LOCUS       NM_001372534            4938 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus E26 avian leukemia oncogene 1, 5' domain (Ets1),
            transcript variant 3, mRNA.
ACCESSION   NM_001372534 XM_006510269
VERSION     NM_001372534.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4938)
  AUTHORS   Cao,Y., Guo,A., Li,M., Ma,X., Bian,X., Chen,Y., Zhang,C., Huang,S.,
            Zhao,W. and Zhao,S.
  TITLE     ETS1 deficiency in macrophages suppresses colorectal cancer
            progression by reducing the F4/80+TIM4+ macrophage population
  JOURNAL   Carcinogenesis 45 (10), 745-758 (2024)
   PUBMED   39162797
  REMARK    GeneRIF: ETS1 deficiency in macrophages suppresses colorectal
            cancer progression by reducing the F4/80+TIM4+ macrophage
            population.
REFERENCE   2  (bases 1 to 4938)
  AUTHORS   Wu,S., Qiu,C., Ni,J., Guo,W., Song,J., Yang,X., Sun,Y., Chen,Y.,
            Zhu,Y., Chang,X., Sun,P., Wang,C., Li,K. and Han,X.
  TITLE     M2 macrophages independently promote beige adipogenesis via
            blocking adipocyte Ets1
  JOURNAL   Nat Commun 15 (1), 1646 (2024)
   PUBMED   38388532
  REMARK    GeneRIF: M2 macrophages independently promote beige adipogenesis
            via blocking adipocyte Ets1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4938)
  AUTHORS   Yang,M., Chen,Y., Huang,X., Shen,F. and Meng,Y.
  TITLE     Lysine demethylase KDM3A alleviates hyperoxia-induced
            bronchopulmonary dysplasia in mice by promoting ETS1 expression
  JOURNAL   Exp Cell Res 435 (2), 113945 (2024)
   PUBMED   38286256
  REMARK    GeneRIF: Lysine demethylase KDM3A alleviates hyperoxia-induced
            bronchopulmonary dysplasia in mice by promoting ETS1 expression.
REFERENCE   4  (bases 1 to 4938)
  AUTHORS   Battaglia,M., Sunshine,A.C., Luo,W., Jin,R., Stith,A.,
            Lindemann,M., Miller,L.S., Sinha,S., Wohlfert,E. and
            Garrett-Sinha,L.A.
  TITLE     Ets1 and IL17RA cooperate to regulate autoimmune responses and skin
            immunity to Staphylococcus aureus
  JOURNAL   Front Immunol 14, 1208200 (2023)
   PUBMED   37691956
  REMARK    GeneRIF: Ets1 and IL17RA cooperate to regulate autoimmune responses
            and skin immunity to Staphylococcus aureus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4938)
  AUTHORS   Yang,M., Chen,Y., Huang,X., Shen,F. and Meng,Y.
  TITLE     ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in
            Mice by Activating Nrf2/HO-1 Mediated Ferroptosis
  JOURNAL   Lung 201 (4), 425-441 (2023)
   PUBMED   37490064
  REMARK    GeneRIF: ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary
            Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
REFERENCE   6  (bases 1 to 4938)
  AUTHORS   Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
  TITLE     Molecular cloning of the murine IL-1 beta converting enzyme cDNA
  JOURNAL   J Immunol 149 (10), 3254-3259 (1992)
   PUBMED   1431103
REFERENCE   7  (bases 1 to 4938)
  AUTHORS   Hagman,J. and Grosschedl,R.
  TITLE     An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates
            differential binding of ETS family factors to promoter sequences of
            the mb-1 gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8889-8893 (1992)
   PUBMED   1409581
REFERENCE   8  (bases 1 to 4938)
  AUTHORS   Rowe,A. and Propst,F.
  TITLE     Ets-1 and Ets-2 protooncogene expression in theca cells of the
            adult mouse ovary
  JOURNAL   Exp Cell Res 202 (1), 199-202 (1992)
   PUBMED   1511734
REFERENCE   9  (bases 1 to 4938)
  AUTHORS   Shapiro,S.D., Griffin,G.L., Gilbert,D.J., Jenkins,N.A.,
            Copeland,N.G., Welgus,H.G., Senior,R.M. and Ley,T.J.
  TITLE     Molecular cloning, chromosomal localization, and bacterial
            expression of a murine macrophage metalloelastase
  JOURNAL   J Biol Chem 267 (7), 4664-4671 (1992)
   PUBMED   1537850
REFERENCE   10 (bases 1 to 4938)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127581.4 and AC139108.3.
