LOCUS       NM_001081222            4540 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus establishment of sister chromatid cohesion
            N-acetyltransferase 1 (Esco1), mRNA.
ACCESSION   NM_001081222 XM_484702
VERSION     NM_001081222.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4540)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4540)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (bases 1 to 4540)
  AUTHORS   Ajam,T., De,I., Petkau,N., Whelan,G., Pena,V. and Eichele,G.
  TITLE     Alternative catalytic residues in the active site of Esco
            acetyltransferases
  JOURNAL   Sci Rep 10 (1), 9828 (2020)
   PUBMED   32555289
  REMARK    GeneRIF: Alternative catalytic residues in the active site of Esco
            acetyltransferases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4540)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4540)
  AUTHORS   Lu,Y., Li,S., Cui,Z., Dai,X., Zhang,M., Miao,Y., Zhou,C., Ou,X. and
            Xiong,B.
  TITLE     The cohesion establishment factor Esco1 acetylates alpha-tubulin to
            ensure proper spindle assembly in oocyte meiosis
  JOURNAL   Nucleic Acids Res 46 (5), 2335-2346 (2018)
   PUBMED   29361031
  REMARK    GeneRIF: Esco1 is required for alpha-tubulin acetylation and
            microtubule stability, which thereby ensures normal spindle
            assembly and proper chromosome alignment to orchestrate the mouse
            oocyte meiotic progression.
REFERENCE   6  (bases 1 to 4540)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 4540)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC105947.11
            and AC102441.6.
            
            On Feb 6, 2007 this sequence version replaced XM_484702.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.110093.1,
                                           SRR1660813.6571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AC105947.11        14422-14748         c
            328-430             AC102441.6         3876-3978
            431-2560            AC102441.6         4442-6571
            2561-2672           AC102441.6         11767-11878
            2673-2736           AC102441.6         14276-14339
            2737-2851           AC102441.6         15955-16069
            2852-2983           AC102441.6         18131-18262
            2984-3073           AC102441.6         23227-23316
            3074-3217           AC102441.6         25299-25442
            3218-3405           AC102441.6         28175-28362
            3406-4540           AC102441.6         32671-33805
FEATURES             Location/Qualifiers
     source          1..4540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 5.21 cM"
     gene            1..4540
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /note="establishment of sister chromatid cohesion
                     N-acetyltransferase 1"
                     /db_xref="GeneID:77805"
                     /db_xref="MGI:MGI:1925055"
     exon            1..327
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            328..430
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            431..2560
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             1022..3553
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /note="ECO1 homolog 1; establisment of cohesion 1 homolog
                     1; establishment of cohesion 1 homolog 1"
                     /codon_start=1
                     /product="N-acetyltransferase ESCO1"
                     /protein_id="NP_001074691.1"
                     /db_xref="CCDS:CCDS37737.1"
                     /db_xref="GeneID:77805"
                     /db_xref="MGI:MGI:1925055"
