LOCUS       NM_023612               2163 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus endothelial cell-specific molecule 1 (Esm1), mRNA.
ACCESSION   NM_023612 XM_906879
VERSION     NM_023612.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Gaudet,A., Zheng,X., Kambham,N. and Bhalla,V.
  TITLE     Esm-1 mediates transcriptional polarization associated with
            diabetic kidney disease
  JOURNAL   Am J Physiol Renal Physiol 326 (6), F1016-F1031 (2024)
   PUBMED   38601985
  REMARK    GeneRIF: Esm-1 mediates transcriptional polarization associated
            with diabetic kidney disease.
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Takasawa,S., Makino,M., Yamauchi,A., Sakuramoto-Tsuchida,S.,
            Hirota,R., Fujii,R., Asai,K., Takeda,Y., Uchiyama,T., Shobatake,R.
            and Ota,H.
  TITLE     Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in
            vascular endothelial cells via the downregulation of microRNA-181a1
  JOURNAL   J Cell Mol Med 28 (1), e18039 (2024)
   PUBMED   37968862
  REMARK    GeneRIF: Intermittent hypoxia increased the expression of ESM1 and
            ICAM-1 in vascular endothelial cells via the downregulation of
            microRNA-181a1.
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Liu,X., Wang,F., Du,W. and Yang,X.
  TITLE     ESM-1 Mediates Cell Progression in Clear Cell Renal Cell Carcinoma
            by Affecting Wnt/beta-Catenin Signalling Pathway
  JOURNAL   Arch Esp Urol 76 (4), 290-297 (2023)
   PUBMED   37455528
  REMARK    GeneRIF: ESM-1 Mediates Cell Progression in Clear Cell Renal Cell
            Carcinoma by Affecting Wnt/beta-Catenin Signalling Pathway.
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Hureau,M., Portier,L., Prin,M., de Nadai,P., Balsamelli,J.,
            Tsicopoulos,A., Mathieu,D., Lassalle,P., Grigoriu,B., Gaudet,A. and
            De Freitas Caires,N.
  TITLE     Evaluation of Endocan as a Treatment for Acute Inflammatory
            Respiratory Failure
  JOURNAL   Cells 12 (2), 257 (2023)
   PUBMED   36672192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Frahm,K.A., Nash,C.P. and Tobet,S.A.
  TITLE     Endocan immunoreactivity in the mouse brain: method for identifying
            nonfunctional blood vessels
  JOURNAL   J Immunol Methods 398-399, 27-32 (2013)
   PUBMED   24055127
  REMARK    GeneRIF: endocan is normally present in the mouse brain and prior
            vascular perfusion with FITC may provide a useful tool for identify
            newly forming blood vessels.
REFERENCE   7  (bases 1 to 2163)
  AUTHORS   Depontieu,F., de Freitas Caires,N., Gourcerol,D., Giordano,J.,
            Grigoriu,B., Delehedde,M. and Lassalle,P.
  TITLE     Development of monoclonal antibodies and ELISA specific for the
            mouse vascular endocan
  JOURNAL   J Immunol Methods 378 (1-2), 88-94 (2012)
   PUBMED   22370430
  REMARK    GeneRIF: Mouse endocan serum level was measured at a median of 0.96
            ng/mL and 1.08 ng/mL in 129Sv mice and C57bl6, respectively.
REFERENCE   8  (bases 1 to 2163)
  AUTHORS   Kisanuki,Y.Y., Emoto,N., Ohuchi,T., Widyantoro,B., Yagi,K.,
            Nakayama,K., Kedzierski,R.M., Hammer,R.E., Yanagisawa,H.,
            Williams,S.C., Richardson,J.A., Suzuki,T. and Yanagisawa,M.
  TITLE     Low blood pressure in endothelial cell-specific endothelin 1
            knockout mice
  JOURNAL   Hypertension 56 (1), 121-128 (2010)
   PUBMED   20516397
  REMARK    GeneRIF: A paracrine vasoregulatory pathway mediated by endothelial
            cell-derived ET-1 acting on the vascular smooth muscle ET(A)
            receptor.
REFERENCE   9  (bases 1 to 2163)
  AUTHORS   Abid,M.R., Yi,X., Yano,K., Shih,S.C. and Aird,W.C.
  TITLE     Vascular endocan is preferentially expressed in tumor endothelium
  JOURNAL   Microvasc Res 72 (3), 136-145 (2006)
   PUBMED   16956626
  REMARK    GeneRIF: Results suggest that endocan (ESM-1)is preferentially
            expressed in tumor endothelium in vivo and that its expression is
            regulated by tumor-derived factors.
REFERENCE   10 (bases 1 to 2163)
  AUTHORS   Cong,R., Jiang,X., Wilson,C.M., Hunter,M.P., Vasavada,H. and
            Bogue,C.W.
  TITLE     Hhex is a direct repressor of endothelial cell-specific molecule 1
            (ESM-1)
  JOURNAL   Biochem Biophys Res Commun 346 (2), 535-545 (2006)
   PUBMED   16764824
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC051919.1.
