LOCUS       NM_194055               3969 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus epithelial splicing regulatory protein 1 (Esrp1),
            transcript variant 1, mRNA.
ACCESSION   NM_194055
VERSION     NM_194055.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3969)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3969)
  AUTHORS   Wang,W., Taufalele,P.V., Millet,M., Homsy,K., Smart,K.,
            Berestesky,E.D., Schunk,C.T., Rowe,M.M., Bordeleau,F. and
            Reinhart-King,C.A.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   3  (bases 1 to 3969)
  AUTHORS   Zhao,Y., Li,M., Wu,W., Miao,W. and Liu,H.
  TITLE     Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma
            through altering FGFR2 splicing and macrophage polarization
  JOURNAL   Front Immunol 14, 1161273 (2023)
   PUBMED   37090731
  REMARK    GeneRIF: Downregulated ESRP1/2 promotes lung metastasis of bladder
            carcinoma through altering FGFR2 splicing and macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3969)
  AUTHORS   Peart,N.J., Hwang,J.Y., Quesnel-Vallieres,M., Sears,M.J., Yang,Y.,
            Stoilov,P., Barash,Y., Park,J.W., Lynch,K.W. and Carstens,R.P.
  TITLE     The global Protein-RNA interaction map of ESRP1 defines a
            post-transcriptional program that is essential for epithelial cell
            function
  JOURNAL   iScience 25 (10), 105205 (2022)
   PUBMED   36238894
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3969)
  AUTHORS   Spruce,T., Plass,M., Gohr,A., Ray,D., Martinez de Lagran,M.,
            Rot,G., Novoa,A., Burguera,D., Permanyer,J., Miret,M., Zheng,H.,
            Swanson,M.S., Morris,Q., Mallo,M., Dierssen,M., Hughes,T.R.,
            Pernaute,B. and Irimia,M.
  TITLE     The X-linked splicing regulator MBNL3 has been co-opted to restrict
            placental growth in eutherians
  JOURNAL   PLoS Biol 20 (4), e3001615 (2022)
   PUBMED   35476669
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3969)
  AUTHORS   Warzecha,C.C., Sato,T.K., Nabet,B., Hogenesch,J.B. and
            Carstens,R.P.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
  REMARK    GeneRIF: Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are
            epithelial cell-type-specific regulators of FGFR2 splicing.
REFERENCE   7  (bases 1 to 3969)
  AUTHORS   Sherwood,R.I., Jitianu,C., Cleaver,O., Shaywitz,D.A., Lamenzo,J.O.,
            Chen,A.E., Golub,T.R. and Melton,D.A.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
REFERENCE   8  (bases 1 to 3969)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 3969)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3969)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140848.1, CJ081693.1, AK042164.1, DV657411.1, DV648780.1 and
            AA647208.1.
            
            On Mar 13, 2014 this sequence version replaced NM_194055.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               AK140848.1         2-609
            609-722             CJ081693.1         240-353
            723-991             AK140848.1         724-992
            992-1580            AK042164.1         604-1192
            1581-2841           AK140848.1         1579-2839
            2842-3171           DV657411.1         225-554
            3172-3752           DV648780.1         59-639
            3753-3969           AA647208.1         1-217               c
FEATURES             Location/Qualifiers
     source          1..3969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.11 cM"
     gene            1..3969
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /note="epithelial splicing regulatory protein 1"
                     /db_xref="GeneID:207920"
                     /db_xref="MGI:MGI:1917326"
     exon            1..479
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..2393
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /note="isoform 1 is encoded by transcript variant 1; RNA
