LOCUS       NM_001286844            5451 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ets variant 3 (Etv3), transcript variant 1, mRNA.
ACCESSION   NM_001286844
VERSION     NM_001286844.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5451)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5451)
  AUTHORS   Villar,J., Cros,A., De Juan,A., Alaoui,L., Bonte,P.E., Lau,C.M.,
            Tiniakou,I., Reizis,B. and Segura,E.
  TITLE     ETV3 and ETV6 enable monocyte differentiation into dendritic cells
            by repressing macrophage fate commitment
  JOURNAL   Nat Immunol 24 (1), 84-95 (2023)
   PUBMED   36543959
REFERENCE   3  (bases 1 to 5451)
  AUTHORS   Sizemore,G.M., Pitarresi,J.R., Balakrishnan,S. and Ostrowski,M.C.
  TITLE     The ETS family of oncogenic transcription factors in solid tumours
  JOURNAL   Nat Rev Cancer 17 (6), 337-351 (2017)
   PUBMED   28450705
  REMARK    Review article
REFERENCE   4  (bases 1 to 5451)
  AUTHORS   Ohta,Y., Okabe,T., Larmour,C., Di Rocco,A., Maijenburg,M.W.,
            Phillips,A., Speck,N.A., Wakitani,S., Nakamura,T., Yamada,Y.,
            Enomoto-Iwamoto,M., Pacifici,M. and Iwamoto,M.
  TITLE     Articular cartilage endurance and resistance to osteoarthritic
            changes require transcription factor Erg
  JOURNAL   Arthritis Rheumatol 67 (10), 2679-2690 (2015)
   PUBMED   26097038
REFERENCE   5  (bases 1 to 5451)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 5451)
  AUTHORS   Schachterle,W., Rojas,A., Xu,S.M. and Black,B.L.
  TITLE     ETS-dependent regulation of a distal Gata4 cardiac enhancer
  JOURNAL   Dev Biol 361 (2), 439-449 (2012)
   PUBMED   22056786
REFERENCE   7  (bases 1 to 5451)
  AUTHORS   Bidder,M., Loewy,A.P., Latifi,T., Newberry,E.P., Ferguson,G.,
            Willis,D.M. and Towler,D.A.
  TITLE     Ets domain transcription factor PE1 suppresses human interstitial
            collagenase promoter activity by antagonizing protein-DNA
            interactions at a critical AP1 element
  JOURNAL   Biochemistry 39 (30), 8917-8928 (2000)
   PUBMED   10913304
REFERENCE   8  (bases 1 to 5451)
  AUTHORS   Klemsz,M., Hromas,R., Raskind,W., Bruno,E. and Hoffman,R.
  TITLE     PE-1, a novel ETS oncogene family member, localizes to chromosome
            1q21-q23
  JOURNAL   Genomics 20 (2), 291-294 (1994)
   PUBMED   8020980
REFERENCE   9  (bases 1 to 5451)
  AUTHORS   Wasylyk,B., Hahn,S.L. and Giovane,A.
  TITLE     The Ets family of transcription factors
  JOURNAL   Eur J Biochem 211 (1-2), 7-18 (1993)
   PUBMED   8425553
  REMARK    Review article
            Erratum:[Eur J Biochem 1993 Aug 1;215(3):907]
REFERENCE   10 (bases 1 to 5451)
  AUTHORS   Macleod,K., Leprince,D. and Stehelin,D.
  TITLE     The ets gene family
  JOURNAL   Trends Biochem Sci 17 (7), 251-256 (1992)
   PUBMED   1502727
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139241.4.
