LOCUS       NP_659115                437 aa            linear   ROD 27-APR-2025
DEFINITION  eukaryotic peptide chain release factor subunit 1 [Mus musculus].
ACCESSION   NP_659115
VERSION     NP_659115.3
DBSOURCE    REFSEQ: accession NM_144866.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 437)
  AUTHORS   Li,N., Cai,Y., Zou,M., Zhou,J., Zhang,L., Zhou,L., Xiang,W., Cui,Y.
            and Li,H.
  TITLE     CFIm-mediated alternative polyadenylation safeguards the
            development of mammalian pre-implantation embryos
  JOURNAL   Stem Cell Reports 18 (1), 81-96 (2023)
   PUBMED   36563685
REFERENCE   2  (residues 1 to 437)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 437)
  AUTHORS   Stoddart,A., Qian,Z., Fernald,A.A., Bergerson,R.J., Wang,J.,
            Karrison,T., Anastasi,J., Bartom,E.T., Sarver,A.L., McNerney,M.E.,
            Largaespada,D.A. and Le Beau,M.M.
  TITLE     Retroviral insertional mutagenesis identifies the del(5q) genes,
            CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential
            targets in del(5q) myeloid neoplasms
  JOURNAL   Haematologica 101 (6), e232-e236 (2016)
   PUBMED   26944478
  REMARK    GeneRIF: Retroviral insertional mutagenesis identifies the del(5q)
            genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as
            potential targets in del(5q) myeloid neoplasms
REFERENCE   4  (residues 1 to 437)
  AUTHORS   Figaro,S., Scrima,N., Buckingham,R.H. and Heurgue-Hamard,V.
  TITLE     HemK2 protein, encoded on human chromosome 21, methylates
            translation termination factor eRF1
  JOURNAL   FEBS Lett 582 (16), 2352-2356 (2008)
   PUBMED   18539146
REFERENCE   5  (residues 1 to 437)
  AUTHORS   Alkalaeva,E.Z., Pisarev,A.V., Frolova,L.Y., Kisselev,L.L. and
            Pestova,T.V.
  TITLE     In vitro reconstitution of eukaryotic translation reveals
            cooperativity between release factors eRF1 and eRF3
  JOURNAL   Cell 125 (6), 1125-1136 (2006)
   PUBMED   16777602
REFERENCE   6  (residues 1 to 437)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (residues 1 to 437)
  AUTHORS   Orlova,M., Yueh,A., Leung,J. and Goff,S.P.
  TITLE     Reverse transcriptase of Moloney murine leukemia virus binds to
            eukaryotic release factor 1 to modulate suppression of
            translational termination
  JOURNAL   Cell 115 (3), 319-331 (2003)
   PUBMED   14636559
  REMARK    GeneRIF: Reverse Transcriptase enhances suppression of termination
            and that the interaction of RT with eRF1 is required for an
            appropriate level of translational readthrough.
REFERENCE   8  (residues 1 to 437)
  AUTHORS   Chavatte,L., Kervestin,S., Favre,A. and Jean-Jean,O.
  TITLE     Stop codon selection in eukaryotic translation termination:
            comparison of the discriminating potential between human and
            ciliate eRF1s
  JOURNAL   EMBO J 22 (7), 1644-1653 (2003)
   PUBMED   12660170
REFERENCE   9  (residues 1 to 437)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 437)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY238984.1, AK169345.1, AC114820.4 and AI844751.1.
            
            On Jan 30, 2007 this sequence version replaced NP_659115.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.190757.1, AK139933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.78 cM"
     Protein         1..437
                     /product="eukaryotic peptide chain release factor subunit
                     1"
                     /note="eukaryotic release factor 1"
                     /calculated_mol_wt=48900
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P62495; propagated from
                     UniProtKB/Swiss-Prot (Q8BWY3.4)"
     Region          13..417
                     /region_name="aRF1/eRF1"
                     /note="peptide chain release factor 1, archaeal and
                     eukaryotic forms; TIGR03676"
                     /db_xref="CDD:274719"
     Region          61..64
                     /region_name="NIKS motif, plays an important role in
                     translational termination.
                     /evidence=ECO:0000250|UniProtKB:P62495"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BWY3.4)"
     Site            185
                     /site_type="methylation"
                     /note="N5-methylglutamine.
                     /evidence=ECO:0000305|PubMed:20606008; propagated from
                     UniProtKB/Swiss-Prot (Q8BWY3.4)"
     Site            347
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P62495; propagated from
                     UniProtKB/Swiss-Prot (Q8BWY3.4)"
     CDS             1..437
                     /gene="Etf1"
                     /gene_synonym="D6Ertd109e; ERF; ERF1; SUP45L1; TB3-1"
                     /coded_by="NM_144866.3:189..1502"
                     /db_xref="CCDS:CCDS29137.1"
                     /db_xref="GeneID:225363"
                     /db_xref="MGI:MGI:2385071"
ORIGIN      
        1 maddpsaadr nveiwkikkl iksleaargn gtsmisliip pkdqisrvak mladefgtas
       61 niksrvnrls vlgaitsvqq rlklynkvpp nglvvycgti vteegkekkv nidfepfkpi
      121 ntslylcdnk fhtealtall sddskfgfiv idgsgalfgt lqgntrevlh kftvdlpkkh
      181 grggqsalrf arlrmekrhn yvrkvaetav qlfisgdkvn vaglvlagsa dfktelsqsd
      241 mfdqrlqskv lklvdisygg engfnqaiel stevlsnvkf iqekkligry fdeisqdtgk
      301 ycfgvedtlk alemgaveil ivyenldimr yvlhcqgtee ekilyltpeq ekdkshftdk
      361 etgqehelie smpllewfan nykkfgatle ivtdksqegs qfvkgfggig gilryrvdfq
      421 gmeyqggdde ffdlddy
//
