGNLPTGTAGGVMEAGELGVAVKEETRE"
     exon            440..572
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /inference="alignment:Splign:2.1.0"
     exon            573..737
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /inference="alignment:Splign:2.1.0"
     exon            738..872
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1403
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1546
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1647
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..5548
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2153..2158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /note="hexamer: AATATA"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /note="hexamer: ATTATA"
     polyA_site      2171
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /note="major polyA site"
     polyA_site      2180
                     /gene="Etv6"
                     /gene_synonym="Tel"
     regulatory      5484..5489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etv6"
                     /gene_synonym="Tel"
                     /note="hexamer: AATAAT"
     polyA_site      5509
                     /gene="Etv6"
                     /gene_synonym="Tel"
ORIGIN      
        1 ttctgccttt cagtttctct cttccaggaa ggaaaacatt cgagaaagag agagggaggg
       61 agggagcgag ggagcgagag agcgagcgag cgagcgccgc gggagggcgg gcgcgccggc
      121 cgcgggtggg aggagacacg ccaggccggc ctgctgcgcc cgggtcgccg cgccgcgacc
      181 cgcacacccc acgccgtgct cgccggctcc tacgcccccg cacctcgcgc ccaatccgcg
      241 cgttgagaag agccccccct ccccctcggg cggccgccgc cagcgatgct gcaagaaact
      301 tcttaaacga ccgcatcccg ctgccccgcc gagcgtttct gggttgggga gaggaaagga
      361 aagtggaaaa aaactgagaa cttcctgatc cctttcgctg tgagacatgt ctgagactcc
      421 tgctcagtct agcattaagc aggaacgaat ttcatacacg cccccagaga gtccagtggc
      481 aagccaccgt tcctcgactc cgcttcatgt tcacacagtg cctcgagcgc tcaggatgga
      541 ggaagactcg atccacctgc caacacacct gcgtttgcag ccgatttact ggagcagaga
      601 tgacgtagcc cagtggctca agtgggcaga aaatgagttt tctttaaggc ccattgagag
      661 caacaagttc gaaatgaatg gcaaggccct cctgctgctg accaaagagg atttccgcta
      721 ccgatctcct cattcaggcg acgtgctcta tgaactcctt cagcatatcc tgaagcagag
      781 gaaatctcga atgctcttct caccattctt cccccctggg gactctatcc acaccaagcc
      841 agaggtcctc ctgcatcaga accatgacga agataactgt gtccagagga cacccaggac
      901 gcccgcggag agcgtgcacc acaaccctcc caccatcgaa ctcttacatc gccctaggtc
      961 acccatcacc acaaaccaca ggccttctcc tgaccccgaa cagcagcggc cccagcggtc
     1021 ccccctagac aacatgagcc gccgcctctc gccagtggag aaagcccagg ggcccaggct
     1081 acagcaggag aacaaccacc aggaaacgta ccccctgtca gtgtctcctg tcgagaataa
     1141 tcactgcctg ccctcaagcc cctggcagga gagcactcga gtgatccagc tgatgcccag
     1201 ccccatcatg caccctttga tcctgaaccc ccggcactcg cactcggtgg acttcaaaca
     1261 gtcccggcac tccgaggatg ggatgaatcg ggaagggaag cccatcaacc tgtctcatcg
     1321 ggaggacctg gcttacttga accacatcat ggtctctatg tccccaccgg aagagcacgc
     1381 catgcccatt gggagaatag cagactgtag actgctttgg gattatgtct atcagttgct
     1441 gtctgacagc cggtacgaaa acttcatccg atgggaggac aaagaatcca aaatattccg
     1501 gatagtggat cccaacggac tggctcgact ctggggaaac cataagaaca gaacaaacat
     1561 gacctatgag aaaatgtcca gagccctgcg ccactactac aaactaaaca ttatcaggaa
     1621 ggagcccgga caaaggcttt tgttcaggtt catgaaaacc ccagatgaga tcatgagtgg
     1681 ccggacagac cgtctagaac acctcgagtc tcaagtgctg gatgaacaaa cgtaccaaga
     1741 ggatgaacct accatagcct caccggtggg ctggccaaga ggaaacctgc ccacggggac
     1801 cgcaggaggc gtgatggaag caggcgagct aggggtggct gtaaaggaag agacccggga
     1861 atagcaggga cacttctcct gccgatcaag agggacccag agcaccttag acaagccacc
     1921 gagcaatggc agggctgaag ttctggcgga gggcacaagc ctgagactca cacgtcacgt
     1981 tcgcttctcc ttctgatctc ttgtctgtaa ctctcaccct ctcccttccc ctacacctgt
     2041 tgtagtctca tggtgtttct ggtttcgttt tttgtttttg ttttttaaga acatgcagtt
     2101 tgactattca ttgttcatac agggaagaca tcacatgttg ttttcctatg gaaatatatc
     2161 tattatatat atattattaa tttttttgtt gttgttgcaa atctcaccaa gtacggccag
     2221 cttggctggt caggaaagag aaaacttgca gaaggaatca ggttcctctt tttcctgcca