            
            On Aug 22, 2022 this sequence version replaced NM_001286844.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR9219382.163909.1, SRR13948564.1457632.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AC139241.4         169664-170058       c
            396-451             AC139241.4         168326-168381       c
            452-689             AC139241.4         167535-167772       c
            690-805             AC139241.4         166303-166418       c
            806-5451            AC139241.4         155486-160131       c
FEATURES             Location/Qualifiers
     source          1..5451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.19 cM"
     gene            1..5451
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /note="ets variant 3"
                     /db_xref="GeneID:27049"
                     /db_xref="MGI:MGI:1350926"
     exon            1..395
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..451
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1947
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /note="isoform 1 is encoded by transcript variant 1; ets
                     variant gene 3; mitogenic Ets transcriptional suppressor
                     METS; ETS domain transcriptional repressor PE1; ETS-domain
                     protein"
                     /codon_start=1
                     /product="ETS translocation variant 3 isoform 1"
                     /protein_id="NP_001273773.1"
                     /db_xref="CCDS:CCDS17453.1"
                     /db_xref="GeneID:27049"
                     /db_xref="MGI:MGI:1350926"
                     /translation="MKAGCSIVEKPEGGGGYQFPDWAYKAESSPGSRQIQLWHFILEL
                     LQKEEFRHVIAWQQGEYGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRI
                     LHKTKGKRFTYKFNFNKLVMPNYPFINIRSSGVVPQSAPPVPTASSRFHFPPLDSHSP
                     TGDVQPGRFSASSLSASGPESGVTTDRKVEPSDLEDGSASDWHRGMDFMPSRNALGGG
                     AVGHQKRKPDILLPLFTRPAMYPDPHSPFAISPVPGRGGVLNVPISPALSLTPTMFSY
                     SPSPGLSPFTSSSCFSFNPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQM
                     HPEEPSQFSIKLQPPPAGRKNRERVESREEAVRGSVPASAPVPSRIKVEPATEKDPDS
                     LRQSTQGKEEQTQEVDSMRSRTIEEGKGTGFAHPSPTWPSVSISTPSDEPLEGTEDSE
                     DRSVREPGVPEKKEDALMPPKLRLKRRWNDDPEARELNKTGKFLWNGAGPQGLATTAT
                     AAADA"
     exon            452..689
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..805
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..5451
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5423..5428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /note="hexamer: ATTAAA"
     polyA_site      5451
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /note="major polyA site"
ORIGIN      
        1 acttccttct gggtggatga ggaggagccc gagctgccgc ggaggagccc gagtggagac
       61 ggacggcgcc ggagaggtga gactggtggc gtcggcggtc gcggcccgcg cgggcaggac
      121 ggaagggacg cggatgaggg cggccgtgga agccgctgcg gaccagcggg agcggcgagc
      181 cccgccgcag gccgggaggg tgaccgagcg ccctggggga gtcgcgaaca cctgcagacg
      241 cgcctgcggg ctccgagggg ctggatgggc acatcggggg ccggaggatc gaggagaggg
      301 tgcccggctc gggcgtcggc cagcgcgagc ccacggacac caggctgaag ggtgttctgg
