LOCUS       NM_022408               2836 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus ess-2 splicing factor (Ess2), transcript variant 1,
            mRNA.
ACCESSION   NM_022408
VERSION     NM_022408.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2836)
  AUTHORS   Takahashi,S., Takada,I., Hashimoto,K., Yokoyama,A., Nakagawa,T.,
            Makishima,M. and Kume,H.
  TITLE     ESS2 controls prostate cancer progression through recruitment of
            chromodomain helicase DNA binding protein 1
  JOURNAL   Sci Rep 13 (1), 12355 (2023)
   PUBMED   37524814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2836)
  AUTHORS   Takada,I., Hidano,S., Takahashi,S., Yanaka,K., Ogawa,H.,
            Tsuchiya,M., Yokoyama,A., Sato,S., Ochi,H., Nakagawa,T.,
            Kobayashi,T., Nakagawa,S. and Makishima,M.
  TITLE     Transcriptional coregulator Ess2 controls survival of post-thymic
            CD4+ T cells through the Myc and IL-7 signaling pathways
  JOURNAL   J Biol Chem 298 (9), 102342 (2022)
   PUBMED   35933014
  REMARK    GeneRIF: Transcriptional coregulator Ess2 controls survival of
            post-thymic CD4(+) T cells through the Myc and IL-7 signaling
            pathways.
REFERENCE   3  (bases 1 to 2836)
  AUTHORS   Paronett,E.M., Meechan,D.W., Karpinski,B.A., LaMantia,A.S. and
            Maynard,T.M.
  TITLE     Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a
            Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical
            Projection Neuron Generation
  JOURNAL   Cereb Cortex 25 (10), 3977-3993 (2015)
   PUBMED   25452572
REFERENCE   4  (bases 1 to 2836)
  AUTHORS   Funato,H., Sato,M., Sinton,C.M., Gautron,L., Williams,S.C.,
            Skach,A., Elmquist,J.K., Skoultchi,A.I. and Yanagisawa,M.
  TITLE     Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in
            interpeduncular nucleus results in altered regulation of rapid eye
            movement sleep
  JOURNAL   Proc Natl Acad Sci U S A 107 (42), 18155-18160 (2010)
   PUBMED   20921407
  REMARK    GeneRIF: results indicate that the absence of Gscl and Dgcr14 in
            the IP results in altered regulation of REM sleep
REFERENCE   5  (bases 1 to 2836)
  AUTHORS   Paylor,R., Glaser,B., Mupo,A., Ataliotis,P., Spencer,C.,
            Sobotka,A., Sparks,C., Choi,C.H., Oghalai,J., Curran,S.,
            Murphy,K.C., Monks,S., Williams,N., O'Donovan,M.C., Owen,M.J.,
            Scambler,P.J. and Lindsay,E.
  TITLE     Tbx1 haploinsufficiency is linked to behavioral disorders in mice
            and humans: implications for 22q11 deletion syndrome
  JOURNAL   Proc Natl Acad Sci U S A 103 (20), 7729-7734 (2006)
   PUBMED   16684884
REFERENCE   6  (bases 1 to 2836)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.I. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (4), 399 (1997)
   PUBMED   9110179
  REMARK    Correction to:[Genome Res. 1997 Jan;7(1):17-26. doi:
            10.1101/gr.7.1.17.. PMID: 9037598]
REFERENCE   7  (bases 1 to 2836)
  AUTHORS   Gong,W., Emanuel,B.S., Galili,N., Kim,D.H., Roe,B., Driscoll,D.A.
            and Budarf,M.L.
  TITLE     Structural and mutational analysis of a conserved gene (DGSI) from
            the minimal DiGeorge syndrome critical region
  JOURNAL   Hum Mol Genet 6 (2), 267-276 (1997)
   PUBMED   9063747
REFERENCE   8  (bases 1 to 2836)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.L. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (1), 17-26 (1997)
   PUBMED   9037598
  REMARK    Erratum:[Genome Res. 1997 Apr;7(4):399.. PMID: 9110179]
REFERENCE   9  (bases 1 to 2836)
  AUTHORS   Rizzu,P., Lindsay,E.A., Taylor,C., O'Donnell,H., Levy,A.,
            Scambler,P. and Baldini,A.
  TITLE     Cloning and comparative mapping of a gene from the commonly deleted
            region of DiGeorge and Velocardiofacial syndromes conserved in C.
            elegans
  JOURNAL   Mamm Genome 7 (9), 639-643 (1996)
   PUBMED   8703114
REFERENCE   10 (bases 1 to 2836)
  AUTHORS   Halford,S., Wilson,D.I., Daw,S.C., Roberts,C., Wadey,R., Kamath,S.,
            Wickremasinghe,A., Burn,J., Goodship,J., Mattei,M.G. et al.
