LOCUS       NM_001038500            1049 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus exocrine gland secreted peptide 1 (Esp1), mRNA.
ACCESSION   NM_001038500
VERSION     NM_001038500.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Hattori,T., Osakada,T., Masaoka,T., Ooyama,R., Horio,N., Mogi,K.,
            Nagasawa,M., Haga-Yamanaka,S., Touhara,K. and Kikusui,T.
  TITLE     Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal
            Responsible for the Bruce Effect in Mice
  JOURNAL   Curr Biol 27 (20), 3197-3201 (2017)
   PUBMED   29033330
  REMARK    GeneRIF: The male pheromone exocrine gland-secreting peptide 1
            (ESP1) is one of the key factors that causes pregnancy block.
            Female mice exhibited high pregnancy failure rates upon
            encountering males that secreted different levels of ESP1 compared
            to the mated male.
REFERENCE   2  (bases 1 to 1049)
  AUTHORS   Yoshinaga,S., Sato,T., Hirakane,M., Esaki,K., Hamaguchi,T.,
            Haga-Yamanaka,S., Tsunoda,M., Kimoto,H., Shimada,I., Touhara,K. and
            Terasawa,H.
  TITLE     Structure of the mouse sex peptide pheromone ESP1 reveals a
            molecular basis for specific binding to the class C
            G-protein-coupled vomeronasal receptor
  JOURNAL   J Biol Chem 288 (22), 16064-16072 (2013)
   PUBMED   23576433
  REMARK    GeneRIF: charge-charge interactions determine the specificity of
            ESP1 binding to V2Rp5 in the large extracellular region
            characteristic of class C GPCRs.
REFERENCE   3  (bases 1 to 1049)
  AUTHORS   Karn,R.C. and Laukaitis,C.M.
  TITLE     The roles of gene duplication, gene conversion and positive
            selection in rodent Esp and Mup pheromone gene families with
            comparison to the Abp family
  JOURNAL   PLoS One 7 (10), e47697 (2012)
   PUBMED   23094077
REFERENCE   4  (bases 1 to 1049)
  AUTHORS   Haga,S., Hattori,T., Sato,T., Sato,K., Matsuda,S., Kobayakawa,R.,
            Sakano,H., Yoshihara,Y., Kikusui,T. and Touhara,K.
  TITLE     The male mouse pheromone ESP1 enhances female sexual receptive
            behaviour through a specific vomeronasal receptor
  JOURNAL   Nature 466 (7302), 118-122 (2010)
   PUBMED   20596023
  REMARK    GeneRIF: ESP1 is a crucial male pheromone that regulates female
            reproductive behaviour through a specific receptor in the mouse
            vomeronasal system.
REFERENCE   5  (bases 1 to 1049)
  AUTHORS   Kimoto,H., Sato,K., Nodari,F., Haga,S., Holy,T.E. and Touhara,K.
  TITLE     Sex- and strain-specific expression and vomeronasal activity of
            mouse ESP family peptides
  JOURNAL   Curr Biol 17 (21), 1879-1884 (2007)
   PUBMED   17935991
REFERENCE   6  (bases 1 to 1049)
  AUTHORS   Kimoto,H., Haga,S., Sato,K. and Touhara,K.
  TITLE     Sex-specific peptides from exocrine glands stimulate mouse
            vomeronasal sensory neurons
  JOURNAL   Nature 437 (7060), 898-901 (2005)
   PUBMED   16208374
  REMARK    GeneRIF: identification of a male-specific 7-kDa peptide secreted
            from the extraorbital lacrimal gland; ESP1 is secreted from the
            eyes and is transferred to the female vomeronasal organ, where it
            stimulates pheromone receptor-expressing vomeronasal sensory
            neurons
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135084.4.
            
            On Apr 8, 2010 this sequence version replaced NM_001038500.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB194091.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC135084.4         111647-111729
            84-154              AC135084.4         113351-113421
            155-1049            AC135084.4         115415-116309
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.54 cM"
     gene            1..1049
                     /gene="Esp1"
                     /gene_synonym="EG619517; Gm6084"
                     /note="exocrine gland secreted peptide 1"
                     /db_xref="GeneID:619517"
                     /db_xref="MGI:MGI:3645915"
     exon            1..83
                     /gene="Esp1"
                     /gene_synonym="EG619517; Gm6084"
                     /inference="alignment:Splign:2.1.0"
     exon            84..154
                     /gene="Esp1"
                     /gene_synonym="EG619517; Gm6084"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..394
                     /gene="Esp1"
                     /gene_synonym="EG619517; Gm6084"
                     /note="exocrine gland-secreting peptide 1"
                     /codon_start=1
                     /product="exocrine gland-secreted peptide 1 precursor"
                     /protein_id="NP_001033589.1"
                     /db_xref="CCDS:CCDS28785.1"
                     /db_xref="GeneID:619517"
                     /db_xref="MGI:MGI:3645915"
                     /translation="MTSLPVLLFLIILLLPSMITEGRVLTQTGKEATIFADQKTNHEA
                     DLKNPDPQEVQRALARILCALGELDKLVKDQANAGQQEFKLPKDFTGRSKCRSLGRIK
                     "
     exon            155..1049
                     /gene="Esp1"
                     /gene_synonym="EG619517; Gm6084"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcagcag aagctgacct gaactgatca tatgaaacaa gtaactcctg ctaagtccaa
       61 ggactgtgac aacaagtttt atgtcatgac atcattacca gtgttgttat ttctcataat
      121 tctactgctg ccatccatga tcactgaagg aagggttctg acacagactg gaaaagaagc
      181 taccatattt gctgatcaaa agacaaacca cgaggctgac ttgaaaaacc ctgaccctca
      241 agaagtacaa agagccttgg cgaggatcct ctgtgccctt ggtgaattag acaagttggt
      301 taaagaccag gcaaatgctg gtcaacagga gtttaaactg cctaaagact ttactggccg
      361 gagcaaatgt cgttcactag gaagaatcaa gtgagcacag taaatttcag aattataccc
      421 cctagggttc acaggaccag agttagggac caagggcaat tatataaagc atgacctcta
      481 ccctttagaa aaattcttga acttacggat gtatctgttc actttcacat aggaggctcc
      541 tagtgtcata cctgctgtgg attttaccag gttctctctc aactcctaca tcctatttgg
      601 ttaaccaccc agatataagc aaaatgtagt ctggaaatta atgcaataaa ctagtctctc
      661 ctccctccac ttaaatacta aacgtagcca taggcagcaa agtatgtgtt ctgaaccaga
      721 tgtgaaagca gcaggcatca cttcagaact aatggtctaa ccttcctttt attaaatgca
      781 catgttattt catggcaaac attcttagtg aattcacatg ggtccctcgc tcttccatac
      841 tgtactctga tgaaaagtga gtggaaatgg tttatgtttc aaacaatgaa gctttgtagt
      901 tataaaacat taagcatagt gctttctcta tcttcttgtg gataatttca ttcaagaata
      961 tgatacattt tgattacatc acagactctc ctacttctat ctctcataaa atattaacac
     1021 ttttcccaat aaattactca cctgcttca
//
