LOCUS       NP_001273773             513 aa            linear   ROD 02-MAY-2024
DEFINITION  ETS translocation variant 3 isoform 1 [Mus musculus].
ACCESSION   NP_001273773
VERSION     NP_001273773.1
DBSOURCE    REFSEQ: accession NM_001286844.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 513)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 513)
  AUTHORS   Villar,J., Cros,A., De Juan,A., Alaoui,L., Bonte,P.E., Lau,C.M.,
            Tiniakou,I., Reizis,B. and Segura,E.
  TITLE     ETV3 and ETV6 enable monocyte differentiation into dendritic cells
            by repressing macrophage fate commitment
  JOURNAL   Nat Immunol 24 (1), 84-95 (2023)
   PUBMED   36543959
REFERENCE   3  (residues 1 to 513)
  AUTHORS   Sizemore,G.M., Pitarresi,J.R., Balakrishnan,S. and Ostrowski,M.C.
  TITLE     The ETS family of oncogenic transcription factors in solid tumours
  JOURNAL   Nat Rev Cancer 17 (6), 337-351 (2017)
   PUBMED   28450705
  REMARK    Review article
REFERENCE   4  (residues 1 to 513)
  AUTHORS   Ohta,Y., Okabe,T., Larmour,C., Di Rocco,A., Maijenburg,M.W.,
            Phillips,A., Speck,N.A., Wakitani,S., Nakamura,T., Yamada,Y.,
            Enomoto-Iwamoto,M., Pacifici,M. and Iwamoto,M.
  TITLE     Articular cartilage endurance and resistance to osteoarthritic
            changes require transcription factor Erg
  JOURNAL   Arthritis Rheumatol 67 (10), 2679-2690 (2015)
   PUBMED   26097038
REFERENCE   5  (residues 1 to 513)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (residues 1 to 513)
  AUTHORS   Schachterle,W., Rojas,A., Xu,S.M. and Black,B.L.
  TITLE     ETS-dependent regulation of a distal Gata4 cardiac enhancer
  JOURNAL   Dev Biol 361 (2), 439-449 (2012)
   PUBMED   22056786
REFERENCE   7  (residues 1 to 513)
  AUTHORS   Bidder,M., Loewy,A.P., Latifi,T., Newberry,E.P., Ferguson,G.,
            Willis,D.M. and Towler,D.A.
  TITLE     Ets domain transcription factor PE1 suppresses human interstitial
            collagenase promoter activity by antagonizing protein-DNA
            interactions at a critical AP1 element
  JOURNAL   Biochemistry 39 (30), 8917-8928 (2000)
   PUBMED   10913304
REFERENCE   8  (residues 1 to 513)
  AUTHORS   Klemsz,M., Hromas,R., Raskind,W., Bruno,E. and Hoffman,R.
  TITLE     PE-1, a novel ETS oncogene family member, localizes to chromosome
            1q21-q23
  JOURNAL   Genomics 20 (2), 291-294 (1994)
   PUBMED   8020980
REFERENCE   9  (residues 1 to 513)
  AUTHORS   Wasylyk,B., Hahn,S.L. and Giovane,A.
  TITLE     The Ets family of transcription factors
  JOURNAL   Eur J Biochem 211 (1-2), 7-18 (1993)
   PUBMED   8425553
  REMARK    Review article
            Erratum:[Eur J Biochem 1993 Aug 1;215(3):907]
REFERENCE   10 (residues 1 to 513)
  AUTHORS   Macleod,K., Leprince,D. and Stehelin,D.
  TITLE     The ets gene family
  JOURNAL   Trends Biochem Sci 17 (7), 251-256 (1992)
   PUBMED   1502727
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139241.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR9219382.163909.1, SRR13948564.1457632.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.19 cM"
     Protein         1..513
                     /product="ETS translocation variant 3 isoform 1"
                     /note="ets variant gene 3; mitogenic Ets transcriptional
                     suppressor METS; ETS domain transcriptional repressor PE1;
                     ETS-domain protein"
                     /calculated_mol_wt=56895
     Region          34..120
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     Region          138..202
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4Z4.2)"
     Site            139
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P41162; propagated from
                     UniProtKB/Swiss-Prot (Q8R4Z4.2)"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P41162; propagated from
                     UniProtKB/Swiss-Prot (Q8R4Z4.2)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8R4Z4.2)"
     Region          333..513
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4Z4.2)"
     Site            388
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P41162; propagated from
                     UniProtKB/Swiss-Prot (Q8R4Z4.2)"
     CDS             1..513
                     /gene="Etv3"
                     /gene_synonym="METS; Pe1"
                     /coded_by="NM_001286844.2:406..1947"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17453.1"
                     /db_xref="GeneID:27049"
                     /db_xref="MGI:MGI:1350926"
ORIGIN      
        1 mkagcsivek peggggyqfp dwaykaessp gsrqiqlwhf ilellqkeef rhviawqqge
       61 ygefvikdpd evarlwgrrk ckpqmnydkl sralryyynk rilhktkgkr ftykfnfnkl
      121 vmpnypfini rssgvvpqsa ppvptassrf hfppldshsp tgdvqpgrfs asslsasgpe
      181 sgvttdrkve psdledgsas dwhrgmdfmp srnalgggav ghqkrkpdil lplftrpamy
      241 pdphspfais pvpgrggvln vpispalslt ptmfsyspsp glspftsssc fsfnpeemkh
      301 ylhsqacsvf nyhlsprtfp rypglmvppl qcqmhpeeps qfsiklqppp agrknrerve
      361 sreeavrgsv pasapvpsri kvepatekdp dslrqstqgk eeqtqevdsm rsrtieegkg
      421 tgfahpsptw psvsistpsd eplegtedse drsvrepgvp ekkedalmpp klrlkrrwnd
      481 dpearelnkt gkflwngagp qglattataa ada
//
