LOCUS       NM_011809               3560 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus E26 avian leukemia oncogene 2, 3' domain (Ets2), mRNA.
ACCESSION   NM_011809
VERSION     NM_011809.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3560)
  AUTHORS   Zhang,B., Zhu,Y., Zhang,Z., Wu,F., Ma,X., Sheng,W., Dai,R., Guo,Z.,
            Yan,W., Hao,L., Huang,G., Ma,D., Hao,B. and Ma,J.
  TITLE     SMC3 contributes to heart development by regulating super-enhancer
            associated genes
  JOURNAL   Exp Mol Med 56 (8), 1826-1842 (2024)
   PUBMED   39085358
REFERENCE   2  (bases 1 to 3560)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   3  (bases 1 to 3560)
  AUTHORS   Chen,S., Zhu,X., Ou,W., Kang,L., Situ,J., Liao,Z., Huang,L., Qi,W.
            and Ni,S.
  TITLE     ETS2 overexpression ameliorates cartilage injury in osteoarthritis
            by the ETS2/miR-155/STAT1/DNMT1 feedback loop pathway
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1866 (4), 194965 (2023)
   PUBMED   37524226
  REMARK    GeneRIF: ETS2 overexpression ameliorates cartilage injury in
            osteoarthritis by the ETS2/miR-155/STAT1/DNMT1 feedback loop
            pathway.
REFERENCE   4  (bases 1 to 3560)
  AUTHORS   He,L., Cai,Q., Liang,X., Xin,J., Shi,D., Ren,K., Li,Y., Chen,J.,
            Sun,S., Guo,B., Yang,H., Li,B., Ma,S., Luo,J., Hu,M., Li,J., Hu,W.,
            Li,P., Yao,H., Li,J., Chen,X., Jiang,J. and Li,J.
  TITLE     ETS2 alleviates acute-on-chronic liver failure by suppressing
            excessive inflammation
  JOURNAL   J Med Virol 95 (4), e28710 (2023)
   PUBMED   36975761
  REMARK    GeneRIF: ETS2 alleviates acute-on-chronic liver failure by
            suppressing excessive inflammation.
REFERENCE   5  (bases 1 to 3560)
  AUTHORS   Solmonson,A., Faubert,B., Gu,W., Rao,A., Cowdin,M.A.,
            Menendez-Montes,I., Kelekar,S., Rogers,T.J., Pan,C., Guevara,G.,
            Tarangelo,A., Zacharias,L.G., Martin-Sandoval,M.S., Do,D.,
            Pachnis,P., Dumesnil,D., Mathews,T.P., Tasdogan,A., Pham,A.,
            Cai,L., Zhao,Z., Ni,M., Cleaver,O., Sadek,H.A., Morrison,S.J. and
            DeBerardinis,R.J.
  TITLE     Compartmentalized metabolism supports midgestation mammalian
            development
  JOURNAL   Nature 604 (7905), 349-353 (2022)
   PUBMED   35388219
REFERENCE   6  (bases 1 to 3560)
  AUTHORS   Hagman,J. and Grosschedl,R.
  TITLE     An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates
            differential binding of ETS family factors to promoter sequences of
            the mb-1 gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8889-8893 (1992)
   PUBMED   1409581
REFERENCE   7  (bases 1 to 3560)
  AUTHORS   Rowe,A. and Propst,F.
  TITLE     Ets-1 and Ets-2 protooncogene expression in theca cells of the
            adult mouse ovary
  JOURNAL   Exp Cell Res 202 (1), 199-202 (1992)
   PUBMED   1511734
REFERENCE   8  (bases 1 to 3560)
  AUTHORS   Brookes,S., Maccarone,P., de Haan,J.B., Tymms,M., Forrest,G.L.,
            Graves,J.A. and Kola,I.
  TITLE     Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR,
            and CBR--to two different chromosomes in the marsupial species
            Macropus eugenii
  JOURNAL   Cytogenet Cell Genet 61 (1), 25-28 (1992)
   PUBMED   1380419
REFERENCE   9  (bases 1 to 3560)
  AUTHORS   Johnson,K.R., Cook,S.A., Bustin,M. and Davisson,M.T.
  TITLE     Genetic mapping of the murine gene and 14 related sequences
            encoding chromosomal protein HMG-14
  JOURNAL   Mamm Genome 3 (11), 625-632 (1992)
   PUBMED   1360278
REFERENCE   10 (bases 1 to 3560)
  AUTHORS   Colombo,M.P., Martinotti,A., Howard,T.A., Schneider,C.,
            D'Eustachio,P. and Seldin,M.F.
