LOCUS       NM_007953               2248 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus estrogen related receptor, alpha (Esrra), transcript
            variant 1, mRNA.
ACCESSION   NM_007953
VERSION     NM_007953.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Desmet,S.J., Thommis,J., Vanderhaeghen,T., Vandenboorn,E.M.F.,
            Clarisse,D., Li,Y., Timmermans,S., Fijalkowska,D., Ratman,D., Van
            Hamme,E., De Cauwer,L., Staels,B., Brunsveld,L., Peelman,F.,
            Libert,C., Tavernier,J. and De Bosscher,K.
  TITLE     Crosstalk interactions between transcription factors ERRalpha and
            PPARalpha assist PPARalpha-mediated gene expression
  JOURNAL   Mol Metab 84, 101938 (2024)
   PUBMED   38631478
  REMARK    GeneRIF: Crosstalk interactions between transcription factors
            ERRalpha and PPARalpha assist PPARalpha-mediated gene expression.
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Huang,T., Lu,Z., Wang,Z., Cheng,L., Gao,L., Gao,J., Zhang,N.,
            Geng,C.A., Zhao,X., Wang,H., Wong,C.W., Yeung,K.W.K., Pan,H.,
            Lu,W.W. and Guan,M.
  TITLE     Targeting adipocyte ESRRA promotes osteogenesis and vascular
            formation in adipocyte-rich bone marrow
  JOURNAL   Nat Commun 15 (1), 3769 (2024)
   PUBMED   38704393
  REMARK    Erratum:[Nat Commun. 2025 Feb 3;16(1):1304. doi:
            10.1038/s41467-025-56599-y.. PMID: 39900904]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Xia,H., Scholtes,C., Dufour,C.R., Guluzian,C. and Giguere,V.
  TITLE     ERRalpha fosters running endurance by driving myofiber aerobic
            transformation and fuel efficiency
  JOURNAL   Mol Metab 78, 101814 (2023)
   PUBMED   37802398
  REMARK    GeneRIF: ERRalpha fosters running endurance by driving myofiber
            aerobic transformation and fuel efficiency.
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Xia,H., Dufour,C.R., Medkour,Y., Scholtes,C., Chen,Y., Guluzian,C.,
            B'chir,W. and Giguere,V.
  TITLE     Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear
            receptors controls systemic energy homeostasis and NASH progression
            in male mice
  JOURNAL   Nat Commun 14 (1), 6982 (2023)
   PUBMED   37914694
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Sladek,R., Beatty,B., Squire,J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Giguere,V.
  TITLE     Chromosomal mapping of the human and murine orphan receptors
            ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel
            human ERRalpha-related pseudogene
  JOURNAL   Genomics 45 (2), 320-326 (1997)
   PUBMED   9344655
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Sladek,R., Bader,J.A. and Giguere,V.
  TITLE     The orphan nuclear receptor estrogen-related receptor alpha is a
            transcriptional regulator of the human medium-chain acyl coenzyme A
            dehydrogenase gene
  JOURNAL   Mol Cell Biol 17 (9), 5400-5409 (1997)
   PUBMED   9271417
REFERENCE   8  (bases 1 to 2248)
  AUTHORS   Bonnelye,E., Vanacker,J.M., Spruyt,N., Alric,S., Fournier,B.,
            Desbiens,X. and Laudet,V.
  TITLE     Expression of the estrogen-related receptor 1 (ERR-1) orphan
            receptor during mouse development
  JOURNAL   Mech Dev 65 (1-2), 71-85 (1997)
   PUBMED   9256346
REFERENCE   9  (bases 1 to 2248)
  AUTHORS   Bonnelye,E., Vanacker,J.M., Dittmar,T., Begue,A., Desbiens,X.,
            Denhardt,D.T., Aubin,J.E., Laudet,V. and Fournier,B.
  TITLE     The ERR-1 orphan receptor is a transcriptional activator expressed
            during bone development
  JOURNAL   Mol Endocrinol 11 (7), 905-916 (1997)
   PUBMED   9178750
REFERENCE   10 (bases 1 to 2248)
  AUTHORS   Pettersson,K., Svensson,K., Mattsson,R., Carlsson,B., Ohlsson,R.
            and Berkenstam,A.
  TITLE     Expression of a novel member of estrogen response element-binding
            nuclear receptors is restricted to the early stages of chorion
            formation during mouse embryogenesis
  JOURNAL   Mech Dev 54 (2), 211-223 (1996)
   PUBMED   8652414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120557.12.
