LOCUS       NM_011935               5312 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus estrogen-related receptor gamma (Esrrg), transcript
            variant 1, mRNA.
ACCESSION   NM_011935
VERSION     NM_011935.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5312)
  AUTHORS   Adkins-Threats,M., Arimura,S., Huang,Y.Z., Divenko,M., To,S.,
            Mao,H., Zeng,Y., Hwang,J.Y., Burclaff,J.R., Jain,S. and Mills,J.C.
  TITLE     Metabolic regulator ERRgamma governs gastric stem cell
            differentiation into acid-secreting parietal cells
  JOURNAL   Cell Stem Cell 31 (6), 886-903 (2024)
   PUBMED   38733994
  REMARK    GeneRIF: Metabolic regulator ERRgamma governs gastric stem cell
            differentiation into acid-secreting parietal cells.
REFERENCE   2  (bases 1 to 5312)
  AUTHORS   Wang,H., Zuo,W., Feng,X., Huo,X., Liang,Y., Wang,B., Sharma,D.,
            Li,X., Yasin,B., Ye,J.H., Hu,H. and Tao,Y.X.
  TITLE     ESRRG-controlled downregulation of KCNN1 in primary sensory neurons
            is required for neuropathic pain
  JOURNAL   JCI Insight 9 (12), e180085 (2024)
   PUBMED   38912580
  REMARK    GeneRIF: ESRRG-controlled downregulation of KCNN1 in primary
            sensory neurons is required for neuropathic pain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5312)
  AUTHORS   Jung,Y.S., Radhakrishnan,K., Hammad,S., Muller,S., Muller,J.,
            Noh,J.R., Kim,J., Lee,I.K., Cho,S.J., Kim,D.K., Kim,Y.H., Lee,C.H.,
            Dooley,S. and Choi,H.S.
  TITLE     ERRgamma-inducible FGF23 promotes alcoholic liver injury through
            enhancing CYP2E1 mediated hepatic oxidative stress
  JOURNAL   Redox Biol 71, 103107 (2024)
   PUBMED   38479224
REFERENCE   4  (bases 1 to 5312)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   5  (bases 1 to 5312)
  AUTHORS   Boogerd,C.J., Perini,I., Kyriakopoulou,E., Han,S.J., La,P., van der
            Swaan,B., Berkhout,J.B., Versteeg,D., Monshouwer-Kloots,J. and van
            Rooij,E.
  TITLE     Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP
            inhibition during cardiac maturation
  JOURNAL   Nat Commun 14 (1), 4716 (2023)
   PUBMED   37543677
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5312)
  AUTHORS   Greschik,H., Wurtz,J.M., Sanglier,S., Bourguet,W., van
            Dorsselaer,A., Moras,D. and Renaud,J.P.
  TITLE     Structural and functional evidence for ligand-independent
            transcriptional activation by the estrogen-related receptor 3
  JOURNAL   Mol Cell 9 (2), 303-313 (2002)
   PUBMED   11864604
  REMARK    GeneRIF: Transcriptional activation by ERR3 can be
            ligand-independent.
REFERENCE   7  (bases 1 to 5312)
  AUTHORS   Hermans-Borgmeyer,I., Susens,U. and Borgmeyer,U.
  TITLE     Developmental expression of the estrogen receptor-related receptor
            gamma in the nervous system during mouse embryogenesis
  JOURNAL   Mech Dev 97 (1-2), 197-199 (2000)
   PUBMED   11025225
REFERENCE   8  (bases 1 to 5312)
  AUTHORS   Susens,U., Hermans-Borgmeyer,I. and Borgmeyer,U.
  TITLE     Alternative splicing and expression of the mouse estrogen
            receptor-related receptor gamma
  JOURNAL   Biochem Biophys Res Commun 267 (2), 532-535 (2000)
   PUBMED   10631096
REFERENCE   9  (bases 1 to 5312)
  AUTHORS   Hong,H., Yang,L. and Stallcup,M.R.
