LOCUS       NM_001316365            2352 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ets variant 4 (Etv4), transcript variant 1, mRNA.
ACCESSION   NM_001316365 XM_006532464
VERSION     NM_001316365.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2352)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2352)
  AUTHORS   Wen,Y., Zhou,S., Gui,Y., Li,Z., Yin,L., Xu,W., Feng,S., Ma,X.,
            Gan,S., Xiong,M., Dong,J., Cheng,K., Wang,X. and Yuan,S.
  TITLE     hnRNPU is required for spermatogonial stem cell pool establishment
            in mice
  JOURNAL   Cell Rep 43 (4), 114113 (2024)
   PUBMED   38625792
REFERENCE   3  (bases 1 to 2352)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   4  (bases 1 to 2352)
  AUTHORS   Thomasen,P.B., Salasova,A., Kjaer-Sorensen,K., Woloszczukova,L.,
            Lavicky,J., Login,H., Tranberg-Jensen,J., Almeida,S., Beel,S.,
            Kavkova,M., Qvist,P., Kjolby,M., Ovesen,P.L., Nolte,S.,
            Vestergaard,B., Udrea,A.C., Nejsum,L.N., Chao,M.V., Van Damme,P.,
            Krivanek,J., Dasen,J., Oxvig,C. and Nykjaer,A.
  TITLE     SorCS2 binds progranulin to regulate motor neuron development
  JOURNAL   Cell Rep 42 (11), 113333 (2023)
   PUBMED   37897724
REFERENCE   5  (bases 1 to 2352)
  AUTHORS   Lee,Y., Yeo,I.S., Kim,N., Lee,D.K., Kim,K.T., Yoon,J., Yi,J.,
            Hong,Y.B., Choi,B.O., Kosodo,Y., Kim,D., Park,J. and Song,M.R.
  TITLE     Transcriptional control of motor pool formation and motor circuit
            connectivity by the LIM-HD protein Isl2
  JOURNAL   Elife 12, e84596 (2023)
   PUBMED   37869988
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2352)
  AUTHORS   Rajan,L. and Dudley,J.P.
  TITLE     An MMTV integration site maps near the distal end of mouse
            chromosome 11
  JOURNAL   Mamm Genome 8 (4), 295-296 (1997)
   PUBMED   9096121
REFERENCE   7  (bases 1 to 2352)
  AUTHORS   Noben-Trauth,K., Naggert,J.K. and Nishina,P.M.
  TITLE     The ets-related mouse Pea3 gene maps to distal chromosome 11
  JOURNAL   Mamm Genome 7 (7), 551 (1996)
   PUBMED   8672139
REFERENCE   8  (bases 1 to 2352)
  AUTHORS   Liu,S.H., Peng,B.H., Ma,J.T., Liu,Y.C. and Ng,S.Y.
  TITLE     Serum response element associated transcription factors in mouse
            embryos: serum response factor, YY1, and PEA3 factor
  JOURNAL   Dev Genet 16 (3), 229-240 (1995)
   PUBMED   7796532
REFERENCE   9  (bases 1 to 2352)
  AUTHORS   Martin,M.E., Yang,X.Y. and Folk,W.R.
  TITLE     Expression of a 91-kilodalton PEA3-binding protein is
            down-regulated during differentiation of F9 embryonal carcinoma
            cells
  JOURNAL   Mol Cell Biol 12 (5), 2213-2221 (1992)
   PUBMED   1569949
REFERENCE   10 (bases 1 to 2352)
  AUTHORS   Xin,J.H., Cowie,A., Lachance,P. and Hassell,J.A.
  TITLE     Molecular cloning and characterization of PEA3, a new member of the
            Ets oncogene family that is differentially expressed in mouse
            embryonic cells
  JOURNAL   Genes Dev 6 (3), 481-496 (1992)
   PUBMED   1547944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591436.8, BY733846.1, AK144538.1 and DQ832277.1.
