LOCUS       NM_145615               1464 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus electron transferring flavoprotein, alpha polypeptide
            (Etfa), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_145615
VERSION     NM_145615.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1464)
  AUTHORS   Xie,H., Wang,Y.H., Liu,X., Gao,J., Yang,C., Huang,T., Zhang,L.,
            Luo,X., Gao,Z., Wang,T., Yan,T., Liu,Y., Yang,P., Yu,Q., Liu,S.,
            Wang,Y., Xiong,F., Zhang,S., Zhou,Q. and Wang,C.Y.
  TITLE     SUMOylation of ERp44 enhances Ero1alpha ER retention contributing
            to the pathogenesis of obesity and insulin resistance
  JOURNAL   Metabolism 139, 155351 (2023)
   PUBMED   36427672
REFERENCE   2  (bases 1 to 1464)
  AUTHORS   Peng,M.Z., Shao,Y.X., Li,X.Z., Zhang,K.D., Cai,Y.N., Lin,Y.T.,
            Jiang,M.Y., Liu,Z.C., Su,X.Y., Zhang,W., Jiang,X.L. and Liu,L.
  TITLE     Mitochondrial FAD shortage in SLC25A32 deficiency affects
            folate-mediated one-carbon metabolism
  JOURNAL   Cell Mol Life Sci 79 (7), 375 (2022)
   PUBMED   35727412
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1464)
  AUTHORS   Gresakova,V., Novosadova,V., Prochazkova,M., Prochazka,J. and
            Sedlacek,R.
  TITLE     Dual role of Fam208a during zygotic cleavage and early embryonic
            development
  JOURNAL   Exp Cell Res 406 (2), 112723 (2021)
   PUBMED   34216590
REFERENCE   4  (bases 1 to 1464)
  AUTHORS   Zhang,X., Zhang,Y.L., Qiu,G., Pian,L., Guo,L., Cao,H., Liu,J.,
            Zhao,Y., Li,X., Xu,Z., Huang,X., Huang,J., Dong,J., Shen,B.,
            Wang,H.X., Ying,X., Zhang,W.J., Cao,X. and Zhang,J.
  TITLE     Hepatic neddylation targets and stabilizes electron transfer
            flavoproteins to facilitate fatty acid beta-oxidation
  JOURNAL   Proc Natl Acad Sci U S A 117 (5), 2473-2483 (2020)
   PUBMED   31941714
  REMARK    GeneRIF: Hepatic neddylation also enhances ETFA and ETFB expression
            in adult mice and prevents fasting-induced steatosis and mortality.
REFERENCE   5  (bases 1 to 1464)
  AUTHORS   Yu,Z., Liu,N., Wang,Y., Li,X. and Wang,X.
  TITLE     Identification of neuroglobin-interacting proteins using yeast
            two-hybrid screening
  JOURNAL   Neuroscience 200, 99-105 (2012)
   PUBMED   22079573
REFERENCE   6  (bases 1 to 1464)
  AUTHORS   DiDonato,C.J., Chen,X.N., Noya,D., Korenberg,J.R., Nadeau,J.H. and
            Simard,L.R.
  TITLE     Cloning, characterization, and copy number of the murine survival
            motor neuron gene: homolog of the spinal muscular
            atrophy-determining gene
  JOURNAL   Genome Res 7 (4), 339-352 (1997)
   PUBMED   9110173
REFERENCE   7  (bases 1 to 1464)
  AUTHORS   DiDonato,C.J., Nadeau,J.H. and Simard,L.R.
  TITLE     The mouse neuronal apoptosis inhibitory protein gene maps to a
            conserved syntenic region of mouse chromosome 13
  JOURNAL   Mamm Genome 8 (3), 222 (1997)
   PUBMED   9069126
REFERENCE   8  (bases 1 to 1464)
  AUTHORS   Scharf,J.M., Damron,D., Frisella,A., Bruno,S., Beggs,A.H.,
            Kunkel,L.M. and Dietrich,W.F.
  TITLE     The mouse region syntenic for human spinal muscular atrophy lies
            within the Lgn1 critical interval and contains multiple copies of
            Naip exon 5
  JOURNAL   Genomics 38 (3), 405-417 (1996)
   PUBMED   8975718
REFERENCE   9  (bases 1 to 1464)
  AUTHORS   White,R.A., Dowler,L.L., Angeloni,S.V. and Koeller,D.M.
  TITLE     Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13:
            the mouse homologs of genes responsible for glutaric acidemia type
            II in human
  JOURNAL   Genomics 33 (1), 131-134 (1996)
   PUBMED   8617498
REFERENCE   10 (bases 1 to 1464)
  AUTHORS   Finocchiaro,G., Colombo,I., Garavaglia,B., Gellera,C.,
            Valdameri,G., Garbuglio,N. and Didonato,S.
  TITLE     cDNA cloning and mitochondrial import of the beta-subunit of the
            human electron-transfer flavoprotein
  JOURNAL   Eur J Biochem 213 (3), 1003-1008 (1993)
   PUBMED   8504797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028118.1, BC096645.1, BY435583.1 and AV289509.2.
