LOCUS       NM_027102               1859 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus endothelial cell-specific adhesion molecule (Esam),
            transcript variant 1, mRNA.
ACCESSION   NM_027102
VERSION     NM_027102.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1859)
  AUTHORS   Buncha,V., Lang,L., Fopiano,K.A., Ilatovskaya,D.V., Kapuku,G.,
            Verin,A.D. and Bagi,Z.
  TITLE     Endothelial cell-selective adhesion molecule deficiency exhibits
            increased pulmonary vascular resistance due to impaired endothelial
            nitric oxide signaling
  JOURNAL   Am J Physiol Heart Circ Physiol 328 (2), H283-H293 (2025)
   PUBMED   39740345
REFERENCE   2  (bases 1 to 1859)
  AUTHORS   Sulczewski,F.B., Maqueda-Alfaro,R.A., Alcantara-Hernandez,M.,
            Perez,O.A., Saravanan,S., Yun,T.J., Seong,D., Arroyo Hornero,R.,
            Raquer-McKay,H.M., Esteva,E., Lanzar,Z.R., Leylek,R.A., Adams,N.M.,
            Das,A., Rahman,A.H., Gottfried-Blackmore,A., Reizis,B. and
            Idoyaga,J.
  TITLE     Transitional dendritic cells are distinct from conventional DC2
            precursors and mediate proinflammatory antiviral responses
  JOURNAL   Nat Immunol 24 (8), 1265-1280 (2023)
   PUBMED   37414907
  REMARK    GeneRIF: Transitional dendritic cells are distinct from
            conventional DC2 precursors and mediate proinflammatory antiviral
            responses.
REFERENCE   3  (bases 1 to 1859)
  AUTHORS   Kazenwadel,J., Venugopal,P., Oszmiana,A., Toubia,J.,
            Arriola-Martinez,L., Panara,V., Piltz,S.G., Brown,C., Ma,W.,
            Schreiber,A.W., Koltowska,K., Taoudi,S., Thomas,P.Q., Scott,H.S.
            and Harvey,N.L.
  TITLE     A Prox1 enhancer represses haematopoiesis in the lymphatic
            vasculature
  JOURNAL   Nature 614 (7947), 343-348 (2023)
   PUBMED   36697821
REFERENCE   4  (bases 1 to 1859)
  AUTHORS   Takahashi,S., Nobuhisa,I., Saito,K., Gerel,M., Itabashi,A.,
            Harada,K., Osawa,M., Endo,T.A., Iwama,A. and Taga,T.
  TITLE     Sox17-mediated expression of adherent molecules is required for the
            maintenance of undifferentiated hematopoietic cluster formation in
            midgestation mouse embryos
  JOURNAL   Differentiation 115, 53-61 (2020)
   PUBMED   32891959
  REMARK    GeneRIF: Sox17-mediated expression of adherent molecules is
            required for the maintenance of undifferentiated hematopoietic
            cluster formation in midgestation mouse embryos.
REFERENCE   5  (bases 1 to 1859)
  AUTHORS   Duong,C.N., Nottebaum,A.F., Butz,S., Volkery,S., Zeuschner,D.,
            Stehling,M. and Vestweber,D.
  TITLE     Interference With ESAM (Endothelial Cell-Selective Adhesion
            Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate
            Lethality and Lung-Specific Blood Coagulation
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (2), 378-393 (2020)
   PUBMED   31826650
REFERENCE   6  (bases 1 to 1859)
  AUTHORS   Wegmann,F., Ebnet,K., Du Pasquier,L., Vestweber,D. and Butz,S.
  TITLE     Endothelial adhesion molecule ESAM binds directly to the
            multidomain adaptor MAGI-1 and recruits it to cell contacts
  JOURNAL   Exp Cell Res 300 (1), 121-133 (2004)
   PUBMED   15383320
  REMARK    GeneRIF: The direct interaction between ESAM and MAGI-1 was
            confirmed by pull-down experiments. The two proteins formed stable
            complexes in transfected CHO cells.
