LOCUS       NM_001081006            7413 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus enhancer trap locus 4 (Etl4), transcript variant c,
            mRNA.
ACCESSION   NM_001081006 XM_001000032
VERSION     NM_001081006.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7413)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7413)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7413)
  AUTHORS   Zhang,G., Li,X., Sun,Y., Wang,X., Liu,G. and Huang,Y.
  TITLE     A Genetic Screen Identifies Etl4-Deficiency Capable of Stabilizing
            the Haploidy in Embryonic Stem Cells
  JOURNAL   Stem Cell Reports 16 (1), 29-38 (2021)
   PUBMED   33440180
  REMARK    GeneRIF: A Genetic Screen Identifies Etl4-Deficiency Capable of
            Stabilizing the Haploidy in Embryonic Stem Cells.
REFERENCE   4  (bases 1 to 7413)
  AUTHORS   Quintana-Urzainqui,I., Kozic,Z., Mitra,S., Tian,T., Manuel,M.,
            Mason,J.O. and Price,D.J.
  TITLE     Tissue-Specific Actions of Pax6 on Proliferation and
            Differentiation Balance in Developing Forebrain Are Foxg1 Dependent
  JOURNAL   iScience 10, 171-191 (2018)
   PUBMED   30529950
REFERENCE   5  (bases 1 to 7413)
  AUTHORS   Serth,K., Beckers,A., Schuster-Gossler,K., Pavlova,M.N., Muller,J.,
            Paul,M.C., Reinhardt,R. and Gossler,A.
  TITLE     Generation of an 870 kb deletion encompassing the Skt/Etl4 locus by
            combination of inter- and intra-chromosomal recombination
  JOURNAL   BMC Genet 16, 143 (2015)
   PUBMED   26678520
  REMARK    GeneRIF: Study deleted 868 kb of genomic DNA encompassing nearly
            the whole coding region of Skt/Etl4. Surprisingly, mice homozygous
            for this deletion were viable and fertile. Despite expression of
            Skt/Etl4 in multiple tissues during embryonic development the
            deletion caused only mild malformations of the axial skeleton.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7413)
  AUTHORS   Zachgo,J., Korn,R. and Gossler,A.
  TITLE     Genetic interactions suggest that Danforth's short tail (Sd) is a
            gain-of-function mutation
  JOURNAL   Dev Genet 23 (1), 86-96 (1998)
   PUBMED   9706697
REFERENCE   7  (bases 1 to 7413)
  AUTHORS   Wallin,J., Mizutani,Y., Imai,K., Miyashita,N., Moriwaki,K.,
            Taniguchi,M., Koseki,H. and Balling,R.
  TITLE     A new Pax gene, Pax-9, maps to mouse chromosome 12
  JOURNAL   Mamm Genome 4 (7), 354-358 (1993)
   PUBMED   8358169
REFERENCE   8  (bases 1 to 7413)
  AUTHORS   Koseki,H., Zachgo,J., Mizutani,Y., Simon-Chazottes,D., Guenet,J.L.,
            Balling,R. and Gossler,A.
  TITLE     Fine genetic mapping of the proximal part of mouse chromosome 2
            excludes Pax-8 as a candidate gene for Danforth's short tail (Sd)
  JOURNAL   Mamm Genome 4 (6), 324-327 (1993)
   PUBMED   8318736
REFERENCE   9  (bases 1 to 7413)
  AUTHORS   Korn,R., Schoor,M., Neuhaus,H., Henseling,U., Soininen,R.,
            Zachgo,J. and Gossler,A.
  TITLE     Enhancer trap integrations in mouse embryonic stem cells give rise
            to staining patterns in chimaeric embryos with a high frequency and
            detect endogenous genes
  JOURNAL   Mech Dev 39 (1-2), 95-109 (1992)
   PUBMED   1283314
REFERENCE   10 (bases 1 to 7413)
  AUTHORS   O'Kane,C.J. and Gehring,W.J.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF744489.1, AB125594.2, BC158051.1, AK147510.1 and AL929100.11.
            
            On Feb 6, 2007 this sequence version replaced XM_001000032.1.
