LOCUS       NM_011934               4208 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus estrogen related receptor, beta (Esrrb), transcript
            variant 1, mRNA.
ACCESSION   NM_011934
VERSION     NM_011934.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4208)
  AUTHORS   Festuccia,N., Vandormael-Pournin,S., Chervova,A., Geiselmann,A.,
            Langa-Vives,F., Coux,R.X., Gonzalez,I., Collet,G.G.,
            Cohen-Tannoudji,M. and Navarro,P.
  TITLE     Nr5a2 is dispensable for zygotic genome activation but essential
            for morula development
  JOURNAL   Science 386 (6717), eadg7325 (2024)
   PUBMED   39361745
REFERENCE   2  (bases 1 to 4208)
  AUTHORS   Chen,R., Fan,R., Chen,F., Govindasamy,N., Brinkmann,H.,
            Stehling,M., Adams,R.H., Jeong,H.W. and Bedzhov,I.
  TITLE     Analyzing embryo dormancy at single-cell resolution reveals dynamic
            transcriptional responses and activation of integrin-Yap/Taz
            prosurvival signaling
  JOURNAL   Cell Stem Cell 31 (9), 1262-1279 (2024)
   PUBMED   39047740
REFERENCE   3  (bases 1 to 4208)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (bases 1 to 4208)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4208)
  AUTHORS   Wang,F., Chander,A., Yoon,Y., Welton,J.M., Wallingford,M.C.,
            Espejo-Serrano,C., Bustos,F., Findlay,G.M., Mager,J. and Bach,I.
  TITLE     Roles of the Rlim-Rex1 axis during X chromosome inactivation in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2313200120 (2023)
   PUBMED   38113263
REFERENCE   6  (bases 1 to 4208)
  AUTHORS   Hunter,P.J., Swanson,B.J., Haendel,M.A., Lyons,G.E. and Cross,J.C.
  TITLE     Mrj encodes a DnaJ-related co-chaperone that is essential for
            murine placental development
  JOURNAL   Development 126 (6), 1247-1258 (1999)
   PUBMED   10021343
REFERENCE   7  (bases 1 to 4208)
  AUTHORS   Dragatsis,I., Efstratiadis,A. and Zeitlin,S.
  TITLE     Mouse mutant embryos lacking huntingtin are rescued from lethality
            by wild-type extraembryonic tissues
  JOURNAL   Development 125 (8), 1529-1539 (1998)
   PUBMED   9502734
REFERENCE   8  (bases 1 to 4208)
  AUTHORS   Sladek,R., Beatty,B., Squire,J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Giguere,V.
  TITLE     Chromosomal mapping of the human and murine orphan receptors
            ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel
            human ERRalpha-related pseudogene
  JOURNAL   Genomics 45 (2), 320-326 (1997)
   PUBMED   9344655
REFERENCE   9  (bases 1 to 4208)
  AUTHORS   Luo,J., Sladek,R., Bader,J.A., Matthyssen,A., Rossant,J. and
            Giguere,V.
  TITLE     Placental abnormalities in mouse embryos lacking the orphan nuclear
            receptor ERR-beta
  JOURNAL   Nature 388 (6644), 778-782 (1997)
   PUBMED   9285590
REFERENCE   10 (bases 1 to 4208)
  AUTHORS   Pettersson,K., Svensson,K., Mattsson,R., Carlsson,B., Ohlsson,R.
            and Berkenstam,A.
  TITLE     Expression of a novel member of estrogen response element-binding
            nuclear receptors is restricted to the early stages of chorion
            formation during mouse embryogenesis
  JOURNAL   Mech Dev 54 (2), 211-223 (1996)
   PUBMED   8652414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB642270.1, AK032025.1, AK052256.1, BC044858.1 and AV496316.1.
