LOCUS       NM_144866               3718 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus eukaryotic translation termination factor 1 (Etf1),
            mRNA.
ACCESSION   NM_144866
VERSION     NM_144866.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3718)
  AUTHORS   Li,N., Cai,Y., Zou,M., Zhou,J., Zhang,L., Zhou,L., Xiang,W., Cui,Y.
            and Li,H.
  TITLE     CFIm-mediated alternative polyadenylation safeguards the
            development of mammalian pre-implantation embryos
  JOURNAL   Stem Cell Reports 18 (1), 81-96 (2023)
   PUBMED   36563685
REFERENCE   2  (bases 1 to 3718)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3718)
  AUTHORS   Stoddart,A., Qian,Z., Fernald,A.A., Bergerson,R.J., Wang,J.,
            Karrison,T., Anastasi,J., Bartom,E.T., Sarver,A.L., McNerney,M.E.,
            Largaespada,D.A. and Le Beau,M.M.
  TITLE     Retroviral insertional mutagenesis identifies the del(5q) genes,
            CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential
            targets in del(5q) myeloid neoplasms
  JOURNAL   Haematologica 101 (6), e232-e236 (2016)
   PUBMED   26944478
  REMARK    GeneRIF: Retroviral insertional mutagenesis identifies the del(5q)
            genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as
            potential targets in del(5q) myeloid neoplasms
REFERENCE   4  (bases 1 to 3718)
  AUTHORS   Figaro,S., Scrima,N., Buckingham,R.H. and Heurgue-Hamard,V.
  TITLE     HemK2 protein, encoded on human chromosome 21, methylates
            translation termination factor eRF1
  JOURNAL   FEBS Lett 582 (16), 2352-2356 (2008)
   PUBMED   18539146
REFERENCE   5  (bases 1 to 3718)
  AUTHORS   Alkalaeva,E.Z., Pisarev,A.V., Frolova,L.Y., Kisselev,L.L. and
            Pestova,T.V.
  TITLE     In vitro reconstitution of eukaryotic translation reveals
            cooperativity between release factors eRF1 and eRF3
  JOURNAL   Cell 125 (6), 1125-1136 (2006)
   PUBMED   16777602
REFERENCE   6  (bases 1 to 3718)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3718)
  AUTHORS   Orlova,M., Yueh,A., Leung,J. and Goff,S.P.
  TITLE     Reverse transcriptase of Moloney murine leukemia virus binds to
            eukaryotic release factor 1 to modulate suppression of
            translational termination
  JOURNAL   Cell 115 (3), 319-331 (2003)
   PUBMED   14636559
  REMARK    GeneRIF: Reverse Transcriptase enhances suppression of termination
            and that the interaction of RT with eRF1 is required for an
            appropriate level of translational readthrough.
REFERENCE   8  (bases 1 to 3718)
  AUTHORS   Chavatte,L., Kervestin,S., Favre,A. and Jean-Jean,O.
  TITLE     Stop codon selection in eukaryotic translation termination:
            comparison of the discriminating potential between human and
            ciliate eRF1s
  JOURNAL   EMBO J 22 (7), 1644-1653 (2003)
   PUBMED   12660170
REFERENCE   9  (bases 1 to 3718)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3718)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY238984.1, AK169345.1, AC114820.4 and AI844751.1.