            
            Transcript Variant: This variant (c) encodes the longest protein
            (isoform c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164132
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               CF744489.1         1-692
            693-1926            AB125594.2         1004-2237
            1927-2555           BC158051.1         1747-2375
            2556-3160           AK147510.1         2456-3060
            3161-3667           BC158051.1         2981-3487
            3668-3865           AK147510.1         3569-3766
            3866-5464           AL929100.11        116848-118446
            5465-5587           AL929100.11        118975-119097
            5588-7413           AL929100.11        119783-121608
FEATURES             Location/Qualifiers
     source          1..7413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 14.27 cM"
     gene            1..7413
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /note="enhancer trap locus 4"
                     /db_xref="GeneID:208618"
                     /db_xref="MGI:MGI:95454"
     exon            1..129
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..6088
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /note="isoform c is encoded by transcript variant c;
                     sickle tail protein"
                     /codon_start=1
                     /product="sickle tail protein isoform c"
                     /protein_id="NP_001074475.1"
                     /db_xref="CCDS:CCDS38053.1"
                     /db_xref="GeneID:208618"
                     /db_xref="MGI:MGI:95454"
                     /translation="MSLCPPPCCLLRSFFTNAAAKLPSSKKDDLSSKQKKTSRGDKTE
                     RIGSEGNLTEYQQVQAAATSAQRKAAAAHKEQGRSNLHVTSQEDAACRRPRERLSNGN
                     ARAQVSKPARNIPRRHTLGGPRSSKEILGMQPSEMDRKREAFLEHLKQKYPHHATAIM
                     GHQERLRDQTKSPKLSHSPQPPNLGDPVEHLSETSGDSLEAMSEGEVPSPFARGSRTR
                     ASLPVVRSANQTKERSLGVLYLQYGDETKQLRMPNEVTSTDTIRALFVSAFPQQLTMK
                     MLESPSVAIYIKDDSRNVYYELNDVRNIQDRSLLKVYNKDPSHAFNHMTKAVNGDMRM
                     QREIVYARGDGLVAPRPGSVAHPPHVIPNSPPSTPVPHSLPPSPSRIPYGGSRPMAIP
                     GNATIPRDRLSSLPVSRSISPSPSAILERRDVKPDEDMSSKNLVMFRNEGFYADPYLY
                     HEGRMSIASSHGGHPLDVPDHVIAYHRTAIRSASAYCSPSLQAEMHMEQSLYRQKSRK
                     YPDSHLPTLGSKTPPASPHRVGDLRMIDLHPHLNTHGPPHTLQPDRASPSRQSFKKEP
                     GTLVYIEKPRNTSGLSSLVDLGPPLVEKQGFAYSTTTIPKDRETRERMQAMEKQIASL
                     TGLVQSALFKGPITSSSKEASSEKMVKATANRNQADGAGTAHVSAGKVLGSVEFSLPP
                     SQPLPAGTSPIHTSLLDMRRNVAELRLQLQQMRQLQLQNQEILRAMMKKAELEISNKV
                     KETMKRLEDPVQRQRTLVEQERQKYLHEEERIVKKLCELEDFVEDLKKDSSSTGRVVT
                     LKDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAVLRIEVEAVRFLKEEPHKLDSLLK
                     RVRSMTDVLTMLRRHVTDGLLKGTDASQAAQYVAMEKATAAEVLKHQEETAHAPGQPL
                     HCSTGSPGDVKSEVVPLSTMTVHHVQSSPVVMQPSQHSSALMNPAQNLPGGTRPHTAS
                     PPAITQEVTSAQSAPGPQSPQTPVNGSSMQSLFIEEIHSVSAKNRAVSIEKAEKKWEE
