LOCUS       NM_007959               1050 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ets variant 2 (Etv2), mRNA.
ACCESSION   NM_007959 XM_909688
VERSION     NM_007959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1050)
  AUTHORS   Shang,X., Jin,Y., Xue,Y., Pan,X., Zhu,H., Meng,X., Cao,Z. and
            Rui,Y.
  TITLE     Overexpression of ETV2 in BMSCs promoted wound healing in cutaneous
            wound mice by triggering the differentiation of BMSCs into
            endothelial cells and modulating the transformation of M1 phenotype
            macrophages to M2 phenotype macrophages
  JOURNAL   Tissue Cell 87, 102334 (2024)
   PUBMED   38430850
  REMARK    GeneRIF: Overexpression of ETV2 in BMSCs promoted wound healing in
            cutaneous wound mice by triggering the differentiation of BMSCs
            into endothelial cells and modulating the transformation of M1
            phenotype macrophages to M2 phenotype macrophages.
REFERENCE   2  (bases 1 to 1050)
  AUTHORS   Cao,X., Mircea,M., Yakala,G.K., van den Hil,F.E., Brescia,M.,
            Mei,H., Mummery,C.L., Semrau,S. and Orlova,V.V.
  TITLE     ETV2 Upregulation Marks the Specification of Early Cardiomyocytes
            and Endothelial Cells During Co-differentiation
  JOURNAL   Stem Cells 41 (2), 140-152 (2023)
   PUBMED   36512477
  REMARK    GeneRIF: ETV2 Upregulation Marks the Specification of Early
            Cardiomyocytes and Endothelial Cells During Co-differentiation.
REFERENCE   3  (bases 1 to 1050)
  AUTHORS   Koyano-Nakagawa,N., Gong,W., Das,S., Theisen,J.W.M., Swanholm,T.B.,
            Van Ly,D., Dsouza,N., Singh,B.N., Kawakami,H., Young,S., Chen,K.Q.,
            Kawakami,Y. and Garry,D.J.
  TITLE     Etv2 regulates enhancer chromatin status to initiate Shh expression
            in the limb bud
  JOURNAL   Nat Commun 13 (1), 4221 (2022)
   PUBMED   35864091
  REMARK    GeneRIF: Etv2 regulates enhancer chromatin status to initiate Shh
            expression in the limb bud.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1050)
  AUTHORS   Sinha,T., Lammerts van Bueren,K., Dickel,D.E., Zlatanova,I.,
            Thomas,R., Lizama,C.O., Xu,S.M., Zovein,A.C., Ikegami,K.,
            Moskowitz,I.P., Pollard,K.S., Pennacchio,L.A. and Black,B.L.
  TITLE     Differential Etv2 threshold requirement for endothelial and
            erythropoietic development
  JOURNAL   Cell Rep 39 (9), 110881 (2022)
   PUBMED   35649376
REFERENCE   5  (bases 1 to 1050)
  AUTHORS   Kabir,A.U., Subramanian,M., Lee,D.H., Wang,X., Krchma,K., Wu,J.,
            Naismith,T., Halabi,C.M., Kim,J.Y., Pulous,F.E., Petrich,B.G.,
            Kim,S., Park,H.C., Hanson,P.I., Pan,H., Wickline,S.A.,
            Fremont,D.H., Park,C. and Choi,K.
  TITLE     Dual role of endothelial Myct1 in tumor angiogenesis and tumor
            immunity
  JOURNAL   Sci Transl Med 13 (583) (2021)
   PUBMED   33658356
REFERENCE   6  (bases 1 to 1050)
  AUTHORS   Knebel,J., De Haro,L. and Janknecht,R.
  TITLE     Repression of transcription by TSGA/Jmjd1a, a novel interaction
            partner of the ETS protein ER71
  JOURNAL   J Cell Biochem 99 (1), 319-329 (2006)
   PUBMED   16619273
  REMARK    GeneRIF: TSGA impairs the ability of ER71 to activate transcription
REFERENCE   7  (bases 1 to 1050)
  AUTHORS   Kageyama,S., Liu,H., Nagata,M. and Aoki,F.