            
            On Jan 30, 2007 this sequence version replaced NM_144866.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.190757.1, AK139933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY238984.1         1-27
            28-1484             AK169345.1         1-1457
            1485-3387           AC114820.4         42274-44176
            3388-3718           AI844751.1         1-331               c
FEATURES             Location/Qualifiers
     source          1..3718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.78 cM"
     gene            1..3718
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /note="eukaryotic translation termination factor 1"
                     /db_xref="GeneID:225363"
                     /db_xref="MGI:MGI:2385071"
     exon            1..170
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..274
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1502
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /note="eukaryotic release factor 1"
                     /codon_start=1
                     /product="eukaryotic peptide chain release factor subunit
                     1"
                     /protein_id="NP_659115.3"
                     /db_xref="CCDS:CCDS29137.1"
                     /db_xref="GeneID:225363"
                     /db_xref="MGI:MGI:2385071"
                     /translation="MADDPSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQ
                     ISRVAKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVT
                     EEGKEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGT
                     LQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFISGDK
                     VNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLS
                     NVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDIMRYVLH
                     CQGTEEEKILYLTPEQEKDKSHFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIV
                     TDKSQEGSQFVKGFGGIGGILRYRVDFQGMEYQGGDDEFFDLDDY"
     exon            275..450
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..590
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..729
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..920
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1050
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1206
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1271
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1419
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..3705
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1991..1996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /note="hexamer: AATATA"
     polyA_site      2011
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
     regulatory      3685..3690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3705
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /note="major polyA site"
ORIGIN      
        1 ttccactccg cccctggcgg aggaagtgag atcagaggcc ccatgtgagc ggattgcaac
       61 acatgcagct gcctggagag agggagccgg tgtcctacgt cagagccgcc gccgccgcgg
      121 agccgccgcc ggggaggagc agccgctgcc gcccaggact gggcccttag ggaggaggag
      181 gcgagaagat ggcggacgac cccagtgctg ccgataggaa cgtggagatc tggaagatca
      241 agaagctcat taagagcttg gaggcggccc gcggcaatgg cacgagcatg atatcgctga
      301 tcattcctcc caaagaccag atttcacgag tggcaaaaat gttagcagac gagtttggaa
      361 ctgcatctaa cattaagtca cgagtaaacc gcctttcagt cctcggagcc atcacatctg
      421 tacaacagag actcaaactt tataacaaag tacctccaaa tggtctggtt gtttactgtg
      481 gaacaattgt aacagaagaa ggaaaggaaa agaaagttaa cattgacttt gaacctttca
      541 aaccaattaa tacatcattg tatttgtgcg acaataagtt tcatacagag gctcttacag
      601 cgttactttc agatgacagc aagtttggtt ttattgtaat agacggaagt ggtgctcttt
      661 ttggcacgct ccaaggaaac accagagaag tcctgcacaa attcactgtg gatctcccaa