     2281 catagatctg gtgtgtcctg tccaagtcag gtcttagatg agaaaggaaa acaaaatgag
     2341 agagatactt tcaaacaatg gaaaagaaga gttctgtctc catctccctc tctcgccgct
     2401 catccccgcc cctttctcct tcccccttct ctgcctgcta tgcacttcac aggcttttca
     2461 tcagagctag cctcactagc acctgaacta cacagtgacc cggctgctct gtgacagtca
     2521 gaccccttgg gcacccatct gaggaaggcc agacatctcc ccccaccaaa tgctgctgta
     2581 ttctagaaag aacaatggga ggatcgagca taagatagga cagagggtgg ccacaggatt
     2641 tgcaaggccc aggcagtttg ggattgtcct gaaagtgcta cacattagga aaatatgaga
     2701 gaccacacag gcctggtagt ttaggagcaa gaacaggtca ccaatgttgt cccaagacat
     2761 catgcccttg tgggattgtc accaccccac acacacactc caagtcctag cctttttctt
     2821 ctatgctggt cctcatggaa cacagaacac acatgaggga ggatgctgga atttagtctc
     2881 aggcacagcc ggtatttgcg cagacaggaa attcctcaga tttagacttt ttcctttttt
     2941 ccgtctgtca tggctgtatt tcaggaggac atatctgtgg ctcttctcca cctcgacata
     3001 aggtcagtag catcttccaa gatgagggta atgctattcc ttaggatttt tgatagcagg
     3061 gattttattt tatttattta tttatttttg ggattttttt ttttgagaca gggtttttct
     3121 gtgtatccct ggaattcact ctgtagacca gactaggact cagagatcta cctgcctctg
     3181 cctcccaagc actgagatta aaggtgtgcg cccccatgct tagctttttt tccttttcta
     3241 gccatctaag tggactcttt gaagttcact gttttaaaac ccagataatg aggcctgcct
     3301 ttcaaaacca ccccttgtcc ttcctgtgtt ctcccacatc atggaatgag cctctcccag
     3361 ccctcctggg tgtgtctctg cttggtcaga cgcaggacac aggtgaggct gacagaccag
     3421 agctgaccta caactactcc taagtggggc acatagaggc taggaggacc tggacaagtc
     3481 actctcccga cgtcagctca caggcggact gtggttcaca gacactggaa ttgagttgac
     3541 tgggtatctt tagtcttgct gtgacttccc cgtgcctccc ccacaaccca caatctgcct
     3601 tcaaagaggt cagtgacctg ggtgaggggt tccctcttaa tattcatggg gaatgatgag
     3661 agtcacgtgc tatgtgtttc ttgaaagcat gacaggggtt cctttttttg gcctctaaaa
     3721 atgactggta ccttatatca aatggggaga ttaagccaaa tacttgtgtt gtatgagcca
     3781 ctgggaggaa gagcaagtga gaaagggtgt gctttttgtt tttgttttga ctgaggtcct
     3841 ttgtgtgaat ataaaatgag aaactacaac acttcatact ggccactttg cccatgcgta
     3901 gaactcagtc ctttaactgc ccaaagaatt gtccatatga actgtgtaag gaaattcctc
     3961 tgttccctaa ggagtcttgg atgacagctt tggccactta cgttagaaat gctcatggca
     4021 gtgccgtctt tatttcacac ctggtgttgc cataattgat ttctttgatt ctcttacctg
     4081 caaaagccct tgtttgtttt ttggagagaa aatatggcca gggttgtctg ggttgtcagg
     4141 gttgtgcagt gctctcaggc ttcagactca cagaatttag atttagccaa tcagaccttg
     4201 gaggaaacac cacaatgggg gtcctgtttt gtctttttgg tttttgagtt ttggtttttt
     4261 gtttgtttgt ttttttacaa tcaactatga tcttctagat cgacattaaa gcgacattaa
     4321 gttcaagagg tgatagaagg aatctaaaag ctcctttagt ggcctttttc tgcagccatt
     4381 gtgggttgag tcaggaaagg aatttgcagg gaagcattgc catgtggagg atgggcattg
     4441 ccacctaggt cctgggattc tgtcctgagt cctcggccgg gctgtcttca ggtctccttc
     4501 agcagaaacc aggggcagct ggtcagatgt tgacagcagc ttctcttccg ataattttca
     4561 tccaaggcca cttagtgcca cttggagaca gggtccctga tgtcccatat ctggttttgg
     4621 aaagagaatg gtcctcataa gaaaagaaca aaacaggctt cttgcctagt acattcaggt
     4681 ccctctgatc cagcatcttt ttacactaat accttgtcca gataagaatg tcactccagc
     4741 tgacatctag atgtctgtga ggagtccctg gaatgaccac tcttgtcttt tcacactgtt
     4801 cgggatccaa ccataaacac agtttggccc attcactgtt gttggcagaa gacaacctga
     4861 gagaggtcgt gtcactttcc gtgggagcag acagcatgac acacagttgg gatcagtatc
     4921 tagccggcct gcacttagca gcaggataag cgttcagaag gcagttagaa attattctgg
     4981 tttaaacccc catttgatcc atccccggca aagagacgaa agatgccaag ggtggttttt
     5041 actgcccagt cattcggtgc tagttagagc tgctgtgcgt tctcagcctg ctcctcttct
     5101 gaacagaaac caaaattgga cgtcatgaga aacccagtgg agcaggggta cagagggaca
     5161 ccccagaacc ctgcctatca acaaggcaca cgggactcac ccagcactct tttggcccca
     5221 tccgcatcaa cactaaacaa cttcaaatgc gcccgactct tttcaccctc acaggtgaac
     5281 cctcttctgg agacttctct ttgtgacggc acccacctgc aagccagatg aatctagaat
     5341 gactttttgt tgttgttgtt gtttagtttc taatctcttg tttatgaggt gtggggttta
     5401 taagggactg aatcaaatga atgtaacaaa aaaagaaaaa aaaacaaaca aaaaatgcct
     5461 tttctcaggg ccagtgagtt gcaaataatt tttaaagaaa aacctataat tacatcatct
     5521 caataaattt tttataaaaa aaaaaaaa
//
