LOCUS       NM_016903               1988 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus esterase D/formylglutathione hydrolase (Esd),
            transcript variant 2, mRNA.
ACCESSION   NM_016903
VERSION     NM_016903.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1988)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1988)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1988)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   4  (bases 1 to 1988)
  AUTHORS   Taylor,B.A., Wnek,C., Kotlus,B.S., Roemer,N., MacTaggart,T. and
            Phillips,S.J.
  TITLE     Genotyping new BXD recombinant inbred mouse strains and comparison
            of BXD and consensus maps
  JOURNAL   Mamm Genome 10 (4), 335-348 (1999)
   PUBMED   10087289
REFERENCE   5  (bases 1 to 1988)
  AUTHORS   Sun,H.S., Cai,L., Davis,S.K., Taylor,J.F., Doud,L.K., Bishop,M.D.,
            Hayes,H., Barendse,W., Vaiman,D., McGraw,R.A., Hirano,T.,
            Sugimoto,Y. and Kirkpatrick,B.W.
  TITLE     Comparative linkage mapping of human chromosome 13 and bovine
            chromosome 12
  JOURNAL   Genomics 39 (1), 47-54 (1997)
   PUBMED   9027485
REFERENCE   6  (bases 1 to 1988)
  AUTHORS   Cumming,R.B., Walton,M.F., Fuscoe,J.C., Taylor,B.A., Womack,J.E.
            and Gaertner,F.H.
  TITLE     Genetics of formamidase-5 (brain formamidase) in the mouse:
            localization of the structural gene on chromosome 14
  JOURNAL   Biochem Genet 17 (5-6), 415-431 (1979)
   PUBMED   92985
REFERENCE   7  (bases 1 to 1988)
  AUTHORS   Peters,J. and Nash,H.R.
  TITLE     Esterases of Mus musculus: substrate and inhibition
            characteristics, new isozymes, and homologies with man
  JOURNAL   Biochem Genet 16 (5-6), 553-569 (1978)
   PUBMED   216346
REFERENCE   8  (bases 1 to 1988)
  AUTHORS   Leinwand,L., Fournier,R.E., Nichols,E.A. and Ruddle,F.H.
  TITLE     Assignment of the gene for adenosine kinase to chromosome 14 in Mus
            musculus by somatic cell hybridization
  JOURNAL   Cytogenet Cell Genet 21 (1-2), 77-85 (1978)
   PUBMED   206412
REFERENCE   9  (bases 1 to 1988)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (bases 1 to 1988)
  AUTHORS   Womack,J.E. and Sharp,M.
  TITLE     Comparative autosomal linkage in mammals: genetics of esterases in
            Mus musculus and Rattus norvegicus
  JOURNAL   Genetics 82 (4), 665-675 (1976)
   PUBMED   57899
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010683.1, AC154621.2 and AK163074.1.
            
            On Oct 19, 2013 this sequence version replaced NM_016903.4.