      721 agaaacacgg cagaggaggt caatcagcct tgcgttttgc ccgtttaaga atggaaaaga
      781 gacataacta tgttcggaaa gtagccgaga ctgctgtgca gctgtttatt tctggagaca
      841 aagtgaatgt ggctggtttg gttttagctg gatcagctga ctttaaaact gaactaagtc
      901 aatctgacat gtttgaccag aggttgcaat ctaaagtttt aaaattagtt gatatatcct
      961 atggtggtga aaatggattc aaccaagcta ttgaattatc tactgaagtt ctctccaacg
     1021 tgaagttcat tcaagagaag aaattaatag gacgatattt tgatgaaatt agccaggaca
     1081 caggcaagta ctgttttgga gttgaagata cactaaaggc tttggaaatg ggagctgtag
     1141 aaattctaat agtctatgaa aatctggata taatgagata cgttcttcat tgccaaggca
     1201 cagaagagga gaaaattctc tatttaactc cagaacaaga gaaggataaa tctcacttca
     1261 cagacaaaga gactggacag gaacacgaac tgatagaaag catgcctctc ttggaatggt
     1321 ttgctaacaa ctataaaaaa tttggagcta cactagaaat tgtcacagat aagtcacaag
     1381 aaggatcaca gtttgtgaaa ggatttggtg gaattggagg tatcttgcgg taccgagtag
     1441 atttccaggg aatggagtac caaggaggag atgatgaatt ttttgacctt gatgactact
     1501 aggtagtcga catgggtccg gcaaccgtgc ctcaccctcc agcattcaac ccaaggagca
     1561 tacccgtggt ggagtccaac agatccctgc cttacaattg gagcatttcc agaacttaat
     1621 ccgtgagcat tggatactga aaagaaaagt gaaacaaaac cagacccaac cctacacttt
     1681 ggtttgtcgt ggtgtcagcg cagcagccga caactaagtc tctaaaggcc actgtggact
     1741 catttaaaaa gaatcccagt ttttactttt acttgatggt aaaattggtt gctcttgtat
     1801 tttatgaaaa aatgattttt ttaaccttca tacatagaag caaaatactt taactgctgt
     1861 aaaccttcaa aagttagtag acgtgaggtc atactggttt gtttcttcct ttgatcggag
     1921 aataactaaa ttgctgcatt tcgcagtgac ccatttacat ggcattctcg gcttagactg
     1981 cacaagaaga aatatatgtg aaatattgga actgtttctc tcttggtctc tgtttaatgt
     2041 tgaaagggtg agctgacagg aggcagtttg agcttcactc cctcacactc cccactccca
     2101 gactgtccct ttcaaaggtg caggttgcgt tgtaaagtca gactgagtgc caacacactg
     2161 gggccagggc actctgggca gtcaccagtg tggaggcaca gttgtgcctg gcatttggga
     2221 gccctctgtg ccattagcgt tactgaggct ccctgtcatc tcagcctact agaaaccagt
     2281 ctgggatgga catgatgggc ttctgtgcta ttgctgggat tgggagaaat aaaacatgca
     2341 acttaagtgg aaccaaaaaa aaattcaaag atgattttgc ttggatctat tcttggtaag
     2401 gggaggcggt ggtgtttcct tgtgttggat ggcatgagat tatgtgaatg ttttgatttt
     2461 atttttttgt tttcaaatga actgcaagat ttttttcacg ggaacgacag acacgacacg
     2521 tatgaccgtg catgtatctc aaacccctgg tggggctgga gcatctattt caaaaagtgg
     2581 gatctacaag cacctctcag atgagaaagt atggaggcgg gtggggaggg taggggtggg
     2641 gtgggtagga cacggctgct ggcaccatgg actatataaa ccatgttaga gccggaagtt
     2701 ggcctgaaaa cctgaggctt aggcttcata gctgggctgt aaattggatt taaacccagt
     2761 tggagtgcaa agtcatggtg tgctcaaggt ggtgacagtg aacagagtat ggggtgcccg
     2821 gtggtagcgg tgggaaaact ataccgagta gactttgaag gaccgaaggt tttttaagtc
     2881 aactggtatc acccacactc accagggtgg tagggtgcat tgggtttcaa attgggtact
     2941 tttaacactt tagtgcctga ctgctgttct tcactgactt gactcagtca cttgtagctt
     3001 tattggtctg aaccagctcc ttgttcccag gttacagacc tgcctatcta tcgttccaat
     3061 aatcctgttt cacttgaatg aagggagtct gtcttcaatg taaagcttct gcttctcaca
     3121 ctgtaccctg aggtccaaat gactgtctgt cctgtaacct gatgtctcaa cccagtgaga
     3181 agagtcagtt ccttagtgtt caccaacacg ggaggcttca ccggaacagg cttttgcttt
     3241 gggctctgct gtttgtttgc agaacaccca agagcgagcg aacacaccct tcccagcagt
     3301 accttagggt tttgccattg taaatgggtc taatgtgata tgacaagacc agagaaattg
     3361 gatgtaaatt tacatttttg aatatgcttg ttgtttcaca tgatacattt agggtatgca
     3421 gctccttttg tagtttttat ttttactatt taagtttgga aatgatgcca aatttttgta
     3481 tttctttaat caatgtgttc tccttggtga tatatattgc attatatatt gatgtgtgta
     3541 tcaatatata ccgatatgtg ttacacttac gcatacaaac acacataagt gaggggtgaa
     3601 accgtagcct gcactcccta gcctctgcag agagacccta agagcagaat ctcggtgttg
     3661 tgatgtacag aaatggagaa gagtattaaa ccatatttaa gaataaaaaa aaaaaaaa
//
