LOCUS       NM_025794               2281 bp    mRNA    linear   ROD 25-MAY-2024
DEFINITION  Mus musculus electron transferring flavoprotein, dehydrogenase
            (Etfdh), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025794
VERSION     NM_025794.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2281)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2281)
  AUTHORS   Herrero Martin,J.C., Salegi Ansa,B., Alvarez-Rivera,G.,
            Dominguez-Zorita,S., Rodriguez-Pombo,P., Perez,B., Calvo,E.,
            Paradela,A., Miguez,D.G., Cifuentes,A., Cuezva,J.M. and
            Formentini,L.
  TITLE     An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal
            muscle by regulating coenzyme Q homeostasis
  JOURNAL   Nat Metab 6 (2), 209-225 (2024)
   PUBMED   38243131
  REMARK    GeneRIF: An ETFDH-driven metabolon supports OXPHOS efficiency in
            skeletal muscle by regulating coenzyme Q homeostasis.
REFERENCE   3  (bases 1 to 2281)
  AUTHORS   Peng,M.Z., Shao,Y.X., Li,X.Z., Zhang,K.D., Cai,Y.N., Lin,Y.T.,
            Jiang,M.Y., Liu,Z.C., Su,X.Y., Zhang,W., Jiang,X.L. and Liu,L.
  TITLE     Mitochondrial FAD shortage in SLC25A32 deficiency affects
            folate-mediated one-carbon metabolism
  JOURNAL   Cell Mol Life Sci 79 (7), 375 (2022)
   PUBMED   35727412
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2281)
  AUTHORS   Beites,T., Jansen,R.S., Wang,R., Jinich,A., Rhee,K.Y.,
            Schnappinger,D. and Ehrt,S.
  TITLE     Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium
            tuberculosis in vitro and during infection
  JOURNAL   Nat Commun 12 (1), 6593 (2021)
   PUBMED   34782606
  REMARK    GeneRIF: Multiple acyl-CoA dehydrogenase deficiency kills
            Mycobacterium tuberculosis in vitro and during infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2281)
  AUTHORS   Chen,Y., Daosukho,C., Opii,W.O., Turner,D.M., Pierce,W.M.,
            Klein,J.B., Vore,M., Butterfield,D.A. and St Clair,D.K.
  TITLE     Redox proteomic identification of oxidized cardiac proteins in
            adriamycin-treated mice
  JOURNAL   Free Radic Biol Med 41 (9), 1470-1477 (2006)
   PUBMED   17023274
REFERENCE   6  (bases 1 to 2281)
  AUTHORS   Mathews,C.E., Dunn,B.D., Hannigan,M.O., Huang,C.K. and Leiter,E.H.
  TITLE     Genetic control of neutrophil superoxide production in
            diabetes-resistant ALR/Lt mice
  JOURNAL   Free Radic Biol Med 32 (8), 744-751 (2002)
   PUBMED   11937300
REFERENCE   7  (bases 1 to 2281)
  AUTHORS   Yamazaki,K., Okada,T., Mori,Y. and Tanaka,I.
  TITLE     Genetic mapping of mouse transient receptor potential (Trrp) genes
            responsible for capacitative calcium entry channels to chromosomes
            3, 7, 9, and X
  JOURNAL   Genomics 51 (2), 303-305 (1998)
   PUBMED   9722956
REFERENCE   8  (bases 1 to 2281)
  AUTHORS   Ellison,J.W., Wardak,Z., Young,M.F., Gehron Robey,P.,
            Laig-Webster,M. and Chiong,W.
  TITLE     PHOG, a candidate gene for involvement in the short stature of
            Turner syndrome
  JOURNAL   Hum Mol Genet 6 (8), 1341-1347 (1997)
   PUBMED   9259282
REFERENCE   9  (bases 1 to 2281)
  AUTHORS   Lutz,C.M., Frankel,W.N., Richards,J.E. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to
            conserved linkage groups on mouse chromosomes 3 and 8
  JOURNAL   Genomics 41 (3), 498-500 (1997)
   PUBMED   9169155
  REMARK    Erratum:[Genomics 1997 Sep 1;44(2):251-2]
REFERENCE   10 (bases 1 to 2281)
  AUTHORS   White,R.A., Dowler,L.L., Angeloni,S.V. and Koeller,D.M.
  TITLE     Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13:
            the mouse homologs of genes responsible for glutaric acidemia type
            II in human
  JOURNAL   Genomics 33 (1), 131-134 (1996)
   PUBMED   8617498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE848473.1, AK152624.1 and AK141684.1.
