LOCUS       NM_176838               2686 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus epithelial splicing regulatory protein 2 (Esrp2),
            mRNA.
ACCESSION   NM_176838
VERSION     NM_176838.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2686)
  AUTHORS   Zhao,Y., Li,M., Wu,W., Miao,W. and Liu,H.
  TITLE     Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma
            through altering FGFR2 splicing and macrophage polarization
  JOURNAL   Front Immunol 14, 1161273 (2023)
   PUBMED   37090731
  REMARK    GeneRIF: Downregulated ESRP1/2 promotes lung metastasis of bladder
            carcinoma through altering FGFR2 splicing and macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2686)
  AUTHORS   Peart,N.J., Hwang,J.Y., Quesnel-Vallieres,M., Sears,M.J., Yang,Y.,
            Stoilov,P., Barash,Y., Park,J.W., Lynch,K.W. and Carstens,R.P.
  TITLE     The global Protein-RNA interaction map of ESRP1 defines a
            post-transcriptional program that is essential for epithelial cell
            function
  JOURNAL   iScience 25 (10), 105205 (2022)
   PUBMED   36238894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2686)
  AUTHORS   Spruce,T., Plass,M., Gohr,A., Ray,D., Martinez de Lagran,M.,
            Rot,G., Novoa,A., Burguera,D., Permanyer,J., Miret,M., Zheng,H.,
            Swanson,M.S., Morris,Q., Mallo,M., Dierssen,M., Hughes,T.R.,
            Pernaute,B. and Irimia,M.
  TITLE     The X-linked splicing regulator MBNL3 has been co-opted to restrict
            placental growth in eutherians
  JOURNAL   PLoS Biol 20 (4), e3001615 (2022)
   PUBMED   35476669
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2686)
  AUTHORS   Carroll,S.H., Macias Trevino,C., Li,E.B., Kawasaki,K., Myers,N.,
            Hallett,S.A., Alhazmi,N., Cotney,J., Carstens,R.P. and Liao,E.C.
  TITLE     An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in
            vertebrates
  JOURNAL   Development 147 (24), 226081 (2020)
   PUBMED   33234718
  REMARK    GeneRIF: An Irf6-Esrp1/2 regulatory axis controls midface
            morphogenesis in vertebrates.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2686)
  AUTHORS   Revil,T. and Jerome-Majewska,L.A.
  TITLE     During embryogenesis, esrp1 expression is restricted to a subset of
            epithelial cells and is associated with splicing of a number of
            developmentally important genes
  JOURNAL   Dev Dyn 242 (3), 281-290 (2013)
   PUBMED   23233200
REFERENCE   7  (bases 1 to 2686)
  AUTHORS   Horiguchi,K., Sakamoto,K., Koinuma,D., Semba,K., Inoue,A.,
            Inoue,S., Fujii,H., Yamaguchi,A., Miyazawa,K., Miyazono,K. and
            Saitoh,M.
  TITLE     TGF-beta drives epithelial-mesenchymal transition through
            deltaEF1-mediated downregulation of ESRP
  JOURNAL   Oncogene 31 (26), 3190-3201 (2012)
   PUBMED   22037216
  REMARK    GeneRIF: deltaEF1 family proteins repress the expression of ESRPs
            to regulate alternative splicing during TGF-beta-induced EMT and
            the progression of breast cancers
REFERENCE   8  (bases 1 to 2686)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
  REMARK    GeneRIF: Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are
            epithelial cell-type-specific regulators of FGFR2 splicing.
REFERENCE   9  (bases 1 to 2686)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2686)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC031444.1.
            
            On Jun 3, 2003 this sequence version replaced NM_176838.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031444.1, AK088755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.1 cM"
     gene            1..2686
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /note="epithelial splicing regulatory protein 2"
                     /db_xref="GeneID:77411"
                     /db_xref="MGI:MGI:1924661"
     exon            1..405
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2361
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /note="RNA-binding protein 35B; RNA-binding motif protein
                     35B; RNA binding motif protein 35b"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 2"
                     /protein_id="NP_789808.1"
                     /db_xref="CCDS:CCDS22629.1"
                     /db_xref="GeneID:77411"
                     /db_xref="MGI:MGI:1924661"
                     /translation="MTPPPPPPPPPGPDPAVDSATDPCPEPQSLVVLFGATAGALGPD
                     LGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSPQCREASGLSADSLARAES
                     LDKVLQQFSQLVSGDVALLGGGPYVLCTDGQQLLRQVLHPEASRKNLVLPDTFFSFYD
                     LRREFHMQHPSTCSARDLTVGTMAQDLGLETDATEDDFGVWEVKTMVAVILHLLEGSN
                     GQLFSKPEVVKQKYETGPCSKADVVDNETVVRARGLPWQSSDQDVARFFKGLNIARGG
                     VALCLNAQGRRNGEALIRFVDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGT
