LOCUS       NM_001302531            6218 bp    mRNA    linear   ROD 20-FEB-2024
DEFINITION  Mus musculus estrogen receptor 1 (alpha) (Esr1), transcript variant
            2, mRNA.
ACCESSION   NM_001302531 XM_006512432
VERSION     NM_001302531.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6218)
  AUTHORS   McGlade,E.A., Stephens,K.K., Winuthayanon,S., Anamthathmakula,P.,
            Holtzman,M.J. and Winuthayanon,W.
  TITLE     Classical Estrogen Signaling in Ciliated Epithelial Cells of the
            Oviduct Is Nonessential for Fertility in Female Mice
  JOURNAL   Endocrinology 165 (1) (2023)
   PUBMED   37942801
REFERENCE   2  (bases 1 to 6218)
  AUTHORS   Moors,T.E., Li,S., McCaffery,T.D., Ho,G.P.H., Bechade,P.A.,
            Pham,L.N., Ericsson,M. and Nuber,S.
  TITLE     Increased palmitoylation improves estrogen receptor alpha-dependent
            hippocampal synaptic deficits in a mouse model of synucleinopathy
  JOURNAL   Sci Adv 9 (46), eadj1454 (2023)
   PUBMED   37976363
  REMARK    GeneRIF: Increased palmitoylation improves estrogen receptor
            alpha-dependent hippocampal synaptic deficits in a mouse model of
            synucleinopathy.
REFERENCE   3  (bases 1 to 6218)
  AUTHORS   Wormsbaecher,C., Cumbia,B.M., Amurgis,E.G., Poska,J.M., Price,M.R.,
            Mo,X.M., Knoblaugh,S.E., Kurita,T. and Burd,C.J.
  TITLE     Mammary gland development and EDC-driven cancer susceptibility in
            mesenchymal ERalpha-knockout mice
  JOURNAL   Endocr Relat Cancer 30 (12), e230062 (2023)
   PUBMED   37855322
  REMARK    GeneRIF: Mammary gland development and EDC-driven cancer
            susceptibility in mesenchymal ERalpha-knockout mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6218)
  AUTHORS   Ammari,R., Monaca,F., Cao,M., Nassar,E., Wai,P., Del Grosso,N.A.,
            Lee,M., Borak,N., Schneider-Luftman,D. and Kohl,J.
  TITLE     Hormone-mediated neural remodeling orchestrates parenting onset
            during pregnancy
  JOURNAL   Science 382 (6666), 76-81 (2023)
   PUBMED   37797007
REFERENCE   5  (bases 1 to 6218)
  AUTHORS   de Bournonville,C., Lemoine,P., Foidart,J.M., Arnal,J.F.,
            Lenfant,F. and Cornil,C.A.
  TITLE     Role of membrane estrogen receptor alpha (ERalpha) in the rapid
            regulation of male sexual behavior
  JOURNAL   J Neuroendocrinol 35 (10), e13341 (2023)
   PUBMED   37806316
REFERENCE   6  (bases 1 to 6218)
  AUTHORS   Wu,T.C., Wang,L. and Wan,Y.J.
  TITLE     Expression of estrogen receptor gene in mouse oocyte and during
            embryogenesis
  JOURNAL   Mol Reprod Dev 33 (4), 407-412 (1992)
   PUBMED   1472372
REFERENCE   7  (bases 1 to 6218)
  AUTHORS   Greco,T.L., Furlow,J.D., Duello,T.M. and Gorski,J.
  TITLE     Immunodetection of estrogen receptors in fetal and neonatal female
            mouse reproductive tracts
  JOURNAL   Endocrinology 129 (3), 1326-1332 (1991)
   PUBMED   1874174
REFERENCE   8  (bases 1 to 6218)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
REFERENCE   9  (bases 1 to 6218)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (bases 1 to 6218)
  AUTHORS   White,R., Lees,J.A., Needham,M., Ham,J. and Parker,M.
  TITLE     Structural organization and expression of the mouse estrogen
            receptor
  JOURNAL   Mol Endocrinol 1 (10), 735-744 (1987)
   PUBMED   2484714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB560752.1, AK036627.1,
            DV662355.1, AC156393.12, BB632250.1 and CK334721.1.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_001302531.2.
            
            On Oct 28, 2014 this sequence version replaced XM_006512432.1.
            
            Summary: This gene encodes an estrogen receptor, a member of the
            nuclear hormone family of intracellular receptors. The encoded
            protein, activated by the sex hormone estrogen, is a transcription
            factor composed of several domains important for hormone binding,
            DNA binding, and activation of transcription. Estrogen and its
            receptors are essential for sexual development and reproductive
            function, but also play a role in other tissues such as bone.
