LOCUS       NM_026695                920 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus electron transferring flavoprotein, beta polypeptide
            (Etfb), transcript variant 1, mRNA.
ACCESSION   NM_026695 XM_916924 XM_924573
VERSION     NM_026695.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 920)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 920)
  AUTHORS   Peng,M.Z., Shao,Y.X., Li,X.Z., Zhang,K.D., Cai,Y.N., Lin,Y.T.,
            Jiang,M.Y., Liu,Z.C., Su,X.Y., Zhang,W., Jiang,X.L. and Liu,L.
  TITLE     Mitochondrial FAD shortage in SLC25A32 deficiency affects
            folate-mediated one-carbon metabolism
  JOURNAL   Cell Mol Life Sci 79 (7), 375 (2022)
   PUBMED   35727412
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 920)
  AUTHORS   Zhang,X., Zhang,Y.L., Qiu,G., Pian,L., Guo,L., Cao,H., Liu,J.,
            Zhao,Y., Li,X., Xu,Z., Huang,X., Huang,J., Dong,J., Shen,B.,
            Wang,H.X., Ying,X., Zhang,W.J., Cao,X. and Zhang,J.
  TITLE     Hepatic neddylation targets and stabilizes electron transfer
            flavoproteins to facilitate fatty acid beta-oxidation
  JOURNAL   Proc Natl Acad Sci U S A 117 (5), 2473-2483 (2020)
   PUBMED   31941714
  REMARK    GeneRIF: Hepatic neddylation also enhances ETFA and ETFB expression
            in adult mice and prevents fasting-induced steatosis and mortality.
REFERENCE   4  (bases 1 to 920)
  AUTHORS   Denuc,A., Nunez,E., Calvo,E., Loureiro,M., Miro-Casas,E.,
            Guaras,A., Vazquez,J. and Garcia-Dorado,D.
  TITLE     New protein-protein interactions of mitochondrial connexin 43 in
            mouse heart
  JOURNAL   J Cell Mol Med 20 (5), 794-803 (2016)
   PUBMED   26915330
  REMARK    GeneRIF: The results identify new protein-protein interactions
            between AIF-Cx43, ETFB-Cx43 and AIF-ETFB as possible players in the
            regulation of the mitochondrial redox state.
REFERENCE   5  (bases 1 to 920)
  AUTHORS   Rhein,V.F., Carroll,J., He,J., Ding,S., Fearnley,I.M. and
            Walker,J.E.
  TITLE     Human METTL20 methylates lysine residues adjacent to the
            recognition loop of the electron transfer flavoprotein in
            mitochondria
  JOURNAL   J Biol Chem 289 (35), 24640-24651 (2014)
   PUBMED   25023281
REFERENCE   6  (bases 1 to 920)
  AUTHORS   Goldsby,R.E., Singh,M. and Preston,B.D.
  TITLE     Mouse DNA polymerase delta gene (Pold1) maps to chromosome 7
  JOURNAL   Mamm Genome 9 (1), 92-93 (1998)
   PUBMED   9434960
REFERENCE   7  (bases 1 to 920)
  AUTHORS   Peters,L.L., Ciciotte,S.L., Su,G.H. and Simon,M.C.
  TITLE     The gene encoding the transcription factor Spi-B maps to mouse
            chromosome 7
  JOURNAL   Mamm Genome 8 (6), 452-453 (1997)
   PUBMED   9166596
REFERENCE   8  (bases 1 to 920)
  AUTHORS   Stubbs,L., Carver,E.A., Shannon,M.E., Kim,J., Geisler,J.,
            Generoso,E.E., Stanford,B.G., Dunn,W.C., Mohrenweiser,H.,
            Zimmermann,W., Watt,S.M. and Ashworth,L.K.
  TITLE     Detailed comparative map of human chromosome 19q and related
            regions of the mouse genome
  JOURNAL   Genomics 35 (3), 499-508 (1996)
   PUBMED   8812484
REFERENCE   9  (bases 1 to 920)
  AUTHORS   White,R.A., Dowler,L.L., Angeloni,S.V. and Koeller,D.M.