            
            On Jul 23, 2009 this sequence version replaced NM_025794.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141684.1, AK152624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BE848473.1         97-129
            34-2259             AK152624.1         3-2228
            2260-2281           AK141684.1         2214-2235
FEATURES             Location/Qualifiers
     source          1..2281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 34.91 cM"
     gene            1..2281
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /note="electron transferring flavoprotein, dehydrogenase"
                     /db_xref="GeneID:66841"
                     /db_xref="MGI:MGI:106100"
     exon            1..250
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2067
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /EC_number="1.5.5.1"
                     /note="electron transfer flavoprotein-ubiquinone
                     oxidoreductase, mitochondrial; ETF-QO; ETF dehydrogenase;
                     ETF-ubiquinone oxidoreductase"
                     /codon_start=1
                     /product="electron transfer flavoprotein-ubiquinone
                     oxidoreductase, mitochondrial precursor"
                     /protein_id="NP_080070.2"
                     /db_xref="CCDS:CCDS17418.1"
                     /db_xref="GeneID:66841"
                     /db_xref="MGI:MGI:106100"
                     /translation="MLVRLTKLSCPAYHWFHALKIKKCLPLCAPRCSSTSAVPQITTH
                     YTVHPREKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAIRLKQLAAEQGKDIRVCLV
                     EKAAQIGAHTLSGACLDPAAFKELFPDWKEKGAPLNTPVTEDRFAILTEKHRIPVPIL
                     PGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLYHEDGSVKGIATNDV
                     GIQKDGAPKTTFERGLELHAKVTVFAEGCHGHLAKQLYKKFDLRASCDAQTYGIGLKE
                     LWIIDEKKWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVAVGFVVGLDYQNPYLS
                     PFREFQRWKHHPSIQPTLEGGKRIAYGARALNEGGLQSIPKLTFPGGLLIGCSPGFMN
                     VPKIKGTHTAMKSGSLAAESIFKQLTSENLQSKTTGLHVTEYEDNLKQSWVWKELHAV
                     RNIRPSCHGILGVYGGMIYTGIFYWILRGMEPWTLKHKGSDSDQLKPAKDCTPIEYPK
                     PDGQISFDLLSSVALSGTNHEHDQPAHLTLKDDSIPVNRNLSIYDGPEQRFCPAGVYE
                     FVPLEQGDGFRLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM"
     exon            251..388
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            389..618
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            619..700
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            701..819
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            820..897
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1044
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1185
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1329
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1498
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1681
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1903
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2281
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2247..2252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2266
                     /gene="Etfdh"
                     /gene_synonym="0610010I20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcctctg tggcgccggc gcaaagcaga agaggggcgg gtacgccgcg aagcaagggc
       61 ggtcggcaga gcccagacgc tgacagaagc tgagcagtcg gggcttcttg gcaggtgatg
      121 gcgcccctcg tagcctagaa gtccagcacc ctcggcaagc cgcagaccca cgcctctctc
      181 ctttgtatct ggtcaagtct ccgggtcact ttgaacatgt tggtgcgact aaccaagctg
      241 tcctgccctg cgtatcactg gtttcatgcc ttaaaaatta agaagtgcct acctctgtgt
      301 gctccaagat gttcttcaac ctctgctgta cctcagatta ccactcacta cactgttcat
      361 ccccgggaga aagacaaaag atgggaagga gtgaatatgg agaggtttgc agaagaagca
      421 gatgtggtca tagttggtgc cggcccagca ggactctctg cagctattcg gctaaagcag
      481 ctggctgctg aacaggggaa ggacatccgt gtgtgtctgg tggagaaagc tgctcagatc
      541 ggagcacaca cgctctcagg ggcttgtctt gatccagctg ccttcaaaga gctcttccca
      601 gactggaagg agaaaggggc tccacttaat actcctgtaa cagaagacag gtttgccatt
      661 ttaacagaga aacacagaat tcctgtgcca attcttccag gtcttccgat gaacaatcat
      721 ggcaattaca tcgtacgcct aggacatctg gtgagctgga tgggagaaca ggcagaggct
      781 cttggagtcg aagtgtatcc tgggtatgct gctgctgagg tcctttatca tgaagatggt
      841 agtgtaaaag gaatcgccac taatgatgta ggcatacaaa aggatggtgc accaaagaca
      901 acatttgaga gaggactgga actgcatgcc aaagtcacag tctttgcaga gggttgccat
      961 ggacacctag ccaagcagct ttataagaaa tttgatctga gggccagctg tgatgcacag
     1021 acttacggaa ttggtttgaa ggagttatgg attattgatg aaaagaagtg gaaacctgga
     1081 agagtagatc acactgttgg ttggcccttg gacagacata cttatggagg ctctttcctt
     1141 taccacttaa atgaaggtga acctctagta gctgttggct ttgtggttgg cctcgactat
     1201 cagaatccgt acctgagtcc attccgagag ttccagaggt ggaagcatca tcccagcatc
     1261 cagccaaccc tggaaggcgg gaagaggata gcctacggag cccgagcgct caatgaaggc
     1321 ggcttgcagt ccataccaaa actcactttt cctggtggct tactaattgg ttgtagtcct
     1381 ggtttcatga atgtccccaa gatcaaaggt acccacacgg caatgaaaag tggaagtttg
     1441 gcagcagaat caatttttaa gcaactaact agtgaaaatc tccagtcaaa gacaacagga
     1501 ctccatgtaa ctgaatatga ggacaatttg aagcaatcct gggtatggaa agagctacac
     1561 gctgttcgaa atataaggcc atcttgccac gggatactgg gagtatatgg agggatgatt
     1621 tacactggga tattttactg gatattgaga ggaatggagc catggactct aaaacataaa
     1681 ggctcagact ctgatcagct caaaccagcc aaggattgta cacccattga gtatccgaaa
     1741 cctgatggac agatcagttt tgacctctta tcctctgtgg ctttgagtgg tactaatcat
     1801 gaacatgacc agccagcaca tttaacctta aaggatgaca gcatacctgt taatagaaac
     1861 ctgtcaatat acgatgggcc tgagcagcga ttctgccctg caggagttta tgaatttgtt
     1921 cctttggaac aaggtgatgg atttcgatta cagataaatg ctcagaactg tgtgcactgt
     1981 aaaacatgtg atatcaaaga cccaagtcaa aatattaact gggtggtccc agaaggagga
     2041 ggagggcctg cttacaatgg catgtaagac actaggcctt cattcactgg cacacctgac
     2101 agccagtttc cataaaactg taaatgtatg ccaaactaac ttcctgtatg tttagataac
     2161 ttctgaacaa gtgtccttca aacattattg aagtaaaaaa ctttgtatct aaagttgccc
     2221 cataaaatca tgaagtattt gtcataaata aaactttata aataaacgag agcatttatt
     2281 t
//