            Similar genes in human have been implicated in pathological
            processes including breast cancer, endometrial cancer, and
            osteoporosis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB560752.1, SRR10223970.12161.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2610              AB560752.1         1-2610
            2611-3270           AK036627.1         2585-3244
            3271-3343           DV662355.1         98-170
            3344-3843           AK036627.1         3319-3818
            3844-3844           AC156393.12        77040-77040         c
            3845-4346           AK036627.1         3820-4321
            4347-4833           BB632250.1         143-629
            4834-4844           CK334721.1         133-143
            4845-6218           AC156393.12        74666-76039         c
FEATURES             Location/Qualifiers
     source          1..6218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.03 cM"
     gene            1..6218
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /note="estrogen receptor 1 (alpha)"
                     /db_xref="GeneID:13982"
                     /db_xref="MGI:MGI:1352467"
     exon            1..137
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..672
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2008
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     estradiol receptor; nuclear receptor subfamily 3 group A
                     member 1; C-terminally-truncated estrogen receptor alpha
                     product-5; C-terminally-truncated estrogen receptor alpha
                     product-6; C-terminally-truncated estrogen receptor alpha
                     product-7; C-terminally-truncated estrogen receptor alpha
                     product-4"
                     /codon_start=1
                     /product="estrogen receptor isoform 1"
                     /protein_id="NP_001289460.1"
                     /db_xref="CCDS:CCDS56678.1"
                     /db_xref="GeneID:13982"
                     /db_xref="MGI:MGI:1352467"
                     /translation="MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYV
                     DNSKPTVFNYPEGAAYEFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFP
                     QLNSVSPSPLMLLHPPPQLSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDN
                     RRQNGRERLSSSNEKGNMIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQ
                     GHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRD
                     DLEGRNEMGASGDMRAANLWPSPLVIKHTKKNSPALSLTADQMVSALLDAEPPMIYSE
                     YDPSRPFSEASMMGLLTNLADRELVHMINWAKRVPGFGDLNLHDQVHLLECAWLEILM
                     IGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFV
                     CLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRL
                     AQLLLILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHRLHAPASRMGVPPEE
                     PSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI"
     exon            673..863
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..980
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1316
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1455
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1589
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1773
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..6218
                     /gene="Esr1"
                     /gene_synonym="ER; ER-alpha; ERa; ERalpha; ESR; Estr;
                     Estra; Nr3a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacacgct ctgccttgat cacacaccgc gccactcgat cattcgagca cattccttcc
       61 ttccgtctta ctgtctcagc ccttgacttc tacaaaccca tggaacattt ctggaaagac
      121 gctcttgaac cagcagggtg gcccacgcgc tgctgagccc tctgcgtgcg cggggagcca