                     /translation="MSIQEKSKENSSIVTKESEDENLEEEVESSQNSPTKKSGSKEAV
                     KTPVRFSNKSKTNESEFGMRMSTRSASCSADKTATNSFNKNTVTLKGQSQESSKTKKL
                     CQEKLSLGILKGNEQLHRRSQRLQQLTECTTRSLRSREIHGQIQTVKQNQQSARREQC
                     NSTQSKCNKVKVNQKHVKRKVLEIKSDCKEDRHSVTNEVINSPKGKKRKVQHQTTSTC
                     SSQCNQGSEKCLQKTSRKEEIKPVPVTADIRKLKAATSVVSKKNELRKSAHTQVSTST
                     KRPQIPLPLVPEHSDDQELEQAGKSKRGSILQLCEEIAGEIESDTVEVKKESSCVESV
                     KEEKPAEVKLQGTDAERQILHHKEANQDVRSNRFFPSRKTKPVKCVLNGINSSTKKNS
                     NWTKIKLSKFNSVQQHKLDSQVSPKLNLLQTGLSTSVLEMPHPVSQSTFLEMKAHGNV
                     TCQRDKMKGIKSEEVKINNIAIEINKATKRDPGNCNLDNHIKPSPDSSLDNQMKLSCE
                     SAPDQNFSICSASEVETNPLENTAAASTLLSQAKIDEDRTFPGSAPNQQHSVLSDEAS
                     INRKNRDVPPNHSQLKHDSHLEITIPKSLKLKDSEKVDEKQLVIDAGHKRFGAVSCNI
                     CGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYAL
                     KKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEK
                     LPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNF
                     IYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNTT"
     exon            2561..2672
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2736
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2851
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2983
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3073
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3217
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3405
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..4540
                     /gene="Esco1"
                     /gene_synonym="A930014I12Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggacgcca gcttgccttc cacccgacgc ccagctgtcg cggccggagt ggaaactgcg
       61 tgacgcgcgg agagcgtggc ggccattttc gtctcctggg cgcgtcagct gagcggcttg
      121 gggcccgaag acaagcgccg cgcaagcgca cccacggcgg cctcaggtaa ctcccatctg
      181 acgggagagg cgtcgccacc gccggaagtt tggtgtttgt gccgcggggc ggcgtcggcc
      241 gccgcagaag cagctgagcg tctccgggta cccggatgtg aggcgacctg cgggctgcag
      301 gagaaccccc ggccgcgcag caggaaggtg ctgtataatg tgttaagaag aggctataag
      361 gaatggtttt atcagatttt cttgagttat ggtggctgaa acatcagttc tatcttgtgg
      421 gaaaagaact aaatggcagc acaaaaggaa atctatatta atagagtact ttactaagcg
      481 aaggagatta aatagaagcc acaaaccaac aaacttggca agcaaggaaa gaaacctgtt
      541 agccataaga catgttacaa attcatcaac atccagtagc tgtagacttc agaagaaaaa
      601 acttttcaga aattttgtca aagcagacag gtcagtgata aataactcct ctagtaatag
      661 ggttaggccg gaaactaatc ataattaaaa caaattggat ctgaatgaag tttattttca
      721 ttaaaaaaat aaaaacttct gaaaacatta aattagaatt ttctgcagat tttcatttcc
      781 ctatccagca gaaagcaagt atctttcaac attcatgcca gcttttctca tgtcttagaa
      841 attgccaaga gcaaaattac ttgaaacaac ctggtatttt tgttggaaat gtacatcagt
      901 ataagttaaa gttgattttt aagatctact ccttagtgac aatactaagt acttagcatc
      961 tgtacctacc tggacacagt cctcaaaaac tcctcagaaa gaaagacatt actcaggaat
     1021 aatgtccatt caggagaaat caaaagaaaa ttcctccata gttactaaag aaagtgaaga
     1081 tgagaattta gaagaagaag ttgaaagttc tcagaacagt ccaacaaaga agtcaggctc
     1141 caaggaagct gtaaagacac cagttagatt ttccaacaaa agtaaaacaa atgagtctga
     1201 atttggaatg cgaatgagta caaggtcagc atcatgttca gctgataaaa ctgctactaa
     1261 ctcctttaat aaaaatacag taactttgaa gggacaatca caagaatctt caaaaacgaa
     1321 gaaattatgt caggaaaaat tatcacttgg aatcttgaaa gggaatgaac agcttcaccg
     1381 cagatcacaa agactacagc agttaacaga gtgtacaacc aggtctttgc gcagtagaga
     1441 gattcatggt caaattcaaa cagttaaaca gaatcagcaa tcagcaagaa gagaacaatg
     1501 taacagtact caaagtaaat gtaataaggt taaggtaaat caaaagcatg tgaaaagaaa
     1561 agtgcttgaa atcaagtctg attgtaagga ggacaggcat tcagttacaa atgaagtaat
