LOCUS       NM_007957               1615 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus extraembryonic, spermatogenesis, homeobox 1 (Esx1),
            mRNA.
ACCESSION   NM_007957 XM_906956
VERSION     NM_007957.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Nobs,E., Laschanzky,K., Munke,K., Movert,E., Valfridsson,C. and
            Carlsson,F.
  TITLE     Cytosolic serpins act in a cytoprotective feedback loop that limits
            ESX-1-dependent death of Mycobacterium marinum-infected macrophages
  JOURNAL   mBio 15 (9), e0038424 (2024)
   PUBMED   39087767
  REMARK    GeneRIF: Cytosolic serpins act in a cytoprotective feedback loop
            that limits ESX-1-dependent death of Mycobacterium marinum-infected
            macrophages.
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Solmonson,A., Faubert,B., Gu,W., Rao,A., Cowdin,M.A.,
            Menendez-Montes,I., Kelekar,S., Rogers,T.J., Pan,C., Guevara,G.,
            Tarangelo,A., Zacharias,L.G., Martin-Sandoval,M.S., Do,D.,
            Pachnis,P., Dumesnil,D., Mathews,T.P., Tasdogan,A., Pham,A.,
            Cai,L., Zhao,Z., Ni,M., Cleaver,O., Sadek,H.A., Morrison,S.J. and
            DeBerardinis,R.J.
  TITLE     Compartmentalized metabolism supports midgestation mammalian
            development
  JOURNAL   Nature 604 (7905), 349-353 (2022)
   PUBMED   35388219
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Shafiei,S. and Dufort,D.
  TITLE     Maternal Cripto is critical for proper development of the mouse
            placenta and the placental vasculature
  JOURNAL   Placenta 107, 13-23 (2021)
   PUBMED   33730615
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Rhee,C., Edwards,M., Dang,C., Harris,J., Brown,M., Kim,J. and
            Tucker,H.O.
  TITLE     ARID3A is required for mammalian placenta development
  JOURNAL   Dev Biol 422 (2), 83-91 (2017)
   PUBMED   27965054
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Chou,A.M., Sem,K.P., Lam,W.J., Ahmed,S. and Lim,C.Y.
  TITLE     Redundant functions of I-BAR family members, IRSp53 and IRTKS, are
            essential for embryonic development
  JOURNAL   Sci Rep 7, 40485 (2017)
   PUBMED   28067313
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Morasso,M.I., Grinberg,A., Robinson,G., Sargent,T.D. and Mahon,K.A.
  TITLE     Placental failure in mice lacking the homeobox gene Dlx3
  JOURNAL   Proc Natl Acad Sci U S A 96 (1), 162-167 (1999)
   PUBMED   9874789
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Li,Y. and Behringer,R.R.
  TITLE     Esx1 is an X-chromosome-imprinted regulator of placental
            development and fetal growth
  JOURNAL   Nat Genet 20 (3), 309-311 (1998)
   PUBMED   9806555
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Pitman,J.L., Lin,T.P., Kleeman,J.E., Erickson,G.F. and MacLeod,C.L.
  TITLE     Normal reproductive and macrophage function in Pem homeobox
            gene-deficient mice
  JOURNAL   Dev Biol 202 (2), 196-214 (1998)
   PUBMED   9769172
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Li,Y., Lemaire,P. and Behringer,R.R.
  TITLE     Esx1, a novel X chromosome-linked homeobox gene expressed in mouse
            extraembryonic tissues and male germ cells
  JOURNAL   Dev Biol 188 (1), 85-95 (1997)
   PUBMED   9245514
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Branford,W.W., Zhao,G.Q., Valerius,M.T., Weinstein,M.,
            Birkenmeier,E.H., Rowe,L.B. and Potter,S.S.
  TITLE     Spx1, a novel X-linked homeobox gene expressed during
            spermatogenesis
  JOURNAL   Mech Dev 65 (1-2), 87-98 (1997)
   PUBMED   9256347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF085715.1.