  TITLE     The role of ETS transcription factors in transcription and
            development of mouse preimplantation embryos
  JOURNAL   Biochem Biophys Res Commun 344 (2), 675-679 (2006)
   PUBMED   16630543
REFERENCE   8  (bases 1 to 1050)
  AUTHORS   De Haro,L. and Janknecht,R.
  TITLE     Cloning of the murine ER71 gene (Etsrp71) and initial
            characterization of its promoter
  JOURNAL   Genomics 85 (4), 493-502 (2005)
   PUBMED   15780752
  REMARK    GeneRIF: Etsrp71 gene was cloned and its promoter was
            characterized.
REFERENCE   9  (bases 1 to 1050)
  AUTHORS   De Haro,L. and Janknecht,R.
  TITLE     Functional analysis of the transcription factor ER71 and its
            activation of the matrix metalloproteinase-1 promoter
  JOURNAL   Nucleic Acids Res 30 (13), 2972-2979 (2002)
   PUBMED   12087183
REFERENCE   10 (bases 1 to 1050)
  AUTHORS   Brown,T.A. and McKnight,S.L.
  TITLE     Specificities of protein-protein and protein-DNA interaction of
            GABP alpha and two newly defined ets-related proteins
  JOURNAL   Genes Dev 6 (12B), 2502-2512 (1992)
   PUBMED   1340465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L10427.1, AB221612.1 and BX638426.1.
            
            On Dec 27, 2006 this sequence version replaced NM_007959.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L10427.1, AB221612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-756               L10427.1           1-756
            757-1028            AB221612.1         740-1011
            1029-1050           BX638426.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.92 cM"
     gene            1..1050
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /note="ets variant 2"
                     /db_xref="GeneID:14008"
                     /db_xref="MGI:MGI:99253"
     exon            1..92
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /inference="alignment:Splign:2.1.0"
     exon            93..179
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /inference="alignment:Splign:2.1.0"
     exon            180..239
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /inference="alignment:Splign:2.1.0"
     exon            240..716
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /inference="alignment:Splign:2.1.0"
     exon            717..829
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1048
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1031..1036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /note="hexamer: AACAAA"
     polyA_site      1048
                     /gene="Etv2"
                     /gene_synonym="Etsrp71"
                     /note="major polyA site"
ORIGIN      
        1 agaaccgtca gaacaagcat ccatggacct gtggaactgg gatgaggcgt cactgcagga
       61 agtgcctcct ggggacaagc tgacaggact gggagcggaa tttggtttct atttccctga
      121 agtggctcta caagaggaca caccgatcac accaatgaac gtagaaggct gctggaaagg
      181 gttcccagag ctggactgga accccgcttt acctcacgaa gacgtacctt tccaggcgga
      241 gcccgttgct cacccccttc cgtggtcgcg agactggaca gacctgggat gcaacacctc
      301 ggacccgtgg agctgtgctt cacagacgcc aggccctgcc cctcctggca cgagcccctc
      361 ccccttcgtc ggctttgaag gggcgaccgg ccagaatcct gccacctcgg caggaggggt
      421 cccctcgtgg tcgcaccctc cagctgcctg gagcactacc agctgggact gttctgtggg
      481 ccccagtggc gccacctact gggacaatgg cctgggcggg gaagcgcatg aggactataa
      541 aatgtcatgg ggcgggtctg ccggttcgga ctacaccacc acgtggaata ctgggctgca
      601 ggactgcagc atccctttcg aggggcacca gagtccagca ttcaccacgc cctccaaatc
      661 gaacaagcag tctgatagag ccacattgac tcgctactcc aaaactaacc accgaggtcc
      721 cattcagctg tggcaattcc tcctggagct gctccacgac ggggctcgca gcagctgcat
      781 ccgctggacg ggcaatagcc gcgagttcca gctgtgcgac cccaaagagg tggcccggct
      841 gtggggcgag cgcaagagga agccgggaat gaattatgag aaactgagtc gaggtctacg
      901 ttattattac cgccgcgaca tcgtgctcaa gagtggtggg cgcaagtaca cataccgctt
      961 cgggggacgt gtgcctgtcc tcgcctatca ggatgatatg gggcatctgc caggtgcaga
     1021 aggccaataa aacaaaaaac aaaaacaaaa
//