      361 agcagggaaa gggccctgcg atccgacagc gcagggaggg cgaaaatgaa agcaggctgt
      421 agcatcgtgg aaaagccaga aggaggtgga gggtatcagt ttccggattg ggcctacaaa
      481 gccgagtcgt cgccgggctc ccggcagatc cagctgtggc acttcatcct ggaactgctg
      541 cagaaggaag agttccgcca tgtcatcgcc tggcagcagg gagagtacgg ggagtttgtc
      601 atcaaggatc cagatgaagt ggctcgcctc tggggccgca ggaagtgcaa accacagatg
      661 aactatgaca agctgagccg ggccctcaga tactattaca acaagaggat ccttcataaa
      721 acaaaaggga aaaggtttac ttacaagttt aacttcaaca agctcgtgat gcccaactac
      781 ccgttcatca acattcgctc gagtggtgtg gttcctcaga gtgcgccacc agtgccaaca
      841 gcctcctccc ggttccattt cccacctcta gacagccatt ctcctactgg cgatgtgcaa
      901 ccgggtcgct tctctgccag ctcactgagt gcttctggcc ctgagtcagg ggttaccact
      961 gacaggaagg tcgagccttc ggacctggaa gatggctcgg cctctgactg gcaccggggc
     1021 atggacttca tgccctcccg aaatgctctg ggcggaggag cagtcggcca ccagaaacgc
     1081 aagcctgaca tactgcttcc tctcttcacc cggccagcca tgtaccctga cccgcacagt
     1141 cccttcgcta tctctccggt ccctggccgc ggaggggtcc ttaatgtccc catctcacca
     1201 gccctgtccc tgactcccac catgttctcc tacagtccct caccaggcct gagccccttc
     1261 accagcagca gttgcttctc cttcaaccca gaggaaatga aacactacct tcattctcaa
     1321 gcctgttcgg tgttcaacta ccatctgagt ccccggactt tcccccgtta cccagggctc
     1381 atggtcccac cgctgcagtg ccaaatgcat cctgaggagc cttcccagtt ctccatcaag
     1441 ctgcagcccc cgccggctgg acggaagaac cgcgagaggg tagagagccg ggaggaggct
     1501 gttcgcggct ctgtgcccgc cagcgctcct gttccctctc ggattaaggt agagccggcc
     1561 acagagaagg atcctgacag cctccggcag tcaacccagg gaaaggagga acagacccaa
     1621 gaagtggaca gcatgcggag caggaccata gaagagggga aaggcaccgg gtttgcccac
     1681 ccctcaccca cctggccctc tgtgtccatt agcactccca gtgacgaacc cctagagggg
     1741 accgaagaca gtgaggacag gtctgtcagg gagcccggtg tacccgagaa gaaagaagac
     1801 gccctgatgc cccctaagct tcggctgaag aggcggtgga atgacgaccc tgaagccagg
     1861 gagctcaaca aaacgggcaa gttcctctgg aatggggcag gaccccaggg cctggccaca
     1921 acggccactg ctgccgctga tgcttaaaac cacagtggaa gggaagctgt tcatattaca
     1981 atcaaaatac atatttatgt agcaagattc tggggcggga ggtggggttc agctggtttg
     2041 ataattctgg ggcgtggact tgtacttttc tgttggggat gggacgagga tcttgtgttg
     2101 tataaataag tggggtatgg acactttttt ttcttggcgc gtaggacata gggaggctat
     2161 gaactttggg gaaggagcct gtttcctgtc ccctcctgct gcctgacaag ctccataggc
     2221 ccatacactg tagtcccatc acaggtcagg ccctatagtc tttcctattg tgtttataca
     2281 tacagaaagc ccatagtggg atagtttgct ttgagaggga gagagaagag gaagaggctg
     2341 gaaggttagg cgtgagaaac atactaacca tgtacctgag tatgtgtttc aggagaggaa
     2401 aaagttcatc gcagtcttac cgaagtgggg ggcatttaga tggggttctc tactcccctc
     2461 tcccccttct ccctcactgg agtgtgtgtg tgtgtgatgt gtgtgtctat gtgtgtgtgt
     2521 gcacacacac agagacacac acatgctctc tcccatgcat gcactctctc tttctctccc
     2581 tggggggagg gtgacacacg cacatttggc tcccctcccc cctttttaga aaatgttttc
     2641 aagacacatg agtgtactgc cagttatact gggcagggag ggcaccggag accccccacc
     2701 cccggcccct cagcttcaga gttgaggtgg gaaggcagcc tggctgcgag gtcctcaaac
     2761 tctcaccttc ttcaccttca aaaagccatg aggagttgta aactcttgat cagggaagaa
     2821 agaagagggc aggaggaagt aacccaatgc ctttaaaaac aaaacaaatg acagaaatag