            
            On Sep 7, 2007 this sequence version replaced NM_007957.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF085715.1, AF017735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1615              AF085715.1         2-1616
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 59.1 cM"
     gene            1..1615
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="extraembryonic, spermatogenesis, homeobox 1"
                     /db_xref="GeneID:13984"
                     /db_xref="MGI:MGI:1096388"
     exon            1..383
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1447
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="similar to Prd protein"
                     /codon_start=1
                     /product="homeobox protein ESX1"
                     /protein_id="NP_031983.2"
                     /db_xref="CCDS:CCDS53199.1"
                     /db_xref="GeneID:13984"
                     /db_xref="MGI:MGI:1096388"
                     /translation="MESHKKCPCCYCTDLKTFVGAVKEETLQDPQPSLSSTLLEGADY
                     QENAESETTFYSDFGASPKEEEVEMENSLFNSMFLEEANYQEPEGFEPSRGEAAAPVA
                     EAPQAWNGNENLGGGFLESNAQLGEADAAPVRQSLMRPLMQPVAQSSPQPLPANPLQA
                     PQQPEEQEEEEEEQPGEEQPQQEPKPRRYRICFTPIQLQELEAFFQRVQYPDLFARVE
                     LARRLGLPEPRVQVWFQNRRAKWRRLRRAQAFRNMVPVAMSPPVGVYLDDHYGPIPIV
                     EVIWKCYPMVPRPMHPQMMPLPPRPPPGFRMPPPFRPPPLPPFPWPPVPPDAHIPNAA
                     REYNPFPFPFPFPFPFPNPFPNPNPNPNPNPNPNPNPNQNFAGPRYRY"
     exon            384..509
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..945
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..991
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1600
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1578..1583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="hexamer: AATAAA"
     polyA_site      1600
                     /gene="Esx1"
                     /gene_synonym="Spx1"
                     /note="major polyA site"
ORIGIN      
        1 aacaaacaca ctccctgtca ccagagcacc ccctacaatg tagtcccacc ctacagtgta
       61 gtcccaccca ttccgaatgg aaacactcct atttctaatg ggggcttgag cggaggcaca
      121 ctacgtaaaa tctgatccct aagaggcaca agggctgacc accctataaa aggggcgtga
      181 ctcctcaacg agcgccactc gggtacggga gaagcagctg gtaccacctc tggccaggac
      241 ctcggaagcc aagaagtccg cagaagctgg tgacttaaca acccaccgcg ctccggtcat
      301 ggaatctcac aaaaagtgcc cctgctgcta ctgcactgac ttgaagacct ttgttggagc
      361 agtgaaggag gaaacacttc aggatccaca gcctagcttg agctcaacgc ttttggaggg
      421 agcagactac caggaaaacg cggaatctga aacaactttc tactccgact ttggagccag
      481 cccgaaggag gaagaagtgg agatggagaa ctctctgttc aactccatgt ttctggaaga
      541 agcaaactac caggaacccg agggattcga accctcaaga ggagaagcag cagcgccggt
      601 tgcagaagca ccgcaagcct ggaatgggaa tgaaaacctt ggaggcggct tcctggagtc
      661 caacgctcag ctgggggagg cggatgccgc ccctgtgcgg cagtccctga tgcgtcctct
      721 gatgcagcct gttgctcagt cttcgccgca acccctgccc gcaaacccgc tgcaggcccc
      781 gcagcagccc gaggagcagg aggaggagga ggaggagcag ccgggggagg agcaacccca
      841 acaggagccg aagcctcgcc gctaccgcat ctgcttcacc ccgatccaac tgcaggagct
      901 ggaggccttt ttccagcgcg tccagtaccc ggacctgttt gctagagtgg agcttgcccg
      961 acgcctgggc ttacctgaac ctagagtgca ggtttggttt cagaacagaa gggccaagtg
     1021 gagacgactt cggcgggcac aggcattcag aaacatggtt ccagtcgcca tgagtccccc
     1081 tgtgggtgtc tatcttgatg atcattatgg ccccatccct attgtggagg ttatttggaa
     1141 gtgctaccca atggtgcctc gtcccatgca tcctcaaatg atgcctcttc cacccaggcc
     1201 ccctccagga ttcagaatgc ctccaccatt taggccacct cctctgccac cttttccctg
     1261 gccacctgta ccacctgatg cgcacatacc caatgcagca agggaatata accccttccc
     1321 cttccccttc ccctttccct ttcccttccc caacccattc cccaacccca accctaaccc
     1381 caaccccaac cccaacccca accccaaccc caaccaaaat tttgcaggtc ccagatacag
     1441 atactgaagt ctacatcagt tttccaaaag tgtttttcaa tcagatttat atcgtttgta
     1501 aacactatca cgcattacct gtcaagaagc tgttaaacga aatgtacaaa gttaatgcct
     1561 tctttgtttt gattttcaat aaaagtttgg attagcagca aaaaaaaaaa aaaaa
//