REFERENCE   7  (bases 1 to 1859)
  AUTHORS   Ishida,T., Kundu,R.K., Yang,E., Hirata,K., Ho,Y.D. and
            Quertermous,T.
  TITLE     Targeted disruption of endothelial cell-selective adhesion molecule
            inhibits angiogenic processes in vitro and in vivo
  JOURNAL   J Biol Chem 278 (36), 34598-34604 (2003)
   PUBMED   12819200
  REMARK    GeneRIF: ESAM has a redundant functional role in physiological
            angiogenesis but serves a unique and essential role in pathological
            angiogenic processes such as tumor growth
REFERENCE   8  (bases 1 to 1859)
  AUTHORS   Nasdala,I., Wolburg-Buchholz,K., Wolburg,H., Kuhn,A., Ebnet,K.,
            Brachtendorf,G., Samulowitz,U., Kuster,B., Engelhardt,B.,
            Vestweber,D. and Butz,S.
  TITLE     A transmembrane tight junction protein selectively expressed on
            endothelial cells and platelets
  JOURNAL   J Biol Chem 277 (18), 16294-16303 (2002)
   PUBMED   11847224
  REMARK    GeneRIF: selectively expressed on endothelial cells and platelets;
            might be involved in interendothelial cell adhesion
REFERENCE   9  (bases 1 to 1859)
  AUTHORS   Hirata,Ki., Ishida,T., Penta,K., Rezaee,M., Yang,E., Wohlgemuth,J.
            and Quertermous,T.
  TITLE     Cloning of an immunoglobulin family adhesion molecule selectively
            expressed by endothelial cells
  JOURNAL   J Biol Chem 276 (19), 16223-16231 (2001)
   PUBMED   11279107
REFERENCE   10 (bases 1 to 1859)
  AUTHORS   Chretien,I., Marcuz,A., Courtet,M., Katevuo,K., Vainio,O.,
            Heath,J.K., White,S.J. and Du Pasquier,L.
  TITLE     CTX, a Xenopus thymocyte receptor, defines a molecular family
            conserved throughout vertebrates
  JOURNAL   Eur J Immunol 28 (12), 4094-4104 (1998)
   PUBMED   9862345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY119695.1, CJ048383.1, BQ043033.1, BG077536.2, AK009223.1 and
            AI414314.1.
            
            On Aug 15, 2009 this sequence version replaced NM_027102.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156399.1, BC049249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY119695.1         1-19
            20-459              CJ048383.1         2-441
            460-566             BQ043033.1         401-507
            567-1154            BG077536.2         1-588
            1155-1841           AK009223.1         1130-1816
            1842-1859           AI414314.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.77 cM"
     gene            1..1859
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /note="endothelial cell-specific adhesion molecule"
                     /db_xref="GeneID:69524"
                     /db_xref="MGI:MGI:1916774"
     exon            1..202
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1317
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /note="endothelial cell-selective adhesion molecule"
                     /codon_start=1
                     /product="endothelial cell-selective adhesion molecule
                     precursor"
                     /protein_id="NP_081378.1"
                     /db_xref="CCDS:CCDS22979.1"
                     /db_xref="GeneID:69524"
                     /db_xref="MGI:MGI:1916774"
                     /translation="MILQAGTPETSLLRVLFLGLSTLAAFSRAQMELHVPPGLNKLEA
                     VEGEEVVLPAWYTMAREESWSHPREVPILIWFLEQEGKEPNQVLSYINGVMTNKPGTA
                     LVHSISSRNVSLRLGALQEGDSGTYRCSVNVQNDEGKSIGHSIKSIELKVLVPPAPPS
