LOCUS       NM_028039               2899 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus establishment of sister chromatid cohesion
            N-acetyltransferase 2 (Esco2), mRNA.
ACCESSION   NM_028039 NM_177021
VERSION     NM_028039.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2899)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2899)
  AUTHORS   Hu,J., Yan,J., Chen,Y., Li,X., Yang,L., Di,H., Zhang,H., Shi,Y.,
            Zhao,J., Shi,Y., Xu,Y., Ren,X. and Wang,Z.
  TITLE     ESCO2 promotes hypopharyngeal carcinoma progression in a
            STAT1-dependent manner
  JOURNAL   BMC Cancer 23 (1), 1114 (2023)
   PUBMED   37968576
  REMARK    GeneRIF: ESCO2 promotes hypopharyngeal carcinoma progression in a
            STAT1-dependent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2899)
  AUTHORS   Saygili Demir,C., Sabine,A., Gong,M., Dormond,O. and Petrova,T.V.
  TITLE     Mechanosensitive mTORC1 signaling maintains lymphatic valves
  JOURNAL   J Cell Biol 222 (6) (2023)
   PUBMED   37036444
REFERENCE   4  (bases 1 to 2899)
  AUTHORS   Wang,J., Thomas,H.R., Chen,Y., Percival,S.M., Waldrep,S.C.,
            Ramaker,R.C., Thompson,R.G., Cooper,S.J., Chong,Z. and Parant,J.M.
  TITLE     Reduced sister chromatid cohesion acts as a tumor penetrance
            modifier
  JOURNAL   PLoS Genet 18 (8), e1010341 (2022)
   PUBMED   35994499
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2899)
  AUTHORS   Eugenin von Bernhardi,J. and Dimou,L.
  TITLE     Oligodendrogenesis is a key process for cognitive performance
            improvement induced by voluntary physical activity
  JOURNAL   Glia 70 (6), 1052-1067 (2022)
   PUBMED   35104015
REFERENCE   6  (bases 1 to 2899)
  AUTHORS   Hogarth,C.A., Mitchell,D., Evanoff,R., Small,C. and Griswold,M.
  TITLE     Identification and expression of potential regulators of the
            mammalian mitotic-to-meiotic transition
  JOURNAL   Biol Reprod 84 (1), 34-42 (2011)
   PUBMED   20826732
REFERENCE   7  (bases 1 to 2899)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   8  (bases 1 to 2899)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   9  (bases 1 to 2899)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2899)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY029949.1, CF168369.1, CF730483.1, AA189671.1, AK010391.1,
            AA881675.1 and AV216701.1.
            
            On Mar 27, 2008 this sequence version replaced NM_028039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144685.1, BC071275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY029949.1         27-45
            20-480              CF168369.1         3-463
            481-986             CF730483.1         1-506
            987-1182            AA189671.1         59-254
            1183-1621           AK010391.1         8-446
            1622-2079           AA881675.1         104-561
            2080-2884           AK010391.1         905-1709
            2885-2899           AV216701.1         231-245
FEATURES             Location/Qualifiers
     source          1..2899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.36 cM"
     gene            1..2899
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /note="establishment of sister chromatid cohesion
                     N-acetyltransferase 2"
                     /db_xref="GeneID:71988"
                     /db_xref="MGI:MGI:1919238"
     exon            1..168
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            169..246
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1960
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /EC_number="2.3.1.-"
                     /note="establishment of cohesion 1 homolog 2; ECO1 homolog
                     2"
                     /codon_start=1
                     /product="N-acetyltransferase ESCO2"
                     /protein_id="NP_082315.3"
                     /db_xref="CCDS:CCDS27216.1"
                     /db_xref="GeneID:71988"
                     /db_xref="MGI:MGI:1919238"
                     /translation="MMATCTPRKRKRYTLNADNDDSLLTDISSSKLRCAENLFPSPNK
                     KHNYQSSVQKEDKSCSHQLHFPSSPLKTTENSRFSFANHSSLFKPAMSTVSFYSKEKY
                     YLNPLERKLIRECRSICLATESGDKPIPSVTENIQRKPVCTKKNKKKQKSLTAKYQPN
                     YKHIKSKSRNLKNSKPNQVTYKPVVDQENSCFPAKNYPNSPPRVLSQKIKPQVTLQGG
                     AAFFVRKRNSLKKLPLEDKPLLLQKNLPEVPEGAPEAKQIPKSLLVDEKSSVKVQNAR
                     SKNEEKLRKNPSGAVVSSKECNLDKHDFPSENSLDENKTISPESVYPIFNVSSVNTKR
                     PEEQSSVGSTACTNFLKQTNVPKNINSRDTNKGGKDQLVIDAGQKHFGTTVCKSCGMI
                     YTASNPEDEIQHLQHHHRFLEGIKFVGWKRERVVAEFWDGKIVLVLPRDPSYAIKKVE