            
            On Sep 4, 2019 this sequence version replaced XM_006510269.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.8737.1,
                                           SRR9219382.242135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC127581.4         55968-56041         c
            75-157              AC127581.4         42844-42926         c
            158-302             AC127581.4         27563-27707         c
            303-422             AC139108.3         91915-92034         c
            423-623             AC139108.3         90454-90654         c
            624-701             AC139108.3         87683-87760         c
            702-950             AC139108.3         86521-86769         c
            951-1211            AC139108.3         82350-82610         c
            1212-1330           AC139108.3         67792-67910         c
            1331-4938           AC139108.3         62889-66496         c
FEATURES             Location/Qualifiers
     source          1..4938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 17.97 cM"
     gene            1..4938
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /note="E26 avian leukemia oncogene 1, 5' domain"
                     /db_xref="GeneID:23871"
                     /db_xref="MGI:MGI:95455"
     exon            1..74
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            75..157
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            158..302
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            303..422
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            423..623
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            624..701
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            702..950
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1211
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1330
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..4938
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4922..4927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /note="hexamer: AAGAAA"
     polyA_site      4938
                     /gene="Ets1"
                     /gene_synonym="D230050P06; Ets-1; p54; Tpl1; vs"
                     /note="major polyA site"
ORIGIN      
        1 aggtagtagc tggaaagagc cgcagacctt cggtgaagct cactccattc ctcacccgtc
       61 tctgcagcaa attagtgtgg agaacagaat gagctactat gtggatccca ctgtgggcag
      121 cccctccact ttctctgcac ctcatcctgc agtggcgagg cagggtccta ttaacgcttt
      181 tgaagatcct cgaatgacct gcggcttcca gtccaattat catcagcaaa gacctcttta
      241 tccactctgg gatgagacag ccactcagga agttcctact ggccttgaac actgcggctc
      301 agacatggaa tgtgcagatg tcccgctgtt aactccgagc agcaaagaaa tgatgtccca
      361 agccttgaaa gctactttca gtggtttcac aaaagaacag cagcgactgg gaatccccaa
      421 agacccccgg cagtggacag aaacccacgt ccgggactgg gtgatgtggg ctgtgaatga
      481 gttcagcctg aaaggtgtgg acttccagaa gttctgtatg agtggagcag cactgtgtgc
      541 cctgggtaaa gaatgcttcc tcgagctggc tccagacttt gttggggata tcctgtggga
      601 gcatctagag atcctgcaga aagaggatgt gaaaccatat caggttaatg gagccaaccc
      661 tacctaccca gaatcctgtt acacctcgga ttacttcatc agctacggta tcgagcatgc
      721 tcagtgtgtt cctccctcag agttctcaga gcccagcttc atcacagagt cctatcagac
      781 gctgcatcct atcagctcgg aagaactcct gtccctcaag tatgagaacg actacccttc
      841 tgtcattctc caggaccctc tccagacaga caccttgcag acagactact ttgccatcaa
      901 gcaagaggtg ttaactccag acaacatgtg cctggggaga gccagtcgtg gtaaactcgg
      961 gggccaggac tcttttgaga gcgtagagag ctacgatagt tgtgaccgcc tcacccagtc
     1021 ctggagcagc cagtcatcct tcaacagcct gcagcgggtc ccctcctatg acagcttcga
     1081 ctacgaggat tatcccgctg ccctgcccaa ccacaagccc aagggcacct tcaaggacta
     1141 tgtgcgtgac cgtgctgacc tcaacaagga caagcctgtc attcctgctg ctgccctggc
     1201 tggctacaca ggaagtgggc cgatccagct gtggcagttt cttctggaat tactcactga
     1261 taagtcttgt cagtccttta tcagctggac aggagatggc tgggaattca agctttctga
     1321 cccagatgag gtggccagga gatggggaaa gaggaaaaac aaacctaaga tgaattatga
     1381 gaaactgagc cgtggccttc gctactatta tgacaaaaat atcatccaca agacggcggg
     1441 caagcgctac gtataccgct ttgtgtgcga cctgcagagc ctgctgggat acacccctga
     1501 agagctgcac gccatgctgg atgtaaagcc ggatgctgac tagtcatgga cagacgcgca