      181 gtctgtaact cgccggctgc cacttaccat gaccatgacc cttcacacca aagcctcggg
      241 aatggccttg ctgcaccaga tccaagggaa cgagctggag cccctcaacc gcccgcagct
      301 caagatgccc atggagaggg ccctgggcga ggtatacgtg gacaacagca agcccactgt
      361 gttcaactac cccgagggcg ccgcctacga gttcaacgcc gccgccgccg ccgccgccgc
      421 cgcctcggcg ccggtctacg gccagtcggg catcgcctac ggccccgggt cggaggcggc
      481 cgccttcagt gccaacagcc tgggggcttt cccccagctc aacagcgtgt cgcctagccc
      541 gctgatgctg ctgcacccgc cgccgcagct gtctcctttc ctgcacccgc acggccagca
      601 ggtgccctac tacctggaga acgagcccag cgcctacgcc gtgcgcgaca ccggccctcc
      661 cgccttctac aggtctaatt ctgacaatcg acgccagaat ggccgagaga gactgtccag
      721 cagtaacgag aaaggaaaca tgatcatgga gtctgccaag gagactcgct actgtgccgt
      781 gtgcaatgac tatgcctctg gctaccatta tggggtctgg tcctgcgaag gctgcaaggc
      841 tttctttaag agaagcattc aaggacacaa tgactacatg tgtccagcta caaaccaatg
      901 caccattgac aagaaccgga ggaagagttg ccaggcctgt cggctgcgca agtgttacga
      961 agtgggcatg atgaaaggcg gcatacggaa agaccgccga ggagggagaa tgttgaagca
     1021 caagcgtcag agagatgact tggaaggccg aaatgaaatg ggtgcttcag gagacatgag
     1081 ggctgccaac ctttggccaa gccctcttgt gattaagcac actaagaaga atagccctgc
     1141 cttgtccttg acagctgacc agatggtcag tgccttgttg gatgctgaac cgcccatgat
     1201 ctattctgaa tatgatcctt ctagaccctt cagtgaagcc tcaatgatgg gcttattgac
     1261 caacctagca gatagggagc tggttcatat gatcaactgg gcaaagagag tgccaggctt
     1321 tggggacttg aatctccatg atcaggtcca ccttctcgag tgtgcctggc tggagattct
     1381 gatgattggt ctcgtctggc gctccatgga acacccgggg aagctcctgt ttgctcctaa
     1441 cttgctcctg gacaggaatc aaggtaaatg tgtggaaggc atggtggaga tctttgacat
     1501 gttgctggct acgtcaagtc ggttccgcat gatgaacctg cagggagaag agtttgtgtg
     1561 cctcaaatcc atcattttgc ttaattccgg agtgtacacg tttctgtcca gcaccttgaa
     1621 gtctctggaa gagaaggacc acatccaccg tgtcctggac aagatcacag acactttgat
     1681 ccacctgatg gccaaagctg gcctgactct gcagcagcag catcgccgcc tagctcagct
     1741 ccttctcatt ctttcccata tccggcacat gagtaacaaa ggcatggagc atctctacaa
     1801 catgaaatgc aagaacgttg tgcccctcta tgacctgctc ctggagatgt tggatgccca
     1861 ccgccttcat gccccagcca gtcgcatggg agtgccccca gaggagccca gccagaccca
     1921 gctggccacc accagctcca cttcagcaca ttccttacaa acctactaca tacccccgga
     1981 agcagagggc ttccccaaca cgatctgaga gctcccaggc tccccgaaag gttctgagaa
     2041 tccctgcaac attttaccca tgtcatgtat gactagcaga attctgtctc ctgcgtacac
     2101 tgtggcatgc atccaccacc agtggctttc tagtatgagt ggccatttat ttgcttgctc
     2161 agttcttagt ggcatgtctt ctgttgggaa caggcaaaag ggattccagg gctaaatctt
     2221 ggtaacagct ctctttctcc ctttgctacg tcactaacta tgaggattcc tatagtcttc
     2281 agtcttcatg aatgaattga gataactgca ttgaagctac ttgttgagac ccaagcctag
     2341 agagtaaaca tttcacctct gataagcact tcataatggc tccaagagga agcctcagca
     2401 aagacttcaa agtggctcct ttaattgaag tcgttgacaa agcgatctca tggcttccta
     2461 atagcacccg cttgcattcc tatagcaaca tgtgacttta ttaaagggaa atcttgagcc
     2521 cctataggaa tatgtgatgc acacagaaaa ggaagatgcc cccagttgtc aagaccatgt
     2581 caactcaata cagtcaacct tttcacttct taaagtgtca gctgccgagt attatataca
     2641 tggtgggttc tagacaattc ttgcttccca tgacttgtgg gaaacagaaa gtctatttca
     2701 gttaataccc tggaatgaat tagtctcctt catgagggct gtagggtgtg ttgattttaa
     2761 tttgatttca ttttataata gtcttctgcc cctggggctt gcagtaaagg cagcttgagg
     2821 acctgttctg gtaaactgga cattcttcag cacaggatgc tagccttgtc tcttccctga
     2881 tgtcaattgc cctaaattgt taccatgtag attgatcaag ggcagtcaca atgaacctgc
     2941 aagctggtga caattttttg gtttgtttag ttttattctt gggggcaggg aacaagtaat
     3001 gtatgggcaa tgactgtgac tcggaggagt ctaagaagga aagtaaggga gaaatgtgga
     3061 gaatgacctg gccagggcag cagcttccca gaggtgcacc tcacagatcc caccatgcac
     3121 agtgaggctg ctctgggatc catgggctga cttcacttac atttcaggta tgagcctgat
