LOCUS       NM_207687               3043 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus espin (Espn), transcript variant 1, mRNA.
ACCESSION   NM_207687 XM_988056
VERSION     NM_207687.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3043)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3043)
  AUTHORS   Feng,S., Wen,H., Liu,K., Xiong,M., Li,J., Gui,Y., Lv,C., Zhang,J.,
            Ma,X., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation
            with PTBP1 and AR, and is essential for male fertility in mice
  JOURNAL   Development 150 (3) (2023)
   PUBMED   36718792
REFERENCE   3  (bases 1 to 3043)
  AUTHORS   Sanders,T.R. and Kelley,M.W.
  TITLE     Specification of neuronal subtypes in the spiral ganglion begins
            prior to birth in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 119 (48), e2203935119 (2022)
   PUBMED   36409884
REFERENCE   4  (bases 1 to 3043)
  AUTHORS   Zheng,L., Adam,S.A., Garcia-Anoveros,J., Mitchell,B.J. and
            Bartles,J.R.
  TITLE     Espin overexpression causes stereocilia defects and provides an
            anti-capping effect on actin polymerization
  JOURNAL   Cytoskeleton (Hoboken) 79 (6-8), 64-74 (2022)
   PUBMED   35844198
  REMARK    GeneRIF: Espin overexpression causes stereocilia defects and
            provides an anti-capping effect on actin polymerization.
REFERENCE   5  (bases 1 to 3043)
  AUTHORS   Garcia-Anoveros,J., Clancy,J.C., Foo,C.Z., Garcia-Gomez,I.,
            Zhou,Y., Homma,K., Cheatham,M.A. and Duggan,A.
  TITLE     Tbx2 is a master regulator of inner versus outer hair cell
            differentiation
  JOURNAL   Nature 605 (7909), 298-303 (2022)
   PUBMED   35508658
REFERENCE   6  (bases 1 to 3043)
  AUTHORS   Martinotti,A., Cariani,C.T., Melani,C., Sozzi,G., Spurr,N.K.,
            Pierotti,M.A. and Colombo,M.P.
  TITLE     Isolation and mapping to 17p12-13 of the human homologous of the
            murine growth arrest specific Gas-3 gene
  JOURNAL   Hum Mol Genet 1 (5), 331-334 (1992)
   PUBMED   1303210
REFERENCE   7  (bases 1 to 3043)
  AUTHORS   Sjostrom,B. and Anniko,M.
  TITLE     Genetically induced inner ear degeneration. A structural and
            functional study
  JOURNAL   Acta Otolaryngol Suppl 493, 141-146 (1992)
   PUBMED   1636414
REFERENCE   8  (bases 1 to 3043)
  AUTHORS   Sjostrom,B. and Anniko,M.
  TITLE     Cochlear structure and function in a recessive type of genetically
            induced inner ear degeneration
  JOURNAL   ORL J Otorhinolaryngol Relat Spec 54 (4), 220-228 (1992)
   PUBMED   1484706
REFERENCE   9  (bases 1 to 3043)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of aldehyde dehydrogenase isozymes in the
            mouse: localization of Ahd-1 encoding the mitochondrial isozyme on
            chromosome 4
  JOURNAL   Biochem Genet 16 (11-12), 1207-1218 (1978)
   PUBMED   751648
REFERENCE   10 (bases 1 to 3043)
  AUTHORS   van Abeelen,J.H.
  TITLE     Behavioural profiles of neurological mutant mice
  JOURNAL   Genetica 37 (2), 149-158 (1966)
   PUBMED   5955164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772240.7.
