LOCUS       NM_133753               3065 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus ERBB receptor feedback inhibitor 1 (Errfi1),
            transcript variant 2, mRNA.
ACCESSION   NM_133753
VERSION     NM_133753.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Zhao,H. and Mao,H.
  TITLE     ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting
            hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner
  JOURNAL   Mol Med 30 (1), 82 (2024)
   PUBMED   38862918
  REMARK    GeneRIF: ERRFI1 exacerbates hepatic ischemia reperfusion injury by
            promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Yoo,J.Y., Kim,T.H., Shin,J.H., Marquardt,R.M., Muller,U.,
            Fazleabas,A.T., Young,S.L., Lessey,B.A., Yoon,H.G. and Jeong,J.W.
  TITLE     Loss of MIG-6 results in endometrial progesterone resistance via
            ERBB2
  JOURNAL   Nat Commun 13 (1), 1101 (2022)
   PUBMED   35232969
  REMARK    GeneRIF: Loss of MIG-6 results in endometrial progesterone
            resistance via ERBB2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3065)
  AUTHORS   Choung,S., Kim,J.M., Joung,K.H., Kim,H.J., Kang,S.M., Jeong,J.W.
            and Ku,B.J.
  TITLE     Mig-6 is essential for glucose homeostasis and thermogenesis in
            brown adipose tissue
  JOURNAL   Biochem Biophys Res Commun 572, 92-97 (2021)
   PUBMED   34358969
  REMARK    GeneRIF: Mig-6 is essential for glucose homeostasis and
            thermogenesis in brown adipose tissue.
REFERENCE   4  (bases 1 to 3065)
  AUTHORS   Denkena,J., Zaisser,A., Merz,B., Klinger,B., Kuhl,D., Bluthgen,N.
            and Hermey,G.
  TITLE     Neuronal activity regulates alternative exon usage
  JOURNAL   Mol Brain 13 (1), 148 (2020)
   PUBMED   33172478
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3065)
  AUTHORS   Liu,J., Wang,T., Creighton,C.J., Wu,S.P., Ray,M., Janardhan,K.S.,
            Willson,C.J., Cho,S.N., Castro,P.D., Ittmann,M.M., Li,J.L.,
            Davis,R.J. and DeMayo,F.J.
  TITLE     JNK1/2 represses Lkb1-deficiency-induced lung squamous cell
            carcinoma progression
  JOURNAL   Nat Commun 10 (1), 2148 (2019)
   PUBMED   31089135
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3065)
  AUTHORS   Pante,G., Thompson,J., Lamballe,F., Iwata,T., Ferby,I., Barr,F.A.,
            Davies,A.M., Maina,F. and Klein,R.
  TITLE     Mitogen-inducible gene 6 is an endogenous inhibitor of
            HGF/Met-induced cell migration and neurite growth
  JOURNAL   J Cell Biol 171 (2), 337-348 (2005)
   PUBMED   16247031
  REMARK    GeneRIF: The Mitogen-inducible gene 6 negatively regulates
            HGF/Met-induced cell migration.
REFERENCE   7  (bases 1 to 3065)
  AUTHORS   Zhang,Y.W., Su,Y., Lanning,N., Swiatek,P.J., Bronson,R.T.,
            Sigler,R., Martin,R.W. and Vande Woude,G.F.
  TITLE     Targeted disruption of Mig-6 in the mouse genome leads to early
            onset degenerative joint disease
  JOURNAL   Proc Natl Acad Sci U S A 102 (33), 11740-11745 (2005)
   PUBMED   16087873
  REMARK    GeneRIF: loss of Mig-6 leads to early onset of joint disease
REFERENCE   8  (bases 1 to 3065)
  AUTHORS   Ballaro,C., Ceccarelli,S., Tiveron,C., Tatangelo,L.,
            Salvatore,A.M., Segatto,O. and Alema,S.
  TITLE     Targeted expression of RALT in mouse skin inhibits epidermal growth
            factor receptor signalling and generates a Waved-like phenotype
  JOURNAL   EMBO Rep 6 (8), 755-761 (2005)
   PUBMED   16007071
  REMARK    GeneRIF: RALT behaves as a suppressor of EGFR signalling in mouse
            skin
REFERENCE   9  (bases 1 to 3065)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   10 (bases 1 to 3065)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB870611.1, AK166791.1 and BP754554.1.