            
            On Oct 19, 2015 this sequence version replaced XM_006532464.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1712238.1,
                                           SRR11927937.3847377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL591436.8         20947-20992         c
            47-651              BY733846.1         1-605
            652-802             AK144538.1         609-759
            803-2352            DQ832277.1         505-2054
FEATURES             Location/Qualifiers
     source          1..2352
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..2352
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /note="ets variant 4"
                     /db_xref="GeneID:18612"
                     /db_xref="MGI:MGI:99423"
     exon            1..203
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..314
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1715
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /note="isoform 1 is encoded by transcript variant 1; ETS
                     variant protein 4; POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3
                     PROTEIN) (ETS TRANSLOCATION VARIANT 4); ets variant gene 4
                     (E1A enhancer binding protein, E1AF)"
                     /codon_start=1
                     /product="ETS translocation variant 4 isoform 1"
                     /protein_id="NP_001303294.1"
                     /db_xref="CCDS:CCDS83903.1"
                     /db_xref="GeneID:18612"
                     /db_xref="MGI:MGI:99423"
                     /translation="MERRMKGGYLDQRVPYTFCSKSPGNGSLGEALMVPQGKLMDPGS
                     LPPSDSEDLFQDLSHFQETWLAEAQVPDSDEQFVPDFHSENLAFHSPTTRIKKEPQSP
                     RTDPALSCSRKPPLPYHHGEQCLYSSAYDSPRQIAIKSPAPGAPGQSPLQPFSRAEQQ
                     QSLLRASSSSQSHPGHGYLGEHSSVFQQPVDMCHSFTSPQGGGREPLPAPYQHQLSEP
                     CPPYPQQNFKQEYHDPLYEQAGQPASSQGGVSGHRYPGAGVVIKQERTDFAYDSDVPG
                     CASMYLHPEGFSGPSPGDGVMGYGYEKSLRPFPDDVCIVPEKFEGDIKQEGIGAFREG
                     PPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAM
                     NYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPV
                     SEEDTVPLSHLDESPAYLPELTGPAPPFGHRGGYSY"
     exon            315..408
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            409..456
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            457..510
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..637
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            638..802
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1071
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1146
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1215
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1388
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1490
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..2333
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2311..2316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /note="hexamer: AATAAA"
     polyA_site      2333
                     /gene="Etv4"
                     /gene_synonym="Pea-3; Pea3"
                     /note="major polyA site"
ORIGIN      
        1 ggaggccaag gcaaaggaaa tgcaccaatc agctgctccc ccgggctcac aactgtctgc
       61 tgcgcccgga aaacaagccg gggctctggg gacccggggc tcaggccgcc tcgctccggc
      121 ctagccccgc caccttagtt gtgtcatccc ccgggcatgc tgagcatccc cccgcggctc
      181 cggcacagac gcccggacct caggtctctg cctccgcgcg ggggcccggc cctgtggccg
      241 gagggagcgg ccggatggag cggaggatga aaggcggata cttggaccag cgagtgccct
      301 acaccttctg cagcaaatct cccggaaatg ggagcttggg cgaagcgctg atggtcccgc
      361 agggaaagct catggacccg ggctccctgc cgccttccga ctcagaagat ctcttccagg
      421 acctcagtca cttccaagag acgtggctcg cagaagctca ggtaccggac agtgatgagc
      481 agtttgttcc tgatttccat tcagaaaact tagctttcca tagccccacc accaggatca
      541 agaaggaacc ccagagtccc cgcacagacc ccgccctgtc ctgcagcagg aagccaccac
      601 tcccctacca ccatggagag cagtgccttt actccagtgc ctatgactcc cccagacaaa
      661 tcgccatcaa gtcccccgcc cccggtgccc ctggacagtc gcccctgcag cccttttcca
      721 gggcagaaca gcagcagagc ctcctgagag cctccagctc ttcccagtcc caccctggcc
      781 acgggtacct tggtgagcac agctccgtct tccagcagcc cgtggacatg tgccactcct
      841 tcacatctcc tcagggaggg ggccgggaac ctctcccagc cccctatcaa caccaactgt
      901 cggagccctg cccaccctac ccccagcaga acttcaagca ggagtaccat gaccccctgt
      961 acgaacaggc tggccagccc gcttcaagcc agggtggggt cagtgggcac aggtacccag
     1021 gggcgggggt ggtgatcaaa caggagcgca cagacttcgc ctacgactca gatgtccctg
     1081 gatgtgcatc aatgtacctc cacccagagg gcttctctgg accctctcca ggtgatggag
     1141 tgatgggtta tggctatgaa aaatcccttc gaccattccc agatgatgtc tgcattgtcc
     1201 ctgaaaaatt tgaaggagac atcaagcagg aagggattgg agctttccgg gaggggccac
     1261 cctaccagcg ccggggtgcc ttacaactgt ggcagtttct ggtggccctg ctggatgacc
     1321 caacaaatgc tcatttcatt gcttggacag gccggggaat ggagtttaaa ctaattgaac
     1381 ctgaagaggt tgccaggctc tggggtatcc agaagaaccg gccagccatg aattatgaca
     1441 agctgagccg ctcgctgcga tactattatg agaaaggcat catgcagaag gtggctggcg
     1501 aacgctacgt gtacaagttt gtgtgcgagc cggaggccct gttctctctg gccttcccag
     1561 ataatcaacg tccagctctg aaggctgagt ttgaccggcc agtcagtgag gaggacacag
     1621 tccctttgtc ccacttggat gagagtcctg cctacctccc agaactcact ggccccgctc
     1681 cgcccttcgg ccacagaggt ggatattctt actaggcacc agtggcttcc ccttgacatg
     1741 gtggggttgc tcagtgtata tatcaactga tttggtattg gtgaaggccc tctttctgat
     1801 gcctgtagaa gtctctgggg tcagagctcc actatcccat ctgatactcc tggccagact
     1861 cagctgctaa ccagagtctg cgggaaagac agtggaggca ggccaaatct aaaggcagta
     1921 gccgaagttc gctgtggctc acctgtacct tcagttcagc ttggcctctg cctaggtctt
     1981 gctcagaggc caagttcctc acccccacca cagagatcca gtgttctatt ctggggacat
     2041 acagggactt cccttgttta ttatggcaac agggccaagg ggattctcag aacaccctgt
     2101 gtctcccctc tcccaacccc ccatgggaga caaagttctg cctgggttct gccctgaaca
     2161 ggggggtcct gtgttcttgg tgctgtgctc tgggaggcag gagcatgtgg gcggcagctg
     2221 gggggggggg ttgggtggaa gagtagggat ggctctctgc cctaggccta cccaggccta
     2281 attccacctt tgcctcttat gccagacctt aataaagcct ctgcttctcc ggtaaaaaaa
     2341 aaaaaaaaaa aa
//