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR,
            lacks an in-frame portion of the 5' coding region and initiates
            translation at a downstream start codon compared to variant 1. The
            resulting isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163074.1, AK010683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AK010683.1         8-28
            22-51               AC154621.2         110755-110784
            52-72               AK010683.1         57-77
            73-657              AK163074.1         1-585
            658-659             AC154621.2         123142-123143
            660-1051            AK163074.1         589-980
            1052-1052           AC154621.2         128266-128266
            1053-1986           AK163074.1         982-1915
            1987-1988           AC154621.2         129201-129202
FEATURES             Location/Qualifiers
     source          1..1988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 39.38 cM"
     gene            1..1988
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /note="esterase D/formylglutathione hydrolase"
                     /db_xref="GeneID:13885"
                     /db_xref="MGI:MGI:95421"
     exon            1..92
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     exon            93..167
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     exon            168..256
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     exon            257..355
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     exon            356..480
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     exon            481..600
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     exon            601..699
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     exon            700..867
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1988
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /note="hexamer: AATAAA"
     regulatory      1057..1062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /note="hexamer: AATATA"
     polyA_site      1071
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
                     /note="major polyA site"
     polyA_site      1081
                     /gene="Esd"
                     /gene_synonym="Es-10; Es10; FGH; sid478"
ORIGIN      
        1 gggacatatg gtgtgggcgg agccagaggc agtgctcggg gcggaagccc caaccttctt
       61 ccctggcgag ttagaagctg cccctcaccg aggaggagaa tggcgctcaa acagatttcc
      121 agcaacaggt gctttggcgg gctccagaaa gttttcgaac atagcagtgt tgagctgaaa
      181 tgtaaaatga gatttgctgt ctacctacca ccccaggccg agagtggaaa gtgtccagcg
      241 ctttactggc tgtctggttt aacttgcaca gaacaaaatt tcatatcaaa gtctggctat
      301 cagcaagctg cctcagagca cggccttgtg gtcattgccc ctgataccag ccctcgtggc
      361 tgcaatatca aaggagaaga tgacagctgg gacttcggca ctggtgctgg gttttatgtg
      421 aatgccactg aagatccttg gaaagctaac tacagaatgt actcttacgt caccgaggag
      481 cttccacaac tcataaatgc caatttccca gtggacccac agaggatgtc tatttttggt
      541 cactccatgg gaggccacgg agctctgatt tgtgctttga aaaatcctgg aaaatacaga
      601 tctgtgtcag catttgctcc aatttgcaac cctgtgctgt gttcttgggg caaaaaagct
      661 tttagtggat atttgggacc agatgaaagt aaatggaagg catacgatgc gacctgtctc
      721 gtgaaggcct attcgggttc ccagattgac atcctaatcg atcaaggaaa agatgacgag
      781 tttctttcaa atgggcagtt actccctgat aacttcatag ctgcctgcac agagaagaaa
      841 atccctgttg tgtttagact acaagagggt tatgatcata gctactactt cattgcaact
      901 ttcatcgctg accacatcag acaccatgct aagtacctga atgcatgaaa agcctcagcc
      961 aagagaatct catcaggagg ccggaaggga atcaacagga gtgctgactt cctcgcagaa
     1021 gatcatgctc ctgcagctga atcgcttttc tgaataaata tatcaaactt tctggtttaa
     1081 attgttattt taccaccatt cacgtaggag tttaatgctt ggtaggtttt ctgagtcatt
     1141 tggaattccc tgttaagtag cctcaagcca tagactgtga ctgcagctct cttggtggtg
     1201 tatgttcaag aacttaaagg gaatttagca caagtttttc atcccatcag acgttaggcc
     1261 actagctctt cttactgcgt acctttctct cctgtctgtc gaggatctga tttctagaag
     1321 gcaatgatgg ccagtcatta agaggatagg gaaacgggca caggagagtc aggcacactg
     1381 tctgtggcag acttcctcag tgctagtcca gttttttctt ccttgatgag ctgaacgcat
     1441 ttgtaaattt tgtttggggg tttgttgagt ctctcaagat tatatagtaa gacccaatct
     1501 gaaaataatg taaggagata aactgtatac tactatcaac aactacttta tcttagttac
     1561 atggagaagt ttttcttagt gagctcacag agaaaagtca ctggtctctg taaataccca
     1621 cactgctccc cgaaaagatc aatagataat gctttttgaa acgtgctaag aagccagttc
     1681 ttctgttaac acaaaggttg tgtcctattt tgccttcctt gtgttttagg gtaaaacacc
     1741 atgactaaaa gcaacataag gaggaaaagg tttatttgtc agtcactgag ggaagtcggg
     1801 gctggtaata gacaagtggg tactccttac tggtttactc tccatgcctt gcttagcctg
     1861 ctttcttaga gtaaccggga ccacattccc aggggcagta ctgccacagt gggctagatc
     1921 ctctcatatc aatcaagaaa agatttgcct aacaggacaa tctaataaag gctaaattct
     1981 gtagctat
//