     3181 tggaagaggt gacatcagat acctgtgttc ctgtagatgc tccaggaact tggggaaagg
     3241 catgggggca agatcttgga gcactcatga ctcaagctgt tgagaagttg ctcagactag
     3301 actgtgcttg attattctga actcatccaa aaaccagcta gtgagatctt ggggagaaaa
     3361 atttcttcct caacacagtt catgatctta aattttgtaa actagaaatg atgaatgacc
     3421 agaattgggt catgagagtc ctttgaacaa ggggataaaa aggaagactt actctatcca
     3481 cagccaccca agacctctgg ggtcttggtc tctctagtac aactaaggat tacttccttt
     3541 tccaaaccaa aatgaaagtt cagtttccat cccggacttc atgatctata atttgaactc
     3601 cattgagata tgatgggtta gccaaaacct aggtgaatgg ctaggcttct cttggcctgt
     3661 actttttgga atggtgggtt ccattaattt ctgctctccc agttaactga ctatcaaaga
     3721 tgtggaaact gggagagcca atttttcttc ttattttttt taaatttctc atacttgttc
     3781 atcaaattca aggacaattt tatgtatatg ctttaagaac atgtttaaga acctaactct
     3841 tttgtttgtg tttaagaagc accttatata gtataatata tatttttgtt gaagtttaat
     3901 tgcttgttta ttggacaatt gaatgtaata gttatgttct gagttttaat ttgattgggt
     3961 ttaacactgc aaaagccaag gggaaaatat ttagtttgtt tttttttttt ttttttgtag
     4021 acgtttcaaa ctaccgtgtc atgtatgcag ttattaatgc ctaaagcctt gtgattttca
     4081 tttaaatgaa gatcacattt cgtatcaact tttgtatcca cagtagacaa aatagaagga
     4141 atccacatgc ctattgctgg gtgttgaatg acagacaatc ttatgtagca gagattatgc
     4201 ctgggaagga aaattattca gggcagctaa ttttgctttt accaaaatat ctgtagtaat
     4261 atttttggac agtagctaat gggtcagtgg gttcttttta atgtttatac tgagattttt
     4321 cttttacaaa aataaaaaca aaaattaaaa aaaaaaacct tctaggactt tagatgatgt
     4381 aataccagct aaatccaaac aatactctag tggagggttt tacattatcc catctactgt
     4441 gtttgtattc atgctatgat aataagtttg aaatgggcaa agaacatcag acagctgaag
     4501 tgttagccca caagtttcaa acaatgtttg gaaatctctt tttaccctta actgaagtgc
     4561 caattttgag cagctgacat ctttcagctg ctatcgtgtt ggagcattgg ggacatgcta
     4621 gagaggctta attgtacttt accctcacct ggaggtaatt taaaatttga atgtcacaat
     4681 ctactcaaag agtcagcatg aggtgggtag ggagatatgg gaatttgaat aacaggtggg
     4741 gaaataggaa tagagagttt aggaattatc ctggcatcct gagtacgccc caggtttcag
     4801 aagttcactt ctgtctgcac tgtaataaag taatactagc tctactggca gccatttcca
     4861 aaatggcaat ttgagttcca aggaagagag tagcggcaac agtgaaatcc aaagaaaaat
     4921 ctagcatggg gtctgcctaa gtttctttta gccattgctt accttgccaa tttgattctg
     4981 gtcatccaaa gaaaagatgc tatcaatgta ggtgacaatg tctagacccc aaggaagttg
     5041 tgtctttgac agatttccct ggtaacattg gagatatgac tttccatgcc atatcttatg
     5101 cctttggggc tgaacaaata agcgacttac tgataatttc tttttaatca catgtcgtgt
     5161 tcatactttg aagtcataca ttgaaaggtc attgtccagc cattggtttg gagttaccca
     5221 tacacctgca tgaagttgat tacaagtctc tttctactca tactttgcaa ctctgagatt
     5281 tactgtggat actgagaatg atcactagga ccatagtaat gtctaatatt cacagtcaga
     5341 cctgcttagg gaacctaagt cttttaaagg caaatagagt catacagtag cacataaggc
     5401 aaccatgact ctctttggta caggtctttg gaggttgatc cagcttacac tgcacacatc
     5461 ctagattaac tccatgaaaa tttactctct tgcaaatgga gcaaacacat ttaactgtgg
     5521 tcccaaatat ccatcttttc attagtgtga atatgctcta tttctagctt catagcctat
     5581 ccatttaaat taaagtgtgg tctcttttaa agtcctttag acttgctttc taagtgatta
     5641 tgtctcaatt tttgcactgt gcttcggaga cttaagagaa atttcccctt tcttttacat
     5701 ccgaatgtgc ctgaactttt tcaaatatgt aaatgctacc atgttccaaa cccatcttta
     5761 gtgtctttgt atggagctgt gcaccctgga aataacacag agtcccagga gcaggtgcct
     5821 gagacatgga cccctttgta gtcacagaga ggtcattggt cgtcgagact tgaattaata
     5881 agtgacatca cgccagttta ttttccttca cagcgtacaa acaacgcttt ctgtgcacta
     5941 catattcttc agtgtagagt tcttgttttt cggggagagg cacagatgcc ccattgtgtt
     6001 ggatggatta ctacaggctt ctgatgcaca ctgctattga tgtgaccccg tttcatcgcc
     6061 gctttgcttt gtttaatgaa acacacgtgt atgcctcttt tgcaccttga aatggtaaag
     6121 aatccagtgg gatgctcaag cccctgtaaa ccatcttctc agcatattca atgttcaaat
     6181 aaaaaataaa ataaaggcag taggttgtgt tattatta
//