            
            On Apr 18, 2009 this sequence version replaced NM_011934.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            CCDS Note: An upstream translation start codon is selected for this
            CCDS for consistency with other family members. The use of an
            alternative upstream start codon would result in a protein that is
            21 aa longer at the N-terminal.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032025.1, SRR7345562.2995768.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               BB642270.1         2-194
            194-1082            AK032025.1         2-890
            1083-3611           AK052256.1         1186-3714
            3612-4148           BC044858.1         3282-3818
            4149-4208           AV496316.1         129-188
FEATURES             Location/Qualifiers
     source          1..4208
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 40.49 cM"
     gene            1..4208
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /note="estrogen related receptor, beta"
                     /db_xref="GeneID:26380"
                     /db_xref="MGI:MGI:1346832"
     exon            1..321
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..1636
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     steroid hormone receptor ERR2; ERR-beta; estrogen
                     receptor-like 2; nuclear receptor subfamily 3 group B
                     member 2; estrogen receptor related 2"
                     /codon_start=1
                     /product="steroid hormone receptor ERR2 isoform 1"
                     /protein_id="NP_036064.3"
                     /db_xref="CCDS:CCDS26066.2"
                     /db_xref="GeneID:26380"
                     /db_xref="MGI:MGI:1346832"
                     /translation="MDVSELCIPDPLGYHNQLLNRMSSEDRHLGSSCGSFIKTEPSSP
                     SSGIDALSHHSPSGSSDASGGFGIALSTHANGLDSPPMFAGAGLGGNPCRKSYEDCTS
                     GIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYNC
                     PATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSENSPYL
                     NLPISPPAKKPLTKIVSNLLGVEQDKLYAMPPNDIPEGDIKALTTLCELADRELVFLI
                     NWAKHIPGFPSLTLGDQMSLLQSAWMEILILGIVYRSLPYDDKLAYAEDYIMDEEHSR
                     LVGLLDLYRAILQLVRRYKKLKVEKEEFMILKALALANSDSMYIENLEAVQKLQDLLH
                     EALQDYELSQRHEEPRRAGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEML
                     EAKV"
     exon            322..731
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..848
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..959
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1121
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1391
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..4199
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4176..4181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /note="hexamer: AATAAA"
     polyA_site      4194
                     /gene="Esrrb"
                     /gene_synonym="Err2; Errb; Estrrb; Nr3b2"
                     /note="major polyA site"
ORIGIN      
        1 agtgggctcc aagtgtcggg cgccccagcc tcctccacgg cttggcgtcc cctctgcccg
       61 ttcgctgagc gcgcggatga gtgggagcgc ggagctgcgc gcggctctct gcctccggct
      121 cccccgccgc ggccgcgtcc tcccactccg ccttctcgcg ctcaccgtgc ccgccggccg
      181 ggactcgcac ctcgcctgtg cccttcactc gtcttccgcg tgatttgccc gccgcctttc
      241 tcctccaact gggaatgcta aaacgggact gatggacgtg tccgaactct gcatcccgga
      301 cccccttggc taccacaacc agctgctgaa ccgaatgtcg tccgaagaca ggcacctggg
      361 ctctagttgc ggctccttca tcaagacgga gccatccagc ccgtcctcgg gcattgatgc
      421 cctcagccac cacagcccca gcggctcgtc ggacgccagt ggtggctttg gcattgccct
      481 gagcacccac gccaacggtc tggactcgcc gcctatgttc gcaggtgcgg ggctgggagg
      541 caacccgtgc cgcaagagct acgaggactg tactagtggt atcatggagg actccgccat
      601 caaatgcgag tacatgctta acgccatccc caagcgcctg tgcctcgtgt gcggggacat
      661 tgcctctggc taccactacg gagtggcctc ctgcgaggct tgcaaggcgt tcttcaagag
      721 aaccattcaa ggcaacatcg agtacaactg cccggccacc aatgaatgtg agatcaccaa
      781 acggaggcgc aagtcctgtc aggcctgccg attcatgaaa tgcctcaaag tggggatgct
      841 gaaggaaggt gtgcgccttg accgagttcg aggaggccgc cagaagtaca agcgacggct
