LOCUS       NM_207707               3362 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus estrogen receptor 2 (beta) (Esr2), transcript variant
            1, mRNA.
ACCESSION   NM_207707
VERSION     NM_207707.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3362)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3362)
  AUTHORS   Park,C.J., Oh,J.E., Lin,P., Zhou,S., Bunnell,M., Bikorimana,E.,
            Spinella,M.J., Lim,H.J. and Ko,C.J.
  TITLE     A Dynamic Shift in Estrogen Receptor Expression During Granulosa
            Cell Differentiation in the Ovary
  JOURNAL   Endocrinology 166 (2) (2025)
   PUBMED   39834231
REFERENCE   3  (bases 1 to 3362)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3362)
  AUTHORS   Guo,B., Zhu,H., Xiao,C., Zhang,J., Liu,X., Fang,Y., Wei,B.,
            Zhang,J., Cao,Y. and Zhan,L.
  TITLE     NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response
  JOURNAL   BMC Med 22 (1), 351 (2024)
   PUBMED   39218863
  REMARK    GeneRIF: NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3362)
  AUTHORS   Douglas,J.C., Sekulovski,N., Arreola,M.R., Oh,Y., Hayashi,K. and
            MacLean,J.A. 2nd.
  TITLE     Normal Ovarian Function in Subfertile Mouse with Amhr2-Cre-Driven
            Ablation of Insr and Igf1r
  JOURNAL   Genes (Basel) 15 (5), 616 (2024)
   PUBMED   38790245
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3362)
  AUTHORS   Johnson,B.D., Zheng,W., Korach,K.S., Scheuer,T., Catterall,W.A. and
            Rubanyi,G.M.
  TITLE     Increased expression of the cardiac L-type calcium channel in
            estrogen receptor-deficient mice
  JOURNAL   J Gen Physiol 110 (2), 135-140 (1997)
   PUBMED   9236206
REFERENCE   7  (bases 1 to 3362)
  AUTHORS   Torchia,J., Rose,D.W., Inostroza,J., Kamei,Y., Westin,S.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     The transcriptional co-activator p/CIP binds CBP and mediates
            nuclear-receptor function
  JOURNAL   Nature 387 (6634), 677-684 (1997)
   PUBMED   9192892
REFERENCE   8  (bases 1 to 3362)
  AUTHORS   Tremblay,G.B., Tremblay,A., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Labrie,F. and Giguere,V.
  TITLE     Cloning, chromosomal localization, and functional analysis of the
            murine estrogen receptor beta
  JOURNAL   Mol Endocrinol 11 (3), 353-365 (1997)
   PUBMED   9058381
REFERENCE   9  (bases 1 to 3362)
  AUTHORS   Chang,P.W., Tsui,S.K., Liew,C., Lee,C.C., Waye,M.M. and Fung,K.P.
  TITLE     Isolation, characterization, and chromosomal mapping of a novel
            cDNA clone encoding human selenium binding protein
  JOURNAL   J Cell Biochem 64 (2), 217-224 (1997)
   PUBMED   9027582
REFERENCE   10 (bases 1 to 3362)
  AUTHORS   Rissman,E.F., Early,A.H., Taylor,J.A., Korach,K.S. and Lubahn,D.B.
  TITLE     Estrogen receptors are essential for female sexual receptivity
  JOURNAL   Endocrinology 138 (1), 507-510 (1997)
   PUBMED   8977441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054413.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054413.1, AK054290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3362              AK054413.1         2-3363
FEATURES             Location/Qualifiers
     source          1..3362
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.52 cM"
     gene            1..3362
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /note="estrogen receptor 2 (beta)"
                     /db_xref="GeneID:13983"
                     /db_xref="MGI:MGI:109392"
     exon            1..313
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            314..766
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..2051
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ER-beta; nuclear receptor subfamily 3 group A member 2;
                     estrogen receptor beta; oestrogen receptor beta"
                     /codon_start=1
                     /product="estrogen receptor beta isoform 1"
                     /protein_id="NP_997590.1"
                     /db_xref="CCDS:CCDS25988.1"
                     /db_xref="GeneID:13983"
                     /db_xref="MGI:MGI:109392"
                     /translation="MSICASSHKDFSQLRPTQDMEIKNSPSSLTSPASYNCSQSILPL
                     EHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTS
                     GHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPS
                     AKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRK
                     SCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVHCLNKAKRTSGHTPRVKE
                     LLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKK
                     IPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRSSEDPHWHV
                     AQTKSAVPRDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPL
                     ATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNK
                     GMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQS
                     Q"
     exon            767..939
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1056
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1356
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1495
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1549
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1683
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1864
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..3362
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3340..3345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /note="putative"
     polyA_site      3362
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /note="putative"
ORIGIN      
        1 gttagtcgtg ggcagtcttt gcagcttctc cagctgctgg cccttttgaa aggcactctc
       61 gggtccctgc cttctcccag gcttctagca tcaaccacct cttgaaactt cctgggagta
      121 gaggaggtgg ggagctggcc tggagggagc ggcttgtgcg gccactggca tcccttggca
      181 tccgggtctg cagtagagtc tggcagccgc cgcaggctga gcgacaacca gtggctgcga
      241 gtcccgctca gggaccgagg aaagtacgtg tctgcattta gagaatgcaa aagagagaat
      301 gtccacccgc taggcattcc acctgcccgt gagtctctga gagcatcatg tccatctgtg
      361 cctcttctca caaggatttt tctcagctga gacctacgca agacatggag atcaaaaact
      421 caccatcaag ccttacttcc cctgcttctt ataactgtag ccagtccatc ctacccttgg
      481 agcatggtcc catctatatc ccttcctcct atgtagagag ccgtcacgaa tactcagcca
      541 tgacattcta cagtcctgct gtgatgaact acagtgttcc cagcagcacc ggtaacctgg
      601 aaggtgggcc tgttcgccag actgcaagcc caaatgtgct atggccaact tctggacacc
      661 tctctccttt agccacccac tgccaatcat cgcttctcta tgcagaacct caaaagagtc
      721 cttggtgtga agcaagatca ctagaacaca ccttgcctgt aaacagagag accctgaaga
      781 ggaagcttgg cgggagcggt tgtgccagcc ctgttactag tccaagcgcc aagagggatg
      841 ctcacttctg cgccgtctgc agtgattatg catctgggta tcattacggt gtctggtcct
      901 gtgaaggatg taaggccttt tttaaaagaa gcattcaagg acataatgac tatatctgtc
      961 cagccacgaa tcagtgtacc atagacaaga accggcgtaa aagctgccag gcctgccgac
     1021 ttcgcaagtg ttacgaagta ggaatggtca agtgtggatc caggagagaa aggtgtgggt
     1081 accgaatagt acgaagacag agaagtgcca gcgagcaggt gcattgcctg aacaaagcca
     1141 agagaaccag tgggcacaca ccccgggtga aggagctact gctgaactct ctgagtcccg
     1201 agcagctggt gctcaccctg ctggaagctg agccacccaa tgtgctagtg agccgtccca
     1261 gcatgccctt caccgaggcc tccatgatga tgtccctcac gaagctggct gacaaggaac
     1321 tggtgcacat gattggctgg gccaagaaaa tccctggctt tgtggagctc agcctgttgg
     1381 accaagtccg cctcttggaa agctgctgga tggaggtgct gatggtgggg ctgatgtggc
     1441 gctccatcga ccaccccggc aagctcatct ttgctccaga cctcgttctg gacaggtcct
     1501 cagaagaccc tcactggcac gttgcgcaga cgaagagtgc tgtcccaagg gatgagggga
     1561 agtgcgtgga agggattctg gaaatctttg acatgctcct ggcgacgacg gcacggttcc
     1621 gtgagttaaa actgcagcac aaagaatatc tgtgtgtgaa ggccatgatt ctcctcaact
     1681 ccagtatgta ccccttggct accgcaagcc aggaagcaga gagtagccgg aagctgacac
     1741 acctattgaa cgcagtgaca gatgccctgg tctgggtgat ttcgaagagt ggaatctctt
     1801 cccagcagca gtcagtccgt ctggccaacc tcctgatgct tctttctcat gtcaggcaca
     1861 tcagtaacaa gggcatggaa catctgctca gcatgaagtg caaaaatgtg gtcccggtgt
     1921 acgacctgct gctggagatg ctgaatgctc acacgcttcg agggtacaag tcctcaatct
     1981 cggggtctga gtgctgctcg acagaggaca gtaagagcaa agagggctcc cagaacctcc
     2041 agtcacagtg acggccaggc tggaggcgga tgattacaat gatggtcaga agtgggacat
     2101 gtaccctagc atcgtgggcc tcaccttagg gctgacttgg tcacgtaccc cttacccacg
     2161 ttgcgcttcc caggagtcag ggtggttggg ttgtggtgtc ccctgtacca ggacttactg
     2221 ctgaatgctg agttctaact tgtataacct tagaaggctc tcgttgtact ttccatctct
     2281 ttgcccactt ggaaaacatc ttaagagttc tggaatgaaa aggtcaaagt ctgacttgga
     2341 aggattggcc ttggacagga aaaggaaagt gacgcgatac accgtctata agaaatggac
     2401 tgtagaacgg tgtggtcatc aaatcgacct ttgaatggtg tcttctagac cacttgattg
     2461 taggactgaa aaccacattg acaatcaact cgtttcgcat tcctacctca caggcctgtg
     2521 aggactcatg acgtgtaatg ggttattgta tcaaagacca agaagataat ggtcaagctt
     2581 ggatgtgacc ttgttcctcc tcctagatcc tctttcttcc tgcttggctt acataactag
     2641 attattcggt ctgtctgaat gtggtcactg tcacagatta agatttaaat atctttttaa
     2701 tgttgagttc cttgaagcta tgttggtgtt ttctctctct ctctctcttt ctcagacaca
     2761 cacacacaca gcttcaggcc ttcatagtgt gtcttccatt gctgtgaagc gataccatga
     2821 ccaaggcaac tgtttttttt ttcccaagac ttatttattt catgtatatg agtgcattgt
     2881 cgctgtcttc agacacacca gaagagggca tcagatccca ttatagatgg ttatgagcca
     2941 ccatgtggtt gctgggagtt gatctcaaga tctccggaag agcagaggtc ttaactgctg
     3001 agacatctct ccagccccaa ggcaactctt taaagaacaa catttaattg gggctggctt
     3061 acagtttcag aggttcagtc ctcattatgg ccagaagcct ggccgcatcc agaagatgtg
     3121 gtgctggaga aggcgctgag aattctacat tttgatctga aggcagccag aagattggct
     3181 ttgtcttcca caggcagcca ggaggaagct ctcaaaagcc catcgacaca gtgacacact
     3241 tcctccaata aggccatacc tattctaaca aggccatacc tcttaagagt gccacttccc
     3301 atgggccaag catattcaaa ccaccatgca cttgaacaca ttaaaaaaaa aaaagcacct
     3361 tc
//