  TITLE     Hormone-independent transcriptional activation and coactivator
            binding by novel orphan nuclear receptor ERR3
  JOURNAL   J Biol Chem 274 (32), 22618-22626 (1999)
   PUBMED   10428842
REFERENCE   10 (bases 1 to 5312)
  AUTHORS   Chen,F., Zhang,Q., McDonald,T., Davidoff,M.J., Bailey,W., Bai,C.,
            Liu,Q. and Caskey,C.T.
  TITLE     Identification of two hERR2-related novel nuclear receptors
            utilizing bioinformatics and inverse PCR
  JOURNAL   Gene 228 (1-2), 101-109 (1999)
   PUBMED   10072763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ062694.1 and BC082324.1.
            
            On Aug 27, 2011 this sequence version replaced NM_011935.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082324.1, AF117254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CJ062694.1         2-33
            33-5312             BC082324.1         1-5280
FEATURES             Location/Qualifiers
     source          1..5312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 91.83 cM"
     gene            1..5312
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /note="estrogen-related receptor gamma"
                     /db_xref="GeneID:26381"
                     /db_xref="MGI:MGI:1347056"
     exon            1..226
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            227..642
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..759
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            760..870
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1032
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1302
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..5292
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5272..5277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /note="hexamer: ATTAAA"
     polyA_site      5292
                     /gene="Esrrg"
                     /gene_synonym="ERR3; Errg; mKIAA0832; NR3B3"
                     /note="major polyA site"
ORIGIN      
        1 ccaatcgggg ctttaagtcc ttgattagga gagagtgtgc gagcctcggt cccaactggc
       61 cgtgcctatg ggcctgtcac caggagaacg cgtgtgttaa ttgcaccggg ctctgtcaag
      121 gaaactttga tttataggtg gggtgcacaa ataatggttg tcgggcgcac atggattcgg
      181 tagaactttg cctgcctgaa tctttttccc tgcactacga agaagagctt ctctgcagaa
      241 tgtcaaacaa agatcgacac attgattcca gctgttcgtc cttcatcaag acggaaccct
      301 ccagcccagc ctccctgacg gacagcgtca accaccacag ccctggtggg tcttccgacg
      361 ccagtgggag ttacagttca accatgaatg gccatcagaa cggactggac tcgccacctc
      421 tctacccctc tgctccgatc ctgggaggca gcgggcctgt ccggaaactg tatgatgact
      481 gctccagcac catcgtagag gatccccaga ccaagtgtga atatatgctc aactccatgc
      541 ccaagagact gtgcttagtg tgtggcgaca tcgcctctgg gtaccactat ggggttgcat
      601 catgtgaagc ctgcaaggca ttcttcaaga ggacgattca aggtaacata gagtacagct
      661 gcccagccac gaatgaatgt gagatcacaa agcgcagacg caaatcctgc caggcctgcc