                     binding motif protein 35A"
                     /codon_start=1
                     /product="epithelial splicing regulatory protein 1 isoform
                     1"
                     /protein_id="NP_918944.2"
                     /db_xref="CCDS:CCDS51119.1"
                     /db_xref="GeneID:207920"
                     /db_xref="MGI:MGI:1917326"
                     /translation="MTASPDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKK
                     VGQLHEVLVRPDQLELTEDCKEETKIDAENLSSAPQLDQALRQFNQSVSNELNIGVGT
                     SFCLCTDGQLHIRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGSPDIDKLDVAA
                     MTESLNFEKSDSVSRYGASQVEDMGNIILAMISEPYNHRFSDPERVNYKFESGTCSKM
                     ELIDDSTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRNGEALVRFVSE
                     EHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMRGLP
                     FTATAEEVVAFFGQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKE
                     LLGKRYIELFRSTAAEVQQVLNRFSSAPLIPLPTPPIIPVLPQQFVPPTNVRDCIRLR
                     GLPYAATIEDILDFLGEFSTDIRTHGVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKY
                     HKKTMKDRYVEVFQCSAEEMNFVLMGGTLNRNGLSPPPCKLPCLSPPSYTFPAPTAVI
                     PTEAAIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANL
                     SSVPPQPGTVVRMQGLAYNTGVKEILNFFQGYQYATEDGLVHTNDQARTLPKEWVCI"
     exon            480..608
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            609..722
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            723..837
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            838..936
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            937..991
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1102
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1235
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1278
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1580
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1799
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1998
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2167
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2318
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2428
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..3969
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2821..2826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /note="hexamer: AATAAA"
     polyA_site      2843
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
     regulatory      3944..3949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /note="hexamer: AATAAA"
     polyA_site      3969
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /note="major polyA site"
ORIGIN      
        1 aggtagagcc acatcccaaa acagaaaagc tttcagccat tgcgcgcgcc tcccgggggt
       61 gcagcccggc tcctgggttt tttcttagac gcaccagcaa ttggatacaa aaagggcagg
      121 cctgctcttc cctccttcca ccccccttcc tgcccagggt gtggagcgcc ggccaggtgt
      181 gggcttgggt ggcaggttac cgccttttgc cctggcggcc tcgaggaggg gggtgggcgc
      241 tttctttttc tcttggaaga gggttttagc acaggttttc tcgttctcac ttccaacccc
      301 acctcgccgc ctcccggccc ccctcctccc cctccccacc tatcgtcatg acggcgtctc
      361 cggattactt ggtggtgctt tttgggatca ctgctggggc caccggagcc aagctgggtt
      421 cggatgagaa ggagctgatc ctgctgttat ggaaagtcgt ggatttggcc aacaagaagg
      481 tgggacagct gcacgaagta ctagttagac cggatcagtt ggaactgaca gaggattgta
      541 aagaagaaac taaaatagac gccgaaaacc tgtcttccgc gccgcagctg gaccaagccc
      601 tccgacagtt taaccagtca gtgagcaatg aactgaacat cggggtaggg acttccttct
      661 gtctctgtac tgacgggcag cttcacatta ggcagatctt gcatcccgag gcttccaaga
      721 agaatgtgtt actgcctgag tgcttctatt cctttttcga tcttcggaaa gagttcaaga
      781 agtgctgccc gggctctccc gatatcgaca agctggatgt cgcagcgatg acagaaagcc
      841 tgaactttga gaagagtgac tctgtgtccc gatacggagc ctcccaagtt gaagacatgg