     2881 tcttcatttt ctttttcttt ttctttttcc attgttggtt tggtttccca aaccaagcgt
     2941 gactgagcac gttttatgag gagcaggata gcgccgttga agatgttttt ctgttgtgtc
     3001 tggttgtctt actgttttct taagtcgagc cttaactacg aacatgcttt aagatgatac
     3061 gggtctgtca acataaacct gtgaagggca tggacgctgt tcagataacc caggaatgtt
     3121 gaggcacagt cgaattccta gctgatagtt attccctctg atgttgccgg tccgggtggc
     3181 aaaagggcag aattgtggga atgaaaggca gatgataacc tgcaaactca atgtactgct
     3241 tgtcgaaact gaaggaagag gtaggaaggt ggtgaccaga tgccaaaagg tctggtgtaa
     3301 aggagagagc ggtgttgcct gcggtggtgt tgcccgcctt gtggtccccc gttgcccaga
     3361 ttgttctgat cggtcgactg ttcccaaaat gcagttcacc aacaggggtc atttgtcctt
     3421 gggaaatccc cttacagcaa cttcaaagga atgggaagat actgatctta ggtgaaacaa
     3481 aacactagca ctagggtaga gagaaagcgg caccagccaa cggcctctgt gcacgtgtgt
     3541 gctctagtag ctcagagcag caagaagaaa tggtttccta tctgctgagg caagggatgg
     3601 cactcgggca tcagagtgat gactcactcc gtccgccacc tgagcctggc caagaactcc
     3661 atactaagtg acatttgagt gttgtcttct gatggagtgt ttgggtttgg tttagtttgg
     3721 ttttattttc tttaactgaa atgcatgcac aaaaggagct caggagacat tagacctggt
     3781 gaaaggtgtg agctgacgtg gatcacttga ggctgtcatt gctgtttctt gatgagtgtc
     3841 ctataacttg gtccagattc cacgcatgtg tgaaaggcca ggaagggggc cgagtggtct
     3901 ctggtgaccc aggctctggt cgggccacga aggacttcaa ccctcctgtt gcctttggtg
     3961 gttgtgtttt gatcagtttc cttctctgca ccttgacgga cctctgaatc agaaagcagg
     4021 cccagcaggt agaggaaggc tctctggttg gtgttgccca tcaaaccagg gaggccagct
     4081 ggccaccggt tgtctgctag tggggacggc cagcgagcat cagtatgaac tcaggaatag
     4141 aagcgtgggg cctttaaaat gagggcagga aatccatgat gcatacctga aacccctaga
     4201 acccaagtgc cggaattcat tctagatgct gcttccattt gaataaagcc actgctttta
     4261 cacttgaaag tgaactccat gaaaaatgct tttggacttt tatgaaacta tttgccgttt
     4321 gtttcccttg attgccattc caccagtaat ctcttggttg attggcactg cacacagttg
     4381 gagtctggat ctggggaagg gtctgtctgc agagcagaac ttgggctcgc tcaggaagtg
     4441 gaccaggaaa tgtagtgatc actgatactt cctggggcag aggagtgaga gtgctcgtct
     4501 ctccccagcc ccagcctggc agttcctgcc tccagcctgg tgtcaccttc tttctacgag
     4561 cacgccattg accatcagcc aggcgaaagg gggctaaaag ccgggcctac ttcctctccc
     4621 tgggtttttt cttccctcta aattttgttg tgccaaatgt gtaaaacttt gtaggtgtaa
     4681 atctattgca atctcactaa tcaagagctt gtttatttaa acagtttgct tttttagctg
     4741 taaagagtag cagactctcg gggcatcagc tctgctgtgc tcgcgggtct tcctagacat
     4801 caggctgcac ttctaacccc agctcgggaa tgcagggaac cctagtgacc cataggccaa
     4861 gaaacttcca gaagcattaa aaaaaaaaaa gttatattcc actaccaagt ggatagtcat
     4921 ttagctgttt gtcccttgtt tttttattta ttccataatt atgtttgtgc tttttcttgt
     4981 gtgaacagta gtggtgaggc ctatgttttt atgtggcttt agagaaaact tcagtcttca
     5041 aagaactctt ctaattagtt ccttcttaga aaaagttatg cgttaatttg tttcaaaata
     5101 tttaggcatt ctttgaatta taaacttgtg atgcagggat ttatgaatga gacgttcaca
     5161 tgtgaagatg acttcactaa gcatctgtgt aagcagaata agatgtgtat atgtacataa
     5221 actataagga acctgaacac cattgtgcag tgccttttag atgttctgct ttctaaagtc
     5281 ttcaaatttt ttgcatatat attatatata tgatgtaatg ttatagaaat atatgtataa
     5341 tatacatatt ttttccaggg gtatctgata gctctgtatt ttgttatgga agtcgaaaga
     5401 aaaaaagtat tttacctcga aaattaaagt taaatttaaa aacaaagagt a
//