            
            On or before Aug 8, 2008 this sequence version replaced
            XM_906879.2, NM_023612.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051919.1, BC020038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.93 cM"
     gene            1..2163
                     /gene="Esm1"
                     /gene_synonym="0610042H23Rik; ESM-1"
                     /note="endothelial cell-specific molecule 1"
                     /db_xref="GeneID:71690"
                     /db_xref="MGI:MGI:1918940"
     exon            1..485
                     /gene="Esm1"
                     /gene_synonym="0610042H23Rik; ESM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..739
                     /gene="Esm1"
                     /gene_synonym="0610042H23Rik; ESM-1"
                     /codon_start=1
                     /product="endothelial cell-specific molecule 1 precursor"
                     /protein_id="NP_076101.1"
                     /db_xref="CCDS:CCDS26784.1"
                     /db_xref="GeneID:71690"
                     /db_xref="MGI:MGI:1918940"
                     /translation="MKSLLLLTTLLVPLHLGMAWSAKYAVDCPEHCDKTECRSSLRCK
                     RTVLDDCGCCQVCAAGPGETCYRTVSGMDGVKCGPGLKCHFYSEEDDFGDEFGICKDC
                     PYGTFGMECKETCNCQSGICDRVTGRCLDFPFFQYAAAKSPSRTSASHTERDSASGDG
                     NAVREEIGEGNAARPSVMKWLNPR"
     exon            486..638
                     /gene="Esm1"
                     /gene_synonym="0610042H23Rik; ESM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..2103
                     /gene="Esm1"
                     /gene_synonym="0610042H23Rik; ESM-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esm1"
                     /gene_synonym="0610042H23Rik; ESM-1"
                     /note="hexamer: AATAAA"
     polyA_site      2097
                     /gene="Esm1"
                     /gene_synonym="0610042H23Rik; ESM-1"
                     /note="major polyA site"
ORIGIN      
        1 gaggctggca agagcacagc gctgctgctg ggttgaggaa attgatgacg gggaagcatg
       61 cgggcaacac agtgtataaa actcataacc gtgtaggctg aagctcagct actactttgg
      121 acggctgctt ccctccagca aagaccacga cggcagggag ctgagcagga gccagctgcg
      181 agacatgaag agcctcttgc tgctgaccac actcctggta cctctgcacc tgggcatggc
      241 ctggagcgcc aaatatgcgg tggattgccc ggaacattgt gacaaaactg agtgcagaag
      301 cagcctgcgt tgcaagagga cagtgctgga tgactgtggc tgctgccagg tgtgcgccgc
      361 gggacctgga gaaacctgct accgtacagt ctcaggcatg gacggggtca agtgtggtcc
      421 ggggctgaag tgtcactttt acagcgagga ggatgatttt ggtgacgagt ttggtatctg
      481 caaagactgt ccctatggca ccttcgggat ggaatgcaaa gagacttgca attgccagtc
      541 gggcatatgt gacagggtga ccggaagatg tctggacttt cccttcttcc agtatgcagc
      601 agccaaatct cccagcagga cctctgcctc ccacacagag cgtgactcag catccggaga
      661 tggcaacgct gtgagagaag agattggaga agggaacgct gctcggccct ccgtgatgaa
      721 atggttaaat ccacgctgat cctggctgag atttgccaag agaaggctcc attttagtga
      781 ccaacattca gccaacattt taagaacggt ctagaacata ggctgtggac atgtaattta
      841 tggagatcaa gtgtgattca gaaaaagaat gtaggctaca tacaacccat aagacacata
      901 tgactgaacc cttttaggta tttgctaaat atttaaattc atatagatct gctaagtgtg
      961 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtggtatca ccaaggaact tgagatggcc
     1021 ttgctgtcga tgagtaatcc aatcaaagct gaaggaccga ccggtggttt cattgacctg
     1081 ggtgcacatt cttattgtga tacaggttga agaagagttg ggagcaggag acagtgggat
     1141 cgttgtgaaa gtaggggtta taatatttgt gtcctccttg tagtagttta aaattttttt
     1201 attttgtctt acttggaggc gataaaacaa gaccagaaaa gccttgaagg aagtgagata
     1261 ttggaagctg aacaactgct ttgaatggaa atgctgttat tacagctcct tgtatctgat
     1321 gagaatgggg gcgggcagag gaggtggaca gaggaaagag tatatattat attcccatca
     1381 cttctcatct ctggtttaaa cactgtgggc cttgagacag atgtagaaag tagtttgccc
     1441 tcctgaggga cagaacaggg tgaaggtgaa tatttatgta tttttataaa caaatcttgt
     1501 agtttaaata tttctccagc acccatatgt ctccccatct tagaaaagtt accctaatgt
     1561 tgcttgttta aaatgggttc tcaaatactc atatatggaa aatgtgttat taacaattgc
     1621 actaatagta ataaaatgta gttactccag gtgtataaaa ttttgaaaat ttttttaaat
     1681 gctatatctt gagtgaattt taaatttaaa tcaaaaatta actttttaga cagtttgaga
     1741 aaggaaagtt aactttcatt aggaaatgtg tcagctttaa ggtatagttt attttcattt
     1801 tttaaaattc tttctaactt gattgatgaa tggacctgag tttttacccg gaggacctta
     1861 gcacaagaag aactgttgtc ctgccaatgc tgggagatat ttgcagagta ttttatttgg
     1921 agtgaagaac ttatttaaga agtatttgct tatttcctta tattttattc tcaaaccttg
     1981 ccaacagagt tgtgaatgta ctcgtgggaa gatccgtgaa tgtaagcgca accggctgtt
     2041 aggttttgtc ttaaaagaac ggtgtattat tgttcaataa aaatggcaca gctgttccat
     2101 gttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2161 aaa
//