                     KRQNLEHYNGKEFEKLLEEAQANIMKSIPNLEMPPASSPVSKGDAAGDKLELSEDSPN
                     SEQELDKIGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRSMSKVSSEDPGPTPQ
                     TRATKCPPEEPASAWAPSPPPVPAPSSKEEEEEEEEGDKIMAELQAFQKCSFMDVNPN
                     SHAEQSRANSHLKDTRAGATAPPKEKKNLEFYHEDVRKSDVECENGPQVESQKVTAGA
                     LRPSGPPKWERVMVDSISDTSRTSECRADTFTEENATPNKSLFRDSRNYSQKNVPKVS
                     FSSSGLNSLEGEINKGPNVSGLQCAIPDLENQKLNFGKTKEIGQQGQENADKSHIPLP
                     TRSAEFSIHDVKTQDQDVPVTGYGQVVLRSKVGRHANMNMNEDGESTPSSPSEEHTAT
                     DNIAFMITKTAVQVLSSGEVHDIVSQKGQDVQTVNIDGRKETASQHEGTEGEEPVVCL
                     DKKPVIIIFDEPMDIRSAYKRLSTIFEECDEELERMLTEEKIEEEEEDENEDSGVRTS
                     SQMSCEQVDSRSDRMGQKAETQSQPHVLSAELLTPGVQGVRKAEQRKLSSADSPDSGN
                     KCGMVDDQFESPKKKFKFKFPKKQLAALTQAIRTGTKTGKKTLQVVVYEEEEEDGTLK
                     QHKEAKRFEITRSQPEDALKTMARRQEQLSPEGTLPASRTDEIRKSTYRTLDSLEQTI
                     KQLENTISEMSPRALVDTSCSSNRDCGASLPHMAQEVSPRSLLVLDEVPPAPEPPTSI
                     SPASRKGSSTTPQTSRMPVPMTSKNRPGSLDKASKQSKLQDPRQYRQANGSAKKAGGD
                     CKPTSPSLPASKIPALSPSSGKSSSLPSASGDSSNLPNAPATKPSIASTPLSPQAGRS
                     AHSASLIPSVSNGSLKFQSPPHAGKGHHHLSFALQTQNGRAAPTTSSSSSPPSPASPT
                     SLNQGARGIRTIHTPSLASYKAQNGSSSKATPSTAKETS"
     exon            130..317
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            318..601
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            602..800
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            801..999
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1093
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1926
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2031
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2081
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2248
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2424
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2555
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2703
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..3160
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3344
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3499
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3667
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3787
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3865
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..5464
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            5465..5587
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     exon            5588..7413
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7384..7389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /note="hexamer: AATAAA"
     polyA_site      7402
                     /gene="Etl4"
                     /gene_synonym="6620402G01Rik; 9430077C05Rik;
                     E330027G05Rik; Etl-4; Skt"
                     /note="major polyA site"
ORIGIN      
        1 aagtttgtaa ctgaccatac catactccag agacaaaggt ggaactgcag cccaggaccc