      901 ggaacataat tttagcaatg atctccgagc cctacaatca cagattttca gatccagaga
      961 gagtaaacta caagtttgaa agtggcactt gcagcaagat ggaacttatt gatgacagca
     1021 cagtggtgag agctcgaggt ttgccctggc aatcttcaga tcaagatatt gcaaggttct
     1081 tcaaaggact caatattgcc aagggtggcg cagcactttg cctgaatgct cagggccgga
     1141 ggaacggaga agctctggtt agatttgtaa gtgaggagca cagagatcta gccctgcaga
     1201 ggcacaaaca tcacatgggg acccggtaca ttgaggttta caaagcaaca ggcgaagatt
     1261 tccttaaaat tgccggaggg acatccaatg aggtagccca gtttctctcc aaggaaaacc
     1321 aagtcatcgt gcgcatgagg gggctccctt tcacggccac ggctgaagaa gtggtggcct
     1381 tctttggaca gcactgcccc atcactggag ggaaggaagg catcctcttc gttacctacc
     1441 cagatggtag gccaaccgga gatgcttttg tgctctttgc ttgtgaggag tatgctcaga
     1501 acgccctgag gaagcacaag gagttgctgg gtaaaagata catcgagctc ttcaggagca
     1561 cagctgccga agttcagcag gtgctgaacc gattctcctc agcccctctg attccacttc
     1621 caacccctcc cattatccct gtactacctc agcagtttgt gcctcccacg aatgtcagag
     1681 actgcatacg tctgcgaggt cttccctatg ctgccacaat agaagacatt ctggacttcc
     1741 tgggggagtt ttccacagat attcgtacac atggagtgca catggtattg aatcaccagg
     1801 gacgcccgtc aggagatgcc tttatccaga tgaagtcaac agacagagca ttcatggctg
     1861 cgcagaagta ccataaaaaa accatgaagg acagatatgt tgaagtcttt cagtgttcag
     1921 ctgaggagat gaactttgtg ttaatggggg gcactttaaa tcgaaatggc ttgtccccac
     1981 cgccatgtaa gttaccatgc ctgtctcctc cctcctacac attcccagct cccacggctg
     2041 tgattcctac cgaagctgcc atttatcaac cttctctgct cttgaaccca cgggcactgc
     2101 agccctccac tgcatactac ccggcaggca ctcagctctt catgaactac acagcctact
     2161 atcccagccc cccaggttcg cctaatagtc ttggctactt ccctacagct gctaatctta
     2221 gcagtgtccc gccccagcct ggcaccgtgg tcagaatgca gggcctggcc tacaatactg
     2281 gagttaagga aattcttaac ttcttccaag gttaccagta tgcaaccgag gatggacttg
     2341 tacacacaaa tgaccaggcc aggactctac ccaaagaatg ggtttgtatt taagggcccc
     2401 agcagttaga gcgtcctcag agaagaagtg tttgaaagac gtatggtgat cctgaaacta
     2461 tcagacaaga gaacttcgag caatttcagg ggatgtttgt ctacagtcag gctgcggcat
     2521 tctcggccaa cacgattgga cagtagtcct gggccttgcc ttttgctgga gtgagaagtg
     2581 aacccagcaa agccttacaa caagcaacac gcatggacct ggctcctggc tgagcacaat
     2641 caggaatttc gatgtgaatt tgaagtcaaa aggtctcact tccagctaac gtggcatcat
     2701 ttatttccta agttgaagac ttggagtaaa atgcattcca ctagcgtcta ccatccgcca
     2761 ttagttgctc cggaagcctc actgtgcatt cccaatcttc tgtctccctg ttctctgtaa
     2821 aataaagcct tcttgctagg taacttaatg tgcattctta gaatacgtaa atcccaaact
     2881 aaggaaagca ataaaataga actaatattt tcctgaatat tagttttctt caataggcca
     2941 tcatggtgcc ttatagttaa aaacaaatat ttttaagacc cttcaggcag gctgggcctg
     3001 tagctcagtg ctaaagggcg tgcctagcat acttgagccc tgggttgtag acctctggcc
     3061 cccttgtgtt ctctccatac atgcacctga gggttcccct tccacacaca caccttgtta
     3121 aaggatttga gggtttttct ctgcaggtac cacctgtaaa taagaagaaa gtaggggcca
     3181 aaatttgaaa ccaaaaacga agcagctaca tgtagctagt tcctagtgtg agctgtaact
     3241 gaatgttggc ttcatatgta ttattttata ttgtactttt ttcattgtta aaggtttgga
     3301 ctttaataag agaaattgca tagtttcaat gtcataaaaa taagactatt tgaacagtgt
     3361 attccagaaa gcaatatact aaccaaagtg aatgcttgta tatattgata aacctttttt
     3421 ttttaatgca tcacctgtcg aggaactaaa acctttaaaa gcgtaggcat gctggcctga
     3481 ggtaaacacc gataagttag agcggctgca gcgctcagtg tttagcaccg cttgtatagc
     3541 tgtgctttgg accagagtgc agtatttggc actagctggt acagctgcct gatggaactc
     3601 ggcgggaaag tgatttgatc caaagcacat gtttctttgt tactctcgtc ctttgcttgg
     3661 atgcaatgcc taggttgtgg ctatttttag tttgcatcat caccttgact gtggagtcga
     3721 gcattgccct ctcacttgac caacagtagc ccttcgactg cagtgggaaa gaagaagaaa
     3781 atgatttgat gtgaaaattg gtgaaatctg gcacttgaaa taaccaagag aaaagttcct
     3841 acttgatgcc ttaagccact cctgctcgaa gctctgaaga actgagatgc cagagatgct
     3901 tactatggta ctactgcatt ttttgtagag ttgttacatt aataataaaa cttgcctgct
     3961 taatctcaa
//
