LOCUS       NM_001316366            2334 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ets variant 4 (Etv4), transcript variant 3, mRNA.
ACCESSION   NM_001316366 XM_006532465
VERSION     NM_001316366.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Wen,Y., Zhou,S., Gui,Y., Li,Z., Yin,L., Xu,W., Feng,S., Ma,X.,
            Gan,S., Xiong,M., Dong,J., Cheng,K., Wang,X. and Yuan,S.
  TITLE     hnRNPU is required for spermatogonial stem cell pool establishment
            in mice
  JOURNAL   Cell Rep 43 (4), 114113 (2024)
   PUBMED   38625792
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   4  (bases 1 to 2334)
  AUTHORS   Thomasen,P.B., Salasova,A., Kjaer-Sorensen,K., Woloszczukova,L.,
            Lavicky,J., Login,H., Tranberg-Jensen,J., Almeida,S., Beel,S.,
            Kavkova,M., Qvist,P., Kjolby,M., Ovesen,P.L., Nolte,S.,
            Vestergaard,B., Udrea,A.C., Nejsum,L.N., Chao,M.V., Van Damme,P.,
            Krivanek,J., Dasen,J., Oxvig,C. and Nykjaer,A.
  TITLE     SorCS2 binds progranulin to regulate motor neuron development
  JOURNAL   Cell Rep 42 (11), 113333 (2023)
   PUBMED   37897724
REFERENCE   5  (bases 1 to 2334)
  AUTHORS   Lee,Y., Yeo,I.S., Kim,N., Lee,D.K., Kim,K.T., Yoon,J., Yi,J.,
            Hong,Y.B., Choi,B.O., Kosodo,Y., Kim,D., Park,J. and Song,M.R.
  TITLE     Transcriptional control of motor pool formation and motor circuit
            connectivity by the LIM-HD protein Isl2
  JOURNAL   Elife 12, e84596 (2023)
   PUBMED   37869988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2334)
  AUTHORS   Rajan,L. and Dudley,J.P.
  TITLE     An MMTV integration site maps near the distal end of mouse
            chromosome 11
  JOURNAL   Mamm Genome 8 (4), 295-296 (1997)
   PUBMED   9096121
REFERENCE   7  (bases 1 to 2334)
  AUTHORS   Noben-Trauth,K., Naggert,J.K. and Nishina,P.M.
  TITLE     The ets-related mouse Pea3 gene maps to distal chromosome 11
  JOURNAL   Mamm Genome 7 (7), 551 (1996)
   PUBMED   8672139
REFERENCE   8  (bases 1 to 2334)
  AUTHORS   Liu,S.H., Peng,B.H., Ma,J.T., Liu,Y.C. and Ng,S.Y.
  TITLE     Serum response element associated transcription factors in mouse
            embryos: serum response factor, YY1, and PEA3 factor
  JOURNAL   Dev Genet 16 (3), 229-240 (1995)
   PUBMED   7796532
REFERENCE   9  (bases 1 to 2334)
  AUTHORS   Martin,M.E., Yang,X.Y. and Folk,W.R.
  TITLE     Expression of a 91-kilodalton PEA3-binding protein is
            down-regulated during differentiation of F9 embryonal carcinoma
            cells
  JOURNAL   Mol Cell Biol 12 (5), 2213-2221 (1992)
   PUBMED   1569949
REFERENCE   10 (bases 1 to 2334)
  AUTHORS   Xin,J.H., Cowie,A., Lachance,P. and Hassell,J.A.
  TITLE     Molecular cloning and characterization of PEA3, a new member of the
            Ets oncogene family that is differentially expressed in mouse
            embryonic cells
  JOURNAL   Genes Dev 6 (3), 481-496 (1992)
   PUBMED   1547944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591436.8, AK144538.1 and DQ832277.1.