      721 gcttcatgaa gtgtctcaaa gtgggcatgc tgaaagaagg ggtccgtctt gacagagtgc
      781 gtggaggtcg gcagaagtac aagcgcagaa tagatgctga gaacagccca tacctgaacc
      841 ctcagctggt gcagccagcc aaaaagccat ataacaagat tgtctcgcat ttgttggtgg
      901 ctgaaccaga gaagatctat gccatgcctg accctactgt ccccgacagt gacatcaaag
      961 ccctcaccac actctgtgac ttggctgacc gagagttggt ggttatcatt ggatgggcaa
     1021 aacatattcc aggcttctcc acactgtccc tggcagacca gatgagcctc ctccagagtg
     1081 catggatgga gattctgatc ctcggcgttg tgtaccgatc gctttcgttt gaggatgaac
     1141 ttgtctatgc agacgattat ataatggatg aagaccagtc taaattagca ggccttcttg
     1201 acctaaataa tgctatcctg cagctggtga agaagtacaa gagcatgaag ctagagaagg
     1261 aagaattcgt caccctcaaa gcaatagctc ttgctaattc agattccatg catatagaag
     1321 atgtggaagc tgtgcagaaa cttcaggatg tgttacatga ggccctgcag gattacgagg
     1381 ctggccagca catggaagac cctcgccgtg caggcaagat gctgatgacg ctgccgctgc
     1441 tgaggcagac ctccaccaag gcagtccagc acttctacaa catcaaactc gaaggcaaag
     1501 tgcccatgca caaacttttt ttggaaatgc tggaggccaa ggtctgacta aaagcccccc
     1561 ctgggccctc ccatcctgca cgttgaaaag ggaagataaa cccaagaatg atgtcgaaga
     1621 atcttagagt ttagtgaaca acattaaaaa tcaacagact gcactgatat tttagcagcc
     1681 acagtacgat gcagcctgcg gattccgcta catcttcctg ataggtttcc tctactttat
     1741 cccacgatcc tctggccaca tccctgcatt cctccactct tccttgttct attattatgt
     1801 ttggcttctt tcactaatag ttcattttcc ctcctcccct cccttctctt ctccctccct
     1861 cctctgtctc ccccttcctt cctttctctt cctttccaca atcttctcct cttgccttgc
     1921 tctcacctct cttcgctttc tcacatctcc tcccactctg cgtacatagt caatacctct
     1981 gattgtatgg aacatttctt ttacctcttg catctcttct ccgtctcttc cttccccact
     2041 tttttttgtt tgtttgtttg tttcctttcc ttccttctgc tgctgaactc ttaatagcag
     2101 tctctaactg gagagagaaa gagagagaga tggaagccag ccctgccaaa ggacagagat
     2161 ccatactatg gatgccagtg aacttgtcat gaaccatgac atccccagtg agtaaggaat
     2221 caaagagaga accgtaccta aagtacattg caacgcaaac ggatcaactt agtgcagtat
     2281 tagattctac cgggcagcct tcgatcagac aacctaagtg gcggcattgg ctgcttctcc
     2341 ttgctttctc atctagatca gttacagcca tttgattcct taattctttt gtcaagtctt
     2401 ccaggtgttg gttagtttag ctactatgta actttttcag ggaatccttt aagctttatt
     2461 cattcatgca atactagaga ggggtaagga taccgcaacc tcgtgctggc tttgaacaat
     2521 tgaacactaa tgaaggacaa atgaaccctg aaggaagatt tttaaaaatg tttcgtttct
     2581 tcttacaaat ggagattttt ttgtaccagc tttaccactt ttcagccatt tattaatatg
     2641 gggatttaac ttactcaagc aatagttgaa gggaaggtgc atattaccac ggatgcaatt
     2701 tatgttgtgt gccagtctgg tcccaaacat cagtttctta catgagctcc agtttgccta
     2761 aatgttcact gacaccaagg attagatgat acctgccgtg acaccgagtg gtcccatcca
     2821 cgagcactgc acatgggatc cctatctgta gaattagcac cagtacacct ccctgccggg
     2881 agggacagtc gccatacggt ttctagctgc cctcgtggtt aggaacaaga tgctgcctgt
     2941 atacaaactc tgtctcagaa ggagctgtga gccaatacca tttcagaggc aataaaggct