       61 ctgaaagtcg ccctcaaagg attatactac ttatatgtca ctctgtcctc caccctgttg
      121 tcttcttaga tccttcttta caaacgcagc tgctaagttg ccgtcctcta agaaggatga
      181 tttaagcagc aagcagaaga aaaccagccg aggtgacaag acagagagaa ttggaagcga
      241 aggaaacttg acagagtatc agcaggtgca ggctgcagca acttcagctc agaggaaggc
      301 agcggcggct cacaaagaac aagggagaag caatcttcat gtaacatctc aggaagatgc
      361 agcatgccgc aggcccaggg aacgcctttc taatggaaac gccagggctc aggtttccaa
      421 gcctgcccga aatatcccaa ggagacacac tctaggtggg ccccgaagtt ccaaagagat
      481 cctgggaatg cagccatctg agatggacag gaagagagag gcgttcctag aacatctaaa
      541 gcagaagtac ccccaccatg ccacagccat catgggccac caggagaggc tgagggacca
      601 gacaaaaagt cccaagctgt cccacagtcc tcaacctccc aatttggggg atccggttga
      661 acatttatca gagacatctg gtgactcttt ggaagccatg tccgagggag aagtaccgag
      721 tcctttcgcc agaggcagtc gtactcgcgc gagccttccc gtggtgaggt cggccaatca
      781 aacaaaggaa agatccctgg gtgtcctcta cctccagtat ggagacgaaa ccaaacagct
      841 gcggatgccg aatgaagtca caagcacaga cacaatccga gctctcttcg tcagtgcctt
      901 tccccagcag ctcaccatga agatgctgga gtcgcccagt gttgccatct acatcaagga
      961 tgacagcaga aatgtctact atgagttaaa tgatgtgagg aatatccaag acagatccct
     1021 tctcaaagta tacaacaagg atccttcaca tgcatttaac cacatgacga aagccgtgaa
     1081 cggagacatg aggatgcaga gagaaattgt ttatgcaaga ggagatgggc ttgttgcccc
     1141 ccgaccagga tctgtggctc acccacctca tgtaattcca aactccccac catcaactcc
     1201 ggtgccccat tccttacctc cctctccatc cagaattcct tacgggggca gccgtccaat
     1261 ggctattcct ggcaatgcca ccatccccag ggacagactc tcgagcctgc cagtatccag
     1321 atccatctcc ccaagcccca gcgccatttt ggaaagaaga gatgtcaaac cggatgaaga
     1381 catgagcagc aaaaacctgg ttatgttcag aaatgagggt ttctatgccg acccttacct
     1441 ctatcatgaa ggacgaatga gcatagcctc atcccatggc ggccaccctt tggatgtccc
     1501 agatcatgtc attgcgtatc accgcacagc gatccggtca gcgagtgctt actgtagccc
     1561 ttccttgcaa gcagaaatgc atatggagca gtcgttatac agacaaaagt caaggaaata
     1621 ccctgatagc catttgccta ccttgggctc caaaacgccc ccagcctctc cacaccgtgt
     1681 gggtgactta agaatgatag acctgcaccc gcatcttaac acacatgggc cccctcacac
     1741 tctgcagcca gaccgggcct cccccagtcg ccagtccttt aaaaaggaac ccggcaccct
     1801 ggtgtacatc gaaaagccac gaaacacttc aggattatcc agccttgtag acctggggcc
     1861 tcctctagtt gagaagcaag gttttgctta cagcaccact acaatcccca aagacagaga
     1921 aaccagagag aggatgcaag ccatggagaa gcagattgcc agtctaactg gccttgttca
     1981 gtctgcgctt tttaaagggc ccattacaag tagtagcaaa gaggcgtcta gtgagaaaat
     2041 ggtgaaagcc acagccaaca ggaaccaagc agatggtgca ggaacggccc atgtttctgc
     2101 agggaaggtt ctgggctctg tggagttctc cctgccgccc agccaacccc tgcctgccgg
     2161 aacctcgccc atccacacta gcctgcttga catgaggagg aacgtggctg aactcaggct
     2221 ccaactccag cagatgaggc agctccagct gcagaaccag gagattctga gggcgatgat
     2281 gaagaaggct gagctggaaa tcagtaacaa agtgaaggag accatgaaga gactagagga
     2341 tccggtacag cgtcagcgca ccctggtgga gcaagagaga cagaagtacc tccacgaaga
     2401 agagcggatt gtcaaaaagt tatgtgagct ggaggacttt gttgaggact tgaagaagga
     2461 ctcttcctcc actggcagag tggtgaccct gaaagatgtg gaagatgggg ctttcctcct