     1621 aaattctccc aaaggaaaga agcgcaaagt acagcatcag acaacttcta cttgtagttc
     1681 tcagtgcaac caagggtctg aaaaatgtct ccagaagact agtagaaaag aagaaataaa
     1741 acctgtgcct gtaactgctg atattagaaa attaaaagca gctacttcag tggtctctaa
     1801 aaagaatgaa ctgaggaaat cagctcatac acaagtgagt actagcacaa aacgccccca
     1861 aatcccactg ccactagtgc ctgaacacag tgatgaccag gaattggagc aagctggaaa
     1921 gagcaaaaga ggtagcattc tccaactctg tgaagaaatt gctggtgaaa ttgaatcaga
     1981 tactgtagag gtaaaaaagg aatcatcatg tgtggaaagt gtaaaggagg agaagcctgc
     2041 agaggtaaaa ctgcaaggga ccgatgctga aagacaaata ctccatcata aagaagccaa
     2101 ccaggatgtg cgctctaatc ggttctttcc cagtaggaaa acaaagcctg tgaaatgcgt
     2161 actaaatgga ataaatagct caactaagaa gaactccaac tggactaaaa ttaagctttc
     2221 aaaatttaac tctgtgcagc aacataaatt ggactctcaa gtgtctccta agttgaactt
     2281 attacaaact ggtttgtcaa catcagtttt agaaatgcct catccagtgt cccaaagtac
     2341 atttttagag atgaaagcgc atggtaatgt aacttgccaa cgggataaaa tgaaaggaat
     2401 taaatctgaa gaagttaaaa ttaataatat tgcaattgaa attaataaag ccacaaaaag
     2461 ggatcctgga aattgtaatt tggataacca tattaaaccc tctcctgact catcattgga
     2521 taatcagatg aaactttctt gtgagtcagc accagatcag aatttcagca tatgttcagc
     2581 atctgaggtg gagactaatc cattagaaaa cactgctgct gcctcaactc ttctcagtca
     2641 agctaagatt gatgaggaca gaacatttcc aggttcagct cctaatcagc agcacagtgt
     2701 actcagtgat gaagcgtcta tcaacagaaa gaacagggat gtaccaccaa accattctca
     2761 gctgaagcat gattctcatt tggagataac aattccaaag tccttgaaac tgaaagactc
     2821 agagaaagtg gatgaaaaac agctggtcat agatgcagga cacaaacgat ttggagcagt
     2881 gtcctgtaat atctgtggaa tgctctatac agcttcaaat ccagaagatg aaacacagca
     2941 cctgcttttc cacaaccagt ttataagcgc tgtaaagtat gtgggctgga aaaaggaaag
     3001 aattcttgct gaatatcctg atggtagaat aataatggtt cttcctgaag acccaaagta
     3061 tgccctgaaa aaggttgatg aaattagaga gatggttgac aatgatctgg gtttccaaca
     3121 ggctccattg atgtgctatt ccagaactaa gacacttctc tttatttcta atgacaaaaa
     3181 agtagttggt tgcctaattg cagaacatat ccagtggggc tatcgagtta tagaagagaa
     3241 acttccagtt atcaggtcag aagaagaaaa agtccgattt gaaaggcaaa aagcctggtg
     3301 ctgctcaaca ttgccagagc ctgcaatatg tgggatcagt cggatatggg tgttcagcat
     3361 gatgcggcgg aagaagatag cttctcgcat gattgaatgc ctaaggagta actttattta
     3421 tggctcatat ttgagtaaag aagaaattgc tttctcagat cccactcctg acggaaagct
     3481 gtttgcaaca cagtactgtg gcactggtca gtttctggtc tataatttta tcaatggaca
     3541 gaataccacc tgatagaaat cttacttgtt gtgccagaag acatcttttg aagagaagga
     3601 attggttgct gactttatcc aggaactagg gccatttttt ttacaaatga actcaggact
     3661 ggcaacaacc atatggttgt tccattttca taaaattgga aacaatgcag taatagctta
     3721 ttattgtttt gtttttttaa agaagatatt ttattatctt ttacagaaat ttatgattgt
     3781 attttatcta tagttattta gacatgttta catgcagcag ataattgttc atagtggact
     3841 gaagattaat gcaaggacta tggtctcatt gataagtata ttttgaagtt cttaatatgg
     3901 aaatatacca gtgtagcttg gtactgtatt tttttatatt gatctgctga taccagttat
     3961 aggtttaaag attgtatttt caaaatgaaa accagtgctt ttgagttact attcaaagag
     4021 ggtacagtat tacacactta agaatttgaa gttactaaag tgtactctta agtatacccc
     4081 acagaaaagg agagctccaa gtgaaaggac ttgtataata gcaagtgtct ccattgctta
     4141 tgtttctgag actgatggtg gaaaggtctc tcctgtgggg agccataaat gactagagtc
     4201 acaaagaact acagaatagt tgtaaactaa atgtggacgg cttggtatct gcgttgttat
     4261 tcctcagaaa tactgcactg agtatacgcc ctcattactg gacttcatct tgatacttgt
     4321 ctgtccttca tagtgccctc tacttttaaa gggttatatg tcgaaaaact gctgtggcct
     4381 tttatgacct gtatataatg tagaataaaa taataaaata cttgatagct ttttctaagt
     4441 gataaatgta cttgatacaa tgttatattg aatgtttgta ccctttcagg gagtttcttt
     4501 ggtttgggac tgaaataaga ttaaaacaca ggcttcttaa
//