     3001 aagtgccaga attcaaacca accaaccatc aaagacagca gacgcctgac caaattctaa
     3061 agtcctgatc cataggagtc gattcactta ggaatggttg tttaaattaa cctgcaggtt
     3121 tgttttgttt ccttgtttgt ttttttacca aaagctaagc caatagatgt gctttttcaa
     3181 caagtatggt cacagcacga aggtcagtca ggtttcagac tgtaaccagg tgtaatctaa
     3241 tgaagaaatc aaatgtcccc tcccgaaacc tacagtcgcc gaataaccag aaaccagtaa
     3301 cctccgtaga acgctttacc aatggaccag tgttagtagc tgctctctgt attctgtgga
     3361 cagtcttatt ctatgtacac agatgtaatt aaagttgtac tcctaacaaa caaaagaata
     3421 gttcagcttc aatgttccat gtttgctgcg cttttctgaa ctttatgttg cattcagaaa
     3481 ctgtcgtctt gttctcgtgg tgtttggatt cttgtggtgt gtgcttttag acacagggta
     3541 gaattagaga cagtattgga tgtatacttc ctcaggagac tacagtagta tattctactc
     3601 cttaccagta ataactaaga gattgaaact ccaaaacagt attcattacg atcagacaca
     3661 catcaaaatc ataataatat tttcaaaaaa gggataattt ctctaatggt ttattataga
     3721 ataccaatgt atagcttaga cataaaactt tgaatattca agaatataga taagtctaat
     3781 ttttaaatgc tgtatataag gcttccacct gatcatctct cagatgttgt tattaactcg
     3841 ctctgtgttg ttgcaaacct ttttggtgcg gacttgcttc caaaactatt gctactttgt
     3901 gtgcgttaag caaaatacct tggactgagg gtgtctcagc cctgtgctag gaatactgtg
     3961 tatctatcat tagctatatg ggaatatatc gtagattgtg gttctcagta gagaaagtga
     4021 ctgtagtgtg actctaggta aatcatcatt agcaattcat tcggatggtc aataacttga
     4081 aattgatagc tgtgataagt tttaaaaaat tggcaaatcc ctgactaaac atcaacagaa
     4141 aatacaactc ctggggggga aaggtgctca tcctgtaaga ttctttcatc atgtaagtgt
     4201 ttgaaacatt actttgcaga aggtttatgc agggtttaag ttactaccgc tcaataatgc
     4261 tatatataca caaatggaat atagacaatg tatgtaccca ccgtttcact gagtcgcaga
     4321 gaagaatctg agcttcagaa gccagagccc acaagtgatc aggtgagaca gaggcacatt
     4381 taaggaagga ggtacaatgt gtagttctcc gtttaaaaga cttggccttt taaaacaaca
     4441 aatatctcac aactatggtg aaaacaacaa cagcttcaag tgtggatcta aaggaaacgc
     4501 acaggtttag ggtaaatacc atttgtacct tgctcgagca aagtttattg ttttgttttt
     4561 ttttgttttg ttttgttttg ttttcaagtt tccagcaaga ccgtttagtt aatgccagct
     4621 gtcaggaaga taccaaggtg tatgttttag ccatgcaatt tgcagtttta ttttcctttt
     4681 aggtttgtcc ttatttaagg cagtgcgatt gttttggctt cttgtagtga ctctcgtgtt
     4741 ttaatcaagc cagattgttg tatttattcc actattttgc atttaaatga tgacataaaa
     4801 gatataaaaa atttaaaact gctatttttc ttatagaaga gaaaatggat gttggtgatt
     4861 gtattttaat tatttaagca tctctgttta cctgcctggg acaacatttt atggcagtct
     4921 tatgtgcaaa gatcgtgaat ggacaaaaca aaaaattaaa ctgcttacaa tgatccagga
     4981 gttgcattat agccagtagt aaaaataata atgataatta ataataatta ataataataa
     5041 tgaaaccatg tctatagctg taggtgggca tcacatctgt aaagcaatca attgtatatt
     5101 tttgtgatgt gtaccatact gtgtgctcca gcaaatgtcc atttgtgtaa atgtatttat
     5161 tttatattgt atatattgtt aaatgcaaaa aggagctatg attctgtgac tccaatcagt
     5221 tcagatatgt aactcaaatt attatgcctt tcaggaggat ggtagaacaa tattaaacaa
     5281 gcttccactt ttaaaaaaaa aaaaaaaaaa aa
//