     2521 gcgacaagtg ggagaagctg tggccactct caaaggagaa tttccaactt tgcaaaataa
     2581 gatgcgtgct gtcctgcgca tagaagttga ggcagtaagg ttcctgaagg aagagccaca
     2641 caagctggac agtctcctga agcgtgtgag gagcatgaca gatgtcttga cgatgttgcg
     2701 gaggcatgtc actgatgggc tcctgaaagg caccgatgca tcccaggctg cacagtatgt
     2761 tgccatggag aaggccacag ctgcagaggt cctgaagcat caggaagaga cagcccatgc
     2821 ccctgggcaa cccctccact gtagcactgg aagccctggc gatgtgaagt cagaagtggt
     2881 gcccctatcc accatgacag ttcaccatgt acagagctcg cctgtggtca tgcaaccttc
     2941 ccagcactcc tcagccttga tgaacccagc ccagaacttg cctggaggaa ccagacctca
     3001 cacagccagc cctccagcaa tcacacagga agtaacctct gcccagtcag ctccaggccc
     3061 ccagtcccct cagaccccag tgaatggttc ctccatgcag agcttgttca ttgaggaaat
     3121 tcacagtgtg agtgccaaga acagggcagt gtccattgag aaggcagaaa agaaatggga
     3181 agaaaaaagg caaaatctgg aacactataa cggaaaggag ttcgagaagc tcctggagga
     3241 agctcaggcc aacatcatga agtcaattcc aaacctggag atgcccccag cttccagccc
     3301 agtgtcaaag ggagatgcgg caggggataa gctggagctg tcagaagatt ctccaaattc
     3361 agagcaggaa ttggacaaga tagggggaaa gtcaccccct cctccacccc caccccctcg
     3421 gagaagctac cttcctggat caggacttac caccacgaga tcaggcgatg tggtctacac
     3481 tggcaggagc atgtctaagg tgagcagtga agaccctggg ccaacaccac agactagagc
     3541 cacaaaatgt cccccggagg aacctgcctc agcctgggcc ccatccccac caccagtccc
     3601 tgccccttcc tccaaggagg aggaggaaga agaagaagaa ggagacaaaa tcatggcaga
     3661 actccaggca ttccagaagt gttcctttat ggatgtaaat ccaaacagtc atgctgagca
     3721 gtcccgagct aacagccacc ttaaagacac tagggcaggc gccacagccc cacccaagga
     3781 gaagaagaat ttggaatttt accacgaaga tgtacgaaaa tctgatgttg aatgtgaaaa
     3841 tggcccccaa gtggaatctc aaaaggttac tgcaggggct ctgagaccta gtggcccccc
     3901 caaatgggaa agagtcatgg tggatagtat atctgacacc tcaagaacat cagaatgtag
     3961 agctgacacc ttcacagagg aaaatgccac acccaataag agcttattca gagacagtag
     4021 aaattattcc cagaaaaatg tgcctaaggt cagtttttct tcctctggcc tgaactcatt
     4081 agaaggtgaa atcaacaaag ggcctaatgt ctcgggacta cagtgtgcta ttcctgactt
     4141 ggaaaatcag aagttaaatt ttggaaagac aaaagagata ggccaacagg gacaagaaaa
     4201 tgcagacaag agtcacattc ctctcccaac tcgatcagca gaattcagta ttcatgatgt
     4261 caaaacacaa gatcaagatg ttcccgtgac aggttatggc caagttgtcc tgagatcgaa
     4321 ggtgggtagg cacgctaata tgaacatgaa tgaggatgga gaatcaactc caagttctcc
     4381 cagtgaggaa cacacagcca ctgataacat cgcctttatg atcaccaaaa ctgctgtcca
     4441 ggttctgtcc agcggggagg tccatgacat agtgagtcaa aaaggacaag atgtacagac
     4501 agttaatatt gatggaagga aagagacagc ctctcagcac gaagggacag aaggggaaga
     4561 accggttgtg tgcctggaca agaaaccagt tattatcatt tttgatgaac ccatggacat
     4621 ccgatctgca tataaaagac tctcaaccat ctttgaggaa tgcgatgagg agctagagag
     4681 aatgctgaca gaggaaaaga tagaggaaga ggaagaggat gaaaacgaag actctggagt
     4741 ccgaacctca tcccaaatgt cctgtgaaca ggtcgactcg agaagtgata ggatgggaca
     4801 aaaggcagag acacagtcac agccccatgt cctgtcagca gagttgctaa ctccaggagt
     4861 gcagggggtt cgtaaagccg agcagagaaa gcttagctca gctgattctc cagactcagg
     4921 gaataagtgt ggcatggttg atgaccagtt tgaaagtccc aagaaaaagt ttaagttcaa