                     DVQELVDLELGFQQTVPVCPDKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSASKE
                     CSRAWRCSDVPEPAICGISRIWVFRLKRRKRIARRLVDTVRNCFMFGCFLSTNEIAFS
                     DPTPDGKLFATKYCNTPNFLVYNFHN"
     exon            247..1036
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1127
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1182
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1303
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1435
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1525
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1666
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1827
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2899
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2870..2875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2888
                     /gene="Esco2"
                     /gene_synonym="2410004I17Rik; D030072L07Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtacgcagc agcgttggtc tcaagtagcg cgcgtgaatt tgaacacact ggcggagcgc
       61 cgggttcctg tgagcaaggt cgtaagcttg ctgaggtgca gaggggtcat ttcgtgcggt
      121 acccccgcag gcgtggacgc cggtccagaa ggagactgag gaacgaagga atttaactaa
      181 gatgatggca acttgtactc caagaaagag gaagcgatat acactgaatg ctgataatga
      241 tgatagccta ttaacagata tttcatcaag caaattaaga tgtgctgaaa atctatttcc
      301 atcacctaat aagaaacata attatcaaag cagtgttcaa aaggaagaca agtcttgctc
      361 ccaccaactc catttccctt caagtccact caaaacaact gaaaatagta ggttttcatt
      421 tgcaaaccac agctcattat ttaaaccagc tatgtctact gtatctttct acagtaaaga
      481 gaaatactac ctcaatccac tcgagaggaa gttgataaga gagtgtagat ctatttgtct
      541 agcaactgaa agtggagata aacctattcc cagtgtgaca gaaaatattc agagaaaacc
      601 agtctgtacc aagaagaata aaaaaaaaca gaagagttta actgccaaat atcaaccaaa
      661 ttataagcac atcaagtcta aatcaagaaa cctgaaaaat tccaagccaa atcaagtgac
      721 ctataagcca gttgtggacc aagagaacag ttgttttcca gcaaaaaatt atccaaattc
      781 tcctcctcgg gttctgagcc aaaaaataaa gcctcaagtt acactccaag gcggagcagc
      841 atttttcgtt aggaaaagaa actctcttaa aaagttacct ctggaagata agcccttact
      901 tttgcagaaa aatttaccag aagtccctga aggtgctcca gaggcaaagc aaataccaaa
      961 gtccttgcta gtggatgaga aatccagtgt taaagtacag aatgcaagaa gtaaaaatga
     1021 agagaaactg agaaagaatc cctcaggtgc agtagtttct tcaaaggaat gtaaccttga
     1081 taaacatgat tttccttcag agaattcact tgatgagaac aagacaattt ccccagagtc
     1141 tgtctatccc atcttcaatg tttcttcagt gaacacaaaa agacctgaag aacagtcttc
     1201 tgtgggatcc actgcatgta ctaacttctt gaaacagaca aatgtaccga aaaatattaa
     1261 ttccagagat acaaataaag gaggaaaaga ccagctcgtc attgacgcag gtcagaaaca
     1321 ttttgggacg actgtgtgta agtcttgtgg catgatctat actgcttcca accctgaaga
     1381 cgaaatacaa catctccaac atcaccaccg atttctggaa ggaattaaat tcgtgggctg
     1441 gaaaagagaa cgggtagtag cagagttttg ggatgggaag attgtgttgg tcctgccacg
     1501 tgatccaagt tatgccatca aaaaggtaga agatgtccaa gaacttgtgg atctggaatt
     1561 aggtttccag cagactgttc ccgtgtgtcc agacaaaacc aaaaccttcc tctttattga
     1621 tgagaagaga gtagttggat gtttaattgc agaacccatc aaacaggcct ttcgggtcct
     1681 gtcagaacca agtgccagta aagaatgttc tagagcttgg cggtgttcag atgtaccaga
     1741 acctgcaatt tgtggaataa gtagaatctg ggtcttcaga ctaaaaagaa ggaagcgcat
     1801 tgcaagacga ctggttgaca ctgtcaggaa ttgcttcatg tttggctgtt tcctcagcac
     1861 taatgaaatt gcattttctg acccaacacc agatggcaaa ttatttgcaa ccaagtactg
     1921 caacacccca aatttccttg tatataattt tcataactaa agccaattgt aaccacaaat
     1981 ctggtactat gtgggaaagt tcagctagat agaaactgat taatcgtagc agaatgaaca
     2041 tactaagact gtgcacatgt acatactagt ttttttttct ttatatgtta atttgctgag
     2101 gattgtttgg gattcaaaga aaaaaagatc tttgtatact ttctaaattc ttaattttga
     2161 aaaacttcac agcaagatgg cttttgcaga aactgggctc ctttataagg aatacatgaa
     2221 cacactttta gaccatggtt gtctcatgct ccatcagtag actctaaaca ccggctatga
     2281 gctaactcct gaattcctta tgtagcaacc actttacaag catattgtag cagtcaagtt
     2341 gaaaatactt aaaaagtatt ttgaatttct gatgtgttaa taagatagga attatctcat
     2401 atccatttat ataaaataat tccataatcc cttagaaaat taatcaaaag catacttata
     2461 aagtttaagg ctatttgcca ctgttatctg attttttaaa aaattattac atgaaaatgc
     2521 tggtaggtaa ttgaagtcat gaatcagact aatggaccta agaacataat gaccttatgg
     2581 aatatttgta cacctaaatg cactcagatt ttctgaaatt ggatactagt ttgtaaaaca
     2641 gaaaattcag gttgttctaa tccttagagg tcattaaact gatacctggc atgagacata
     2701 aaggaagagg ggtttttttt tgttttgttt tttgtattat agtttgttgt aaaattggtt
     2761 catctttaat ttgcctgtaa tacttccaaa aatagtgagg aagtatttaa attataatta
     2821 tgcaagcatt ttaatgctat tttctgtaca aaatctcttt aagtgtttta ttaaaagttt
     2881 tactagcatt tcattgttc
//