                     CSLQGVPYVGTNVTLNCKSPRSKPTAQYQWERLAPSSQVFFGPALDAVRGSLKLTNLS
                     IAMSGVYVCKAQNRVGFAKCNVTLDVMTGSKAAVVAGAVVGTFVGLVLIAGLVLLYQR
                     RSKTLEELANDIKEDAIAPRTLPWTKGSDTISKNGTLSSVTSARALRPPKAAPPRPGT
                     FTPTPSVSSQALSSPRLPRVDEPPPQAVSLTPGGVSSSALSRMGAVPVMVPAQSQAGS
                     LV"
     exon            203..390
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /inference="alignment:Splign:2.1.0"
     exon            391..592
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /inference="alignment:Splign:2.1.0"
     exon            593..748
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /inference="alignment:Splign:2.1.0"
     exon            749..871
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /inference="alignment:Splign:2.1.0"
     exon            872..998
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1854
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="Esam"
                     /gene_synonym="2310008D05Rik; Esam1; W117m"
                     /note="major polyA site"
ORIGIN      
        1 gctgacttgg gttggagcca ccctggtcag tagcctggtt cctgtgcaca ttcgggttgc
       61 cgccgctcac ccacaacacc tgtagacacc gtgtgtccaa ctctccctga gtactccggg
      121 ccaaggaggg ccatgattct tcaggctgga acccccgaga ccagcttgct gcgggttttg
      181 ttcctgggac tgagtaccct tgctgccttc tcccgagctc agatggagtt gcacgtgccc
      241 ccgggcctca acaaattgga agcggtagag ggagaagaag tggtgctccc cgcctggtac
      301 acgatggcac gggaggagtc gtggtcccac ccccgggagg tgcccatcct gatctggttc
      361 ttggaacaag aagggaagga accaaaccag gtgttgtctt acattaatgg agtcatgaca
      421 aataaacctg gaacagccct ggtccactct atctcttcac ggaatgtgtc cctgcgcctg
      481 ggggcactcc aggagggaga ctctgggact taccgctgtt ctgtcaatgt gcagaatgat
      541 gaaggcaaaa gtataggcca cagcatcaaa agcatagagc tcaaagtgct ggttcctcca
      601 gctcctccat cctgtagttt acagggtgta ccctatgtcg ggaccaatgt gaccctgaac
      661 tgcaagtccc caaggagtaa acctactgct cagtaccagt gggagaggct ggccccatcc
      721 tcccaggtct tctttggacc agccttagat gctgttcgtg gatctttaaa gctcactaac
      781 ctttccattg ccatgtctgg agtctatgtc tgcaaggctc aaaacagagt gggctttgcc
      841 aagtgcaacg tgaccttgga cgtgatgaca gggtccaagg ctgcagtggt cgctggagca
      901 gttgtgggca cttttgttgg gttggtgctg atagctgggc tggtcctgtt gtaccagcgc
      961 cggagcaaga ccttggaaga gctggccaat gatatcaagg aagatgccat tgctccccgg
     1021 accttgcctt ggaccaaagg ctcagacaca atctccaaga atgggacact ttcttcggtc
     1081 acctcagcac gagctctgcg gccacccaag gctgctcctc caagacctgg cacatttact
     1141 cccacaccca gtgtctctag ccaggccctg tcctcaccaa gactgcccag ggtagatgaa
     1201 cccccacctc aggcagtgtc cctgacccca ggtggggttt cttcttctgc tctgagccgc
     1261 atgggtgctg tgcctgtgat ggtgcctgca cagagtcagg ctgggtctct tgtgtgatag
     1321 cccaggcact cattagctac atctggtatc tgacctttct gtaaaggtct ccttgtggca
     1381 cagaggactc aatcttggga ggatgcccac attctagacc tccagtcctt tgctcctacc
     1441 tccttctatt gttggaatac tgggcctcag taagactaaa atctgggtca aaggacaaaa
     1501 ggaggaaatg gacctgaggt agggggttgg gagtgaggag gcttcacttc ctccctgctt
     1561 ctccctgaag ccagatgaat gctgcggaag atcggctacc ctccaagggc tctggaggag
     1621 actgccagtc agtgatgccc ctggctctgt gatctgtaca acacccttat ctaatgctgt
     1681 cctttgccgt tcgctccatc tccctgtatt aatataacct gtcctgctgg cttggctggg
     1741 ttttgttgta gcagggggat aggaaagaca ttttaaaatc tgacttgaaa ttgatgtttt
     1801 tgtttttatt ttgcaaattt caataaagat acatcgcatt tgcatggaca agaaaaaaa
//