     4981 attccctaaa aagcagcttg ctgctcttac acaggcaatt cgcacaggca ccaaaacggg
     5041 aaagaaaacc ctgcaggtgg ttgtctatga ggaagaggaa gaggacggta ctttgaaaca
     5101 gcacaaagaa gccaagcggt ttgaaatcac caggtcacag cctgaagatg ccctcaaaac
     5161 catggctagg aggcaagagc agctcagccc tgagggcacc cttccggcat caaggactga
     5221 tgaaattagg aaaagtactt acagaacact ggacagcctg gagcagacca taaagcaact
     5281 tgaaaataca atcagtgaaa tgagccccag ggccctagtt gatacctcat gttcttccaa
     5341 cagagattgt ggtgcaagct tgccccacat ggcccaagag gtctctcccc ggtccttgct
     5401 agttctggat gaagtacccc ctgccccaga gccccccaca tccatatctc cagcttcacg
     5461 taagggctcc agcaccaccc cacagacaag ccggatgcca gtccccatga cttccaagaa
     5521 cagacccgga agcctggata aggccagcaa gcagtccaaa ctacaggatc cccgccaata
     5581 ccgtcaggct aatggaagtg ctaagaaagc tggtggggac tgtaagccta cttccccctc
     5641 cttacctgct tctaagattc cagccctttc tcccagctct gggaaaagca gttctctgcc
     5701 ttccgctagt ggggacagct ctaacctccc caatgcacct gctactaaac catcgattgc
     5761 ttctacccct ctcagccccc aagcaggacg gtccgctcac tccgcttccc tcatcccttc
     5821 tgtctctaat ggctccttaa agtttcagag cccacctcac gcaggtaaag gccatcatca
     5881 cctttcgttc gcactgcaga ctcaaaatgg ccgagctgcc cctactacct cttcctcctc
     5941 atcccctcct tcccctgcct cccccacctc cctgaatcaa ggtgccaggg gcatcaggac
     6001 catccatact cctagcctcg ccagctacaa agcacagaat ggaagttcaa gcaaagccac
     6061 cccatccaca gcaaaagaaa cgtcttaaag gccagatcct attaggcaca aggtggaatt
     6121 gcatccttgt ttttaatttt cagcaatctg gaacaagtgt tttcataaga gaatgtatca
     6181 tattgctgta tcgttcaagg cttcatgcag agtatgtgct aagtactgag ttggtagctg
     6241 cagtaaagct tgtttttttt ccactctgtt gctgttgtaa ttgcatagtg tttactgtct
     6301 agattcgata cctattacat gaagaaagca tgtgctataa aaagagagag tatgatgaga
     6361 gtgaagacat gtgtgagaca agctgactgt actatgcatg taaaacatgt atgattccag
     6421 aattttagta tgttttgtat aaaaatattt ttcattacag agactagagg caaacagaga
     6481 aataaatacg caagcgtgac tatataaatt gtaaagcata tattatgata ttttctttta
     6541 ttttagtgtt atttagcttt attacagatt tctatttttg tcaaaacttc atggttcctt
     6601 tcaaaatctt ttttgccaaa acattttgat actacagcat tgtacatttg aaagtagcgt
     6661 gctagccttt aagccaatga gcttctacag tcgtagaaag aaattcagca aaactcctgc
     6721 actgccagca aaagtttgta tgataattcg ctagcgcaag ccagctcatt tttttctttg
     6781 ttttcttttc attttcttct tccttttttt tttttaaaga caaaacatct gagtattctg
     6841 tagctgtttt ctttgcactg tctgaccccc ttttatgttt tcttagacct ggtaattcat
     6901 accattgcat tgtggatttt aaaatgtaca cttctgtatg gttctgtaca ctgaggaact
     6961 tttgtaaata tacaaatata aataaacatc aaaatactat ctgtgacagc acatagagta
     7021 gttttcccac accaaagtta atttgtatgc atgcttaaga gtctatattg ggatgggcag
     7081 aaatgggact atccatacat ttttaaaaag caacaagttt gcacagttag ggtggttttg
     7141 tagataactg tatttgtata acacagccat gtaacatatg gagctataag cagagacttg
     7201 gcaaaactaa ataaagggct gcatgcttat tatttttttt ttgtaccttg tcactataac
     7261 gtctttcagt caacgaatat gtaactattg ccacagggtt tcagctctga gggcattcta
     7321 agcaacgtgt aatcacatcc actcatacag tgttgcttcc tcgaaaggga aggatgaatt
     7381 cctaataaac tcatcaacca tgtggccgtc tgg
//
