LOCUS       NM_001411079            1228 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ets variant 3 (Etv3), transcript variant 6, mRNA.
ACCESSION   NM_001411079
VERSION     NM_001411079.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1228)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1228)
  AUTHORS   Villar,J., Cros,A., De Juan,A., Alaoui,L., Bonte,P.E., Lau,C.M.,
            Tiniakou,I., Reizis,B. and Segura,E.
  TITLE     ETV3 and ETV6 enable monocyte differentiation into dendritic cells
            by repressing macrophage fate commitment
  JOURNAL   Nat Immunol 24 (1), 84-95 (2023)
   PUBMED   36543959
REFERENCE   3  (bases 1 to 1228)
  AUTHORS   Sizemore,G.M., Pitarresi,J.R., Balakrishnan,S. and Ostrowski,M.C.
  TITLE     The ETS family of oncogenic transcription factors in solid tumours
  JOURNAL   Nat Rev Cancer 17 (6), 337-351 (2017)
   PUBMED   28450705
  REMARK    Review article
REFERENCE   4  (bases 1 to 1228)
  AUTHORS   Ohta,Y., Okabe,T., Larmour,C., Di Rocco,A., Maijenburg,M.W.,
            Phillips,A., Speck,N.A., Wakitani,S., Nakamura,T., Yamada,Y.,
            Enomoto-Iwamoto,M., Pacifici,M. and Iwamoto,M.
  TITLE     Articular cartilage endurance and resistance to osteoarthritic
            changes require transcription factor Erg
  JOURNAL   Arthritis Rheumatol 67 (10), 2679-2690 (2015)
   PUBMED   26097038
REFERENCE   5  (bases 1 to 1228)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1228)
  AUTHORS   Schachterle,W., Rojas,A., Xu,S.M. and Black,B.L.
  TITLE     ETS-dependent regulation of a distal Gata4 cardiac enhancer
  JOURNAL   Dev Biol 361 (2), 439-449 (2012)
   PUBMED   22056786
REFERENCE   7  (bases 1 to 1228)
  AUTHORS   Bidder,M., Loewy,A.P., Latifi,T., Newberry,E.P., Ferguson,G.,
            Willis,D.M. and Towler,D.A.
  TITLE     Ets domain transcription factor PE1 suppresses human interstitial
            collagenase promoter activity by antagonizing protein-DNA
            interactions at a critical AP1 element
  JOURNAL   Biochemistry 39 (30), 8917-8928 (2000)
   PUBMED   10913304
REFERENCE   8  (bases 1 to 1228)
  AUTHORS   Klemsz,M., Hromas,R., Raskind,W., Bruno,E. and Hoffman,R.
  TITLE     PE-1, a novel ETS oncogene family member, localizes to chromosome
            1q21-q23
  JOURNAL   Genomics 20 (2), 291-294 (1994)
   PUBMED   8020980
REFERENCE   9  (bases 1 to 1228)
  AUTHORS   Wasylyk,B., Hahn,S.L. and Giovane,A.
  TITLE     The Ets family of transcription factors
  JOURNAL   Eur J Biochem 211 (1-2), 7-18 (1993)
   PUBMED   8425553
  REMARK    Review article
            Erratum:[Eur J Biochem 1993 Aug 1;215(3):907]
REFERENCE   10 (bases 1 to 1228)
  AUTHORS   Macleod,K., Leprince,D. and Stehelin,D.
  TITLE     The ets gene family
  JOURNAL   Trends Biochem Sci 17 (7), 251-256 (1992)
   PUBMED   1502727
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139241.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4998406.1, BI654651.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC139241.4         169983-170058       c
            77-135              AC139241.4         168326-168384       c
            136-373             AC139241.4         167535-167772       c
            374-1228            AC139241.4         165564-166418       c
FEATURES             Location/Qualifiers
     source          1..1228
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.19 cM"
     gene            1..1228
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /note="ets variant 3"
                     /db_xref="GeneID:27049"
                     /db_xref="MGI:MGI:1350926"
     exon            1..76
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..135
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..530
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /note="isoform 3 is encoded by transcript variant 6; ets
                     variant gene 3; mitogenic Ets transcriptional suppressor
                     METS; ETS domain transcriptional repressor PE1; ETS-domain
                     protein"
                     /codon_start=1
                     /product="ETS translocation variant 3 isoform 3"
                     /protein_id="NP_001398008.1"
                     /db_xref="GeneID:27049"
                     /db_xref="MGI:MGI:1350926"
                     /translation="MKAGCSIVEKPEGGGGYQFPDWAYKAESSPGSRQIQLWHFILEL
                     LQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRI
                     LHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGKMQASTCDGEWV"
     exon            136..373
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..1228
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /note="hexamer: ATTAAA"
     polyA_site      1228
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /note="major polyA site"
ORIGIN      
        1 acttccttct gggtggatga ggaggagccc gagctgccgc ggaggagccc gagtggagac
       61 ggacggcgcc ggagagcagg agggcgaaaa tgaaagcagg ctgtagcatc gtggaaaagc
      121 cagaaggagg tggagggtat cagtttccgg attgggccta caaagccgag tcgtcgccgg
      181 gctcccggca gatccagctg tggcacttca tcctggaact gctgcagaag gaagagttcc
      241 gccatgtcat cgcctggcag cagggagagt acggggagtt tgtcatcaag gatccagatg
      301 aagtggctcg cctctggggc cgcaggaagt gcaaaccaca gatgaactat gacaagctga
      361 gccgggccct cagatactat tacaacaaga ggatccttca taaaacaaaa gggaaaaggt
      421 ttacttacaa gtttaacttc aacaagctcg tgatgcccaa ctacccgttc atcaacattc
      481 gctcgagtgg taagatgcag gcaagcacct gtgatggaga gtgggtttga attctaaaag
      541 aatttttaaa agcccaaatc tgagacattc cccgtgtaag gagatgttta gaagcagtga
      601 agtaacgtga tcccctagac tacctcaagc cctccttact catctatggg ggtagtgggc
      661 tgcgcggggc tccgatgagc tgtgcggggc tccgatacgc ttgcttcccc ctttatatga
      721 actattttca gtctcctgga gagcaactga actcaatttg gggaatgagc ccataggttt
      781 atgttgtgtt ttaagttcaa gactctgttt taacaccttg cccagtggct gtttcatagc
      841 tgtgaacctg tttctacaaa cgtttccgat tttctatgaa actacatgct ctcccttatc
      901 acgtgaatgc catcaaaacc acagcatcct tgatcggaga aggggaagtt gacgtgttcg
      961 cagtgaaagg ctgaggctgt gatgtgcagc agcgctcagc tccgtgcctc agtgcagggc
     1021 tcagggctgc aagcaggctt tcccagtcca ggttacagca ttgcatcaca gctcccagcc
     1081 tctcggtctg cccctcgata aagacacggc cacttagaaa agtgtcagat gtagttgatg
     1141 gtgagattag agttttcttt ttgcttcggg gttttttttt gttgtttttt tttttggttg
     1201 gggggcagca ttaaaagatg ataaatta
//