            
            On Jun 19, 2019 this sequence version replaced NM_207687.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF239886.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AL772240.7         43563-44038         c
            477-670             AL772240.7         40508-40701         c
            671-857             AL772240.7         30688-30874         c
            858-1040            AL772240.7         30385-30567         c
            1041-1172           AL772240.7         30079-30210         c
            1173-1374           AL772240.7         27122-27323         c
            1375-1655           AL772240.7         25810-26090         c
            1656-1688           AL772240.7         24573-24605         c
            1689-1931           AL772240.7         22701-22943         c
            1932-2124           AL772240.7         22418-22610         c
            2125-2151           AL772240.7         21261-21287         c
            2152-2297           AL772240.7         20057-20202         c
            2298-2561           AL772240.7         19718-19981         c
            2562-2641           AL772240.7         15363-15442         c
            2642-2653           AL772240.7         15266-15277         c
            2654-3043           AL772240.7         12525-12914         c
FEATURES             Location/Qualifiers
     source          1..3043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 82.9 cM"
     gene            1..3043
                     /gene="Espn"
                     /gene_synonym="je"
                     /note="espin"
                     /db_xref="GeneID:56226"
                     /db_xref="MGI:MGI:1861630"
     exon            1..476
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2798
                     /gene="Espn"
                     /gene_synonym="je"
                     /note="isoform 1 is encoded by transcript variant 1; actin
                     cytoskeletal regulatory protein; ectoplasmic
                     specialization protein; jerker"
                     /codon_start=1
                     /product="espin isoform 1"
                     /protein_id="NP_997570.1"
                     /db_xref="CCDS:CCDS18989.1"
                     /db_xref="GeneID:56226"
                     /db_xref="MGI:MGI:1861630"
                     /translation="MALEQALQAARRGDLDVLRSLHAAGLLGPSLRDSLDALPVHHAA
                     RSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDN
                     SGATVLHLAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGDLPSLKLLVGH
                     YPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGH
                     NPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEISQDLWGGTPL
                     HDAAENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGHTHCSRYLRTVQTLSLEH
                     RVLSRDQSMDLEAKQLDSGMSSPNTTMSVQPMTFDLGSPTSTFSNYDSCSSSHSSSKG
                     QRSNRGIPGARAADLQSYMDMLNPEKSLPRGKLGKPSPPPPPPPPPPSFPPPPPPTGT
                     QPPPPPPGYPAPNPPVGLHLNNIYMQTKNKLRHVEVDSLKEPKVELNDQFAQPSSGDG
                     HSGLHRQDSGLLRQDSELLHRQELLRHSTGLRRQDSDRKQRSFSKQPSTGDYYRQLGR
                     SPGEPLAARPGMAHSEEAALLPGNHVHNGCSADSKASRELPPPPPPPPLPEALSSPPP
                     APPLPIEGAGAACGQRRSSSSTGKVRVLRHRKSTKSFNMMSPTGDNSELLAEIKAGKS
                     LKPTPQSKGLTTVFSGSGQPASQPESPQPLVSPAPSRTRSPTPPASGSQPLLNGSVVP
                     APPATPAPGVHLDVEALIPTLDEQGRPIPEWKRQVMVRKLQQKMQEEEEQRRKEEEEE
                     ARLASLPAWRRDILRKKLEEEREQKRKEEERQKLEEIQRAKEQSEKLRTLGYDEAKLA
                     PWQRQVILKKGEIPK"
     exon            477..670
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            671..857
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1040
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1172
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1374
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1655
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1688
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1931
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2124
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2151
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2297