            
            On Oct 27, 2022 this sequence version replaced NM_007953.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039774.1, U85259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC120557.12        77164-77356
            194-530             AC120557.12        78579-78915
            531-647             AC120557.12        84783-84899
            648-776             AC120557.12        85030-85158
            777-944             AC120557.12        86095-86262
            945-1214            AC120557.12        86354-86623
            1215-2248           AC120557.12        86968-88001
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.08 cM"
     gene            1..2248
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /note="estrogen related receptor, alpha"
                     /db_xref="GeneID:26379"
                     /db_xref="MGI:MGI:1346831"
     exon            1..193
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..530
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1474
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ERR-alpha; estrogen receptor-like 1; nuclear receptor
                     subfamily 3 group B member 1; estrogen receptor related 1;
                     Steroid hormone receptor ERR1 (Estrogen-related receptor,
                     alpha) (ERR-alpha) (Estrogen receptor-like 1)"
                     /codon_start=1
                     /product="steroid hormone receptor ERR1 isoform 1"
                     /protein_id="NP_031979.2"
                     /db_xref="CCDS:CCDS29509.1"
                     /db_xref="GeneID:26379"
                     /db_xref="MGI:MGI:1346831"
                     /translation="MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPA
                     RCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAF
                     FKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQK
                     YKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPD
                     GHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRS
                     LPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALA
                     NSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAG
                     KVLAHFYGVKLEGKVPMHKLFLEMLEAMMD"
     exon            531..647
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..776
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..944
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1214
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..2248
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /note="hexamer: AATATA"
     polyA_site      2248
                     /gene="Esrra"
                     /gene_synonym="Err1; ERRalpha; Estrra; Nr3b1"
                     /note="major polyA site"
ORIGIN      
        1 gtcagctgga ggaagcggag taggaagcag ccgcgatgtc cttttgtgtc ctacaagcag
       61 ccagcggcgc cgccgagtga ggggggacgc agcgcggcgg ggcggtgcgg ccggaggagg
      121 cggcccccgc tcaccccggc gctccgggcc gctcggcccc catgcctgcc cgccagccct
      181 gccggagccc aaggtgacca gcaccatgtc cagccaggtg gtgggcatcg agcctctcta
      241 catcaaggca gagccagcca gtcctgacag tccaaagggt tcctcagaga ctgagactga
      301 acccccggtg accctggcct ctggtccagc tccagcccgc tgccttccag ggcacaagga
      361 ggaggaggat ggggaggggg cagggtctgg tgagcagggc agtgggaagc tagtgctcag
      421 ctctctaccc aaacgcctct gcctggtctg tggggatgtg gcctctggct accactacgg
      481 tgtggcatcc tgtgaggcct gcaaagcctt cttcaagagg accatccagg ggagcatcga
      541 gtacagctgt ccggcctcca atgagtgtga gatcaccaag cggagacgca aggcctgtca
      601 ggcctgccgc ttcaccaagt gcctgcgggt gggcatgctc aaggagggtg tgcgtctgga
      661 ccgtgtccgc ggcggacggc agaagtacaa acggcggcca gaggtggacc ctttgccttt
      721 cccgggcccc ttccctgctg gacctctggc agtagctgga ggacccagga agacagcccc
      781 agtgaacgct ctggtgtcgc atctgctggt ggttgaacct gagaagctgt acgccatgcc
      841 tgacccagca agccccgatg gacacctccc cgctgtggcc actctctgtg acctttttga
      901 tcgagagata gtggtcacca tcagctgggc caagagcatc ccaggcttct cctcactgtc
      961 actgtctgac cagatgtcag tactgcagag tgtgtggatg gaagtgctgg tgctgggtgt
     1021 ggcccagcgc tcactgccac tgcaggatga gctggccttt gctgaggacc tggtcctaga
     1081 tgaagagggg gcacgggcag ctggcctggg ggatctgggg gcagccctgc tgcagctggt
     1141 tcggcgactg caagctcttc ggctggagcg ggaggagtac gtcctgctga aagctctggc
     1201 ccttgccaat tctgactctg tgcacattga agatgctgag gctgtggagc agctgcgcga
     1261 agccctgcat gaggccctgc tggagtatga agctggccgg gctggccctg gagggggtgc
     1321 tgagcggagg cgtgcaggca ggctgctgct tacgctgcca ctcctccgcc agacagcagg
     1381 caaagtcctg gcccatttct atggggtgaa gctggagggc aaggtgccca tgcacaagct
     1441 gtttttggaa atgcttgagg ccatgatgga ctgaggcaag gggtgggaca gggtggggtg
     1501 gctggcagga tctgcccagc atagggtgtt agccccaaag gggcaaagct ggagtctggg
     1561 cagtgccata gcctgctggc agggccaggg caatgccatc cgcccctggg agaaggcttc
     1621 atgcccttcc ctccccactt tgtgtgtgtg ggggattgtc agaagccagg aaagtgaatg
     1681 cccaggtgtg ggcacagtgc tgccccttgc aagccataac gtgcccccca agagtgttgg
     1741 gggcctcgcg gaagccatag ggggctgcag gggatgtgca ggaggcagac actgatctca
     1801 gggagggaag ggatggaggc cgccggctcc cactgggtga tgcttttgct gctgcttaat
     1861 ccgatctcct ctccggagca gaggggggct tggaaagcaa aggccccgtc ccttcgctcc
     1921 tctcctcatc cgcattgggc attattgccc ccccttgaag caataactcc aagcaggctc
     1981 cagcccctgg accccagggg tggccagggc cccctatcag ctcccacctc aaggggtggg
     2041 ggacagcact gcctctatgc cctgcagagc aataacacta tatttatttt tgggtttggc
     2101 cagggaggcg cagggccatg gggcaagcca gggcccagag cccttggctg tacagagact
     2161 ctattttaat gtatatttgc tgcaaagaga aaccgctttt ggttttgaac ctttaatgag
     2221 aaaaaaaata tactatggag ctcaagta
//