     1561 gaaggaaggg gctgggggaa ccctgctgag acctttcaaa gagcaaccct gttggttgga
     1621 ctcttcattt ttaattgtta ttcaatgttt tattttccag aactcatttt tcacattcag
     1681 gggtgggagc tgagggagcg ccgctgtatt ccattggcca ttggtgggcc ggaaagagga
     1741 ggtcaggacc tgcggggtgg gcggggcaat agctcctgag cagactttca gaagggagag
     1801 gtcttctcag aagcctgttg gacctggctt gcagaggaaa aaaaaactta agtgtccgtt
     1861 tttttttttt ttttttttaa atcaaagaaa aaaaaattca tcttgagttg tggatctact
     1921 agtgggagga atgatcacat tgagatgaaa gagattgatg aaagccagtc agttttgtgg
     1981 gtgggctgaa aacagtttct tcaggggatt actaaactca agaattatta acctttctac
     2041 tttttgaaac aatgatggac tttgattgaa ggggtccaaa actgttttta tgttgaagtt
     2101 tattttatta aattttgtgc cagtattttt ttttccttaa aaaaatatcg tcttaagctc
     2161 taaggtggtc tcagtattgc agtattgtga gtttgttgtt atttgctggc tgaggactct
     2221 tgtcacagtg aaagacaact gtttatatag accccattgg aaaaatccca gttctgtact
     2281 gagatcagag accccaaact cttacagcta aaggaaacga atgctgatct ggggacaggg
     2341 ggactgtgcg tgtgacttcc acctgcggtt tgtaaaaact gttttccttt gattcactgt
     2401 caggctttgg acttagtgtt agttacgggg cgttaagtct ctgcactgaa tgtattctgc
     2461 agctcttcta tggaatcgtc ggcatcatag cacagttcaa gtcttggaaa cgaaatccaa
     2521 ggagcaggat taacctgggt tttggttaaa ccgctacccg aaacatggaa gactcagaat
     2581 aaaagccgtt tgcatgggca ttaccccgag ggtcttaagg cctcaatgca tgccattcca
     2641 aactaacatt ctcagttctc ctctactttg tcttatgttc cccccggcat ccctcattgc
     2701 tgcccctccc tcatcactga tcagtgaaag tggagtgtaa tgcatcctga cacgtgactg
     2761 aaagtgtagt ttcagccatc acaacacaaa tccaagagtc cagacttgct agggctcgga
     2821 ggccacggca gtggagaggg tatttcagta gcatgtgact cggcctcctt tgaagacttg
     2881 gtgctcgtca ggtaggattt caggtgagac tgcttgccgg gaagtggcag ggagcactgg
     2941 cacttgacct gttaccacct cagcagaggg caagcccagg tcaactgcgg tgagagggag
     3001 acggagaaaa tacaagggaa ggcgcttagg taaggaaaat aaggtggccc gagacagtta
     3061 gatagatgtt tagtttcctc caagtttaaa ctcagactta attgaggcag ccatcatcct
     3121 gcctgatggg agaggagacc tgaaaataag ccattgtggg ttaaaaaaaa aagtaaggag
     3181 acatgcctgg gatcattaga atcccttcca ctgtatagct gcctagttaa gacagtgaca
     3241 gtgacatccc tgagagaaga gaggcaattg gctgaggtgg gcctctccag gctcaccctt
     3301 cggggtttgt agctccctgg tatcatcttc caggagagtt gatggctgac tcccacattc
     3361 ccttgaagac tctgaattac taagactata actcttgtcc gtgggtgttc tgtactgact
     3421 gagtggagca tccccacaag gaagcaaagg ccaaacattc cagctatata ttttgatctt
     3481 acaaatgcag gtgccttaat gaagctctca aaatatttag gagctgctca gggagtgtta
     3541 ggtgggatca tttggattat gctgttttct cttatgttat gtgatctttg ttgggcactg
     3601 acagtgtgag tgtgtgtgtg tgtgtgtgtg tacatttgta taaagttgca gctgaaatag
     3661 tactgaattt tctacttaga gtctgttcac atttccataa tggtgaatga aagagtacag
     3721 ccggggctgg tattgttgtt tgctctttgc aacagggctt aaaaaaatca cttccccaag
     3781 tcttcaccct tctccatatt gggttcctgc tgggaatgcc cctcctgaga gcctaccacc
     3841 tgcagtcccc tagcagagaa gacataagaa agtgtctccc acactcctca gcgtgctgac
     3901 ttgcctgcct tgatgccctt tctccctagg tccaccactt ttcaggattt gtagatagta
     3961 tattagtcag acagctttgt tgtccatctg gccagatgct ttcccccatc tcctccgaag
     4021 gccagagacc atcccaggaa gagtggcggg tggtttatac actggaaatg tagcagcatt
     4081 gctgcattga tgctctttta aaacacgttc acttcacagg aaggatgaac agatctgacc
     4141 tagctgggcg actccatcat tttcccagag aaatgcttta acctgtgtgg ctggctttgg
     4201 gctcagaggc ggggctaagg atgctccctg cggagagctc tgatggtgtg gccatggaga
     4261 ccttgtaagc attcaggatc agagatgctc ttcctcactt tggagaccag cactctgggt
     4321 tttaaagcat taaccttcat ggtgaaatca caccttctct ctcctagcca tgctgtgcat
     4381 gcggccttct ctgttggggt ctatataaac ctgttgaact cttacgtaca ttccaaagac
     4441 gtttcaagga accacaagta tatgtataca aatacatata tgaagtatat atgttaaagt
     4501 gaatttatct ctatcaggaa tactgcctca gttattgaat tttttttaag gatacttttt
     4561 tttttaaagc tgagaattat tgaggtgaaa aagatgttat attgtgtttg actttttcca
     4621 acttgtattt tcatataatt tatatttttt aaatgctgaa aatttaaaag caagatttaa
     4681 aaaggaaaag caggtgcttt ttaaaaatca gaactgaggt agcttagaga tgtagcgatg
     4741 taagtgtctt aaatgttttt tgtttttttt ttaaaaacaa atgcaaaaaa ttcttatggg
     4801 ggagtttttg gtttgtttca tttaagtagc tgatgctggc acatcatttt gctggaaaat
     4861 tttttatata ctgtaggctg atttcatatt gtattttaaa ctgtgtgaaa ttaaagaaac
     4921 aaagaaattc attcataa
//
