LOCUS       NM_010157               3308 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus estrogen receptor 2 (beta) (Esr2), transcript variant
            2, mRNA.
ACCESSION   NM_010157
VERSION     NM_010157.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3308)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3308)
  AUTHORS   Park,C.J., Oh,J.E., Lin,P., Zhou,S., Bunnell,M., Bikorimana,E.,
            Spinella,M.J., Lim,H.J. and Ko,C.J.
  TITLE     A Dynamic Shift in Estrogen Receptor Expression During Granulosa
            Cell Differentiation in the Ovary
  JOURNAL   Endocrinology 166 (2) (2025)
   PUBMED   39834231
REFERENCE   3  (bases 1 to 3308)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3308)
  AUTHORS   Guo,B., Zhu,H., Xiao,C., Zhang,J., Liu,X., Fang,Y., Wei,B.,
            Zhang,J., Cao,Y. and Zhan,L.
  TITLE     NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response
  JOURNAL   BMC Med 22 (1), 351 (2024)
   PUBMED   39218863
  REMARK    GeneRIF: NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3308)
  AUTHORS   Douglas,J.C., Sekulovski,N., Arreola,M.R., Oh,Y., Hayashi,K. and
            MacLean,J.A. 2nd.
  TITLE     Normal Ovarian Function in Subfertile Mouse with Amhr2-Cre-Driven
            Ablation of Insr and Igf1r
  JOURNAL   Genes (Basel) 15 (5), 616 (2024)
   PUBMED   38790245
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3308)
  AUTHORS   Johnson,B.D., Zheng,W., Korach,K.S., Scheuer,T., Catterall,W.A. and
            Rubanyi,G.M.
  TITLE     Increased expression of the cardiac L-type calcium channel in
            estrogen receptor-deficient mice
  JOURNAL   J Gen Physiol 110 (2), 135-140 (1997)
   PUBMED   9236206
REFERENCE   7  (bases 1 to 3308)
  AUTHORS   Torchia,J., Rose,D.W., Inostroza,J., Kamei,Y., Westin,S.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     The transcriptional co-activator p/CIP binds CBP and mediates
            nuclear-receptor function
  JOURNAL   Nature 387 (6634), 677-684 (1997)
   PUBMED   9192892
REFERENCE   8  (bases 1 to 3308)
  AUTHORS   Tremblay,G.B., Tremblay,A., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Labrie,F. and Giguere,V.
  TITLE     Cloning, chromosomal localization, and functional analysis of the
            murine estrogen receptor beta
  JOURNAL   Mol Endocrinol 11 (3), 353-365 (1997)
   PUBMED   9058381
REFERENCE   9  (bases 1 to 3308)
  AUTHORS   Chang,P.W., Tsui,S.K., Liew,C., Lee,C.C., Waye,M.M. and Fung,K.P.
  TITLE     Isolation, characterization, and chromosomal mapping of a novel
            cDNA clone encoding human selenium binding protein
  JOURNAL   J Cell Biochem 64 (2), 217-224 (1997)
   PUBMED   9027582
REFERENCE   10 (bases 1 to 3308)
  AUTHORS   Rissman,E.F., Early,A.H., Taylor,J.A., Korach,K.S. and Lubahn,D.B.
  TITLE     Estrogen receptors are essential for female sexual receptivity
  JOURNAL   Endocrinology 138 (1), 507-510 (1997)
   PUBMED   8977441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054413.1.
            
            On Apr 29, 2004 this sequence version replaced NM_010157.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. The resulting isoform (2)
            lacks an internal segment, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1495              AK054413.1         2-1496
            1496-3308           AK054413.1         1551-3363
FEATURES             Location/Qualifiers
     source          1..3308
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.52 cM"
     gene            1..3308
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /note="estrogen receptor 2 (beta)"
                     /db_xref="GeneID:13983"
                     /db_xref="MGI:MGI:109392"
     exon            1..313
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            314..766
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..1997
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ER-beta; nuclear receptor subfamily 3 group A member 2;
                     estrogen receptor beta; oestrogen receptor beta"
                     /codon_start=1
                     /product="estrogen receptor beta isoform 2"
                     /protein_id="NP_034287.3"
                     /db_xref="CCDS:CCDS25987.1"
                     /db_xref="GeneID:13983"
                     /db_xref="MGI:MGI:109392"
                     /translation="MSICASSHKDFSQLRPTQDMEIKNSPSSLTSPASYNCSQSILPL
                     EHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTS
                     GHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPS
                     AKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRK
                     SCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVHCLNKAKRTSGHTPRVKE
                     LLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKK
                     IPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGI
                     LEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEAESSRKLTHLLN
                     AVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYD
                     LLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ"
     exon            767..939
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1056
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1356
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1495
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1629
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1810
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..3308
                     /gene="Esr2"
                     /gene_synonym="ERbeta; ER[b]; Estrb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttagtcgtg ggcagtcttt gcagcttctc cagctgctgg cccttttgaa aggcactctc
       61 gggtccctgc cttctcccag gcttctagca tcaaccacct cttgaaactt cctgggagta
      121 gaggaggtgg ggagctggcc tggagggagc ggcttgtgcg gccactggca tcccttggca
      181 tccgggtctg cagtagagtc tggcagccgc cgcaggctga gcgacaacca gtggctgcga
      241 gtcccgctca gggaccgagg aaagtacgtg tctgcattta gagaatgcaa aagagagaat
      301 gtccacccgc taggcattcc acctgcccgt gagtctctga gagcatcatg tccatctgtg
      361 cctcttctca caaggatttt tctcagctga gacctacgca agacatggag atcaaaaact
      421 caccatcaag ccttacttcc cctgcttctt ataactgtag ccagtccatc ctacccttgg
      481 agcatggtcc catctatatc ccttcctcct atgtagagag ccgtcacgaa tactcagcca
      541 tgacattcta cagtcctgct gtgatgaact acagtgttcc cagcagcacc ggtaacctgg
      601 aaggtgggcc tgttcgccag actgcaagcc caaatgtgct atggccaact tctggacacc
      661 tctctccttt agccacccac tgccaatcat cgcttctcta tgcagaacct caaaagagtc
      721 cttggtgtga agcaagatca ctagaacaca ccttgcctgt aaacagagag accctgaaga
      781 ggaagcttgg cgggagcggt tgtgccagcc ctgttactag tccaagcgcc aagagggatg
      841 ctcacttctg cgccgtctgc agtgattatg catctgggta tcattacggt gtctggtcct
      901 gtgaaggatg taaggccttt tttaaaagaa gcattcaagg acataatgac tatatctgtc
      961 cagccacgaa tcagtgtacc atagacaaga accggcgtaa aagctgccag gcctgccgac
     1021 ttcgcaagtg ttacgaagta ggaatggtca agtgtggatc caggagagaa aggtgtgggt
     1081 accgaatagt acgaagacag agaagtgcca gcgagcaggt gcattgcctg aacaaagcca
     1141 agagaaccag tgggcacaca ccccgggtga aggagctact gctgaactct ctgagtcccg
     1201 agcagctggt gctcaccctg ctggaagctg agccacccaa tgtgctagtg agccgtccca
     1261 gcatgccctt caccgaggcc tccatgatga tgtccctcac gaagctggct gacaaggaac
     1321 tggtgcacat gattggctgg gccaagaaaa tccctggctt tgtggagctc agcctgttgg
     1381 accaagtccg cctcttggaa agctgctgga tggaggtgct gatggtgggg ctgatgtggc
     1441 gctccatcga ccaccccggc aagctcatct ttgctccaga cctcgttctg gacagggatg
     1501 aggggaagtg cgtggaaggg attctggaaa tctttgacat gctcctggcg acgacggcac
     1561 ggttccgtga gttaaaactg cagcacaaag aatatctgtg tgtgaaggcc atgattctcc
     1621 tcaactccag tatgtacccc ttggctaccg caagccagga agcagagagt agccggaagc
     1681 tgacacacct attgaacgca gtgacagatg ccctggtctg ggtgatttcg aagagtggaa
     1741 tctcttccca gcagcagtca gtccgtctgg ccaacctcct gatgcttctt tctcatgtca
     1801 ggcacatcag taacaagggc atggaacatc tgctcagcat gaagtgcaaa aatgtggtcc
     1861 cggtgtacga cctgctgctg gagatgctga atgctcacac gcttcgaggg tacaagtcct
     1921 caatctcggg gtctgagtgc tgctcgacag aggacagtaa gagcaaagag ggctcccaga
     1981 acctccagtc acagtgacgg ccaggctgga ggcggatgat tacaatgatg gtcagaagtg
     2041 ggacatgtac cctagcatcg tgggcctcac cttagggctg acttggtcac gtacccctta
     2101 cccacgttgc gcttcccagg agtcagggtg gttgggttgt ggtgtcccct gtaccaggac
     2161 ttactgctga atgctgagtt ctaacttgta taaccttaga aggctctcgt tgtactttcc
     2221 atctctttgc ccacttggaa aacatcttaa gagttctgga atgaaaaggt caaagtctga
     2281 cttggaagga ttggccttgg acaggaaaag gaaagtgacg cgatacaccg tctataagaa
     2341 atggactgta gaacggtgtg gtcatcaaat cgacctttga atggtgtctt ctagaccact
     2401 tgattgtagg actgaaaacc acattgacaa tcaactcgtt tcgcattcct acctcacagg
     2461 cctgtgagga ctcatgacgt gtaatgggtt attgtatcaa agaccaagaa gataatggtc
     2521 aagcttggat gtgaccttgt tcctcctcct agatcctctt tcttcctgct tggcttacat
     2581 aactagatta ttcggtctgt ctgaatgtgg tcactgtcac agattaagat ttaaatatct
     2641 ttttaatgtt gagttccttg aagctatgtt ggtgttttct ctctctctct ctctttctca
     2701 gacacacaca cacacagctt caggccttca tagtgtgtct tccattgctg tgaagcgata
     2761 ccatgaccaa ggcaactgtt ttttttttcc caagacttat ttatttcatg tatatgagtg
     2821 cattgtcgct gtcttcagac acaccagaag agggcatcag atcccattat agatggttat
     2881 gagccaccat gtggttgctg ggagttgatc tcaagatctc cggaagagca gaggtcttaa
     2941 ctgctgagac atctctccag ccccaaggca actctttaaa gaacaacatt taattggggc
     3001 tggcttacag tttcagaggt tcagtcctca ttatggccag aagcctggcc gcatccagaa
     3061 gatgtggtgc tggagaaggc gctgagaatt ctacattttg atctgaaggc agccagaaga
     3121 ttggctttgt cttccacagg cagccaggag gaagctctca aaagcccatc gacacagtga
     3181 cacacttcct ccaataaggc catacctatt ctaacaaggc catacctctt aagagtgcca
     3241 cttcccatgg gccaagcata ttcaaaccac catgcacttg aacacattaa aaaaaaaaaa
     3301 gcaccttc
//