      901 ggattcggag aacagcccct acctgaacct gccgatttcc ccacctgcta aaaagccatt
      961 gactaagatc gtctcgaatc tactaggggt tgagcaggac aagctgtatg ctatgcctcc
     1021 caacgatatc cccgagggag atatcaaggc cctgaccact ctctgtgaat tggcagatcg
     1081 ggagcttgtg ttcctcatca actgggccaa gcacatccca ggcttcccca gtctgacact
     1141 tggggaccag atgagcctgc tgcagagtgc ctggatggag attctcatct tgggcatcgt
     1201 gtaccgctcg ctcccatacg atgacaagct ggcatacgcc gaggactata tcatggatga
     1261 ggaacactct cgcctggtag ggctgctgga cctttaccga gccatcctgc agctggtgcg
     1321 caggtacaag aaactcaagg tagagaagga agagtttatg atcctcaagg ccctggccct
     1381 cgccaactca gattcgatgt acattgagaa cctggaggcg gtgcagaagc tccaggacct
     1441 gctgcacgag gcgctgcagg actatgagct gagtcagcgc cacgaggagc cgcggagggc
     1501 cggcaagctg ctgctgacgc tgcccctgct gaggcagaca gccgccaaag ccgtgcaaca
     1561 cttctacagt gtgaaactgc agggcaaggt gcccatgcac aaactcttcc tggagatgct
     1621 ggaggccaag gtgtgatggc ccagcacatg gacggacgga cacgatccaa gtggagacct
     1681 ccacagccac cagcctcgac ttttttcaca cccgcatcgg ggctctgagc tgtcccagaa
     1741 gaaggggtct tcttgcttcc tggccatgtg cagactcctg gggacagcag atggggaggt
     1801 ggggatgggg agggtagggg cggggggctc atctgtcacc cgcattttct ttggaatttt
     1861 ttttttcctt ctccatgggc agtgctaagg cttgggccag ggacgacttc ccttagagct
     1921 ggagaccacc agaggaagca gccttcctgc aagggatcca tttctggacc tctccctatt
     1981 taggacctgg aggtatctgg atgggcagtg cttagtgccc gggacccaag agacatagat
     2041 tgggggctcc tgaaggtgtt ggtgtcacgg tgggcagtcc cttggggcag aacgtctctg
     2101 tggcctatcc cgaggctctg ttcctcctcc atctagctgg ctccctccac tttccccttt
     2161 cttattgtcc cagtacaccc agttctcagt ggatgctcct gctagagtag ccacatcccc
     2221 accccgaaga acccctcccc tgcttcctgc ccctacctca gccagccgga actcactggc
     2281 tcagaaaaga gttgggttct gtacccactg ctctttttgc ctgctgtttc tccttctcct
     2341 cttgggcatg gccagtctag aaacctatgg agaattcagg acctggcccc accagaggtc
     2401 acttgaggga ctctcaaggt cagtagctta ggttggggtg taggatagca gagagaccca
     2461 gcggtagagg gaaagtctca ttgcacctcg gaaaggaagg agctctaaag gtcccccttg
     2521 gcccctccct tacctcataa aaaggcaagg cttggctttg tgccatagga gggcagcctc
     2581 ctggcatttg caccagggat gtttgatgca gccctcctgg gtcaattccc ggcaagaccc
     2641 tgcagtctgg ttgtcgtata gggtgctcca ccaacccacc gcagtcctaa aacccctcag
     2701 ccctaggcac atgaatgcac ctttcaccca cccaaaaggc agtcccaggc tcatgctgtg
     2761 tgtgtccttg ggtttgggtt gacaggatgt cctaaagatg aagcggttca ttctggaaaa
     2821 tggacacgcc actttcatga caagtcctcc ggctttacct gctctgatcc cttcctggag
     2881 tgcaagggtc ccctctttca ggcgttctgg cacctgccac tactgctggc tctgcctccc
     2941 gggtgacacc tctaggagac tggtcacttc acagacttaa tgctaaactt ccccagagag
     3001 cctttccctg cccttttgcc cacaaagggg ttcatgcctc tgcatgggct ctccttgccc
     3061 atgatccaag gtagatacca cttttgtgtt aaactgggtt aactcttagg ggctgggttt
     3121 agctatcctg gcttctgaaa actcccccca gccacactgt ggagaggggg tgtcacctaa
     3181 aattccacct agttctcaga atgtcttctg ggcctatgaa cacaccagca agggttggac
     3241 aaacacccac agctgcctga gcggacacac tgctttgaag cagcagcagc agcagttaaa
     3301 tgggcacctc ggctcggctc cttgatctag tgatgcaagc accccatacg gctgcttacc
     3361 tgccgaagag aatggaccag tgacagttgg gtgccctgta gggaagctgg gtgccctggg
     3421 cacctggagt cagagggtag agcccacttg ttcaaagact agccagatga gagacatctg
     3481 tgatgccagg gtgctcaaaa caggaaaaag caagagagac cctctcctat tcccacctcc
     3541 ccccagtcag agcaaaaacc caggctacct tccatatcca tttctggaac ccatggagag
     3601 gaggcctctc tctgctagtg tgtattcaga taaagattat ttcaacccag aaatataaac
     3661 atagctaacc ttgtaccttg tagaaggagg tgctggctgg gatctctttc tctcgttccc
     3721 taacctttct gaagattctg gatggttctg gcgtgcctcc caggttttgc atccgtgaac
     3781 agatgacttc ccatggacag agcttgagaa atacgaggct ctcatttggg cctagcaggg
     3841 tcagagcctt tactatctgt gcctggtcct tccctccaga cttgactact catgagaaac
     3901 aggtggcagg caaggatgac agacgtgtga caaggagaca ggagggccca gagtccaagc
     3961 ccatggaaca gcaccaaaga gaagcactat gtggagagat tgctttattt tctgataatg
     4021 acgttgtggc tggaatgact taagatgtat atatttttta accggcagtc cttcgtgctg
     4081 tctcaccccc ctgtatggac atgtcctccc acggccctca tgtaaactac atgccctggg
     4141 attatctccc atccagtccc atgtatctga aatctaataa ataaggaaag gtctgctgaa
     4201 aaaaaaaa
//