                     SLEVARFLSREDQVILRLRGLPFSAGPTDVLGFLGPECPVTGGADGLLFVRHPDGRPT
                     GDAFALFACEELAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYAASPLLPTLTAP
                     LLPIPFPLAGGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPS
                     GDAFIQMMSVERALAAAQRCHKKMMKERYVEVVPCSTEEMSRVLMGGSLSRSGLSPPP
                     CKLPCLSPPTYATFQATPALIPTETTALYPSSALLPAARVPAAATPLAYYPGPATQLY
                     MNYTAYYPSPPVSPTTVGYLTTPPTALASTPTTMLSQPGALVRMQGVPYTAGMKDLLS
                     VFQAYQLAPDDYTTLMPVGDPPRTVLQAPKEWVCL"
     exon            406..534
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            535..648
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            649..763
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            764..862
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            863..917
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1028
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1161
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1204
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1506
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1719
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1918
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2105
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2271
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2672
                     /gene="Esrp2"
                     /gene_synonym="9530027K23Rik; Rbm35b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccggagta ggcagggata ggcagccgca ccgcccagcc ccaaagggca ccgcgggcgg
       61 gtctctgcag ctcccactac acccggccgc aggtgccgcc cccaacacac cggatcccgc
      121 ccaagctcgt ctgtctgctg tcggtcggta cgtgtgtgcg cctcgtcggt ccgcgtgtgt
      181 ggccgagcgc ccccttcctc tgcggccatg actccgccgc cgccgccgcc cccacccccg
      241 ggcccagatc ccgcagtaga ctcggccaca gacccttgtc ccgaacctca gtcgctggtg
      301 gttttgttcg gggccactgc cggtgcgctg gggccggacc taggctcgga cgagaccgac
      361 ttaatcctcc tagtttggca agtggtggag ccgcgcagcc gacaggtggg gacgctgcac
      421 aagtcgctag ttcgcgccga ggcggctgcc ctgagtccac aatgccgcga ggcgagtgga
      481 ctcagcgcag acagcctagc gcgggcggag tccctggaca aagtgctgca acagttctca
      541 cagctggtga gcggggatgt ggctctgctg ggcgggggcc cctatgtgct ctgcactgat
      601 gggcagcagc tgttgcgaca ggttctgcat cctgaggcct ccaggaagaa cctggtgctc
      661 cccgacacct tcttctcctt ctacgacctc cgcagagaat tccatatgca gcacccaagc
      721 acctgctccg ccagagacct cacagtgggc accatggcac aggacttggg actagaaaca
      781 gatgctaccg aagatgactt tggggtctgg gaagtgaaga ctatggtagc tgttattctc
      841 cacctacttg aagggtccaa tggtcagttg ttctcgaagc cagaagtggt aaagcagaaa
      901 tacgagacag gcccttgcag caaggctgat gtggtggaca atgagactgt agtacgggcc
      961 cgtgggttgc cctggcaatc atcagaccag gatgtggctc gattcttcaa agggctcaac
     1021 attgccaggg gtggtgtggc cctctgtctc aacgcccagg gccgcagaaa tggcgaggcc
     1081 ctcatccgat tcgtggacag cgagcagcgg gacctagcgc tgcagagaca caaacaccac
     1141 atgggtgtcc gctatattga ggtatataaa gccacagggg aggaattcgt aaagattgca
     1201 gggggcacat cactagaggt ggcccgtttc ctatcacggg aagatcaagt gatcctgagg
     1261 ctacggggac tacccttttc agccgggcca acagatgttc taggcttcct ggggccagaa
     1321 tgcccagtga ctgggggtgc tgatgggctg ctctttgtcc gccaccctga tggcaggcct
     1381 actggggatg cctttgctct ctttgcctgt gaggagctgg cacaggctgc tctgcgcagg
     1441 cacaaaggca tgctgggtaa gcgatacatt gaactcttca ggagcacggc agccgaggtg
     1501 cagcaggtcc ttaaccgcta tgcagccagt ccactccttc ccacactgac tgctccactg
     1561 ctgcccattc cctttccact ggcaggagga actgggaggg actgtgttcg ccttagaggc
     1621 ctgccctaca cagccaccat tgaagacatt ctgagttttc taggagaggc agcagctgac
     1681 attcggcctc atggtgtgca tatggtgctc aaccaacagg gccggccatc cggtgacgcc
     1741 ttcatccaga tgatgtcggt ggagcgtgct ctggctgctg cccagcgatg ccacaagaag
     1801 atgatgaaag aacgctatgt ggaagtagtc ccttgttcca cagaggagat gagccgtgtg
     1861 ctgatggggg gttccctgag ccgcagtggc ctgtcccctc caccctgcaa actgccctgc
     1921 ctctcaccac ctacctacgc caccttccag gccaccccag ccctcattcc cacagagacg
     1981 acagcactat atccctcttc tgcactgctg ccagctgcca gggtacccgc tgctgccact
     2041 cctcttgcct attacccagg gccagccact caactctaca tgaactacac agcctactat
     2101 cccagccccc cagtctcccc cactactgtg ggctacctca ccacacctcc tactgccttg
     2161 gcctctacgc ccaccacaat gctgtcccaa ccaggagccc tggtccgaat gcagggggtg
     2221 ccatacacag ctggtatgaa ggacctactc agtgtctttc aagcctacca gctggctcct
     2281 gatgactaca ccactctgat gcctgttggt gacccacctc gcactgtgtt acaagcccct
     2341 aaggagtggg tgtgtttgta gaagaggaaa ccaggagaca gaatgagctg atgtccccag
     2401 ctaacaagcc tctgctgagc ccagagcacc ctcaatccag cagcttcttt atggctcgtc
     2461 aaagctctac aaggcacctg gaaaagacca agctcagcat cgctctcctt cctcccatgt
     2521 ccccttgttc ctctgcctgc ttattctaaa gatgatggcc gccttacagg cagggctgga
     2581 gatgtgatag ggctgctcca tccctgatgg tgtgacagcc agaaaacctt ccatctgtct
     2641 ttggccctca aatactgagt ttgaagggtg caaaaaaaaa aaaaaa
//