            
            On Oct 19, 2015 this sequence version replaced XM_006532465.2.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (3) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166136.1, SRR7345562.2156532.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL591436.8         20950-20992         c
            44-280              AK144538.1         1-237
            281-2334            DQ832277.1         1-2054
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..2334
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /note="ets variant 4"
                     /db_xref="GeneID:18612"
                     /db_xref="MGI:MGI:99423"
     exon            1..203
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..314
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1697
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /note="isoform 3 is encoded by transcript variant 3; ETS
                     variant protein 4; POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3
                     PROTEIN) (ETS TRANSLOCATION VARIANT 4); ets variant gene 4
                     (E1A enhancer binding protein, E1AF)"
                     /codon_start=1
                     /product="ETS translocation variant 4 isoform 3"
                     /protein_id="NP_001303295.1"
                     /db_xref="CCDS:CCDS83902.1"
                     /db_xref="GeneID:18612"
                     /db_xref="MGI:MGI:99423"
                     /translation="MERRMKGGYLDQRVPYTFCSKSPGNGSLGEALMVPQGKLMDPGS
                     LPPSDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSP
                     RTDPALSCSRKPPLPYHHGEQCLYSRQIAIKSPAPGAPGQSPLQPFSRAEQQQSLLRA
                     SSSSQSHPGHGYLGEHSSVFQQPVDMCHSFTSPQGGGREPLPAPYQHQLSEPCPPYPQ
                     QNFKQEYHDPLYEQAGQPASSQGGVSGHRYPGAGVVIKQERTDFAYDSDVPGCASMYL
                     HPEGFSGPSPGDGVMGYGYEKSLRPFPDDVCIVPEKFEGDIKQEGIGAFREGPPYQRR
                     GALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLS
                     RSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTV
                     PLSHLDESPAYLPELTGPAPPFGHRGGYSY"
     exon            315..408
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            409..456
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..510
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..637
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            638..784
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1053
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1128
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1197
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1370
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1472
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..2315
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2293..2298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /note="hexamer: AATAAA"
     polyA_site      2315
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /note="major polyA site"
ORIGIN      
        1 ggaggccaag gcaaaggaaa tgcaccaatc agctgctccc ccgggctcac aactgtctgc
       61 tgcgcccgga aaacaagccg gggctctggg gacccggggc tcaggccgcc tcgctccggc
      121 ctagccccgc caccttagtt gtgtcatccc ccgggcatgc tgagcatccc cccgcggctc
      181 cggcacagac gcccggacct caggtctctg cctccgcgcg ggggcccggc cctgtggccg
      241 gagggagcgg ccggatggag cggaggatga aaggcggata cttggaccag cgagtgccct
      301 acaccttctg cagcaaatct cccggaaatg ggagcttggg cgaagcgctg atggtcccgc
      361 agggaaagct catggacccg ggctccctgc cgccttccga ctcagaagat ctcttccagg
      421 acctcagtca cttccaagag acgtggctcg cagaagctca ggtaccggac agtgatgagc
      481 agtttgttcc tgatttccat tcagaaaact tagctttcca tagccccacc accaggatca
      541 agaaggaacc ccagagtccc cgcacagacc ccgccctgtc ctgcagcagg aagccaccac
      601 tcccctacca ccatggagag cagtgccttt actccagaca aatcgccatc aagtcccccg
      661 cccccggtgc ccctggacag tcgcccctgc agcccttttc cagggcagaa cagcagcaga
      721 gcctcctgag agcctccagc tcttcccagt cccaccctgg ccacgggtac cttggtgagc
      781 acagctccgt cttccagcag cccgtggaca tgtgccactc cttcacatct cctcagggag
      841 ggggccggga acctctccca gccccctatc aacaccaact gtcggagccc tgcccaccct
      901 acccccagca gaacttcaag caggagtacc atgaccccct gtacgaacag gctggccagc
      961 ccgcttcaag ccagggtggg gtcagtgggc acaggtaccc aggggcgggg gtggtgatca
     1021 aacaggagcg cacagacttc gcctacgact cagatgtccc tggatgtgca tcaatgtacc
     1081 tccacccaga gggcttctct ggaccctctc caggtgatgg agtgatgggt tatggctatg
     1141 aaaaatccct tcgaccattc ccagatgatg tctgcattgt ccctgaaaaa tttgaaggag
     1201 acatcaagca ggaagggatt ggagctttcc gggaggggcc accctaccag cgccggggtg
     1261 ccttacaact gtggcagttt ctggtggccc tgctggatga cccaacaaat gctcatttca
     1321 ttgcttggac aggccgggga atggagttta aactaattga acctgaagag gttgccaggc
     1381 tctggggtat ccagaagaac cggccagcca tgaattatga caagctgagc cgctcgctgc
     1441 gatactatta tgagaaaggc atcatgcaga aggtggctgg cgaacgctac gtgtacaagt
     1501 ttgtgtgcga gccggaggcc ctgttctctc tggccttccc agataatcaa cgtccagctc
     1561 tgaaggctga gtttgaccgg ccagtcagtg aggaggacac agtccctttg tcccacttgg
     1621 atgagagtcc tgcctacctc ccagaactca ctggccccgc tccgcccttc ggccacagag
     1681 gtggatattc ttactaggca ccagtggctt ccccttgaca tggtggggtt gctcagtgta
     1741 tatatcaact gatttggtat tggtgaaggc cctctttctg atgcctgtag aagtctctgg
     1801 ggtcagagct ccactatccc atctgatact cctggccaga ctcagctgct aaccagagtc
     1861 tgcgggaaag acagtggagg caggccaaat ctaaaggcag tagccgaagt tcgctgtggc
     1921 tcacctgtac cttcagttca gcttggcctc tgcctaggtc ttgctcagag gccaagttcc
     1981 tcacccccac cacagagatc cagtgttcta ttctggggac atacagggac ttcccttgtt
     2041 tattatggca acagggccaa ggggattctc agaacaccct gtgtctcccc tctcccaacc
     2101 ccccatggga gacaaagttc tgcctgggtt ctgccctgaa caggggggtc ctgtgttctt
     2161 ggtgctgtgc tctgggaggc aggagcatgt gggcggcagc tggggggggg ggttgggtgg
     2221 aagagtaggg atggctctct gccctaggcc tacccaggcc taattccacc tttgcctctt
     2281 atgccagacc ttaataaagc ctctgcttct ccggtaaaaa aaaaaaaaaa aaaa
//