  TITLE     Localization of growth arrest-specific genes on mouse chromosomes
            1, 7, 8, 11, 13, and 16
  JOURNAL   Mamm Genome 2 (2), 130-134 (1992)
   PUBMED   1347472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY140250.1, AK038348.1 and BE134375.1.
            
            On Sep 3, 2009 this sequence version replaced NM_011809.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005486.1, AK038348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY140250.1         1-14
            15-3552             AK038348.1         2-3539
            3553-3560           BE134375.1         1-8                 c
FEATURES             Location/Qualifiers
     source          1..3560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.64 cM"
     gene            1..3560
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /note="E26 avian leukemia oncogene 2, 3' domain"
                     /db_xref="GeneID:23872"
                     /db_xref="MGI:MGI:95456"
     exon            1..238
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1645
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /codon_start=1
                     /product="protein C-ets-2"
                     /protein_id="NP_035939.3"
                     /db_xref="CCDS:CCDS37412.1"
                     /db_xref="GeneID:23872"
                     /db_xref="MGI:MGI:95456"
                     /translation="MNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLS
                     EDQTLQEVPTGLDSVSHDSASCELPLLTPCSKAVMSQALKATFSGFQKEQRRLGIPKN
                     PWLWSEQQVCQWLLWATNEFSLVNVNLHQFGMNGQMLCNLGKERFLELAPDFVGDILW
                     EHLEQMIKENQEKTEDQYEENSHLNAVPHWINSNTLGFSMEQAPYGMQAPNYPKDNLL
                     DSMCPPSATPAALGSELQMLPKSRLNTVNVNYCSISQDFPSSNVNLLNNNSGKPKDHD
                     SPENGGDSFESSDSLLRSWNSQSSLLDVQRVPSFESFEEDCSQSLCLSKLTMSFKDYI
                     QERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKL
                     ADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLG
                     FTPEELHAILGVQPDTED"
     exon            239..310
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..422
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..542
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..743
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     exon            744..827
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1046
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1310
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1429
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..3556
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3533..3538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /note="hexamer: AATAAA"
     polyA_site      3556
                     /gene="Ets2"
                     /gene_synonym="Ets-2"
                     /note="major polyA site"
ORIGIN      
        1 tccggccctc ccccagctcc agaagagcgc gcggctagga gatcgggctg gttacttcct
       61 tcaccgcggc gttgagcaca gagtggacac cactgaggcc cgtcagtccc cgccaccttc
      121 cccggccccg cgcgcccgga tcggccctac ggcctcgtct cgcccggcct tgcgcgccgg
      181 gaccgccgcg atctcctctc cccgccgccc tccggctggc cctgcctgct gcggcgcgat
      241 gaatgacttt ggaatcaaga acatggacca agtggcccct gtcgccaaca gttttcgtgg
      301 gacactcaag cgccagccag cctttgacac cttcgatggc tctctgtttg ctgtgctccc
      361 ttctctcagt gaagatcaga cactccaaga agtgcccacg ggcctggatt ctgtctccca
      421 tgactcggcc agctgcgagc tgcctttgct cactccctgc agcaaggcag tgatgagcca
      481 agccttaaaa gccaccttca gtggcttcca aaaggagcaa cgacgtcttg gcatccccaa
      541 aaacccctgg ctgtggagcg agcagcaggt gtgccagtgg cttctctggg ccaccaacga
      601 gttcagcctg gtgaatgtga acctgcacca gtttggcatg aacggccaga tgctgtgtaa