  TITLE     Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13:
            the mouse homologs of genes responsible for glutaric acidemia type
            II in human
  JOURNAL   Genomics 33 (1), 131-134 (1996)
   PUBMED   8617498
REFERENCE   10 (bases 1 to 920)
  AUTHORS   Finocchiaro,G., Colombo,I., Garavaglia,B., Gellera,C.,
            Valdameri,G., Garbuglio,N. and Didonato,S.
  TITLE     cDNA cloning and mitochondrial import of the beta-subunit of the
            human electron-transfer flavoprotein
  JOURNAL   Eur J Biochem 213 (3), 1003-1008 (1993)
   PUBMED   8504797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY292045.1, AK150293.1 and AI848359.1.
            
            On Feb 16, 2013 this sequence version replaced NM_026695.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013284.1, DV057934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BY292045.1         2-59
            59-883              AK150293.1         2-826
            884-920             AI848359.1         1-37                c
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.25 cM"
     gene            1..920
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /note="electron transferring flavoprotein, beta
                     polypeptide"
                     /db_xref="GeneID:110826"
                     /db_xref="MGI:MGI:106098"
     exon            1..133
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..844
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /note="beta-ETF"
                     /codon_start=1
                     /product="electron transfer flavoprotein subunit beta"
                     /protein_id="NP_080971.2"
                     /db_xref="CCDS:CCDS21171.1"
                     /db_xref="GeneID:110826"
                     /db_xref="MGI:MGI:106098"
                     /translation="MAELRALVAVKRVIDFAVKIRVKPDKSGVVTDGVKHSMNPFCEI
                     AVEEAVRLKEKKLVKEIIAVSCGPSQCQETIRTALAMGADRGIHVEIPGAQAESLGPL
                     QVARVLAKLAEKEKVDLLFLGKQAIDDDCNQTGQMTAGLLDWPQGTFASQVTLEGDKV
                     KVEREIDGGLETLRLKLPAVVTADLRLNEPRYATLPNIMKAKKKKIEVVKAGDLGVDL
                     TSKVSVISVEEPPQRSAGVKVETTEDLVAKLKEVGRI"
     exon            134..292
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            293..451
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            452..514
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            515..673
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            674..904
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      865..870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      885
                     /gene="Etfb"
                     /gene_synonym="0610009I16Rik; 2810441H06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagacagata cggggcggag tgtgtgacta tctggattag gagcaacctg acccggccag
       61 tgactgctgc aggaagatgg cggagctgcg cgcgctcgtg gctgtcaaga gggtcatcga
      121 cttcgctgtg aagattcggg taaagccgga caagtctgga gtggtcactg atggtgtgaa
      181 gcactccatg aaccccttct gtgagattgc agtggaagag gctgtgcggc taaaggagaa
      241 gaaactggtg aaggagatca ttgccgtcag ctgtggcccc tcacagtgcc aggagaccat
      301 ccgaactgct ctggccatgg gtgcagacag aggcatccac gtggagatac caggggcaca
      361 ggcagaaagc ttaggccccc tgcaggtggc ccgggtcctg gccaagctgg ctgaaaagga
      421 gaaagtggac cttttgttcc tgggcaagca ggctattgat gatgactgta accagacagg
      481 tcagatgaca gctggacttc tggactggcc gcagggtaca ttcgcctctc aggtgacact
      541 ggagggggac aaggtaaaag tggaacggga aattgacggg ggtctggaga cccttcgcct
      601 gaagctgccc gctgtggtga ctgctgacct aaggctcaat gagcctcgct atgccaccct
      661 gcccaacatc atgaaagcca agaagaagaa gattgaagtg gtcaaggctg gagacctggg
      721 cgtggacctg acctccaagg tctctgtgat cagtgtggaa gagccccctc agcgctcagc
      781 aggagtcaag gtggagacca cagaagacct ggtggccaag ctgaaggagg tggggcggat
      841 ctgagaccct ccctgatact ctgcaataaa actgtgcctt tccaagccac tgcctctttc
      901 ctcaaaaaaa aaaaaaaaaa
//