  TITLE     Isolation of a gene expressed during early embryogenesis from the
            region of 22q11 commonly deleted in DiGeorge syndrome
  JOURNAL   Hum Mol Genet 2 (10), 1577-1582 (1993)
   PUBMED   8268909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY069641.1, AK148404.1,
            AC078895.34 and AI853516.1.
            
            On Feb 28, 2007 this sequence version replaced NM_022408.1.
            
            Summary: The human ortholog of this gene is located within the
            minimal DGS critical region (MDGCR) thought to contain the gene(s)
            responsible for a group of developmental disorders. These disorders
            include DiGeorge syndrome, velocardiofacial syndrome, conotruncal
            anomaly face syndrome, and some familial or sporadic conotruncal
            cardiac defects which have been associated with microdeletion of
            human chromosome band 22q11.2. The encoded protein localizes to the
            nucleus, and the orthologous protein in humans co-purifies with C
            complex spliceosomes. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148404.1, SRR7345562.3099608.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY069641.1         2-35
            35-408              AK148404.1         3-376
            409-409             AC078895.34        77081-77081
            410-2530            AK148404.1         378-2498
            2531-2836           AI853516.1         1-306               c
FEATURES             Location/Qualifiers
     source          1..2836
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.09 cM"
     gene            1..2836
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /note="ess-2 splicing factor"
                     /db_xref="GeneID:27886"
                     /db_xref="MGI:MGI:107854"
     exon            1..187
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1486
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DiGeorge syndrome critical region protein 14; protein
                     DGCR14; diGeorge syndrome critical region 14 homolog;
                     splicing factor ESS-2 homolog; DiGeorge syndrome critical
                     region gene 14"
                     /codon_start=1
                     /product="splicing factor ESS-2 homolog isoform 1"
                     /protein_id="NP_071853.2"
                     /db_xref="CCDS:CCDS28013.1"
                     /db_xref="GeneID:27886"
                     /db_xref="MGI:MGI:107854"
                     /translation="MGTPGTSAGALFLSSASAPSRKRAAGEAGEAGVARSRQRVLDEE
                     EYIEGLQTVIQRDFFPDVEKLQAQKEYLEAEENGDLERMRQIAIKFGSALGKISREPP
                     PPYVTPATFETPEVHPGSAVLGNKPRPQGRDLDDAGEAGEEEEKEPLPSLDVFLSQYT
                     SEDNASFQEIMEVAKEKSHARHAWLYQAEEEFEKRQKDNLELPSAEHQAIESSQAGVE
                     TWKYKAKNSLMYYPEGVPDEEQLFKKPRQIVHKNTRFLRDPFSQALSRSQLQQAAALN
                     AQHKQGKVGPDGKELIPQESPRVGGFGFVATPSPAPGVNESPLMTWGEVENTPLRVEG
                     SESPYVDRTPGPTFKILEPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLASLTPK
                     GLSPAMSPALQRLVSRTASKYTDRALRASYTPSPARSSHLKTPAGGPQTPTSTPAPGS
                     ATRTPLTQDPASITDNLLQLPARRKASDFF"
     exon            188..356
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     exon            357..452
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     exon            453..625
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     exon            626..743
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     exon            744..877
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     exon            878..980
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1090
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1206
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..2821
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1743..1748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /note="hexamer: ATTAAA"
     polyA_site      1765