            
            On Apr 25, 2009 this sequence version replaced NM_145615.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133525.1, AK028118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AK028118.1         2-151
            151-1379            BC096645.1         10-1238
            1380-1430           BY435583.1         335-385
            1431-1464           AV289509.2         612-645
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.13 cM"
     gene            1..1464
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /note="electron transferring flavoprotein, alpha
                     polypeptide"
                     /db_xref="GeneID:110842"
                     /db_xref="MGI:MGI:106092"
     exon            1..213
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1176
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /note="Alpha-ETF"
                     /codon_start=1
                     /product="electron transfer flavoprotein subunit alpha,
                     mitochondrial"
                     /protein_id="NP_663590.3"
                     /db_xref="CCDS:CCDS23204.1"
                     /db_xref="GeneID:110842"
                     /db_xref="MGI:MGI:106092"
                     /translation="MFRAAAPGQLRRAASLLRFQSTLVIAEHANDSLAPITLNTITAA
                     GRLGGEVSCLVAGTKCDKVVQDLCKVAGVAKVLVAQHDAYKGLLPEELTPLILETQKQ
                     FSYTHICAGASAFGKNLLPRVAAKLNVAPVSDIIEIKSPDTFVRTIYAGNALCTVKCD
                     EKVKVFSVRGTSFEAAATSGGSASSEKAPSSSSVGISEWLDQKLTKSDRPELTGAKVV
                     VSGGRGLKSGENFKLLYDLADQLHAAVGASRAAVDAGFVPNDMQVGQTGKIVAPELYI
                     AVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGIVADLFKVVPEMTEILKKK"
     exon            214..360
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            361..442
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            443..525
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            526..625
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            626..736
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            737..838
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            839..907
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            908..990
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1056
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1137
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1464
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /note="hexamer: AATAAA"
     regulatory      1370..1375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /note="major polyA site"
     polyA_site      1397
                     /gene="Etfa"
                     /gene_synonym="2010200I21Rik; D9Ertd394e"
                     /note="major polyA site"
ORIGIN      
        1 ccgggaagcg cgagcccccg cagtccagga ctaagctgtc agctctcgtg ctcgcatctc
       61 gcgagcgttc gggtctctgg tagaggaggc ggcggcggtg gcggcggcgg tggttcccgc
      121 gcgctccggg tctctgaggc tgagggtact gcggggctga ctagaacaga gacaatgttt
      181 cgagcagcgg cgcctgggca gctccggcgg gcggcctcat tgctccgttt tcagagtacc
      241 ttggtaatag ctgagcatgc aaatgattcc ctagcaccca ttactctaaa tactatcact
      301 gcagctggac gtcttggagg tgaagtgtcc tgcttagtag ctggaaccaa gtgtgacaag
      361 gtggtacagg atctatgtaa agtagctggc gtagcaaagg ttctggtggc tcagcatgat
      421 gcatacaaag gccttcttcc agaggaactc acaccattga ttttggaaac tcagaagcag
      481 ttcagttaca cacacatctg tgctggagcg tctgcttttg gaaagaacct tctgcccaga
      541 gtagctgcca aacttaatgt tgctccagtt tctgacatca ttgagatcaa gtcacctgac
      601 acatttgtga gaactatcta tgcaggaaat gcgttgtgta cagtaaagtg tgatgagaaa
      661 gtaaaggtgt tttctgttcg aggaacatct tttgaggctg cagcaacaag tggaggtagt
      721 gctagttcag aaaaggcacc aagttcttca tcagtgggaa tatcagagtg gcttgaccag
      781 aaattgacaa aaagtgaccg accagaacta actggtgcca aagtggtggt atctggtggt
      841 cggggtttga agagtggaga gaactttaaa ctgctgtatg acctggcaga tcaactacat
      901 gctgcagttg gtgcttcccg agctgctgtt gatgctggct ttgttcccaa tgacatgcaa
      961 gttggtcaga caggaaaaat agtagctcca gaactttata ttgctgtagg aatatctgga
     1021 gccattcaac atttagctgg gatgaaggac agcaagacaa tcgtggctat taacaaagat
     1081 ccagaagctc caattttcca ggtggcagat tatggaatag ttgcagattt atttaaggtg
     1141 gttcctgaaa tgacagaaat actgaagaaa aaataagtca aaatcatatc ttaaggaaac
     1201 tgttgaaagt attcagctga aatcatagaa attcataatc tgaagaaaga aattatgcta
     1261 acagcagcta gaatgccttt tgatgaatca attattatat tcctttttaa ttttttgtgg
     1321 tttcaaacaa ttattttttg acattttcta attctgaaat aaaaaacata ataaagtttt
     1381 gtcatccttt aagattacta tcagaaacat gcctagcttc ttaataaaag aacaaattga
     1441 agaaagggaa taaaatccag ttct
//