            
            On Sep 29, 2017 this sequence version replaced NM_133753.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004851.1, AK166791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BB870611.1         3-5
            4-3046              AK166791.1         2-3044
            3047-3065           BP754554.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 81.5 cM"
     gene            1..3065
                     /gene="Errfi1"
                     /gene_synonym="1300002F13Rik; Mig-6; Mig6; RALT"
                     /note="ERBB receptor feedback inhibitor 1"
                     /db_xref="GeneID:74155"
                     /db_xref="MGI:MGI:1921405"
     exon            1..202
                     /gene="Errfi1"
                     /gene_synonym="1300002F13Rik; Mig-6; Mig6; RALT"
                     /inference="alignment:Splign:2.1.0"
     exon            203..397
                     /gene="Errfi1"
                     /gene_synonym="1300002F13Rik; Mig-6; Mig6; RALT"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1661
                     /gene="Errfi1"
                     /gene_synonym="1300002F13Rik; Mig-6; Mig6; RALT"
                     /note="mitogen-inducible gene 6 protein homolog"
                     /codon_start=1
                     /product="ERBB receptor feedback inhibitor 1"
                     /protein_id="NP_598514.1"
                     /db_xref="CCDS:CCDS18974.1"
                     /db_xref="GeneID:74155"
                     /db_xref="MGI:MGI:1921405"
                     /translation="MSTAGVAAQDIRVPLKTGFLHNGQALGNMKSCWGSHSEFENNFL
                     NIDPITMAYNLNSPAQEHLTTVGCAARSAPGSGHFFAECGPSPRSSLPPLVISPSESS
                     GQREEDQVMCGFKKLSVNGVCTSTPPLTPIKSCPSPFPCAALCDRGSRPLPPLPISED
                     LCVDEADSEVELLTTSSDTDLLLEDSAPSDFKYDAPGRRSFRGCGQINYAYFDSPTVS
                     VADLSCASDQNRVVPDPNPPPPQSHRRLRRSHSGPAGSFNKPAIRISSCTHRASPSSD
                     EDKPEVPPRVPIPPRPAKPDYRRWSAEVTSNTYSDEDRPPKVPPREPLSRSNSRTPSP
                     KSLPSYLNGVMPPTQSFAPDPKYVSSKALQRQSSEGSANKVPCILPIIENGKKVSSTH
                     YYLLPERPPYLDKYEKYFKEAEETNPSTQIQPLPAACGMASATEKLASRMKIDMGSHG
                     KRKHLSYVVSP"
     exon            398..474
                     /gene="Errfi1"
                     /gene_synonym="1300002F13Rik; Mig-6; Mig6; RALT"
                     /inference="alignment:Splign:2.1.0"
     exon            475..3048
                     /gene="Errfi1"
                     /gene_synonym="1300002F13Rik; Mig-6; Mig6; RALT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Errfi1"
                     /gene_synonym="1300002F13Rik; Mig-6; Mig6; RALT"
                     /note="hexamer: AATAAA"
     polyA_site      3048
                     /gene="Errfi1"
                     /gene_synonym="1300002F13Rik; Mig-6; Mig6; RALT"
                     /note="major polyA site"
ORIGIN      
        1 gtcggcggcc gagtgcgagg cgcggagcgt gagctgtgcg agcgagcgag cgcgagcata
       61 gcctgcgagc gagcagagag aaagagcgag ggcaagagag cggcgaggcg cctgcgcgat
      121 gctcgggccc ctaagcccgc ggcgctgagc cagccgggac ggacatgcgc gggagggcgc
      181 cgcggggtcc cgctcccttg ggggaatgaa agctactggt tgacttaaaa acacctgggc
      241 tttacaaatt tgaaggcatc ccagagtggg gcacaatgtc aacagcagga gttgctgctc
      301 aggatattcg agtcccatta aaaactggat ttctccataa tggtcaggcc ttggggaata
      361 tgaagtcctg ctggggcagt cacagtgagt ttgaaaataa ctttttaaat attgatccaa