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /note="major polyA site"
     regulatory      2799..2804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /note="hexamer: AATAAA"
     polyA_site      2821
                     /gene="Ess2"
                     /gene_synonym="D16H22S1269E; Dgcr1; Dgcr14; Dgsi; ES2;
                     Es2el"
                     /note="major polyA site"
ORIGIN      
        1 gttggagcgg tgcagacgcc gcccgagcga ttctgggata gcgatgggga cgcccgggac
       61 ctcggcgggt gctctgtttc tgtcctccgc gtccgcgccc tcaaggaagc gcgcggctgg
      121 ggaggctgga gaggccggag ttgcgagaag caggcagcgg gtcctggatg aagaagagta
      181 catcgaggga cttcagacag ttatccagag agacttcttc cctgatgtgg agaagctaca
      241 ggcacagaag gagtacctgg aggccgagga aaacggagat ttggagcgca tgcgccagat
      301 tgccatcaag tttggctctg ccctgggcaa gatatctcgg gaacctccac caccctatgt
      361 tactccagcc acctttgaaa ctcctgaggt acacccaggc tctgctgtgc tgggcaacaa
      421 gccccggccc cagggccgag acctagatga tgcaggagag gctggagagg aagaggagaa
      481 ggagccactg cccagcctgg atgtcttctt gagccagtac acaagtgagg acaatgcctc
      541 cttccaggag atcatggagg tggccaagga aaaaagccat gcacggcacg cgtggctcta
      601 ccaggctgag gaggaatttg agaagcgaca gaaagataat cttgaactcc catcggcaga
      661 gcatcaagcc attgagagca gtcaggctgg agtggagacc tggaagtaca aggccaagaa
      721 ctctctcatg tactatcccg agggtgtccc tgatgaagag cagttgttta agaagccgag
      781 acagatagta cataagaaca cacgtttcct ccgagatccc ttcagtcagg ctttgagcag
      841 gtcccagctt cagcaggcgg ctgccctcaa tgcccagcac aaacagggca aggtcggccc
      901 tgacggcaag gaactcattc cccaggagtc ccccagagtg ggcggctttg gatttgttgc
      961 cactccttct cctgctcctg gtgtgaatga gtccccactg atgacatggg gagaggttga
     1021 gaacacgccc ctgcgagtag aaggatccga gagcccctat gtggacagga cacctggacc
     1081 cacattcaag atcttggagc caggacgcag ggagcgtctg ggcctgaaga tggccaatga
     1141 agcggctgcc aaaaaccggg cgaagaagca ggaagcgttg cggagagtta cagagaactt
     1201 ggccagtctt actcccaaag gcttgagccc agccatgtcc ccagccctac agcgcctcgt
     1261 aagcaggaca gccagcaagt acacagatcg tgccctgcgg gccagctata caccatcccc
     1321 agcacgatct tcccacctca agaccccagc tggtgggccg cagacaccca caagcactcc
     1381 agcccctggg tctgctacac gcacacccct cacacaggac ccagcctcca tcacagacaa
     1441 cctgctgcag ctccctgccc gacgcaaagc ttcagacttc ttttagagcc aggcctgact
     1501 ggacctgtgg atgttttgtg gaacactttg tggagcatct agggcagctt tctaccactc
     1561 agaggattcc aggccttgga gacacagacc acagttgatt attccaggag ccacaaatat
     1621 ctagtgttgt tcccgtggcc aggttggcac attacgcgga ccagtccctt ggaagtacag
     1681 cgttggtgct gttcccaggg ccctgctgaa atgccttcta gctaaccccc aattgaatcc
     1741 tcattaaaga acacctggaa ctgtctggcc aggctgctga tccatgtcct ggggcccacg
     1801 tgggtgtctc agggttggaa gcaaggggtg ctggggagct gccttctatg ctgagatcac
     1861 cccccgagcc tcccactgta aaggatacca cagaccccaa aagtggagcc attgagcttg
     1921 tgggcctcct agtcagagct ggccattcgg tttgttggtt ctgggctttc gtatcaggtg
     1981 tcttcatatc aggctcacca ggaccagttc tcttcctgtg actcgaacca gtacctccca
     2041 gcaacctggc tgcctccctg tcctcctctc tgcttgaccc actgttcttc agctctgcct
     2101 gctggactct gctgagacac cagctttacc tcagcctgag ctgtactatg aaaagaaaga
     2161 gtgcaggctc cctgcaaaca tgcaaatgcc atgcgcacca gcaactaaga gtaactagtc
     2221 ctcaggtgac tagaggccag ctacgcctgt tagcctgtgc ctacagagag ctgaagggtc
     2281 ccttctcggc ctaacagagt caaaaactat gacctaattc cccagcctac gtacggtttt
     2341 caggccacaa gtggcatcct atggccggcc ctatgttaag ggcagcctta agcacaccag
     2401 acttttctga cacctgggtc ttgctttgat tgcatgagag ccaccttttc tagtctgctg
     2461 gcattgggcc tctgaggcgg ggttgggtac cttcctcctt gggcctcata ctacttagtt
     2521 tttgtcagtt tgacagaagc tagaatcacc tgggaagaag gaacctcaat tgaattacct
     2581 ctcatcagat gggcttgacg gcatgtctgc aggcattttc ttgatcgtca atcgatgtag
     2641 gagggcagtg gtcttgggtt gagtcagaaa gcctgggagg aaactagaga ggaagccagc
     2701 caggacgtga cactccttca tggtgtctgc ttcagctcct acttgaggtc ctgctctggc
     2761 ttccctcagt gatggactgt gatggaaagt gtgagctgaa taaacccatt tcctccctta
     2821 aaaaaaaaaa aaaaaa
//