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2561
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2641
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2653
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..3043
                     /gene="Espn"
                     /gene_synonym="je"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgctgc agagctggag ttgagtcccc gggatcgcag agccggctgg caggctctct
       61 gcatcccggg tccgcactcc tccgacggct gcacggcgag gttgctcctg gagcctggga
      121 ccacccgcat gacgccccgg ggagcccact gagcgccgga tcgcggcgcc gagggcgaca
      181 ccatggccct ggagcaggcg ctgcaggcgg cacggcgggg cgacctggac gtgctgaggt
      241 ccctgcacgc cgccggcctg ctggggcctt ctctgcgcga ctcgctagac gccctgccgg
      301 tgcaccatgc ggcccgctca ggcaagctgc actgtctgcg ctacttggtg gaggaggttg
      361 ccctcccagc cgtgtcccgc gcgcgcaacg gcgccacacc agcccatgac gccgccgcca
      421 caggctacct ctcttgcctg cagtggctgc tcacacaggg tggctgcagg gtgcaggaaa
      481 aagataactc tggtgccaca gtcctgcatc tggctgcccg ctttggccac ccggatgtgg
      541 tgaagtggct gctgtaccag ggcggtgcaa attcggccat caccacagac acgggcgccc
      601 tgcctatcca ctacgctgcc gccaaaggag acctcccctc gctgaagctt ctggtcgggc
      661 attaccctga gggagtgaat gcccaaacca acaacggtgc cacgcccctg tacctggcgt
      721 gccaggaggg ccacctggaa gtgacgaagt accttgtgca ggagtgcagt gcagatccgc
      781 acctgcgcgc ccaagacggc atgacacccc tacatgccgc agcacagatg ggccacaacc
      841 cagtcttggt gtggctggtg agctttgcag acgttagctt ttcagagcag gaccacgacg
      901 gcgccacggc catgcacttt gctgccagtc gcggccacac caaagtgctc agctggctcc
      961 tgctgcacgg ggcagagatc tcgcaggacc tgtggggcgg aaccccgctg catgacgctg
     1021 ctgagaacgg ggaactggag tgctgccaga tcctcgcggt gaacggcgct gggctggacg
     1081 tccgcgacca cgatgggtac accgctgccg acctggcaga gttcaatggc cacacccact
     1141 gttcccgcta cctacgtacg gtgcaaaccc tgagcttgga acaccgagtc ttgtcccggg
     1201 atcaatccat ggacctggag gcaaagcagc tggactcggg tatgtcctcg cccaacacca
     1261 ccatgtcggt ccagccaatg acctttgacc tgggctcgcc tactagcacg ttctccaact
     1321 atgactcctg ctcctccagt cactccagca gcaaggggca gcgatcgaat cgagggattc
     1381 caggtgcaag agctgcagac ttacagagct acatggacat gctgaaccca gagaagagct
     1441 tgcctcgggg caagctaggg aagccttccc cgccaccacc tccaccacca ccaccaccaa
     1501 gcttcccgcc acccccacca cccacaggca cccagccgcc cccacctcca ccaggctacc
     1561 cagctcccaa tccccctgtg ggactgcatc tgaataacat ttacatgcag accaagaaca
     1621 agcttcgcca tgtggaggtg gactcgctca aggagcccaa ggtggagctg aacgatcagt
     1681 ttgcacagcc gagctcgggc gacggccact cggggctaca caggcaggac tccgggctgc
     1741 tcaggcagga ttcggagctg ctgcacaggc aggagctgct caggcacagc accggactgc
     1801 gcaggcagga ctccgaccgc aaacagcgct cgttcagtaa acagcccagc acgggggact
     1861 actaccgcca gctgggccgc agcccggggg agccgctggc cgcacgcccg ggcatggccc
     1921 acagcgagga ggcggcgctg ctccccggga accacgtgca caacggctgc tcagcggact
     1981 ccaaagcgtc cagggagctg ccgccgccac cgccgccgcc gccgctgccc gaggccctga
     2041 gttcgccgcc gcccgcccca cctctgccca tcgagggcgc gggcgcagcc tgcgggcagc
     2101 gtcgttcctc gtcttctact ggcaaagtga gagtcctgag acacaggaag agcaccaaat
     2161 ctttcaacat gatgtcccca acgggtgata actcagagct tctggctgag ataaaggcgg
     2221 gcaagagcct gaagccgaca ccgcagagca aggggctgac aaccgtgttc tcaggcagtg
     2281 ggcagccagc ctcccagcct gagtcaccgc agcctctggt gtcacctgcg ccatctcgga
     2341 ctcggagccc caccccgcca gcctctgggt ctcagccact gctcaatggc agtgtggtgc
     2401 cggcaccacc tgccaccccg gcacctggag tccatctgga tgtggaggcc ctcattccca
     2461 ctcttgatga gcagggccgg cccatcccgg agtggaagcg ccaggtgatg gtccgcaagc
     2521 tgcagcagaa gatgcaggag gaagaggagc agcggaggaa ggaggaagag gaggaggccc
     2581 ggctcgccag cctgcctgcc tggagacgag acattcttcg gaagaagctg gaggaggaga
     2641 gggagcagaa gcgaaaagag gaggagcggc aaaagctgga ggaaatacag agggcgaaag
     2701 aacagtcgga gaagctgcgg acactaggct acgacgaagc caagctcgcg ccctggcagc
     2761 gacaggtcat cttgaagaag ggggagatcc ctaagtaata ggagtctctc ggcttcttgc
     2821 gtgtagcctc acaagttctg agagatgggg agcggccccc agcccccgcc ccatcctgtc
     2881 aggttggtgc ggaagggcta ggatccttgc cgcccttccc ttcggtgccg gaaccctccc
     2941 aattcccctc cctggcccca catccccaac cctgctgctg gagtgctctc gcaaacccct
     3001 gctgtcgcct ggaaaaaagt gcccaagctg ctgacgcaaa aag
//