      421 taaccatggc ctacaatctg aactcccctg ctcaggagca cctaacaact gttggatgtg
      481 ctgctcggtc tgctccaggg agcggccact tctttgcaga gtgtggtcca tctccaaggt
      541 caagcttgcc ccctcttgtt atctcaccaa gtgaaagctc gggacagcgt gaagaggatc
      601 aagttatgtg tggttttaag aaactctcag tgaatggggt ctgcacttcc acacctccac
      661 ttacacccat taaaagctgc ccttcccctt tcccctgtgc ggctctgtgt gatcggggtt
      721 ctcggccgct cccgccactg cccatctctg aagacctatg tgtggatgag gccgacagtg
      781 aggtagagct tctaaccacc agctcagaca cagacttgct tttagaagac tctgcgcctt
      841 cagatttcaa atacgatgct cctggcaggc gcagcttccg tgggtgcggc cagatcaact
      901 atgcatattt tgacagccca actgtttctg tggcagatct tagctgtgca tctgaccaga
      961 acagagttgt tccagaccca aaccctcccc cacctcaaag ccatcgcaga ttaaggaggt
     1021 ctcactcagg accagctggg tcatttaaca agccagccat tcggatatct agctgcacac
     1081 acagagcttc tcctagctct gatgaagaca agcctgaggt ccctcccagg gttcctatac
     1141 ctcctaggcc agcaaagcca gactatagac ggtggtcagc agaagtgacc tccaacacct
     1201 acagtgatga agataggcct cccaaagtcc ccccgagaga acctttgtct cggagtaact
     1261 cccgtacccc aagtcctaaa agccttccgt cttacctcaa tggggtcatg cccccaacac
     1321 agagcttcgc tcctgacccc aagtatgtca gcagcaaagc cctgcagaga cagagcagcg
     1381 aaggatctgc caacaaggtt ccttgcatcc tgcccattat tgaaaatggg aagaaggtta
     1441 gctcaacgca ttattactta ctacctgaga ggccaccgta cctggacaaa tatgaaaagt
     1501 attttaagga agcagaagaa acaaacccaa gcacccaaat tcagccatta cctgctgcct
     1561 gtggtatggc ctctgccaca gaaaagctgg cctccagaat gaaaatagat atgggtagcc
     1621 acgggaagcg caaacactta tcctacgtgg tttctccata aatatggggg tcatgattca
     1681 acagaagtta catgggatga atggctccca gttttccagt ttgaggttcg tagaacaatg
     1741 tcaagtggca aaatgaagtt ggtggactcc gccttaatga gaaaggctta gagcagttat
     1801 gaggtgctgt tatgctggga gtccctgatc tatcagcata ggagaaaaaa gtatgattta
     1861 aagatgtgct agggggaggg aaaaatgggc aacttttaca tttgactaca ttatatacct
     1921 atgtataaaa gtgcggtgta accatagacc atagctgcag gataaccaat tagtcactct
     1981 tagagtaatc tgtattcaga acaattcaaa caagctggag gaacagctcc tgatagtgtg
     2041 agaattgagc aaatgggaga aagcaatatt gttagatcag attataaatt tgttaagttt
     2101 aaagattcct ggcatacagg cctgctctat aaatttgttt tccccttccc tgccagcagt
     2161 cttctccata cacgacaggg cgtgttctcc accaggcctg taacatcttg ttgagatcat
     2221 ttctatggcc caatacttgt cgctctgggg ttttgtcttg ttgaggagag gacagcagtt
     2281 tctggaccat gttatcacct gtgtgtgtct catatcttgg aaattgacag atttggtgaa
     2341 taacttttcc atactattcc tgcttttccc atccactgaa acagcctgtt gtagcaagag
     2401 gctttcaaga gtgcagtgga gttgcgctgg ccatcagtgt ttggggtctg agtttgatag
     2461 actagtgcag cgatcagcca tatgattgag agctactttg gggatatatg gtacgttgtt
     2521 tttgtttttt agacttaata aaggacaaca cgagctggtc ttgtgttgct ggttcctatt
     2581 cagtatttcc tggggattgt ttgcttttta agtgaaacac ttctgaccaa tagcacagaa
     2641 cgtcttaatg ccagaggtca cttcagcatc ttcctgcttt gaaaactcac gctggctgct
     2701 tcactgccct gagattcagt gagacacgca gtttgtgttc agtttttaca tcctctgatt
     2761 gtttatcttg tgcagataaa cacaaagaga aggtgcttgc tagcagggac actgctgcca
     2821 tgtcccaaca agctgttcag tttaaactgc tgaatgacat tatttgagct atttaaagct
     2881 tactttagta tgaactaaat gaaggttaaa acatgcttta gaaaaatgca ctgatctccg
     2941 cactgtgtgt acagtattgg acaaaggatt tattcatttt gttgcattat tttgaatatt
     3001 gtcttttcat tttaataaag ttatattact tatttatgac accgttaaaa aaaaaaaaaa
     3061 aaaaa
//