      661 cctcggcaag gagcgcttcc tggagctggc gcctgacttt gtgggtgaca tcctctggga
      721 acatctagag cagatgatca aagagaacca agaaaagaca gaagaccaat atgaggaaaa
      781 ctctcacctc aacgcggttc ctcattggat caacagcaat acattaggct tcagcatgga
      841 acaggctcca tatggaatgc aggcaccaaa ctaccccaaa gacaatctcc tggacagcat
      901 gtgcccgcca tcggccacgc ctgcagctct gggctctgag ctccagatgt tgcccaagtc
      961 tcggctcaac accgtcaatg tcaattactg ttccatcagc caggacttcc ccagcagcaa
     1021 cgtgaatttg ctcaacaaca attctggaaa acccaaggac cacgactctc cagagaacgg
     1081 tggggacagc ttcgagagct ccgactcgct gctgaggtcc tggaacagcc agtcgtccct
     1141 actggatgta cagcgggtac cttccttcga gagctttgag gaggactgta gccagtctct
     1201 gtgcctcagt aagctgacca tgtccttcaa ggactacatc caagagagga gcgacccagt
     1261 cgagcaaggc aaaccagtta ttcctgcagc agtactggct ggcttcactg gaagcggacc
     1321 aatccagttg tggcagtttc ttctggagct actctctgac aagtcctgtc aatctttcat
     1381 cagctggacg ggggatggat gggagttcaa gcttgctgac cccgatgagg ttgcccgccg
     1441 gtgggggaag aggaaaaata aaccaaagat gaactacgag aagctgagcc ggggcttacg
     1501 ttactactac gacaagaaca tcatccacaa gacttcgggc aagcgctacg tgtaccgttt
     1561 cgtatgtgac ctgcagaact tgctgggctt cactccggag gaactgcatg ccatcctggg
     1621 cgtccagcct gatacagaag actgagggcc tcaggaccac cctgagccag ccccgggccc
     1681 agggactgag tgggaagccc gtcctgaccc acttgctcca aagacccatg ggagggcagg
     1741 atggtacccc tcgggagaga gccaccaagc agcagtggcc tttcatccac gcctcttcca
     1801 caagccaatg ccccatggtg gaaaccggca tagcctctct gtcctgtatg agacccccct
     1861 gaagggaaga gtctctggga agccaccgtg gcaccgagca ggccctgtgc attgtggcta
     1921 tttgagatgc tccagggagc cagcatgtgg tggatacaca gacactgaga aacattgttt
     1981 ttcctttggc cttttgcctc caggagtagc aaatgcaaaa agccacctct gcttgagagg
     2041 gcccggcagg tggagagtgt gattgtccat ttcagaagtc agtttgtttg tacatactat
     2101 tgtatcttat aattgtccta atcctccaac agttctattt aacagaaatt gtatattgta
     2161 tttaaagtaa ttataacttg tctgaatcaa gaatgcagat acctaatagg ttatcctttt
     2221 atttttttca ctcctacata ggaacgtcat tttacaccga tttaatctct tagaatccaa
     2281 ctgagagaaa ccgtgatatt ctgtttttgt tttatttacc agcaggaatg ggctctgaag
     2341 ggtgacctgg ttttttcttt tgttttgctc tcttgttatt gttgctcatt atctgaccag
     2401 gactttgtat attggttttt ttttataaga aacttaatgt tattatttga gggtccatat
     2461 ggcctctcca ctctcctgga ctgtaaaagc tgtaaagcgg tatttttctt gacacatggc
     2521 acatgttttc cacttccctg catgccttaa gccaatttat acacaaatgt attttatttt
     2581 ttggcgtaac tgggttttcc aggcaactcc cctcccccag ccagtccttc ccttccttcg
     2641 ccccaagata ttctgtgtga ctacaacaag aagactattt ttggaaatat atgggattta
     2701 tgtagcagct atttttactg caaaagtaac tcactggaaa aaaatattgt aatttgtacg
     2761 aaagctttat ttttatctta gtcacgtaaa gggagatgtg tcgggtgggc agggctcagg
     2821 gcaatcagga gggatcttcc atcagccttg accttaaacg aagtgtggtg cttcctgtct
     2881 tgctgacctg ctatgtctct taaccatctg ggctgcatgc tcctctttct gctccgtgtg
     2941 ctcagagatt tgctcctctt atttttttgg ccatggatac ccagaagcac agacagagca
     3001 agcatgctgg gaaatggtgt cttggaccag ttctgtacga ggaggttctc atctagtgaa
     3061 gagctaactc caccatgaga cccccacgct ttcatctagt tgtgaactgg cttcgccgtt
     3121 taccagcatg gtgacctcag atcagcaagt gacattgata aagagccgtt ataccatgag
     3181 accacacggg acgtaggacc agctgggacc tgctgtgcca gtcctgggag gtcttggcct
     3241 gcatgcccca agagaaatgc tttgtggtta agcacaggga cctgtttgtc gctgggacat
     3301 ctgtgtgtaa tataaacaga catgggactt ggagcatcct cctgtcagag gcctaatcct
     3361 cagtcagttt atgtacagtg gagccacatg acattgccaa gtttaacctg agtcttgtca
     3421 gccaacatga cggttttacc tggttgaatc taacagtcat ggaagtcctc agaagtcttt
     3481 ggctgggtct taagtatgaa ggttttgtaa tttggcctcc tctttctcaa ataataaagt
     3541 atttggttta tgacaaaaaa
//
